Currently, due to the increase in the level of stress factors, many are interested in how medication can reduce anxiety, strengthen disturbed sleep and stabilize their condition.
Among over-the-counter pharmacies, there are often drugs recommended as antidepressants, but they are mostly homeopathic remedies that do not provide full relief in some cases.
Pictures of depression
Before getting carried away with MAO inhibitors, drugs should be thoroughly studied or consult a doctor. Drugs of the "antidepressants" group can affect many functions of the body: the above-mentioned MAO (monoamine oxidase) inhibitors have a wide range of side effects, which will be discussed below. But even earlier, you should realize whether the body requires such intervention, or is it just a whim caused by a desire to make certain moments of your life easier. Most people on Earth have experienced depressive states, and their presence is due to the need for stress.
Written about the benefits of moderate stressmany authoritative works of our contemporaries and predecessors. In most cases, the negative perception of stress is due to advertising of antidepressants, which suggests that consumers get rid of it as an unnecessary thing that spoils our lives, as “slags and toxins”, so to speak…
Stress drives progress
However, stressful conditions serve as a kind of motor that helps a person to experience and feel the “black stripes” of his life, so that he can see the “white ones”. If there were no darkness, we would not know what light is (F. Aquinas). If there was no stress, no one would feel calm. But, in addition to the theosophical, stress has a completely scientifically based physiological background. Stress improves immunity, stimulates the regenerative abilities of the body, improves memory and increases endurance. These facts are scientifically proven. Therefore, before using sedatives, antidepressants, drugs - MAO inhibitors, you should determine how necessary they are in a given situation.
Herbal drugs (antidepressants and MAOIs)
A favorite among over-the-counter, weak MAOIs is St. John's wort. This plant has been studied for centuries, unlike new drugs, more studied. It is the main component of such popular drugs as Negrustin, Deprim.
A cheaper analogue is the alcohol tincture of St. John's wort, which is the least convenient ineveryday use, however excludes the presence of additives, which in some cases may manifest the effects of individual intolerance.
Valerian. It is also the basis for the preparation of many dosage forms. Does not belong to the group "MAO inhibitors". The list of drugs from the group of selective and non-selective monoamine oxidase inhibitors, contrary to popular belief, does not include valerian as an auxiliary drug - due to incompatibility. Like St. John's wort, valerian is a drug with a balanced natural biochemical composition and is available in pharmacies without a prescription.
Motherwort. Certain types of this plant are used not only in neurology, but also in general therapy and cardiology. Motherwort-based tinctures have a calming and tonic effect when used regularly. Medicinal preparations based on motherwort serve as the basis for herbal teas, and its extract, in combination with eucalyptus, is an effective remedy for inhalation.
Synthetic drugs
Non-herbal medicines have a shorter history, and the treatment experience of the '50s pioneers' was very questionable. However, due to the spasmodic development of the pharmaceutical industry, the drug market currently offers a fairly wide range of drugs that are more effective than herbal drugs.
MAO inhibitors have become a big leap forward in the treatment of mental disorders and borderline depressive states. ListThis group of drugs has 145 trade names.
How MAOIs work
The principle of action of drugs in this group is based on slowing down the destruction of one or more groups of monoamines and increasing the concentration of certain mediators between two synapses. These mediators include norepinephrine, serotonin, dopamine and others. In the future, by increasing the concentration of a certain mediator, the desired therapeutic effect is achieved. The question of what belongs to selective MAO inhibitors and what to non-selective ones is solved by a simple formulation. If the drug stimulates an increase in the concentration of one mediator, then it is considered selective. If there are several, then indiscriminate, respectively.
What are MAO inhibitors: a list of requirements and precautions for the use of drugs of this group due to the possibility of side effects
1. Mandatory medical intervention. Preparations of this group, with the exception of drugs of plant origin, for the most part belong to the group of drugs dispensed only by prescription. And for good reason (see next paragraph).
2. Precise dosage. Taking drugs of this group should be carried out regularly and in certain doses, taking into account the physiological characteristics of the body. You can not take these drugs, based on the principle "I'm more nervous - I drink more pills." The effect of an overdose can be diametrically opposed to what is expected. Recently, unconscious poisoning with MAO inhibitors has often been observed.
Drugs are taken in large doses in a domestic environment in order to "calm down". And, sadly, it is not uncommon for people to calm down forever.
3. Differentiation with the type of human activity. In all instructions for drugs of this group, the column “with caution” is indicated and a group of people is named for which taking drugs in connection with the performance of a certain work is incompatible or incompatible. Antidepressants of this group can affect the reaction rate, which can have a deplorable effect on the work of drivers, pilots, and law enforcement officers. The presence in the blood and urine of residual enzymes of drugs of this group can show positive results in athletes (like doping).
4. The principle of calculating the side effect common to the MAOI group. Drugs of this group can cause mental and somatic disorders. On the part of the psyche - lethargy, fatigue, withdrawal syndrome. In difficult cases - mental disorders: exacerbation of schizophrenia, suicidal tendencies. From the side of somatics: violation of blood pressure, a negative effect on parenchymal organs (liver, kidneys).
MAO inhibitors. List of drugs commonly used in the practice of neurologists and psychiatrists
| Drug | View | Indications | Note |
| Aurorix | Reversible MAOIs | Depression of various etiologies, social phobia | Undemanding diet. Trade name of the currentmaclobenide substances |
| Pyrazidol | Electoral MAOI | Depression of various origins, withdrawal syndrome, b. Alzheimer's | Domestic drug at affordable price |
| Befol | Selective MAOI reversible | Shallow depression, hypochondria | Domestic drug |
| Inkazan | Selective MAOI reversible | Depression of various origins. Schizophrenia, manic-depressive psychoses | Also known as metrailindol |
| Selegelin | Electoral MAOI | Parkinson's disease, polyetiological parkinsonian syndromes (excluding drug) | Synergism with Levodopa |
These drugs are the most commonly used in practice due to their high efficiency and predictable predictive effect. These are the most profitable drugs in terms of price / effectiveness among the group of "MAO inhibitors". The list of drugs with similar and similar effects and other commercial names is more extensive, since the domestic market is supplied with products from 43 pharmaceutical manufacturers, and many drugs are generics.
Conclusions
However, the price/quality duet should include a third element, which many people consider to be “third wheel”. This is individuality. Only a doctor can fully determine which antidepressant drug is suitable for a particular person. And to decide what place depression occupies in a person’s life, whether he will be happy or not,only he can.
The given data are not recommendations for self-treatment and are published for informational purposes only.
