What is the drug "Mydocalm"? What does this remedy help with? We will present the indications and features of the medication in question below. You will also learn how to treat with this drug, how much it costs and what its composition is.
Medication form, packaging, description, composition
In what form does Mydocalm come to pharmacies (what does this medicine help with, we will tell below)? This tool is available in tablets, as well as in a solution intended for parenteral administration.
Round and white tablets "Mydocalm", the price of which is indicated below, consist of tolperisone hydrochloride. As additional ingredients, the composition of the drug in question includes: anhydrous colloidal silicone, citric acid monohydrate, corn starch, stearin, hydroxypropyl methylcellulose 2910, talc, macrogol 6000, microcrystalline cellulose, dye, lactose monohydrate and titanium dioxide.
This tool is produced in blisters, which are placed in paper boxes.
Transparent solution "Mydocalm" in ampoules also contains tolperisone hydrochloride and lidocaine. ExceptIn addition, this medicine contains the following ingredients: talc, citric acid monohydrate, lactose monohydrate, anhydrous colloidal silicone, macrogol 6000, microcrystalline cellulose, stearin, titanium dioxide, corn starch, black iron oxide, hydroxypropyl methylcellulose 2910, red iron oxide and yellow iron oxide.
The drug "Mydocalm" in ampoules is contained in plastic containers, which are placed in cardboard boxes.
Basic Features
What is Mydocalm? What helps this drug? According to the instructions, the agent in question belongs to the muscle relaxants of the aminoketone group, which has a central effect.
The effectiveness of this drug is related to the regulation of the part of the (caudal) reticular formation. The use of this medication contributes to the inhibition of increased reflex excitability of the spinal cord. It also affects nerve endings (peripheral).
Features of the drug
The drug "Mydocalm" (the compatibility of this drug with others is acceptable, but under special conditions) is an N-anticholinergic. Its active substance has a stabilizing effect on the membranes in the primary fibers (afferent), as well as motor neurons. This effect of the drug is due to its ability to influence the reflex work of the spinal synapses.
It should also be noted that this drug secondarily slows down the excretion of mediators. This happens due to the inhibition of the process of calcium entry intosynaptic structures found in nerve fibers.
The influence of this agent on the reticulospinal pathway is especially pronounced when the excitation processes are slowed down. Similarly, the local anesthetic effect of the drug is revealed (due to the content of lidocaine in it).
Drug kinetics
The agent in question is well absorbed from the intestines. Its concentration (maximum) in the blood is reached 65 minutes after ingestion. Metabolism of the drug occurs in the kidneys and liver. Tolperisone derivatives are excreted in the urine.
A repeated course of "Mydocalm" has no effect on the functioning of the kidneys and liver, as well as on the process of hematopoiesis.
This remedy reduces experimentally induced stiffness and hypertonicity of muscle tissues. The medicinal properties of this drug are actively used to reduce muscle rigidity and pathological hypertonicity, which are associated with extrapyramidal disorders.
It should also be noted that this drug promotes human activity (his movements). In addition, it does not affect the cerebral cortex in any way, fully maintaining the level of wakefulness of the patient.
According to the instructions, treatment with "Mydocalm" causes slightly pronounced antispasmodic and adrenoblocking effects. This improves tissue perfusion.
In the course of long-term clinical studies, this drug did not have a pronounced effect on hematopoiesis and kidney function.
The drug "Mydocalm": from whathelps?
This tool is indicated for use in the following cases:
- In pediatric practice for the treatment of Little's disease (that is, spastic paralysis). In addition, this drug is used for encephalopathy of another origin with symptoms of muscular dystonia.
- In conditions that are accompanied by pathological hypertonicity of striated muscle tissues, developing due to pathologies of (neurological) organic origin (for example, with multiple sclerosis, encephalomyelitis, myelopathy, residual effects of acute disorders of cerebral circulation, lesions of the pyramidal tract).
- In conditions that have arisen as a result of damage to the innervation of blood vessels (for example, with acrocyanosis, intermittent angioedema).
- With muscle hypertonicity, muscle contracture that accompany diseases of the organs of movement (for example, spondylosis, arthrosis of the elbow, knee and hip joints, spondylarthrosis, lumbar and cervical syndromes).
- In case of post-thrombotic disorders of venous blood flow and lymphodynamics.
- As a restorative postoperative treatment in orthopedic and trauma practice.
- With trophic ulcers that form on the lower extremities, angiopathy (including diabetogenic), angiosclerosis obliterans and thromboangiitis, as well as autoimmune diseases (with Raynaud's disease and systemic scleroderma).
Prohibited use
In what cases it is impossibleprescribe pills and injections "Mydocalm"? The use of this medicine is contraindicated in:
- myasthenia gravis;
- hypersensitivity to tolperisone and known allergy to lidocaine;
- up to three months of age (in tablet form up to one year).
How to use
The regimen for the use of this remedy is established by the doctor depending on the course of the disease, as well as the tolerance of the drug.
For adults, the drug is prescribed in the amount of 150-450 mg (daily dose) in three divided doses. The starting dosage of this medicine is 50 mg three times a day. With insufficient efficiency, it is increased.
For intramuscular injections, the drug is used in an amount of 200 mg per day (in two injections), and intravenous - 100 mg (once a day). In the second case, a very slow infusion of the drug is required.
For children older than three months (up to 6 years), the dosage of the medication in question is calculated according to the following scheme: 5-10 mg per kg of weight (three times a day). For a child 7-14 years old, it is recommended to use tablets in a daily dose of 2-4 mg per kg of body (three times a day).
Oral intake of "Mydocalm" must be combined with food intake.
Side actions
Taking the drug with individual hypersensitivity can cause muscle weakness, dyspeptic symptoms (nausea, discomfort and vomiting), as well as headaches.
With a rapid intravenous infusion of a solution, a decrease inAD.
With individual intolerance to the drug, allergic reactions develop. As a rule, when the dose of the drug is reduced, the side effects disappear very quickly.
Drug interaction
No interactions known to limit the use of the drug in question. However, it should be noted that tolperisone has an effect on the central nervous system. At the same time, the drug does not cause drowsiness, so it can be combined with hypnotics and sedatives, as well as medicines containing ethanol.
When taken simultaneously, "Mydocalm" enhances the effect of niflumic acid. If it is necessary to combine such agents, it may be necessary to reduce the dose of the latter.
Peripheral muscle relaxants, drugs for general anesthesia and psychotropic drugs, as well as "Clonidine" increase the effectiveness of tolperisone.
Cost and reviews
How much does Mydocalm cost? The price of this tool is about 185 rubles.
Patient reviews say that the medication in question is very effective, especially in diseases of the joints. In addition, this remedy helps well with impaired blood circulation in the brain, including those that have arisen after a traumatic brain injury.
Among the negative reviews are those that say that the drug "Mydocalm" is not a panacea. Most often, this medicine is used as a maintenance treatment.
