Medication "Anastrozole TL" consists of the active element of the same name and auxiliary components that form a shell and improve the absorption of the main substance. This drug has an antitumor effect and is prescribed for breast cancer.
The absolute analogue of this medication is the drug "Anastrozole". The difference between "Anastrozole" and "Anastrozole TL" is that the latter is enhanced by some components that make it easier to absorb and smooth out side effects. Otherwise, these medicines are absolutely identical.
The manufacturer of "Anastrozole TL" is the Russian pharmaceutical company LLC Technology of Drugs.
Features of the drug
A feature of the use of the drug "Anastrozole TL" is its selective effect, within which it does not affect the secretion of other hormones, suppressing onlythe production of estrogen. This reduces stress on the body and eliminates the need to introduce corticosteroids into the therapeutic course to compensate for the negative effects of the drug. It is rapidly absorbed into the tissues from the digestive tract (less than two hours) regardless of the time of the meal. If the drug is taken with meals, this may only slightly affect the process of its absorption. Active substances do not accumulate in the body and do not tend to accumulate. The drug reduces the concentration of estradiol in the blood by 80%.
Scope of application
The scope of the "Anastrozole TL" is quite narrow. It is prescribed exclusively for breast cancer, with menopause, if there is a connection between the level of estrogen and the progression of the development of neoplasms.
Contraindications
According to the instructions for "Anastrozole TL", treatment with a cancer drug has some contraindications:
- reproductive age, lactation, pregnancy;
- renal, liver failure;
- the presence of other pathologies that cast doubt on the effectiveness of the upcoming therapy.
Adverse reactions
After changing the type of hormonal treatment against the background of severe stress, side effects may occur that differ in their intensity and severity for he alth. According to reviews of "Anastrozole TL", most often observed in patients:
- nervous disorders: dizziness, lethargyor, on the contrary, excessive excitement, headache, drowsiness, neurosis, insomnia;
- digestive disorders: diarrhea, constipation, nausea, loss of appetite, dry mouth;
- disturbance of coordination, deterioration of the reactions of the nervous system to the influence of external factors;
- dermatological manifestations: skin rashes, itching, burning, excessive sweating.
Other negative manifestations
Also often there are such negative consequences as partial baldness, pain in the back and chest, uterine bleeding. In most cases, these symptoms are characteristic of the period of initiation of the drug. Further, after a certain time, when the body gets used to the changed hormonal background, the side effects become insignificant and imperceptible. This is confirmed by the instructions for use for Anastrozole TL.
Analogues
The list of analogues of this drug includes:
- "Egistrazol" is a strong and highly selective non-steroidal aromatase inhibitor, an enzyme that converts testosterone and androstenedione in tissues into estradiol and estrone in women. A decrease in the concentration of estradiol circulating in the blood in patients with oncological tumors of the mammary gland has the necessary therapeutic effect. The main substance of this medication is anastrozole. It has no androgenic, progestogenic and estrogenic activity, and in daily dosages it has no effect on the production of cortisol and aldosterone. When using anastrozole, replacement therapy with corticosteroids is not required. This medicine is indicated for the adjuvant treatment of early-stage hormone-receptor-positive breast cancer in postmenopausal women. Also, the drug can be prescribed in the treatment of metastatic or locally advanced cancer of the gland, with an unknown or positive hormonal status, and in advanced cancer after previous treatment with tamoxifen. Produced in tablets.
- "Anastera" - an antitumor medicine. It is a selective non-steroidal substance that suppresses the production of aromatase. In postmenopausal women, estradiol is formed mainly from estrone, which is synthesized in peripheral tissues from androstenedione (with the participation of aromatase). Reducing the level of estradiol has a high therapeutic efficacy in women with breast cancer. It can be prescribed exclusively to those women who are in the postmenopausal period. This drug is contraindicated in the premenopausal period, with severe renal failure, moderate and severe liver failure, during pregnancy, lactation, hypersensitivity. This medicine is available in tablet form.
- Selana is a drug that has an inhibitory effect on an enzyme that promotes the conversion of androstenedione to estrone in postmenopausal women. The main element present in the composition of the drug has a high antitumor efficacy against estrogen-dependent neoplasms of the mammaryglands. It has the same list of indications, contraindications and negative side effects as "Anastrozole TL" and the above analogues of this drug.
