Inflammatory processes caused by various infections cause people a lot of suffering and inconvenience. They cause serious and dangerous diseases of the ENT organs and the urinary system, provoke skin rashes and the occurrence of gynecological ailments. Is there a drug that could overcome all these diseases caused by a bacterial infection? Yes.
Quite often, for the diseases mentioned above, doctors prescribe Unidox Solutab. Instructions for use of this tool are of interest to many patients. It is about this medication that will be discussed in this article.
What is a drug? What side effects does it cause? Under what ailments is its use justified? This information is covered in detail in the instructions for use "Unidox Solutab". However, before we figure out what the medicine is prescribed for and how to take it, let's find out what the medicine consists of.
Quick line-up
According to the annotation to the drug, “Unidox Solutab” is a broad-spectrum antibiotic. Its main component is semi-synthetica substance from the group of tetracyclines called doxycycline.
The drug is available in the form of tablets. The pills are round in shape and light yellow in color. Each tablet contains one hundred milligrams of doxycycline.
Auxiliary substances, according to the instructions for use for Unidox Solutab, are microcrystalline cellulose, low-substituted hyprolose, saccharin, colloidal anhydrous silicon dioxide, hypromellose, lactose monohydrate, magnesium stearate.
How does the drug work when it enters the human body?
Pharmacological possibilities
The effect of the use of "Unidox Solutab" is achieved due to the fact that the active substance of the drug has an inhibitory effect on the microorganisms that caused a particular disease. Doxycycline ribosomal membranes located in the cell of the pathogen, and also interferes with the implementation of the processes of RNA synthesis of some pathogens.
According to the instructions for use, "Unidox Solutab" is able to destroy gram-positive (streptococci, staphylococci, etc.), as well as gram-negative bacteria (treponema, klebsiella, salmonella, and so on).
Yet some microorganisms are resistant to the effects of doxycillin. Therefore, only the attending physician should prescribe the drug. It is he who, on the basis of tests, knows which bacteria caused the disease.
Pharmacokinetic properties
As written in the instructions for use, "Unidox Solutab" is absorbed from the gastrointestinal tract rather quickly. Two hours afterreception, the active substance is found in many tissues of the human body (organs, saliva, teeth). However, the substance practically does not enter the cerebrospinal fluid.
By binding to plasma proteins (about 80-95%), doxycillin is evenly distributed throughout the body, providing an antibacterial effect on pathogens.
According to the annotation, the half-life of "Unidox Solutab 100 mg" ranges between 12 and 22 hours. It all depends on the individual characteristics of the patient. The drug is excreted unchanged by the kidneys (approximately forty percent) and intestines (about sixty percent).
In what cases does the doctor prescribe Unidox Solutab?
For what ailments take pills
According to the instructions for use, “Unidox Solutab” is prescribed for infectious and inflammatory diseases of various localization. For example, in diseases of the ENT organs (such as tonsillitis, sinusitis, otitis), as well as the respiratory system (for example, bronchitis, pharyngitis, lung abscess, tracheitis).
Urogenital ailments caused by pathogens are also effectively treated with this antibiotic. Such diseases include cystitis, urethritis, prostatitis, pyelonephritis and others.
Also, doctors prescribe Unidox Solutab for ureaplasma and other sexually transmitted infections. Among them, gonorrhea, chlamydia and syphilis should also be mentioned.
It is noteworthy that the drug is able to cope withinfections located in the organs of the gastrointestinal tract, provoking dysentery, cholecystitis, diarrhea, cholera, gastroenterocolitis and others.
Such ailments as typhus, malaria, plague, osteomyelitis, whooping cough, anthrax, peritonitis, sepsis can be treated with Unidox Solutab. Doxycycline may also be prescribed for severe purulent rashes or acne.
In some cases, your doctor may consider it appropriate to prescribe an antibiotic for prophylactic purposes, for example, after surgery to prevent suppuration, and before visiting an area where there is a malaria epidemic.
As you can see, the spectrum of action of the antibiotic is quite wide. However, does this mean that Unidox Solutab can be taken by everyone indiscriminately? Of course not. Only the attending physician has the right to prescribe drug therapy. It is he who determines the duration of the course and the daily dosage of doxycycline.
Moreover, the drug has some limitations in its use. Which ones?
When not to use the remedy?
