Reviews about "Insulin Tresiba" should be of interest to all patients who in their lives have faced such a serious disease as diabetes mellitus. This is a modern ultra-long-acting drug produced by the international company Novo Nordisk, headquartered in the suburbs of Copenhagen. Many claim that it is far superior in effectiveness to many other well-known insulin-containing drugs, with each injection lasting up to 42 hours. All this makes it even easier and more reliable to maintain a stable level of sugar in the blood. In this article, we will give the main points of the instructions that come with this drug, reviews of patients who have already tried the drug on themselves.
Description
In reviews of "InsulinTresiba" many claim that they have already evaluated the effectiveness and benefits of this drug. In fact, it is an analogue of human insulin. At the same time, it must be understood that the insulin molecule is not completely repeated. With the help of advances in biotechnology, it was possible to change it, which allowed it to acquire fundamentally new properties It is known that initially this drug was created only for patients with type 2 diabetes, but now it turned out that it is successfully used in the first type of this disease.
The effect of "Insulin Tresiba" is on the human body for more than 40 hours. However, manufacturers recommend daily injections, although the drug works for more than one day.
In Russia, it is known under two INNs "Insulin Tresiba" - these are "Tresiba FlexTach" and "Tresiba Penfill". The first form is disposable pens that are thrown away after the insulin runs out. The second form is refillable syringe pen cartridges. It is noteworthy that they are suitable not only for this drug, but also for NovoPen.
New drug recommended for use in type 1 and type 2 diabetes. It is worth remembering the existing contraindications, it should be used especially carefully by pregnant and lactating women, since its effect on their body has not yet been properly studied.
Operation principle
Insulin "Tresiba FlexTouch" principlework is almost the same as that of the Lantus drug, well known to many diabetics. After the molecules enter the human body, they combine into larger formations, which are also called multichambers. They create a drug depot. Further, small pieces break off from it, which makes it possible to achieve such a long-lasting effect.
Manufacturers claim that the duration of the drug is more than 40 hours. According to some studies, it can even reach exactly two days. In this regard, it may seem that this agent can be used less frequently than regular insulin. Not every day, but once every two days. But in reality this is not so. Experts strongly advise not to skip daily injections, so as not to weaken the action and effect produced by this drug.
Studies of the new "Insulin Tresiba" proved that the drug is equally effective in young and old patients. Also, there were no negative reviews from patients who are also concerned about liver and kidney problems.
The main active ingredient of the extended "Insulin Tresiba" - degludec has shown itself to be beneficial. Compared to the glargine used in Lantus, it causes significantly fewer cases of hypoglycemia.
Dosage
In the instructions for the use of "Insulin Tresiba" the dosage for each category of patients is prescribed in detail. The drug is administered exclusivelysubcutaneous, intravenous administration is contraindicated. This should be done once a day.
It is worth noting that the drug is compatible with all hypoglycemic drugs that are available in tablets, as well as with various other types of insulin. As a result, it is prescribed separately, and in some cases as part of complex therapy.
If the patient is injecting insulin initially, the dose should be 10 units. Then it is gradually corrected, which will depend on the individual needs of each person.
If the patient receives some other type of insulin, and then decides to switch to Tresiba, the initial dose is calculated in a ratio of one to one. This means that the insulin degludec should be given exactly as much as the basal insulin was injected.
If the patient has been on a double regimen of receiving basal insulin for a certain time, then the dose should be determined with the attending physician on an individual basis. There is a possibility that it will decrease. The same situation will be observed if the level of glycated hemoglobin in a patient is less than 8%.
Of course, in the future, the patient will definitely need individual dose adjustment under the control of blood sugar levels.
Side effects
The instructions for "Insulin Tresiba" describe in detail the side effects that this drug can provoke. Unfortunately, you can’t do without them, as well as when taking any pharmacologicaldrug.
Among the most common problems are complaints of hypoglycemia. Although it is less common than with most other insulin-containing drugs.
Other side effects include:
- allergic reactions (such as anaphylaxis or hives);
- hypersensitivity reaction may manifest as frequent stools, numbness of the tongue, skin itching, fatigue);
- lipodystrophy that appears at the injection site (unpleasant consequences can be avoided by regularly changing the injection site);
- local reactions and manifestations at the injection site (swelling, bruising, connective tissue nodules, redness, induration, itching).
In the instructions for the use of "Insulin Tresiba" it is advised to store it in the same conditions as other similar drugs. It is important for them to avoid freezing and overheating, otherwise they will lose almost all of their healing properties.
Indications and contraindications
The instructions for "Insulin Tresiba" clearly recommends the use of this drug in the treatment of diabetes in adult patients.
The drug is contraindicated in the following categories of patients:
- children and adolescents under the age of 18;
- pregnant women;
- nursing moms;
- patients with individual sensitivity to the main active substance of the drug or any of its auxiliary components.
Composition
The drug is available as a solution for subcutaneous administration. The main active ingredient is insulin degludec.
Phenol, glycerol, zinc, hydrochloric acid, and water for injection are used as excipients in this medicinal product.
One package contains five syringes of 3 ml each.
Insulin degludec is able to specifically bind to the human endogenous insulin receptor. Directly interacting with it, it realizes its pharmacological effect, which is almost similar to the action of human insulin.