- "Abitaxel" is a remedy that is not a structural analogue of the drug in question, but has an identical therapeutic effect. It is an antitumor drug, an inhibitor of mitosis. Paclitaxel, present in the composition, binds to microtubule beta-tubulin, which disrupts the depolymerization of this protein and helps to suppress the correct dynamic reorganization of microtubules. This plays a decisive role during the interphase period, without which cellular functions in the mitosis phase are impossible. In addition, this active substance causes the formation of abnormal microtubule bundles during the entire cell cycle and the appearance of several centrioles during mitosis. This medication is prescribed for oncological diseases of the breast, ovaries, lungs, esophagus, bladder, etc. It is contraindicated in the development of neutropenia, during pregnancy and high sensitivity to the active element. The drug is produced in the form of a concentrate for the preparation of an infusion solution.
- "Bilem" - an antitumor antiestrogen drug. Competitively suppresses estrogen receptors in tumors and target organs. As a result, a complex arises that, after translocation to the cell nuclei, prevents cell hypertrophy, which depends on estrogen regulation. The medicine hasantigonadotropic properties, inhibits the synthesis of Pg in tumor tissues, inhibits the progression of the malignant process, which is stimulated by estrogens. The ability to block these hormones may persist for several weeks after a single dose. In addition, the drug can induce ovulation in women by stimulating the release of GRF from the hypothalamus. In men with oligospermia, it increases the concentration of FSH and LH, as well as estrogen and testosterone in the blood. The main substance and certain of its metabolites are inhibitors of the oxidase function of the cytochrome P450 system in the liver, but the clinical significance of these effects has not been determined. This medication is indicated for breast cancer, kidney oncology, melanoma and soft tissue sarcoma, malignant ovarian tumors, endometrial cancer, prostate cancer, etc. The drug is contraindicated for hypersensitivity, pregnancy, lactation, eye diseases, hyperlipidemia, thrombophlebitis, leukopenia, hypercalcemia, thromboembolic disease.
Drug interaction
The dosage at which "Anastrozole TL" poses a threat to life has not been established. In case of drug poisoning, symptomatic therapy is performed and measures are taken to resuscitate the patient.
The medical preparation "Anastrozole TL" is not prescribed with other anticancer drugs, as well as with estrogen-containing medicines due to their mutual substitution when taken in combination.
Clinical trials have shown that whenWhen using this drug with substances such as antipyrine and cimetidine, a drug interaction due to induction of microsomal liver enzymes is unlikely.
Special Recommendations
The drug "Anastrozole TL" cannot be administered as a stand-alone therapy. Its reception requires a preliminary examination with the study of the patient's history. A strict ban on therapy is the suspicion of pregnancy. It is also mandatory to conduct laboratory tests that confirm the state of menopause in a woman. The development of bleeding from the genital tract during treatment is a reason to see a doctor.
Other interactions
It has also been proven that the medical product reduces the density of tissues of the musculoskeletal organs. It must be remembered that the effectiveness of therapy with the drug is significantly reduced with the parallel administration of drugs that contain estrogens. Reviews of doctors about "Anastrozole TL" in this regard are available.
It is impossible to use the drug together with tamoxifen. In addition, it is not advisable to use Anastrozole in the development of oncological tumors that are not estrogen-dependent, since such therapy will be useless.
Reviews
This pharmacological agent is quite specific and is not used often. Only a qualified specialist should appoint it.
There are a lot of reviews of patients about "Anastrozole TL"positive information about its effectiveness. Women in the postmenopausal period who were prescribed medication noted its positive effect, while the growth of a malignant tumor in the mammary gland quickly stopped. This was confirmed by laboratory blood counts and instrumental methods of diagnostic measures (for example, ultrasound).
The only thing that is a negative point in the treatment of this medicine, according to patients, is the numerous adverse reactions that occur after taking the first pill.
Expert comments
Reviews of doctors about "Anastrozole TL" warn against self-administration of this drug, because, according to experts, this can be very dangerous to he alth. In general, doctors consider this medication to be quite effective and the most popular among analogues.
Now it has become clear to many how Anastrozole differs from Anastrozole TL.
