Consider the instructions and reviews for Ramazid N. This drug is classified as a therapeutic agent with a combined effect. It is suitable for normalizing high blood pressure in patients. The main active ingredients of this pharmaceutical are hydrochlorothiazide and ramipril.
Composition
The main components of the presented drug are ramipril and hydrochlorothiazide. Additional substances are the s alt of sodium carbonic acid along with milk sugar, croscarmellose and corn flour (starch). Reviews of "Ramazid N" will be presented at the end of the article.
Issue format
"Ramazid N" is produced in the form of tablets. The color of the pills is white, and their shape is oval. Packing type: blister. This remedy is made in two dosages:
- The substance ramipril is 2.5mg and hydrochlorothiazide is 12.5mg.
- Ramipril 5 mg and hydrochlorothiazide 25 mg.
The medicine in question is produced by Icelandicby Actavis.
Product properties
The substance ramipril is classified as an angiotensin-converting enzyme inhibitor. This component accelerates the coronary circulation, decreases the total peripheral vascular resistance, normalizes the pressure in the capillaries and pulmonary arteries. Among other things, the described medication reduces the production of aldosterone along with the loss of potassium. The drug in question begins to act one and a half hours after ingestion. As a rule, the effect of treatment persists throughout the day. This is confirmed by the instructions and reviews for the Ramazid N tablets.
The second ingredient, hydrochlorothiazide, is considered a thiazide-type diuretic, its main function is to inhibit the absorption of chloride, sodium, potassium, magnesium and water ions. It blocks the excretion of calcium and uric acid from the body.
The effect is usually achieved due to a decrease in the amount of circulating blood, a change in vascular reactivity, as well as an increase in the depressant effect on the nerve nodes. This medicine begins to work one or two hours after taking the pill, the therapeutic effect of it lasts from six to 24 hours. Under the condition of constant intake of the drug in question, the volume of the myocardium in the body decreases, the process of gluing platelets decreases, the heart rate improves along with blood flow. According to reviews, "Ramazid N" is very effective.
Pharmacokinetics
The main component, ramipril, can be absorbed in two to four hours. The process of assimilation of hydrochlorothiazide takes, as a rule, from one to five hours. This active ingredient binds to plasma proteins by 73%, and the second substance, which is hydrochlorothiazide, by 65%. The withdrawal of the drug occurs through the kidneys. The cleansing time of the body is from five to fourteen hours.
Indications for use
Ramazid N pills are used only if patients have arterial hypertension. This drug is suitable for use in those patients who are prescribed combination therapy with ramipril and hydrochlorothiazide.
Instructions for taking and doses
As a rule, treatment with Ramazid N pills begins with a minimum dosage. If necessary, the volume of the drug can be gradually increased to the maximum level (10 mg of ramipril and 25 mg of hydrochlorothiazide per day). This volume of medication is used until the required pressure indicator is reached.
If the patient is receiving diuretics, then before starting treatment, you need to reduce their number or stop taking them altogether. In general, the doctor selects the dose for each patient individually, depending on what kind of blood pressure is observed in the patient and his general condition is taken into account. The drug is taken once a day, preferably in the morning. It must not be chewed or crushed.
Interactions with other medicines
It is better to familiarize yourself with reviews of Ramazid N tablets in advance. The effect of the considered therapeutic agent is enhanceddrugs to normalize high blood pressure, as well as vasodilators, barbiturates, phenothiazine drugs, tricyclic antidepressants and ethyl alcohol.
S alt intake, use of vasopressor-type sympathomimetics, non-steroidal anti-inflammatory drugs, indirect antithrombotic drugs, and medicines containing clofibrate may reduce the effect of taking this drug. The use of "Ramazid N" and drugs that contain a high dose of lithium leads to the accumulation of this element in the body.
Side effects
According to reviews of Ramazid N, the pharmaceutical agent in question can cause headaches in people along with tightness in the temples. During treatment, patients may experience side effects in the form of a significant decrease in blood pressure, orthostatic collapse, rapid heart rate, kidney failure and decreased urine output.
In addition, the appearance of migraine, weakness and drowsiness, anxiety, various disorders of the normal functioning of the auditory, visual, tactile and olfactory organs, deviations in the functioning of the intestines and liver are not excluded.
According to reviews, the body can react to Ramazid N tablets with nausea, pain or discomfort in the epigastric region, a feeling of dry mouth, shortness of breath, rash, itching of the skin, photosensitivity, muscle cramps, fever and so on. It should be noted that all of the above side effects directly depend onindividual characteristics of the organism of a particular patient.
Contraindications
The medication in question is not recommended for use against the background of the following conditions and diseases:
- In the presence of angioedema and kidney pathologies.
- In case of undergoing artificial kidney therapy.
- Against the background of the development of stenosis of the aorta or mitral heart valve.