It is worth noting that the hypoglycemic property of this drug is due to the ability to significantly increase the utilization of glucose. This happens due to the binding of insulin itself to the receptors of fat and muscle cells. It is important that in parallel, the rate of glucose production by the liver is significantly reduced.
How to use
Once again, this medicinal product is for subcutaneous administration only. It should not be administered intravenously, as this can lead to the development of severe hypoglycemia. It is also forbidden to administer it intramuscularly, since in this case there is a risk that the absorption of the main active substances will change. In this case, it is almost impossible to predict how this tool will act in the future. Among the warnings, one more thing should be remembered: "Insulin Tresiba" should not beuse in pumps.
The drug is injected subcutaneously into the region of the anterior abdominal wall, thigh or shoulder area. Remember to change the injection site regularly within the same anatomical area to minimize the risk of developing lipodystrophy.
Externally, the drug is a pre-filled syringe pen, which is designed for use with injection disposable needles.
It is important that the drug itself and the needles are intended exclusively for individual use. Do not refill the pen cartridge.
Watch the condition and appearance of the solution. You can not take it if the solution has ceased to be colorless and transparent. It also loses all its useful properties after it has been frozen. Discard the needle without fail after each injection.
Carefully follow local regulations that apply to the disposal of used medical supplies in your area. The pen is used by the patient himself after he has mastered its use under the supervision of a doctor or nurse.
There are several main steps into which injection procedures can be divided. To begin with, the syringe pen should be prepared for use. To do this, start by carefully checking the dosage and the name on the label of the syringe pen. Make sure it contains the medicine you need. It is especially important to pay attention to this stage if you are taking several drugs at the same time or alternately.different types of insulin. In this case, you need not get confused so as not to harm yourself, and the effect of using the drug was maximum. Only then remove the cap from the syringe pen.
Make sure the medicine in the syringe is colorless and clear. To do this, pay attention to the window of the insulin balance scale. If the product becomes cloudy, it should not be used.
Remove the protective sticker from the disposable needle. Put the needle on the syringe pen, and then turn it so that the needle is held on it as tightly as possible. After removing the outer cap, do not throw it away. You will need it after the injection is completed to safely remove the needle. But you can immediately throw away the inner cap of the needle. Never try to put it back on, as in this case there is a high probability of pricking.
Make sure that a drop of insulin appears at the very tip of the needle. This should be done in order to check the flow of the drug in the syringe.
Use a new needle for each injection to prevent clogging, infection, and injecting the wrong dose. Do not use the needle if it is damaged or bent.
Overdose
In some cases, there is a possibility of overdose with this drug. It should be noted that the specific dose that leads to a similar effect has not been established. Hypoglycemia, which most diabetics fear, tends to develop gradually.
With lighthypoglycemia the patient is able to cope on their own by taking sugar-containing foods or glucose. Patients with diabetes are advised to carry sugar-containing products with them at all times.
In case of severe hypoglycemia, when the patient is unconscious, he should be injected with glucagon or dextrose solution. You should also introduce dextrose if a quarter of an hour after the administration of glucagon, the patient does not regain consciousness. When consciousness is restored, it is recommended to eat a meal rich in carbohydrates as soon as possible in order to prevent relapse.
Patient testimonials
Reviews of diabetics about "Insulin Tresiba" can often be found simply enthusiastic. The injection is usually given at night. This allows a person to wake up in the morning with a normal level of sugar, in a normal state.
The main thing is that the dose is chosen correctly. In the reviews of diabetics with experience about Insulin Tresiba, it is noted that before the appearance of this variety of this drug, all previous variations acted for a much shorter time, which caused a lot of trouble. Fasting glucose control was very difficult.
At the same time, in the reviews and "Insulin Tresibe", many emphasize that an important advantage of the drug lies in the fact that with its help it is possible to more smoothly reduce blood sugar compared to many other similar means. For example, with Lantus or Levemir. Besidesthe risk of developing hypoglycemia is significantly reduced, although it still remains in case of overdose. This is noted both in the reviews and in the instructions for use of Insulin Tresiba.
Negative
With all the positive aspects, it is worth noting that negative opinions about this drug are still found. True, the negative reviews about "Insulin Tresiba" are not associated with its effectiveness, but with its high cost.
It should be noted that only very we althy patients can afford it, since this drug is much more expensive than many other analogues. If you have such free money, you should discuss the transition to a new insulin with your doctor. We emphasize that in diabetes mellitus, many drugs are prescribed individually, depending on the patient's condition. In addition, it is important to determine the dosage based on the he alth status of a particular patient.
It should be noted that Insulin Tresiba currently costs about three times as much as Levemir and Lantus, which are also actively used for diabetes by many patients.
Experts who are close to the pharmaceutical business note that in the coming years you can count on the emergence of analogues, the properties of which will be no less impressive than that of Insulin Tresiba. The reviews and instructions for these funds have yet to be carefully read, however, it is not possible to expect that these medicines will cost less.account for. This is mainly due to the fact that there are currently only a few reputable companies in the world that produce modern and high-quality insulin. At the same time, there is an opinion that there is a corporate agreement between them, which allows maintaining prices at a consistently high level.
