Venotonics and angioprotectors are a category of substances that make it possible to strengthen and restore the walls of blood vessels. Such pharmacological substances include, according to the instructions for use, Troxevasin tablets, the price of which is 650 rubles. The drug has been known for a long time and is widely used for diseases of the legs, in particular varicose veins, angiopathy, venous spasms and circulatory pathology as a result of injuries. "Troxevasin" can help improve blood flow in places of trophic tissue damage due to impaired venous blood flow. This drug is used by many patients, as it is highly effective in the treatment of many pathologies.
Composition
One tablet contains 300mg of an active ingredient called troxerutin. It performs the main function of the drug. The excipients are as follows: lactose monohydrate, magnesium, gelatin, E104, E110, E171.
Pharmacodynamics
"Troxevasin" - a complex of bioflavonoids, including at least 95% troxerutin. It has anti-inflammatory and antioxidant effects, inhibits hyaluronidase, prevents oxidation. Troxerutin reduces the high permeability and fragility of capillaries, prevents the disruption of the basal membrane of endothelial cells, and, in addition, it also has antioxidant, membrane-stabilizing, anti-hemorrhagic, anti-inflammatory, venotonic effects. The drug reduces swelling, improves trophism, microcirculation, microvascular perfusion and other signs associated with venous insufficiency or impaired outflow of lymphoid fluid.
Pharmacokinetics
Instruction tablets "Troxevasin" indicates that Cmax in plasma is set between 1-9 hours after taking the drug. The reduction in plasma congestion is bioexponential. Connection with blood plasma proteins in the range of 27–29%, in maximum proportions accumulates in the endothelial matter. It does not pass through the BBB, seeps through the placental barrier in small quantities, and in small concentrations enters breast milk. Metabolized via glucuronidation in the liver. It is mainly excreted from the body with bile, in a small amount - with urine.
Assigned to whom?
Instructions for the use of Troxevasin tablets and reviews suggest that the drug is prescribed to people with a history and directly suffering from the following diseases:
- varicose veins and allwhat is connected with it;
- phlebitis, thrombophlebitis and post-phlebitis condition;
- venous insufficiency in chronic form;
- hemorrhoids;
- in combination with other drugs for the treatment of diabetic retinopathy;
- for dislocations, sprains, contusions.
Application
"Troxevasin" is mainly used in the European Union. In our country, in the pharmacy network, capsules of a pharmaceutical preparation are presented more. There is no particular difference in pharmaceutical forms. For this reason, the instructions for use are similar for capsules and tablets: ingestion on an empty stomach with the required amount of water. During the reception period, it is forbidden to drink other pharmaceutical preparations half an hour before and within an hour after. The terms of taking the substance are long, with systematic repetitions of courses. As a rule, therapy is practiced for 40 days in spring and autumn. This makes it possible to completely stop the progression of venous insufficiency. Also, with prolonged use, it is possible to partially restore damaged vascular valves.
Side effects
Adverse reactions rarely occur during drug therapy.
Immune system: dermatological allergic reactions - rash, irritation, urticaria; very rarely - anaphylactic shock, anaphylactoid reactions, hypersensitivity reactions.
Nervous: rather rare - dizziness, headache and sleep disorders.
Vascular pathology: very rarely - ecchymosis.
Digestive system: extremely rare possible stomach discomfort, dyspepsia, vomiting, nausea, bloating, diarrhea.
General pathologies: quite rare - high asthenicity.
Due to the presence of the dye (E110), substance therapy may provoke an allergic reaction, including asthma.
Consequences and contraindications
Unconditional contraindications to the use of the drug is not defined. With caution, it is recommended to use the substance in the first trimester of pregnancy and for those who have ulcerative lesions of the gastrointestinal tract (GU, DU, ulcerative nonspecific colitis, peptic ulcer of the alimentary tract).
Minor symptoms are headaches, dizziness and tinnitus. All without exception, this is considered a direct result of the effect of a pharmaceutical agent on the vascular bed: cerebral blood flow improves, in accordance with this, the saturation of blood vessels with blood changes. In exceptional cases, urticaria occurs, which tends to turn into an allergic dermatitis. In this case, drug withdrawal is indicated.
Special Instructions
The product will not be effective for swelling of the legs due to diseases of the liver, kidneys or cardiovascular system. The drug is prescribed with caution to patients with serious diseases of the liver and gallbladder.
Since the drug can irritate the mucous layer of the stomach, it must be used during meals. A drugcontains lactose, for this reason it should not be used in patients with rare hereditary diseases such as galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. The risk of allergy is greater in patients with high sensitivity to acetylsalicylic acid.
Pregnancy. There are no data on the negative effects on pregnant women and girls who are breastfeeding, however, despite this, its use in the first trimester of pregnancy is not recommended.
Breastfeeding. The drug passes into breast milk in small doses, but there is no information that they caused clinically important reactions in newborns. The decision on the possibility of using a substance of this group by women is made by the doctor.
"Troxevasin" does not have a big effect on the ability to drive vehicles and work with mechanisms.
