Throughout his life, a person often encounters pain. They can haunt the body for a very long time. It can be both a temporary headache and a constant pain in connection with certain diseases. There are cases when conventional analgesics do not help, and then the drug "Nimesulide" comes to the rescue, which is a strong antipyretic and analgesic.
Composition and release form
This drug is synthetic. The active ingredient is nimesulide. The drug has 4 forms of release. First of all, these are tablets, which include 100 mg of active ingredient. Tablets are in blisters of 10 pieces, in a carton there may be 1, 2 or 3 blisters. Also, "Nimesulide" is available in the form of a powder, from which a suspension can be made. One sachet contains 100 mg of the active ingredient. The carton may contain 30, 15 or 9 sachets. In addition, this drug has the form of a ready-made suspension, with a volume of 5 ml, which contains 0.05 mg of nimesulide. Another form of release of the drug "Nimesulide" is a gel that hasvolume 30 g.
Pharmacological action
Nimesulide is an analgesic, anti-inflammatory, antiplatelet and antipyretic agent.
Indications for use
It should not be forgotten that this medicine does not affect the progression of the disease, it is intended for symptomatic treatment and reduces or relieves pain only for the duration of its use. The medicine "Nimesulide" is used for toothache and headache, as well as for some diseases of the muscles and joints. Such diseases are osteoarthritis, rheumatoid arthritis, arthralgia, myalgia, tendinitis, bursitis, algomenorrhea and pain in the postoperative period. Also indications for use are various infectious and gynecological diseases. It is also used for fever.
Contraindications
Both the powder and Nimesulide tablets have a fairly large number of contraindications. Instructions for use defines exactly these:
- active bleeding of the gastrointestinal tract;
- erosion or ulcers on the mucous membrane of the stomach or duodenum;
- cerebrovascular bleeding;
- hemophilia or other causes of blood clotting;
- any inflammatory bowel disease in an exacerbation, such as ulcerative colitis or Crohn's disease.
In addition, contraindications are:
- active liver disease or liver failure;
- heart failure;
- bronchialasthma;
- recurrent polyposis;
- advanced kidney disease or kidney failure;
- hypersensitivity to any components of the drug;
- alcoholism and drug addiction.
It is also forbidden for children under the age of 12, women who are expecting a baby or breastfeeding a baby, to take Nimesulide tablets. The instructions for use show that this drug should be used with caution in patients who have cerebrovascular diseases, dyslipidemia, CHF, diabetes mellitus. Patients with bad habits and the elderly should also take the medicine with caution.
Using the drug
"Nimesulide" in the form of tablets, suspension or powder is taken orally. Nimesulide gel is applied to the skin in the area with pain. The use of the drug is possible only in patients over 12 years of age. Tablets and suspension are applied 2 times a day (100 mg of the active substance). The maximum dose of the drug is 400 mg. When using the drug in the form of a gel, it must be applied to the affected area of the body (no more than 3 cm) and rubbed with light massaging movements. The gel should not be applied under a dressing.
When preparing the Nimesulide suspension, the powder must be dissolved in 100-150 ml of water. Patients who have renal insufficiency should reduce the daily dose, it should be 100 mg of nimesulide. For the elderly, dose reduction is notrequired. It is necessary to follow some rules when using the drug "Nimesulide". Not everyone knows what it is, therefore, in order not to cause adverse reactions, it is necessary to drink this medicine with a large volume of water, and also use the maximum dose per day for a very short time. With a minimum intake of the drug, the course of treatment can be continued for about 2 weeks. If long-term treatment is required, it is necessary to be constantly monitored by a doctor.
Adverse reactions
This drug may cause side effects. It can manifest itself as allergic, and other similar reactions. Side effects can cause both gel and powder, and "Nimesulide" tablets. The instruction determines the possibility of such skin reactions:
- the appearance of itching and rashes on the skin;
- increased sweating;
- dermatitis;
- erythema;
- swelling of the face;
- urticaria.
The following reactions of the nervous system are possible:
- nervousness;
- feeling of fear;
- dizziness and headache;
- drowsiness and nightmares;
- encephalopathy.
Regarding the urinary system:
- dysuria;
- swelling;
- hematuria;
- kidney failure;
- urinary retention;
- oliguria;
- hyperkalemia;
- institial jade.
There may also be side effects regarding the digestive system:
- vomiting and nausea;
-diarrhea or constipation;
- abdominal pain, gastritis;
- flatulence;
- stomatitis;
- stomach ulcer;
- stomach bleeding.
These are the adverse reactions that Nimesulide (tablets) can provoke. The instruction shows that there may also be a side effect regarding the hematopoietic system:
- thrombocytopenia;
- anemia;
- pancytopenia;
- eosinophilia.
For the respiratory system, reactions such as:
- shortness of breath;
- bronchospasm;
- asthma.
Also possible general weakness, tachycardia, hypertension, blurred vision and hypothermia.
Overdose
In case of overdose, side effects may increase. To put the body in order after an overdose of Nimesulide, it is necessary to wash the stomach and take activated charcoal. At the same time, it is necessary to constantly monitor the function of the kidneys and liver.
Interaction with other drugs
Do not use Nimesulide tablets with inhibitors and GCS, use in this case can lead to the development of gastric bleeding. Taking this drug together with a diuretic is not recommended, as renal hemodynamics can be disturbed. "Nimesulide" helps to reduce the bioavailability of furosemide. It also has the ability to replace furosemide and salicylic acid in plasma proteins. Do not use this medicine with alcoholic beverages.
Special Instructions
If improvement does not occur, it is necessary to stop using the drug "Nimesulide". What it is and why the medicine does not work, the doctor should explain and prescribe another remedy. The maximum daily dose should be taken for a very short time to avoid side effects. The use of the drug should be discontinued if, while taking it, there is an increase in temperature or flu-like symptoms develop.
The development of side effects most often occurs in the elderly, so it is imperative to monitor the patient's condition during treatment with Nimesulide. Analogues of this drug should also be used with caution in elderly patients.
"Nimesulide" has a negative effect on the fertility of women. Therefore, you should not take it during pregnancy planning. This drug affects the central nervous system, so you should not drive a car. Activities that require increased concentration should be avoided.
Drug storage
"Nimesulide" should be stored in a dark and dry place. The temperature should not exceed 24 degrees. Do not use the medicine after the expiration date, which is 48 months.
"Nimesulide". Analogues
This drug contains the active ingredient nimesulide, and this substance is also found in all substitutes for this drug. The need for an analogue may arise for various reasons, for example, some substitutescontain a smaller dose of nimesulide, and some have many additional substances that give the drug a more pleasant taste and smell. Most often, pharmacies offer such drugs instead of Nimesulide: Nimesulide Maxpharma, Nise, Nimesil, Nimika, Nimulide, Mesulide, Nemulex, Kokstral, Novolid, Prolid, Florida, Aulin, Aponil, Ameolin. Many of these drugs are available in both tablet and powder form and as a gel to rub into the skin.
Prepart Reviews
Basically, reviews about this drug are only positive. In addition, the price for it is quite affordable. Many patients believe that Nimesulide is the best way to cope with pain. What it is, every adult knows who has had to deal with severe pain or high fever. Many patients say that the drug practically does not cause side effects, some think differently, indicating that after taking the medicine they get sleepy. The instruction warns about this and advises not to drive a car at the same time. Also, patients highlight the fact that "Nimesulide" acts quickly and gently relative to its counterparts. But in any case, you should not take the drug for a very long time, and if necessary, you should consult a doctor and, if possible, replace it with a weaker drug, which includes nimesulide. What it is? The main active ingredient in many pain medications.