Before answering this question, it is necessary to find out what negative effect this antibiotic has. According to studies, doxycycline accumulates in bone tissue, thereby forming insoluble compounds with calcium. Because of this, Unidox Solutab tablets are contraindicated during pregnancy and breastfeeding. Also, they are not recommended for children under eight years of age, when the little man is actively developingskeleton and molars appear.
Also, an antibacterial agent cannot be used in treatment if a person is allergic to tetracyclines or any other component that is part of the medication.
In addition, leukopenia, porphyria and serious disorders in the functioning of the kidneys or liver are clear contraindications for the use of the drug.
How should an antibiotic be taken to get the desired effect?
General rules
Regarding taking pills, the manufacturer recommends taking them orally with meals. The pill can be swallowed whole or crushed and mixed with a small amount of water. The maximum amount of doxycycline per day for adult patients is 300-600 mg. "Unidox Solutab" is also prescribed for children who have reached the age of eight. In this case, the daily rate of the active substance is calculated as follows: two to four milligrams per kilogram of the child's weight.
Most often, doctors prescribe two hundred milligrams per day for the treatment of an adult patient. The therapy lasts for several days, then the dosage is halved.
Dosage and course of treatment
First of all, you should know that the individual schedule for taking the drug is determined only by the attending physician. However, the manufacturer in the annotation to the medication provided general recommendations regarding the use of the drug. The appointment schedule depends on the ailment and its severity.
For example, with ureoplasma, chlamydia, endocervicitis and urethritis, the patient is prescribed a drug for seven days a hundredmilligram twice a day. If a person suffers from gonorrhea or syphilis, then the attending physician may prescribe the same treatment regimen, but the course of treatment will be longer - from two to four weeks, depending on the stage of the disease.
With abundant purulent rashes on the skin, the medication is prescribed one hundred milligrams per day for a long time (from one and a half to three months).
For preventive purposes, "Unidox Solutab" is prescribed one tablet (one hundred milligrams of the active substance) two days before departure, throughout the stay in the danger zone and a month after returning home. If a person is to undergo surgery, then the remedy is taken in the amount of one tablet sixty minutes before the manipulation. After the operation, the patient needs to take two more pills.
Are there any negative reactions when taking the drug? Of course, and we will talk about this below.
Overdose
"Unidox Solutab" is a serious antibiotic, so it is very important to take it in accordance with the doctor's prescription. However, due to negligence, the patient may take more than necessary.
What are the symptoms of an overdose? First of all, a person will be disturbed by severe nausea, vomiting, headache and diarrhea. The treatment of such an unpleasant condition is to wash the stomach. You can also take enterosorbents.
What about the side effects of taking this antibiotic?
Side Effects
Drug maybe accompanied by unpleasant symptoms. This information is contained in the instructions for Unidox Solutab. Patient reviews about this remedy confirm that antibiotic treatment may be accompanied by unpleasant manifestations.
For example, from the digestive system, such negative phenomena as nausea and even vomiting, constipation or diarrhea, and abdominal pain are possible. More serious diseases are extremely rare and manifest as anorexia, dysphagia, glossitis, increased levels of bilirubin and liver transaminases.
The hematopoietic system may also react negatively to antibiotics by developing thrombocytopenia, hemolytic anemia, and neutropenia.
Many patients, judging by the reviews, experienced side effects such as a rash on the body, eosinophilia. Very rarely, manifestations of Quincke's edema and photosensitivity are possible.
Also, many people note that taking Unidox Solutab tablets provoked candidiasis, tinnitus, dizziness, dysbacteriosis, tachycardia, lowering blood pressure. Moreover, such unpleasant symptoms as blackening of tooth enamel, fragility of bones, hallucinations, shortness of breath are possible.
As you can see, “Unidox Solutab” is a very serious antibiotic, which only the attending physician has the right to prescribe. In order to avoid overdose and negative consequences, it is necessary to strictly follow the recommendations of a specialist.
Combination with other medicines
Very important to know about antibiotic interactions with otherspharmacological agents. For example, the instructions for use recommend not taking doxycycline and medicines based on metal ions at the same time (these can be antacids or iron, calcium or magnesium preparations).
If it is necessary to use the active substance in combination with carbamazepine, barbiturates or phenytoin, then it should be borne in mind that such an interaction reduces the antibacterial effect of the drug of interest to us.
