Bismuth tripotassium dicitrate (trade name - the drug "De-Nol") is an effective antiulcer drug with a pronounced bactericidal activity against microorganisms of the Helicobacter pylori species. In addition, this medicine has antacid, anti-inflammatory and astringent effects. Taking this remedy significantly improves the protective characteristics of the mucous surface of the gastrointestinal tract, forming a special insoluble coating directly at the site of the ulcer. Bismuth tripotassium dicitrate also increases the resistance of the stomach and intestines to the negative effects of enzymes, pepsin and hydrochloric acid, increases mucus production, bicarbonate secretion and the synthesis of prostaglandin type E. In addition to all of the above, experts note its ability to stimulateactivity of cytoprotective mechanisms.
As for the pharmacokinetics of this anti-ulcer agent, as a result of its course use, equilibrium concentrations in the blood are reached in four to five days, and the half-life is about five days. In this case, the fully active component is excreted from the body only twelve weeks after the start of taking such a remedy as bismuth tripotassium dicitrate. Analogues of this tool - capsules "Bismay", "Desmol" and "Novobismol" - have a similar mechanism of action.
This anti-ulcer drug is produced mainly in the form of conventional drug-coated pills. Taking tablets "De-Nol" (bismuth tripotassium dicitrate), the price of which is very affordable, the manufacturer recommends exclusively for the treatment of duodenal ulcers or stomach ulcers. People suffering from chronic gastritis should also start taking this drug regularly. In addition, bismuth tripotassium dicitrate will quickly help in case of dyspepsia not associated with organic diseases of the gastrointestinal tract.
Doctors categorically prohibit taking this antiulcer drug in severe forms of kidney dysfunction, as well as during pregnancy. Hypersensitivity and the period of breastfeeding a newborn baby are similarly included in the list of strict contraindications. Patients under the age of twelve should also notstart taking drugs that include bismuth tripotassium dicitrate. In addition, it must always be remembered that people with various kinds of abnormalities in kidney function may develop encephalopathy as a result of prolonged use of high dosages of this remedy.
If we consider the most common adverse reactions that may be caused by taking this anti-ulcer drug, then vomiting, nausea and diarrhea should be highlighted first. In addition, there is a rather high risk of skin rash, itching, flushing of the skin and angioedema.
