There are many bisoprolol-based medicines that have been successfully used to treat high blood pressure and heart failure. Among them, the domestic drug "Bisoprolol-Prana" is distinguished.
Characteristic
This selective beta-adrenergic blocking agent is produced by the Russian company PRANAPHARM LLC.
Available in the form of round, biconvex tablets that are divided and film-coated.
When using Bisoprolol-Prana, the instructions for use are the first thing you need to pay attention to. The drug is available in the following dosages: 5 and 10 mg. The color of the shell of the smaller tablets is light yellow, and the large ones are light orange. The contents of the medicine are almost white.
Composition
One tablet of the drug "Bisoprolol-Prana" contains 5 and 10 mg of bisoprolol hemifumarate as an active substance. Availabilitymagnesium stearate, corn starch, microcrystalline cellulose, crospovidone, colloidal silicon oxide, calcium anhydrous hydrogen phosphate allows you to form a drug and provide the necessary solubility and bioavailability.
The 5mg film coating contains yellow iron oxide, polyethylene glycol (grade 400), titanium dioxide, silicone. The coating that wraps around the large pill contains another colorant in the form of red iron oxide.
Mechanism of action
Bisoprolol-Prana is referred to selective beta-adrenergic blocking agents that do not have their own sympathomimetic activity. Instructions for use describe its pharmacodynamic features. Tablets have the effect of reducing pressure, normalizing the rhythm and eliminating myocardial muscle ischemia. When blocking beta 1-adrenergic receptors of the heart with small doses of the drug, there is a decrease in the production of cyclic adenosine monophosphate and the flow of calcium ions inside the cells. There is also a decrease in the contraction of the heart rate and its frequency, processes associated with conduction and excitability are inhibited.
Hypotensive effect is manifested by underestimation of the value that determines the minute volume of blood circulation, reducing the impact on the peripheral vascular bed. A decrease in high pressure occurs after a few days, and a two-month treatment is necessary to stabilize the action.
Antiarrhythmicthe effect is manifested when the causes that violate the heartbeat are eliminated. These include the state of tachycardia, increased activity of the nervous system in the sympathetic department, an increased content of cyclic adenosine monophosphate, arterial hypertension.
Indications for use
Before use, it is necessary to study for which groups of patients "Bisoprolol-Prana" is intended. Indications for use are associated with antianginal effects. It is due to the lower need of the cardiac myocardium for oxygen molecules due to a decrease in the frequency of contractions, an increase in blood supply and time during diastole.
What is the effect of a drug such as Bisoprolol-Prana tablets, what are they taken from? Given their pharmacotherapeutic characteristics, they are used for:
- hypertension therapy;
- ischemic heart disease;
- strain angina;
- for the prevention of secondary myocardial infarction:
- chronic deficiencies.
Here are the main groups for which the use of the drug "Bisoprolol-Prana" is desirable. Indications for use are associated with impaired cardiac work. These include sinus increase in rhythm, supraventricular and ventricular extrasystole, changes in heart rate with protrusion of the mitral valve and hyperthyroidism.
Specific use of the drug
Instructions for use "Bisoprolol-Prana" recommends taking the medicine in the morning before breakfast, entirely without chewing.
For the treatment of hypertension, cardiac ischemia and the prevention of angina pectoris, a single dose of a smaller dose of tablets, including 5 mg of bisoprolol, is used. If necessary, the dosage is doubled, but it is also used once. The maximum amount of bisoprolol should not exceed the daily allowance of 20 mg.
Only the attending physician can prescribe the dosage and time of taking the "Bisoprolol-Prana" remedy. Indications must comply with the instructions of the drug. Before the appointment, check the frequency of contractions of the heart muscle. It is possible to adjust the number of tablets after studying the therapeutic response.
Many patients wonder if Bisoprolol-Prana can be divided in half. The presence of a separator makes it possible to reduce the tablet if a different dosage is needed.
