Of course, to maintain the life process, each person must receive the substances he needs. To do this, we take food and with it proteins, fats, carbohydrates, minerals and vitamins. However, there are conditions when a person simply cannot eat. In this case, it is transferred to intravenous nutrition. The drug "Kabiven Central" is designed for this.
In the article we will talk about what this tool is, and also find out what are the indications and contraindications for its use, and get acquainted with the features of its use. Read the information provided carefully and you will be able to find answers to all your questions.
A few words about the composition and form of release
"Kabiven Central" is a drug placed in three-chamber bags. The drug is produced in various volumes, and its calorie content will depend on this. The smallest bag has volume1026 ml, and at the same time its energy value is 900 kcal. As we said, the package consists of three bags, each of which has components such as:
- glucose;
- vamin 18 Novum;
- intralipid.
When used, the contents of the three bags will mix, resulting in a white liquid emulsion. The composition of "Kabivena Central" includes all the necessary substances to maintain the correct process of human life. For this reason, the remedy is a real salvation for those who cannot eat on their own.
There are such volumes of Kabiven Central: 1540 ml, 1026 ml, 2053 ml and 2566 ml.
Pharmacological features of the drug
The described remedy is intended for parenteral nutrition, that is, for intravenous administration. The glucose included in the composition is a very important source of released energy, which is so necessary for the body. It also takes an active part in the metabolic processes of amino acids. Vamin 18 Novum is a source of protein that does not completely enter the human body or is supplied in very small quantities. Intralipids are a valuable source of energy and essential fatty acids.
When should I use the remedy?
According to the instructions, Kabiven Central is prescribed for those patients for whom enteral or oral nutrition is impossible, or it is contraindicated. Also, the tool canbe used if for some reason natural nutrition is not enough. The drug can be used by adults, as well as children who have reached the age of two.
Are there any contraindications for use?
Kabiven central, despite its effectiveness, can still be used by no means in all cases. So, its use will have to be abandoned by patients who are hypersensitive to soy or egg proteins, as well as to any component that is part of this drug.
Let's consider under what other circumstances the medication will have to be abandoned:
- Presence of severe liver failure, as well as problems with blood clotting.
- Violation of metabolic processes of amino acids. This is especially true in cases where the violations are congenital.
- Also do not use if you have acute liver failure.
- It is also very important to pay attention to the concentration in the blood of the elements that make up the medication. If they are pathologically enlarged, then when using the solution, the patient's condition will worsen even more.
- Also, do not use the remedy if there are general contraindications to infusion therapy. This includes pulmonary edema, heart failure, and many other conditions.
- The product should not be administered to the patient in the presence of unstable conditions, such as acute stage of diabetes mellitus, severe sepsis, and so on.
When it's worthbe extra careful?
The instruction for use recommends using "Kabiven Central" very carefully in the presence of lipid metabolism disorders in the body that have arisen against the background of diabetes mellitus, liver or kidney failure, as well as sepsis. In the presence of such contraindications, the agent must be administered very carefully, carefully monitoring the patient's condition.
Is it possible to develop adverse reactions?
Despite the fact that the described drug is very necessary and effective, yet its use can lead to side effects. Consider what exactly can happen:
- If the patient has allergic reactions to the components included in the composition, then they can manifest themselves in the form of a skin bittern, urticaria, fever or chills.
- The drug can also have a negative effect on blood pressure, lowering or raising it. A change in respiratory function is also possible.
- Patients may experience abdominal pain.
- It is possible to increase the efficiency of liver enzymes.
- Local reactions such as thrombophlebitis may occur during infusions.
If the drug is administered correctly, taking into account the instructions for use, then the likelihood that side effects may be detected is extremely small.
"Kabiven Central": instructions for use
Please note that the presented drug can only be injected into the central veins. This is done using an infusionmethod. Many patients are interested in the question: “Kabiven central” or “Peripheral” - what is the difference? These medications are injected into different types of veins. It is because of this that the drug has a different name. There is no general data on how much and how long to inject. It depends on the condition of the patient, as well as on the need of his body for nutrients. The dosage, as well as the rate of administration of the drug, should depend on how quickly the body can remove lipids, as well as metabolize glucose.
As mentioned above, the drug is available in special bags that can have four volumes. When choosing one of them, you need to consider how much a person needs nutrients. In order to carry out complete infusion nutrition with the help of the drug, it is also recommended to additionally administer a vitamin-mineral complex to the patient.
The dosage of the agent is selected purely individually, taking into account the patient's need for nutrients, as well as his body weight and the general condition of the patient. If a person is obese, then in this case the dosage should be calculated as if the patient currently has his ideal weight.
