"Mexibel" from "Belmedpreparatov" is a drug that has an antihypoxant, antioxidant, nootropic, anticonvulsant, membrane-protective, anxiolytic effect.
Forms of release and composition specifics
The drug has two forms of release.
1) Coated tablets.
Each Mexibel tablet from Belmedpreparat contains the active substance: methylethylpyridinol succinate (one hundred twenty-five milligrams). The excipients are as follows: methylcellulose, calcium stearate, lactose monohydrate, colloidal anhydrous silica, povidone K-25, Opadry II color (batch 85F), white, potato starch, croscarmellose sodium.
2) Solution for injection in a five percent concentration, which contains 0.2 grams of mexidol as an active ingredient. Reviews of "Mexibel" from "Belmedpreparatov" are presented below.
Pharmacological properties
The drug increases the patient's resistance to stress andthe influence of the main damaging symptoms, as well as oxygen-dependent pathological conditions (hypoxia, intoxication with antipsychotic drugs and alcohol, shock, ischemia, cerebral circulatory defects, etc.). Has a moderate hypolipidemic effect.
Thanks to the use of the drug, the state of the membrane structures of blood cells is stabilized, leukocytes and platelets become more stable during hemolysis, the physicochemical changes in the properties of the membranes of nervous tissue cells due to hypoxia are eliminated (the viscosity of the lipid bilayer decreases, the membrane fluidity increases and the proportion of lipid- protein), and this, in turn, has a beneficial effect on biosynthetic and metabolic activity.
Lipid peroxidation is inhibited, the activity of superoxide dismutase increases, the content of cGMP and cAMP inside the cell increases, the activity of membrane-bound enzymes is modulated (acetylcholinesterase, adenylate cyclase, Ca-independent phosphodiesterase), receptor complexes (acetylcholine, GABA, benzodiazepine), there is an increase in their ability to bind to receptors and improve the transport of neurotransmitters, as well as synaptic transmission). According to reviews, instructions for "Mexibel" "Belmedpreparatov" are available in each pack.
Due to the use of the drug, the content of dopamine in the brain increases, the compensatory activation of aerobic glycolysis increases, andredox processes in mitochondria under conditions of hypoxia, the synthesis of creatinine phosphate and ATP increases. Reduced toxemia of enzymes and endogenous intoxication in acute pancreatitis.
Efficiency
Injections "Mexibel" ("Belmedpreparaty") improve the working capacity and memory of patients, have an anxiolytic effect, eliminate tension, anxiety, anxiety, fear, improve the emotional background. In addition, the drug has a neuroprotective effect, stimulates the recovery and adaptive processes in the brain in the presence of a traumatic brain injury.
Accelerates the evolution of hemorrhages occurring inside the brain, including also post-traumatic ones. In patients who have suffered a serious defect in cerebral circulation, as a component of complex treatment, it favorably affects the processes of oxygen transfer in the brain during hypoxia, reducing the maximum respiratory rate and increasing the stationary level of oxygen partial pressure in the nervous tissue. It also reduces the consequences determined by the reperfusion syndrome during coronary insufficiency.
Reviews about "Mexibel" ("Belmedpreparaty") are of interest to many.
When is the drug used?
The product is used as an integral part of complex therapy for:
- circulatory disorders of the brain of an acute nature, determined by traumatic brain injury;
- cognitive disorders withatherosclerotic lesions of the cerebral vessels of the head;
- intellectual insufficiency and memory impairment in elderly patients;
- intoxication;
- withdrawal syndrome on the background of alcoholism, if there are vegetovascular and neurosis-like defects;
- anxiety disorders in neurotic and neurotic conditions;
- purulent-inflammatory processes of acute form occurring in the abdominal cavity (peritonitis, necrotizing acute pancreatitis);
- acute poisoning with antipsychotic drugs. According to reviews, Mexibel injections (Belmedpreparaty) are very effective.
Dosage
The drug in the form of tablets is taken orally from 0.25 to 0.5 grams per day in two to three doses. In this case, the maximum dose ranges from 0.6 to 0.8 grams. The duration of therapy is from two to six weeks. In order to suppress alcohol withdrawal - from five to seven days. The dosage of the drug is individually selected for each patient, which is determined by the degree of the disease. Gradually, treatment is stopped, the dose is reduced over two to three days.
In the form of a solution, the drug is injected into a vein, drip, from forty to sixty drops per minute. The dosage is also selected individually. It is recommended to use five to ten milligrams per kilogram per day. The maximum daily allowance is 800 mg. This points to the tablets "Mexibel" ("Belmedpreparaty") instruction.
Special Instructions
Whentherapy of the blood circulation of the brain of an acute nature, the drug is used as part of a complex treatment by drip-intravenous injection of two hundred to three hundred milligrams once a day for five to seven days, after which the transition to intramuscular use of the drug is carried out in the form of an injection of two hundred milligrams twice a day. The maximum dose can be increased to five hundred milligrams if the course of the disease is more severe. The treatment lasts from ten to fourteen days.
In case of dyscirculatory encephalopathy, which is in a state of decompensation, the drug should be prescribed intravenously-drip at one hundred to two hundred milligrams two to three times a day for two weeks, and after that - the introduction of two hundred milligrams into the muscle for the same period.
With alcohol withdrawal syndrome, intravenous drip application of the drug is carried out, two hundred to three hundred milligrams from five to seven days.
Intoxication with acute antipsychotic drugs involves intravenous use, one hundred to three hundred milligrams over one to two weeks.
In purulent-inflammatory processes occurring in an acute form in the abdominal cavity, the dosage is determined by the severity of the pathology, the course options, the prevalence of processes. Cancellation is carried out gradually, only after achieving a stable clinical and laboratory effect of a positive nature.
In acute interstitial edematous pancreatitis, one hundred milligrams are prescribed three times a day drip.
With a mild course of necrotizing pancreatitis, from one hundred to two hundred milligrams is administered intravenously three times a day: with an average degree - two hundred milligrams; with severe on the first day, it is used in a pulse dose of eight hundred milligrams, divided into two doses, then three hundred milligrams twice a day, gradually the daily dose decreases. If the course of the disease is very severe, then the initial dose is eight hundred milligrams per day until the symptoms of pancreatogenic shock are permanently blocked, as soon as the condition stabilizes, three hundred to four hundred milligrams are intravenously administered twice a day, the daily dose is gradually reduced. Cancellation also should not be abrupt, carried out after a steady improvement in performance.
Side symptoms
According to reviews, the digestive system can react to Mexibel (Belmedpreparaty) as follows: a “metallic” taste, dryness, flatulence, nausea and diarrhea. Other side effects include a state of spreading heat throughout the body, drowsiness, and allergic reactions.
Contraindications
Sensitivity of an individual nature to a drug. Hepatic and / or renal failure of an acute nature, age up to eighteen years, pregnancy, lactation. The drug is used with caution in the presence of a history of hypersensitivity reactions.
Reviews about "Mexibel"("Belmedpreparaty")
Reviews of patients about the use of the drug are controversial. Among its advantages, efficiency and affordable price are noted. The drug quickly helps, eliminates severe headaches. However, injections are quite painful, so they need to be administered gradually to reduce discomfort. At the same time, it is noted that there is a high risk of side effects, such as chills, muscle weakness, and a sharp increase in pressure. Therefore, the drug should be used only after medical consultation.