Doxycycline is best not taken concomitantly with other antibiotics (penicillins or cephalosporins). Also, the interaction of the component with cholestyramine and colestipol is undesirable, since they reduce its absorption. If joint treatment is necessary, an interval of three hours should be observed between taking the drugs.
When using oral contraceptives containing estrogen, their reliability decreases due to complex use with doxycycline. With the combined therapy of the component and anticoagulants, it is necessary to adjust the dosage of the latter. It should also be borne in mind that the simultaneous use of an antibiotic and retinol increases intracranial pressure.
Is Unidox Solutab compatible with alcohol? Like any antibiotic, it is better not to combine this drug with alcohol-containing drinks. This is very important, since such an interaction can not only reduce the therapeutic effect of taking medications, but also provoke the occurrence of side effects and unpredictable reactions.
Storage Tips
Regarding the storage of the antibiotic, it should be mentioned that it is necessarysave at 15-25 degrees Celsius for five years from the date of manufacture of the medication. The drug is best stored in a dark place, out of the reach of children and animals.
What patients say
Many patients note the effectiveness of tablets in the treatment of serious diseases such as ureaplasma, chlamydia, tonsillitis, pneumonia, cystitis and even purulent acne. However, very often consumers in their reviews note that they suffered from side effects of the antibiotic. For example, patients were worried about nausea, headaches, bowel problems and other solvable problems.
It is very rare to find reviews that the drug did not suit patients, or that it turned out to be ineffective at all. Although such cases are also possible, because "Unidox Solutab" is not a universal remedy, completely suitable for the treatment of all people without exception.
With regard to the rules for taking the drug, patients are advised to take it strictly according to the instructions and in accordance with the recommendations of doctors. Also, people recommend combining this antibiotic with probiotics so as not to cause irreparable harm to the intestines. Moreover, patients are strongly advised to take the tablets after meals, and not on an empty stomach, as this can provoke severe bouts of nausea and vomiting. Also, many have noticed that the antibiotic of interest to us lowers immunity. Moreover, there is an opinion that it is an outdated medicine and, moreover, is capable of causing temporary infertility.
Therefore, whether to take Unidox Solutab or not is up to you. Upon acceptancedecisions should not be based solely on consumer feedback. It is important to listen to the opinion of a doctor who is experienced and trustworthy, and follow the recommendations of a specialist.
What are the analogues
Due to the fact that the drug has a wide list of contraindications and side effects, it may be necessary to cancel it and switch to other drugs.
What medicines can serve as analogues of Unidox Solutab?
If we talk about a full-fledged analogue, then it is “Vibramycin”, the active ingredient of which is also doxycycline. The drug is available in the form of capsules and has the same indications and contraindications as Unidox Solutab.
Also, a 100% analogue of the antibiotic we are interested in is “Doxycycline”, a drug produced in the form of capsules, tablets and lyophilisate, which is used to prepare a solution for injection. This tool is used in infectious and inflammatory processes of the respiratory system and ENT organs, such as bronchitis, tonsillitis, pharyngitis, tracheitis, otitis, and so on. Also, the remedy is actively used for pathologies of the genitourinary system (ureaplasma, urethritis, prostatitis, gonorrhea). Infectious diseases of the eyes, skin and soft tissues, the gastrointestinal tract and the biliary system are also effectively treated with this antibiotic. It is often used for typhoid, malaria, dysentery, cholera, and so on.
As you can see, “Doxycycline” is a full-fledged substitute for “Unidox Solutab”. However, many patients note that it is worse tolerated,than the medicine we are interested in.
Among the inexpensive analogues of Unidox Solutab, there are Oletetrin tablets, the active ingredients of which are aleandomycin and tetracycline. Additional substances are magnesium carbonate, calcium hydrogen phosphate dihydrate, calcium stearate. This antibiotic is prescribed for the same ailments as the drug of interest to us. These medicines have not only a similar spectrum of action, but also the same contraindications and side effects.
“Tygacil” is another antibiotic analogue of “Unidox Solutab”. Its active ingredient is tigecycline. The drug is an orange powder for solution for injection and infusion. The drug can be prescribed for complicated infections of soft tissues and skin, community-acquired pneumonia and complicated intra-abdominal infections.
We have analyzed the instructions for use of Unidox Solutab. Patient reviews and analogues of the drug were also presented to your attention.