To eliminate chronic heart failure, use 1.25 mg of bisoprolol for the first week. This dose can be obtained by dividing the tablet containing the active substance 2.5 mg. However, you will have to start therapy with a drug from another manufacturer, since Bisoprolol-Prana is only available in 5 and 10 mg. During the second week appoint 2.5 mg. From the 14th day of treatment, take 3.75 mg of medication. On the fourth week, the dosage is increased to 5 mg, and after two months of therapy, 7.5 mg of bisoprolol is used. The twelfth week starts with a dose of 10 mg.
If the patient has various disorders in the functioning of the kidneys or liver, and the creatinine clearance values \u200b\u200bare less than 20 ml per 1 minute, then the maximum possibleprescribe no more than 10 mg of the drug.
When carrying out a planned operation, bisoprolol is canceled two days in advance so that it does not affect anesthesia. If a pill has been drunk, then a painkiller is selected that exhibits an inotropic effect, negative in the minimum amount.
When an elderly patient has an attack of bradycardia with a heart rate of less than 52 beats per minute, arterial hypotension with a systolic pressure of less than 100 millimeters of mercury, bronchospasm, ventricular arrhythmia, hepatic and renal work is disturbed, then the dosage is reduced, up to complete withdrawal of therapy. The exclusion of bisoprolol can cause the development of a depressive state, which is caused by this beta-blocker.
Dosage adjustments are not made for the elderly.
A sharp interruption of treatment is not allowed, which can cause the development of a severe form of arrhythmia or myocardial infarction. Cancellation of the drug is carried out by gradually reducing the dose over 14 days. For three days, a dosage reduction of 25% is allowed.
Features of treatment
For the use of "Bisoprolol-Prana" instructions for use include a list of measures that control the condition of a sick person. These include daily, at the initial stages, the determination of the heart rate and the measurement of pressure, which are then checked after three months. Other important indicators are the electrocardiogram and sugar levels in diabetics, which are measured no more often than after 5 months.
Elderly patients need periodic monitoring of kidney function, which is carried out after 4 months.
Treatment of chronic heart failure at the initial stage of taking a low dose requires a four-hour examination of the patient, during which the heart rate, blood pressure are checked and an electrocardiogram is taken.
Before prescribing treatment with bisoprolol, the patient is taught how to calculate heart rate. In case of low values of this indicator (up to 50 beats per minute), medical consultation is required.
Also describing the effect of the drug "Bisoprolol-Prana", the instruction includes information on the need for studies that determine external respiration for patients with bronchopulmonary diseases.
Beta-blockers do not help treat angina pectoris for all patients. Their inefficiency is due to the presence of severe coronary atherosclerosis, which has a low ischemic threshold. In this state, the heart rate will be less than 100 beats per minute, and there is also an increase in the end-diastolic volume in the left ventricle with a violation of subendocardial blood flow. Bisoprolol also helps smokers worse.
People with bronchospastic disorders are prescribed such a cardioselective agent if there is intolerance and low effectiveness of drugs that reduce blood pressure. Overdose is more likely to cause bronchial spasm.
If patients with thyrotoxicosis are treated with a beta-blocker, masking is possibleindividual clinical signs of excessive thyroid function, primarily tachycardia. Such patients should not be abruptly discontinued to avoid worsening symptoms.
If patients wear contact lenses, then taking bisoprolol can cause a decrease in the production of tear fluid, which requires additional instillation of special eye drops.
When the drug is used by patients with pheochromocytoma, paradoxical arterial hypertension is possible. In this case, preliminary alpha-blockade action is necessary.
The presence of diabetes masks attacks of tachycardia caused by a decrease in blood glucose levels. Being a selective beta-blocker, the drug is not able to enhance the insulin hypoglycemic state and slow down the normalization of glucose levels to the desired values.
Catecholamines, normetanephrine, antinuclear antibodies and vanillylmandelic acid in the blood and urine are determined only when Bisoprolol-Prana is excluded.
