"Sustagard Arthro" acts as a drug that stimulates the process of regeneration of cartilage tissue. This medication has anti-inflammatory and analgesic effects on the body. For ampoules "Sustagard Arthro" instructions and reviews will be presented below.
Form of release of the drug and its composition
The drug is produced in the form of ampoules. Each of them contains glucosamine sulfate, which is the active substance, as well as sodium chloride. As additional components, the drug includes sodium disulfite, lidocaine hydrochloride, as well as high concentration hydrochloric acid and water for injection.
This is indicated by the instruction attached to Sustagard Arthro. Prices will be discussed later.
Pharmacological properties of the drug
The drug works as a regeneration stimulator, and also performs anti-catabolic, anti-inflammatory, chondroprotective, analgesic and anabolic effects on the body.
The active substance of this medical product, which is glucosamine sulfate, is found in the human body and serves as s alt. "Sustagard Arthro" activates the production of proteoglycans through chondrocytes and synovial fluid, thus inhibiting enzymes that lead to the destruction of cartilage tissue. In addition, the drug counteracts the formation of superoxide radicals, reducing the activity of lysosomal enzymes and ensuring the normal process of calcium deposition in bone tissues. This stimulates the production of sulfur during the synthesis of chondroitin sulfuric acid, while avoiding the damaging effects of corticosteroids. There is also a normalization of the production of glycosaminoglycans, which is disturbed due to non-steroidal anti-inflammatory drugs.
Sulfonic groups are involved in the metabolic processes of cartilage tissues and in the formation of glycosaminoglycans. Elements such as sulfoesters are able to retain water, maintaining the elasticity of cartilage. This confirms the instructions for use for the preparation "Sustagard Arthro". Many people are interested in the price.
In osteoarthritis, glucosamine sulfate reduces the incidence and severity of the symptoms of this disease, preventing cartilage destruction. The weakening of clinical symptoms is usually noted a couple of weeks after the start of the course. This improvement may last up to two months after stopping this drug.
Glucosamine sulfate is characterized by rapid passage through biological barriers, followed bypenetration into the structure of tissues, especially in areas of articular cartilage. The withdrawal period is approximately sixty hours.
According to reviews of Sustagard Arthro ampoules, instructions are included in each package.
Indications for use of the drug
This medicine should be used for ailments such as:
- Chondromalacia of the patella.
- Spondylarthrosis.
- Primary or secondary osteoarthritis.
- Presence of osteochondrosis.
- Spondylosis and humeroscapular periarthritis.
Contraindications for use
According to the instructions for use for the drug "Sustagard Arthro", the list of contraindications for the use of the drug is quite extensive. Thus, it should not be consumed under the following restrictions:
- Presence of phenylketonuria.
- Under the age of twelve.
- Sensitivity to any of the components of the drug.
- The presence of acute heart failure along with violations of its conduction.
- Pregnancy period.
- Pathology of hepatic or renal function.
- Probability of epileptiform seizures.
Also with Sustagard, the instructions for use inform that the drug should be treated with extreme caution in conditions such as:
- Hypotension.
- Circulatory pathology.
- Patient propensity for malignanthyperthermia.
- Diseases of the respiratory system.
- Epilepsy and old age.
In the event that the patient has a tendency to intolerance to various seafood, then during treatment with the drug there is a risk of allergic reactions of the body.
This is confirmed by the instructions and reviews for Sustagard Arthro ampoules.
Dosage and method of administration of the medicine
The solution of the drug "Sustagard Arthro" is intended exclusively for intramuscular injection. Intravenous infusion is strictly contraindicated.
To prepare the medicine, mix the contents of the ampoule "A" with the solvent "B", this is done in one syringe before the injection procedure. The finished solution is administered three times a week in a volume of three milliliters per day. The course of treatment is usually four to six weeks.
The powder "Sustagard Arthro" instructions for use are also very detailed.
Drug side effects
As part of the use of the drug, undesirable effects such as various allergic reactions, for example, itching and urticaria, may occur. In addition, flatulence, constipation and diarrhea are not excluded. Against the background of the use of an injection solution, the following reactions are also likely due to the influence of lidocaine:
- Impaired cardiac conduction function.
- The appearance of dizziness, diplopia, pain, numbness of the oral mucosa and tongue. In addition, from the sidenervous system confusion may be observed along with tremors, drowsiness and euphoria.
- As part of allergic reactions, anaphylactic shock can occur. Sometimes there is swelling.
- Appearance of nausea and vomiting.
