Aromatase inhibitors, or blockers, are a type of healing agent that is used to reduce the concentration of estrogen in the blood and increase the level of gonadotropic hormones and testosterone. These substances are also used to treat and prevent male gynecomastia.
Aromatase inhibitors in bodybuilding are very often used during the cycle of anabolic steroids for:
- increasing anabolic hormone levels in the blood;
- gynecomastia prevention;
- prevent hypertension;
- increase in relief (due to the elimination of the negative effects of estrogens);
- reducing estrogen destruction of the testicular-pituitary-hypothalamus axis, leading to speedy reconstruction.
Building a course, it is necessary to take into account the fact that aromatizationNot all anabolic steroids are affected. Use is justified when using products such as methandrostenolone, methyltestosterone, testosterone and its derivatives. Slightly aromatized Halotestin, boldenone.
Efficiency
The most affordable and preferred aromatase inhibitors (almost similar in terms of fruitfulness):
|
Product (worldwide name) |
Brand name (sold by pharmacies) | Approximate price | Issue form | Prophylactic use in bodybuilding | When gynecomastia appears |
| Exemestane | Aromasin | 1600 rub. | 30 tab. 25 mg each | 2.5 mg (1/2 tablet) every other day | 25mg daily until symptom relief. Then reduce the dosage to prophylactic. |
| Letrozole |
Letromara (pharmac.) Letroza Estrolet |
3200 rub. 1000 rub. |
30 tab. 2.5mg each | 0.5mg (1/5 tablet) every other day | 2.5mg daily until symptom relief. Then reduce the dosage to preventive. |
| Anastrozole |
Selana "Egistrazol" "Anastrozole Kabi" |
1500 rub. 350 RUB 1300 rub. |
28 tab. 1 mg each | 0.5 mg (1/2 tablet) every other day | 1mg daily until symptom relief. Further reduction of dosage to prophylactic. |
It should be noted that a moderate concentration of estrogen is beneficial for muscle growth, so preventive dosages are indicated in volumes that affect the maintenance of the physiologically necessary level of male estrogens.
Course Usage
Most domestic athletes, using aromatase inhibitors, use the following tactics: drugs are used only when the first signs of gynecomastia appear (itching in the nipples, swelling, redness). Unfortunately, this approach cannot be called optimal.
The most rational decision is to test estradiol after about ten days of using anabolic steroids with a short half-life (Methandrostenolone, Testosterone Propionate) or after three to four weeks of using long-acting esters (Sustanon, Enanthate, " cypionate"). Next, the average portion of "Anastrozole" is prescribed - 0.5 mg every other day. After ten days, a control analysis of estradiol is performed and the dosage is adjusted according to the results.
A compromise option is to use low and moderate portions of Anastrozole, focused on personal impressions. If depression appears after such treatment, erectile dysfunctionfunction, a drop in libido, which means you need to lower the dose.
Research
The emergence of the publicly available trademark "Letrazole" brought this product to the forefront. There are many tests that prove the high effectiveness of this remedy in men. The introduction of the substance was accompanied by a noticeable rise in gonadotropin (LH). A productive dosage starts from 0.02 mg (100 times lower than the therapeutic one): with it, you can reduce the concentration of estrogen by a third. 50% of "Letrozole" is excreted from the body within 2-4 days, which allows you to drink it every other day. The basic disadvantage is its ability to reduce estrogen levels even in small doses.
"Anastrozole" is popular in bodybuilding: it has been remarkably studied in men as a means of reducing estradiol. Empirically, it has been shown that a dose of 1-0.5 mg can reduce the level of estradiol by approximately 50%. You can buy this product from dealers almost ten times cheaper than in a pharmacy. Cheap "Anastrozole Kabi" is found in megacities.
In his book, Dr. Mauro G. De Pascale wrote: "It is assumed that estrogens, formed due to the aromatization of testosterone and other anabolic steroids in the hypothalamus and brain, reduce the secretion of luteinizing hormone, and, therefore, the production of testosterone". Gilmann and Goodmann report that the feedback is activated by estrogen accumulation rather than testosterone. In this way, it is explained that aromatase inhibitors can significantly reduce the inhibitory effectanabolic substances on the release of personal sex hormones.
Side Effects
What are the dangers of aromatase inhibitors for men? We know that estrogens in small doses have a positive effect on the male body. Estrogen hormones increase both the effectiveness of the course and the susceptibility of androgen receptors. In addition, they themselves have a protective and anabolic effect.
