Bismuth subsalicylate is a substance that is used to treat ulcers of the gastrointestinal tract and diarrhea of various origins. The component has antiulcer, enveloping, analgesic, astringent, antidiarrheal, antiseptic, carminative action. Penetrating initially into the stomach, then into the duodenum, the substance combines with proteins and forms chelate compounds. Bismuth subsalicylate is a protective film that covers the surface of the gastrointestinal tract. Thus, it helps to protect the mucous cavity from the harmful effects of s alts, enzymes, as well as hydrochloric acid and pepsin. The substance improves the production of mucus in the stomach and the healing of ulcerative foci. Has antimicrobial activity against Helicobacter pylori.
The drug exhibits an antidiarrheal effect, which is due to the astringent and enveloping effect ofbismuth subsalicylate. A positive result appears within a day. The content of the substance in the blood increases gradually with its long use. May accumulate in small amounts in bones and tissues.
Absorbable is excreted in urine (within three months). Bismuth that has not been excreted is eliminated from the body in the form of sulfide, which stains the stool and tongue dark. This form of bismuth promotes the speedy healing of ulcers.
According to the instructions, bismuth subsalicylate is used in diseases of the gastrointestinal tract to eliminate gastric and duodenal ulcers.
The component has the properties of three pharmacological groups at once: enveloping, adsorbing and antacid.
Indications
The drug is used for the following diseases and conditions:
- Increased secretory function of the stomach.
- Heartburn - a feeling of discomfort or burning behind the sternum, spreading upward from the epigastric region, sometimes extending to the neck.
- Duodenitis - an inflammatory disease of the duodenum, often only the mucous membrane.
- Gastroduodenitis - an inflammatory disease of the duodenal mucosa and the pyloric zone of the stomach.
- Intestinal upset.
- Gastritis is a long-term disease characterized by dystrophic-inflammatory changes in the gastric mucosa.
- Post-resection ulcer - a disease of the mucous membranesmall intestine in the form of one or more ulcers.
- Gastroenteritis is a disease characterized by an inflammatory process in the stomach and small intestine, which can be caused by a bacterial, viral or protozoal lesion.
- Dyspepsia - a violation of the normal activity of the stomach, difficulty and painful digestion. Dyspepsia syndrome is defined as a feeling of pain or discomfort.
Instructions for use
The most popular pharmacological forms of release are tablets and gel. The manufacturer puts the gel in bottles with dark glass. Bismuth subsalicylate may precipitate, so shake the contents of the bottle well before each use.
Based on clinical studies, it is known that the drug is recommended for use in children from the age of three. The use of subsalicylate by children under this age is carried out strictly with the permission of the doctor and under his supervision.
In childhood, the dosage is determined by the medical specialist based on the weight of the patient. Adults are advised to take pills no more than six to eight times a day, depending on the diagnosis. If the disease progresses further (more than two days), while severe hyperthermia is observed, it is necessary to monitor the water and electrolyte balance.
Adverse reactions
The following are considered common debuffs:
- Constipation.
- Vomiting.
- Nausea.
- Tinnitus.
- Dizziness.
- Violation of consciousness.
- Bismuth encephalopathy.
- Tremor.
- Confusion.
- Paresthesias.
- Change in color of feces and tongue.
Overdose
Bismuth poisoning occurs only in situations where it is used in higher dosages or with longer treatment than indicated in the instructions for use of bismuth subsalicylate. As a result, there is an excess of the content of the substance in the blood. The main indicator of poisoning are signs of kidney and liver disease, which occur ten days later.
And there are also situations when the following unpleasant states appear:
- Dermatitis.
- Stomatitis.
- Gastrointestinal disorders.
- Dark border on the gums.
- Insomnia.
- Memory deterioration.
- Paresthesia.
In the early stages of intoxication, gastric lavage and osmotic laxatives should be taken to eliminate unabsorbed bismuth from the body. Next, you need to use activated charcoal or Polysorb. In the later stages of poisoning, hemodialysis is carried out, they take "Unitol" or "Complexon".
Prohibited use
Bismuth subsalicylate is not recommended if you have a history of allergies to aspirin and other salicylates. You can not simultaneously take a substance with anticoagulants, as well as anti-gout and antidiabetic drugs.
This component should not be used by children under three years of age. Taking the drug during pregnancy is strictly prohibited, since there is no reliable information about the effect of this substance on the fetus. Due to complications, bismuth should not be used if kidney function is impaired.
Features
It is important to observe a certain period of time between the use of an antacid and dairy products, as well as fruit juices (thirty minutes). Do not use bismuth subsalicylate for too long.
The risk of side effects is minimal if you follow the prescribed dosage of the drug. It is not recommended to combine with other drugs containing bismuth in the structure.
Teenagers and children who suffer from an acute respiratory viral infection should use bismuth only with the permission of a medical professional. Bismuth subsalicylate does not require a prescription.
Drug Interactions
Bismuth reduces the absorption of tetracyclines. The effectiveness of "Doxycycline" is reduced. The bioavailability of fluoroquinols decreases when interacting with bismuth subsalicylate. Preparations based on this substance:
- "De-Nol".
- "Gastronorm".
- "Vis-Nol".
- "Vikalin".
You can not take this substance in addition to them at the same time. There is a possibility of a sharp jump in the content of bismuth in the blood, which can lead to an increase in negativereactions and intoxication.