For pregnant and lactating women, medication is prescribed taking into account the benefits for the mother's body, but there is a possibility of undesirable consequences in the embryo.
Who is the treatment contraindicated for?
Tablets "Bisoprolol-Prana" instructions for use do not recommend using with increased susceptibility, acute or chronic form of decompensated insufficiency of the heart muscle, cardiogenic shock, blockade of the sinoauricular and atrioventricular of the second and third type, with a syndrome,associated with weakness in the sinus node, slow heartbeat with an intensity of less than 60 beats.
Contraindication is the presence of:
- cardiomegaly with increasing size and mass of the heart muscle;
- low pressure in arteries with systolic value less than 90 millimeters of mercury;
- chronic obstructive pulmonary disease;
- bronchial asthma;
- circulatory disorders in the peripheral vessels in the later stages.
Unwanted consequences
The drug "Bisoprolol-Prana" can provoke various side effects that affect the central and peripheral zones of the nervous system. They are manifested by headache, fatigue, sleep disturbance, depression and hallucinations.
Undesirable processes in the heart and blood vessels are caused by orthostatic hypotension, hot flashes, sweating, slow heartbeat and myocardial insufficiency.
Other manifestations of side effects are reduced secretion of the lacrimal gland, the development of conjunctivitis, diarrhea, itchy skin, constipation, nausea, muscle weakness and cramps. Obstructive symptoms may appear in the bronchi.
Similar preparations
The original remedy based on bisoprolol are tablets "Concor". They are produced by the German company Merck.
Based on this medication, similar preparations were developed containing the substance of bisoprolol as an active ingredientfumarate.
Russian drug manufacturers produce beta-blockers with different trade names. An example is the remedy "Bisoprolol-Prana": its analogues have a dosage of 2.5 mg, 5 mg and 10 mg. These medicines include pills:
- "Bisogamma";
- Niperten;
- "Kordinorm";
- Biprol.
Similar products are also produced by foreign companies. There are drugs on the pharmaceutical market, the name of which contains the name of the enterprise, for example, Bisoprolol-Teva, Bisoprolol-Ratiopharm, Bisoprolol-Sandoz, Bisoprolol-Lugal.
There are analogues that are simply called "Bisoprolol". Such medicines are produced by Russian factories: CJSC Vertex, CJSC Severnaya Zvezda, LLC Ozon Pharmaceuticals, CJSC Biokom.
If we compare the tablets "Bisoprolol" and "Bisoprolol-Prana", the difference will be in the qualitative and quantitative composition of the auxiliary components. Such discrepancies do not affect the bioavailability and permeability of the active substance in the body, which means that the therapeutic effect of the drug will be the same.
Reviews
Many patients note the convenience of using medications containing bisoprolol, because they are taken only once a day. One tablet is enough for the whole day to normalize blood pressure.
About the tool "Bisoprolol-Prana" reviews are not bad. They indicate its high selectivity, which is why taking pills is accompanied by a smaller amountside effects compared to other beta-blockers.
Patients report ease of use and rare side effects that encourage some patients to switch to this drug.
Men say that taking the drug does not cause potency disorders. In addition, this fact has been proven through numerous studies.
The drug "Bisoprolol-Prana" shows metabolic neutrality in relation to cholesterol, triglyceride and glucose metabolism. This property allows it to be prescribed to patients with type 2 diabetes mellitus or a predisposition to increased blood glucose levels. Accordingly, such patients also leave positive feedback about the drug.
Due to the low number of adverse reactions, tablets are prescribed to patients in old age. Patients claim that the drug is more effective and safer than other beta-blocker antihypertensive drugs.
The advantage of the drug "Bisoprolol-Prana" is its low price, which is quite affordable for low-income people, which is also reflected in the grateful reviews.
But despite all the advantages of pills, only a doctor can prescribe them based on the results of the examination.