The importance of muscle estrogen receptors is thoroughly described in Anna Wiik's dissertation. In fact, large doses of blockers can actually lower estrogen levels unnecessarily, leading to side effects such as:
- inhibition of muscle growth;
- joint pain (arthralgia);
- deterioration of well-being and drop in libido;
- depression;
- lipid blood profile disorder (high cholesterol);
- decrease in bone strength.
Subjectively, the drugs are better tolerated than Tamoxifen.
Natural inhibitors
The following stand out:
- caffeine;
- resveratrol;
- zinc;
- nicotine;
- apigenin;
- catechins;
- eriodictyol.
Application of "Anastrozole"
What else are aromatase inhibitors good for? These drugs are widely used in bodybuilding. For example, "Anastrozole" is needed to retain water in the human body and prevent the occurrence of gynecomastia (often in combination with androgens such as testosterone and dianobol, or in combination withfinasteride). But in this case, the athlete also receives an impressive complex of prohibited drugs from the "List of Prohibited Methods and Substances", which also have their own range of secondary effects.
Uncontrolled use of "Anastrozole" by athletes who are fond of, in particular, bodybuilding, can lead to arthralgia, asthenia, or to a decrease in joint mobility, headache, drowsiness. Of course, occasionally thromboembolic problems and strokes can develop.
Much has been written about Anastrozole in the literature for athletes as a very harmless drug. But the remote and immediate effects of its reception can be the most unpredictable and tragic. After all, if you take just one tablet (1 mg) daily, you can get a pronounced hormonal surge. By the way, this phenomenon is observed in more than 80% of people who used this product.
In general, aromatase inhibitors are well-known drugs. Samples of the third generation blockers "Anastrozole" and, later, "Vorozol" and"Letrozole", were created as first and second line products for the treatment of disseminated receptor-positive breast cancer.
Krizin
For weightlifters, the pharmacological market also offers 5, 7-dihydroxyflavone ("Kryzin"), which athletes use in very high doses. It has anti-aromatase properties and is produced in two forms - MRM-Chrysin, containing 500 mg of flawless chrysin per capsule, and SciFit-Chrysin ES, containing twiceless active ingredient.
The developers do not describe side effects, but it should be remembered that all substances and preparations with anti-aromatase action can cause significant harm to the athlete's body. In addition, they are on the "List of Prohibited Methods and Substances."
Reviews
Many bodybuilders say that, based on the experience of using Letrozole (Femara), they concluded that this product, solving one problem (increased estrogen levels), contributes to many other problems. Of course, aromatase inhibitors for men are important. After all, the body (including men) uses estrogens to maintain a he althy immune system, brain function, normal cholesterol levels, he althy joints, ligaments, and so on.
Athletes say that estrogen triggers muscle growth in the body. Taking 2.5 mg of "Letrozole" per day, they begin to feel serious injuries of the articular-ligamentous apparatus and become vulnerable to infectious and viral diseases.
Many athletes believe that Letrozole can only be used by professional bodybuilders in preparation for competitions. Thanks to him, they get rid of excess fluid in the body (professionals don’t feel sorry for he alth for the sake of victory). They gladly purchase this aromatase inhibitor. The price suits them just fine.
Some athletes say that Letrozole has a positive effect on the body even at a dosage of 0.1-0.5 mg. They report that his secondary influence is no worse than others.inhibitors and standard for this type of drugs. They assure that, according to subjective sensations, the product reconstructs the volume of the testicles faster than Tamoxifen and Clomid. They also claim that aromatase inhibitors are worth the price.
Some athletes report that any blocker can be used, but given the high productivity of Letrozole in small doses, it turns out to be the most inexpensive.
Anastrozole
Today "Anastrozole" is the most popular blocker. The cheapest is considered "Selana". Some aromatase inhibitors rarely appear in pharmacies, for example, Anastrozole Kabi.
Many people do not save on their he alth and choose quality.
Take "Anastrozole" in accordance with their own level of estradiol. Therefore, the level of estradiol is first tested in order to adjust the portion based on the analysis. The average classical dosage is 0.5 mg per day.
After ten days, I need to get tested again. If the level of estradiol is standard, dosages can be reduced to 0.5 mg twice a week. If it is still high, the reception should be continued. And so it should be done until the level of estradiol is fully restored.