If a person suffers from severe or moderate catabolic stress, then the daily dosage of the drug should be 27-40 ml per kilogram of weight. Without the presence of catabolic stress - 19-38 ml of the drug per kilogram of body weight.
Please note that the maximum dosage of the drug should be no more than forty milliliters of the active substance per kilogrambody weight. Therefore, a large bag is ideal for the average adult. However, the dosage should be monitored daily and adjusted if necessary, depending on the clinical condition of the patient at the time.
In order to correctly calculate the dose for a child, it is very important to take into account the ability of his body to metabolize certain substances. For children under the age of ten, it is recommended to increase the dosage gradually, starting from 14-28 ml per kilogram of body weight per day. The next day, you can already add about 10 milliliters to this. In children, as in adults, the maximum daily dosage should not exceed forty milliliters of the active substance. For patients older than ten years, the dosage is set exactly the same as for adults.
Infusion rate should also be determined individually. It is necessary to inject the drug into the central veins by drip, very slowly. The duration of one procedure should be about twelve to twenty-four hours.
How to use the bag?
What is the difference between "Kabiven Central" and "Peripheral"? It is very important to find an answer to this question. Please note that if the first agent can only be injected into the central veins, then the second one can be administered both into the central and peripheral ones. Only a doctor, depending on the patient's condition, will be able to determine which remedy is most suitable.
So, before you drive the tool, you need to understand how, in fact, to use a three-chamber bag. Let's see how it's done:
- First you need to remove the outer bag. To do this, tear it apart in a special place with an incision and gently pull along the bag itself.
- Now pull the sides of the bag to release the latches and turn the bag over a few times to mix thoroughly.
- After you have done this, place the bag on a table or other smooth surface and insert the needle through the center of the membrane. Thus, you can add the necessary vitamins and other components to the medication. However, it should be borne in mind that they must be compatible with Kabiven Central and Peripheral.
- Now remove the cap that is on the needle for infusion by grasping the ring to be pulled up. Please note that when you use the infusion set, you need to do this without access to air. In order to properly secure the needle, insert it completely. If necessary, it must be rotated and pushed through.
- Now hang the bag on the rack and follow all the steps you need to take to inject the medicine into the central vein.
What happens in case of an overdose?
"Central Kabiven" OKPD2 has 21.20.10.134. According to these numbers, you can find out the code of the all-Russian classification of products.
If the dosage of the medicine has not been observed correctly, then the patient may experience a condition such as fat overload syndrome. If the body is not able to remove such a large amount of fat entering it, then this can lead tothis syndrome. Such a phenomenon can occur not only as a result of an overdose, but also in the event of acute liver and kidney failure.
Usually this syndrome manifests itself in the form of fever, thrombocytosis, hyperlipidemia and coagulopathy. In order to get rid of such a condition, it is necessary to stop the introduction of lipids, as well as to carry out symptomatic therapy.
Are there any analogues?
Differences between "Kabiven Central" and "Peripheral" are insignificant, so both tools can be considered analogues. There are also other drug substitutes, namely:
- "Nutriflex";
- "Oliklinomel";
- "Aminoven";
- "Nefrotekt" and many others.
However, only an experienced specialist will be able to determine what kind of remedy can replace the drug "Kaviben Central". The composition of the listed medicines, of course, differs little, but nevertheless, the same remedy cannot be suitable for all people at the same time.
About drug interactions
Simultaneous use of the described medication with "Heparin" can cause the release of lipoprotein lipase into the blood, which will lead to a significant increase in lipolysis.
Insulin can also influence lipase activity. However, there is no evidence that it will reduce the therapeutic efficacy of Kabiven Central (1400 kcal are contained in a package containing 1540 ml of solution).
If the patient is forced to additionallytake vitamin K1, then you need to regularly monitor the process of blood clotting.
Please note, "Kabiven Central" can be mixed with some solutions, but not with all. It is worth using only those drugs whose compatibility has been scientifically proven.
Conclusions
The described drug can significantly improve the patient's condition, as well as provide his body with nutrients in cases where a person cannot eat on his own and needs infusion nutrition. One bag with three components is enough for daily use. If the entire contents of the bag has not been used in one day, it cannot be re-used.
It is very important to correctly calculate the dosage for maximum therapeutic effect, as well as to minimize the risk of adverse events. While using the medication in question, you need to regularly check blood counts and, if necessary, reduce or, conversely, increase the dosage.
According to doctors, the remedy is really very effective and is perfectly absorbed by the human body. If the drug was administered correctly, then usually negative reactions do not occur at all. If the dosage was incorrectly calculated or the agent was administered very quickly, then this can lead to such a phenomenon as fat overload syndrome.