Interaction with other drugs
When taken simultaneously with other substances, this drug can change both its effect and the effect of other substances on the body. This should be taken into account if "Troxevasin" is not the only pharmaceutical substance that is used.
If necessary, you need to immediately adjust the course of treatment or choose the most effective, as well as extremely harmless analogues and alternative medicines. However, "Troxevasin" very rarely interacts with any substances. It was found that the result of strengtheningthe vascular wall increases if taken together with ascorbic acid.
But this does not mean at all that all kinds of medicines can be freely taken together with this substance. It is better to consult a doctor so that the course of treatment is extremely effective and does not pose any danger to he alth.
In medicine, there are many analogues of this drug. Let's take a look at some of them below.
Troxerutin
"Troxerutin" (capsules) is a drug that belongs to the group of angioprotectors, the pharmacological action of which is to reduce the permeability of the vascular walls due to an increase in their density. "Troxerutin" acts as an analogue of "Troxevasin", it is available in the form of capsules and is intended for ingestion. Capsules of the drug are hard, gelatinous, yellow.
Indications for the use of "Troxerutin" is severe venous insufficiency and preventive measures for problems of intravenous circulation. This drug is prescribed for the following diseases and pathological conditions:
- Varicose venous disease of the lower extremities and venous insufficiency.
- Thrombophlebitis.
- Dermatitis, trophic ulcers.
- Post-traumatic hematomas and edema.
- Hemorrhoids complicated by bleeding and itching.
Troxerutin is also applicable for complication of diabetes mellitus: retinopathy anddiabetic angiopathy.
Contraindications and usage
Contraindications to the use of "Troxerutin" are: acute forms of pathologies of the gastrointestinal tract (gastric ulcer, as well as duodenal ulcers, gastritis), the first trimester of pregnancy, weak or incomplete lactation, children under 12 years old, individual intolerance to this drug.
Capsules "Troxerutin" after appointment by the attending physician are taken orally (the capsule is washed down with water) during meals, as a rule, 3 times a day at a daily dose of 900 mg. Upon reaching the therapeutic effect, the daily dose is reduced to 600 mg. The average duration of application is about 4 weeks. Individual dosage is determined by the attending physician.
Phleboton
"Phleboton" is an analogue of "Troxevasin" tablets. The price of the drug, whose action is aimed at toning capillaries and veins, is 389 rubles. The tool has an anti-inflammatory and antioxidant effect. It is used in the treatment of the following diseases:
- Varicose ulcers.
- Varicose dermatitis.
- Venous insufficiency.
- Pre- and varicose syndromes.
- Hemorrhoidal disease.
- Pain with varicose veins.
Release form - hard capsules, 300 mg. The active substance is troxerutin. Available without a doctor's prescription.
Contraindications
Contraindications for taking Phleboton are:
- increasedsensitivity to the active substance;
- chronic diseases of the gastrointestinal tract (gastric and duodenal ulcers, gastritis during an exacerbation).
The following side effects and reactions may develop:
- headache and dizziness;
- insomnia;
- pain in the abdomen;
- flatulence and diarrhea;
- anaphylactic shock;
- violation of the functions of the gastrointestinal tract;
- itching and skin rashes;
- increase in general fatigue;
- ecchymosis.
During therapy with the use of Phleboton, special indications that are characteristic of the drug should be taken into account:
- when pregnant - should be avoided in the first 3 months, further use is allowed by prescription if the effectiveness of therapy exceeds the risk to the fetus;
- with chronic diseases of the liver, as well as the gallbladder, the drug should be taken with caution.
Venorutinol
"Venorutinol" is used as a regular and local therapy for chronic varicose insufficiency, which is accompanied by trophic disorders, swelling and constant pain in the lower extremities. In addition, the gel and tablets are prescribed for vein pathology, including after surgery and during pregnancy. "Venorutinol" is prescribed for patients with hemorrhoids. The drug is not prescribed to patients with individual intolerance to troxerutin. Tablets should not be prescribed to patients with duodenal and gastric ulcers, andalso an exacerbation of chronic gastritis.
Use
Specialized for oral use. Do not split or crush the capsule. To reduce the risk of formation of unnecessary results, the drug is recommended to be taken with meals. The duration of therapy and dose is determined by the attending physician.
In most cases, it is recommended to prescribe 1 capsule of the substance twice a day. After the condition improves, they switch to a maintenance dose - 1 capsule per day. With a complicated course of the disease, the dose of the substance is increased to 1-2 capsules three times a day. Patients with paresthesia and nocturnal tonic convulsions are recommended to take the medication 1 capsule per day (Venorutinol should be consumed before bedtime).
Patients often write about the effectiveness of the drug and reasonable price in reviews of Troxevasin tablets. Also taking this drug indicate its beneficial properties, effectiveness. But it is not recommended to take without an appointment, the consequences are different. And most of them are difficult to treat. By following all the recommendations and prescriptions of the doctor, having carefully studied the instructions for using Troxevasin tablets (the price of the medicine is acceptable), you can forget about he alth problems for a long time.