- If you have cardiomyopathy, Conn's syndrome or gout.
- Insufficient levels of potassium and sodium in the blood.
- Against the background of an excess of calcium in the body.
- Under the age of 18.
- In case of individual intolerance to the substances that are part of the medicinal product in question.
- When pregnant. It is strictly contraindicated to take "Ramazid N" during gestation and in case of breastfeeding.
Overdose
According to reviews of Ramazid N pressure tablets, taking excessive doses of the described therapeutic agent threatens the appearance of the following overdose symptoms: excessive lowering of blood pressure, weak heart rate, weakness and shock, dryness in the oral cavity, water and electrolyte balance. As part of first aid, a person is required to be placed in a supine position, and then his lower limbs should be raised.
In the event of a mild overdose, patients undergo a gastric lavage procedure along with taking sorbents. In the presence of severeconditions, patients are being treated in a hospital.
What else should I know about the drug?
Give more information about this drug:
- When eating food together, the rate of absorption of the described drug decreases.
- Using medication as part of therapy reduces the effects of oral contraception.
- Elderly patients should take this drug with great care.
- Ramazid N is a prescription drug.
- It has an impact on driving and on the work associated with the interaction with complex mechanisms.
- At the start of taking the pills, a regular check-up of kidney function is required.
Special Instructions
Some care must be taken when prescribing this remedy to patients who are on a s alt-free diet (because of the increased risk of developing low blood pressure). Symptomatic hypotension may occur in patients with low blood volume (as a result of diuretic treatment) during dialysis, vomiting and diarrhea.
In patients undergoing major surgery or receiving other drugs that cause pressure reduction during general anesthesia, ramipril can provoke blockade of angiotensin formation due to the renin release process. If the doctor attributes the appearance of low blood pressure to the mentioned mechanism, then this condition should be corrected by increasing the volume of blood plasma.
Arterial transient hypotension is not a contraindication for continuing therapy after pressure stabilization. In the event of a recurrence of a pronounced decrease in indicators, the dosage should be reduced or the drug should be discontinued altogether.
Terms and conditions of storage
The drug must be kept away from the rays of the sun and it is also necessary to limit the access of children to it. Such a product should be stored in a dry place at temperatures up to 25 degrees. Its shelf life is three years.
Price
In Russia, for 30 tablets with a dosage of 2.5 mg of ramipril + 12.5 mg of hydrochlorothiazide, you need to pay an average of 400 rubles. It all depends on the region.
Analogues
If the need arises, you can replace the described medicine with an alternative medicine. For example, among its analogues it is worth mentioning "Amprilan" along with "Khartil-D", "Aritel Plus", "Bisangil", "Renipril", "Triamtel", "Enalapril N", "Akkuzid", "Simartan N", " Enap", "Mikardis", "Lizoretic", "Lodoz", "Coaprovel" and others. According to reviews, analogues of "Ramazid N" work no worse.
It is important to note that, if necessary, a substitute drug is prescribed only by a doctor according to the individual characteristics of the patient's state of he alth.
Reviews about Ramazid N
On the Internet, on various sites and forums, there are not many comments about this tool. But those people who suffer from high blood pressure and have ever taken the medicine "Ramazid H 2, 5" report in their reviews about iteffectiveness, and at the same time about a fairly quick effect on the body.
The disadvantages of the described tablets, consumers include a large number of different contraindications and adverse reactions, as well as the existing ban on taking this drug for pregnant and lactating women.
Some write that after prescribing them, this medication, unfortunately, did not fit, against the background of its use, side effects occurred in the form of nausea and a general deterioration in well-being. Doctors, in turn, comment on such situations with the need to replace "Ramazid N" 2.5 mg.
In the reviews, people also say that this drug, on the contrary, serves as a good helper with pressure, and therefore patients can use it for years and achieve the desired therapeutic effect. According to doctors, a lot depends on the body, so some take this medicine, while others have to select analogues.
As reported in the reviews of Ramazid N, if the drug is suitable, it can be drunk for a long time, it helps to feel good, keeping the pressure always normal, and the side effects do not bother at all. Thus, quite often in the comments you can read that these pills do their job. They do not cause allergies in most patients.
Some people complain that this drug costs a little more than Russian counterparts, but many people believe that it is better to pay a little more for the quality to achieve the desired therapeutic effect. It is also noted that these pills are not large andswallow without problems. This is confirmed by reviews of Ramazid N 5 mg / 25 mg. 30 tablets per pack is very convenient.
Thus, the drug is a combined drug suitable for the effective treatment of arterial hypertension. Regular intake of the considered pharmaceutical helps to control blood pressure and has a diuretic effect. The tool has a number of contraindications, which must be familiarized with before starting treatment. This can be done through the instructions for use. Reviews of Ramazid N should also be read before use.