- There may be a slight burning sensation with an anesthetic effect that usually subsides within one minute. Thrombophlebitis is also possible.
Sodium disulphite contained in the solution in rare situations can provoke the occurrence of bronchospasm, as well as severe reactions associated with hypersensitivity.
What else does Sustagard Arthro ampoules say about the instructions for use?
Drug overdose
Cases of drug overdose have not yet been recorded. Symptoms of this condition, which can be caused by the action of the additional ingredient of the solution in the form of lidocaine hydrochloride, can be the presence of tinnitus, tremors, dizziness, drowsiness, anxiety, depression, agitation, blurred vision, numbness of the lips and tongue.
In case of suspected overdose, control of respiratory function and proper functioning of the cardiovascular system should be carried out. If changes corresponding to the above parameters are detected, then this will indicate the use of the drug in doses that largely exceed the permissible limits. As a result, the patient will require immediate access to oxygen. SoTherefore, symptomatic treatment should be started if any complications occur.
Special instructions for the use of Sustagard Arthro ampoules
Instructions for use indicates that the injection solution should be used with caution in the presence of bronchial asthma, or disorders of the body's susceptibility to glucose. Patients who follow a strict s alt-free diet should take into account that one dose of the drug contains forty milligrams of sodium. Before intramuscular injection, a skin test is required to establish the presence of individual sensitivity to lidocaine. When conducting this experiment, it is important to know that such sensitivity is expressed by the appearance of edema and redness of the injection site.
During the treatment with this drug, it is important to be careful when driving a car, or when using machinery, which requires increased concentration. This is due to the fact that after the injection of the drug, sudden dizziness, drowsiness and double vision are likely to appear. This is confirmed by the instructions and reviews for the Sustagard Arthro ampoules. Analogues will be considered below.
Medicine drug interaction
Glucosamine sulfate is allowed to be used in combination with non-steroidal anti-inflammatory drugs, as well as with glucocorticosteroids and paracetamol as well. When using this drug with penicillins, the absorption of substances fromdigestive tract, and in the case of taking with tetracyclines, on the contrary, it increases. The reactions observed when combining lidocaine, which is contained in the solution "Sustagard Arthro" with other drugs, are usually as follows:
- With Phenytoin, the cardiodepressive effect of lidocaine is enhanced.
- When combined with antiarrhythmic drugs such as Disopyramide and Quinidine, atrioventricular block develops or ventricular fibrillation may occur.
- Against the background of "Peptidine", "Propranolol", "Cimetidine" and "Chlorpromazine", the concentration of lidocaine in the blood plasma increases, and the hepatic metabolism of this substance is significantly reduced.
- Under the influence of ethanol, there is an increase in the inhibitory effect of lidocaine on breathing. And in combination with "Procainamide" the appearance of hallucinations and delirium is likely.
- Medicines that have a sedative effect, when combined with Sustagard Arthro, their sedative effects are enhanced.
- Medications that predetermine the blocking of neuromuscular transmission increase the effect due to a decrease in the degree of conduction of impulses of the nervous system according to the instructions for Sustagard Arthro ampoules. According to reviews, the price is quite high.
Medicine analogues
Analogues of this drug are solutions intended for intramuscular injection, which are medical products "Don" and "Elbon". Before replacing the prescribed drug with one of the indicated analogues to the patientbe sure to consult your doctor.
Terms of storage and dispensing of the drug
According to the instructions and reviews, Sustagard Artro ampoules are dispensed in pharmacies strictly on prescription. It is necessary to store this drug in a dry and dark, as well as a cool place, which is inaccessible to children. The shelf life of the product is two years from the date of issue. In Russian pharmacies, the average price of the drug is seven hundred and fifty rubles.
Reviews about the drug "Sustagard Arthro"
The few reviews on the Internet about the drug "Sustagard Arthro" are mostly positive. People who have used this drug note its effectiveness in the treatment of osteoarthritis, arthrosis, and osteochondrosis.
People write that this medicine greatly alleviates the symptoms of diseases, providing an analgesic effect. In some situations, patients experience a feeling of slight soreness when performing injections, which persists for some time.
There are no complaints about any side effects in the comments. But at the same time, the main disadvantage of the drug is an extensive list of contraindications, since not all patients can take Sustagard Arthro. For this reason, before starting treatment with this medicine, it is necessary to undergo a medical examination and consult with your doctor.
We reviewed the instructions for using the solution for Sustagard Arthro, as well as reviews andanalogues.
