According to the instructions, Beretta tablets are among the anti-ulcer drugs and are an inhibitor of H-K-ATPase or the proton pump. This drug acts by inhibiting the H-K-ATPase enzyme in the parietal gastric cells, as a result of which the final stage of the occurrence of hydrochloric acid is blocked. This action is characterized by dose-dependence and inhibits not only basal, but also stimulated secretion of hydrochloric acid, regardless of the nature of the stimulus.
Shape, packaging and composition
"Bereta" - a drug used for acid disorders. It is produced in the form of biconvex round tablets with a shell that dissolves in the intestine. In addition, two layers are presented on their transverse section. Color - yellow with a grayish tint. Releases itpharmaceutical company "Veropharm" (Russia).
The active substance of the drug is sodium rabeprazole, additional components are the substances of giprolose and low-substituted giprolose, mannitol, magnesium stearate and magnesium oxide. The inner shell contains magnesium oxide and ethylcellulose.
The shell, dissolving in the intestine, contains yellow acrylic with copolymers of methacrylic acid included in it, and titanium dioxide and colloidal silicon, iron yellow oxide dye, sodium lauryl sulfate, sodium bicarbonate, triethyl citrate. This confirms the instructions for use for Beretta tablets. Analogues will be presented below.
Sold in pharmacies in carton packs with embedded contour packs containing seven and ten tablets. There are either two packages in a pack, or one, but containing fourteen tablets. In addition, they contain a polymer bottle with twenty or fourteen tablets.
The drug is allowed to be stored for two years after its production. The temperature should not be higher than twenty-five degrees. Children should be restricted access to the place where the drug is stored. What else does the instruction say to the Beret tablets? Let's find out.
Pharmacology
Bereta is a drug used against ulcers and acts as a proton pump inhibitor. The mechanism of the functioning of the drug is based on the process, under the influence of which the pump enzyme is inhibited in a specific gastric region, and as a result, the final stageacid formation is blocked.
Pharmacokinetics
After taking the medicine "Bereta", it is absorbed from the gastrointestinal tract. The therapeutic effect of a dose of twenty milligrams culminates in three and a half hours. "Beret" is about fifty-two percent bioavailable, as it passes through the liver. But repeated use of the drug does not contribute to the growth of bioavailability. This points to the Beret tablets instruction.
Absorption of the drug is also not affected by the time of its intake and food.
A component such as rabeprazole is responsible for ninety-seven percent of the connection with plasma proteins. The metabolism of this drug is carried out in the liver with the participation of certain isoenzymes.
In elderly patients, rabeprazole is excreted more slowly. What are the indications for Beret tablets? This will be discussed further.
Indications for use
The drug is prescribed for patients suffering from stomach ulcers and duodenal ulcers. It is especially recommended for their exacerbations. It is most often taken in combination with certain antibiotics. In addition, this drug is indicated for children with gastroesophageal reflux.
Contraindications
The drug should not be used by pregnant women and nursing mothers, as well as patients who have a specific sensitivity to the main components of the drug.
Instructions for using the drug
According to the instructions, Beretta tablets are indicated for internal use, while a single dose can be from ten to twenty milligrams. Depending on the individual characteristics of the disease, the doctor will prescribe a treatment regimen for the patient.
Negative effects of application
"Beret" has a very impressive list of side effects from their use, and they must be taken into account in the process of prescribing this drug to the patient.
The digestive system may respond as follows:
- attacks of nausea, diarrhea, vomiting, abdominal pain, constipation, flatulence;
- may experience less dry mouth, belching and dyspepsia;
- in isolated cases, gastritis, anorexia, stomatitis and increased liver transaminase activity were noted.
The nervous system can respond with the following reactions:
- headaches, insomnia, dizziness, asthenia;
- less often - drowsiness, nervousness;
- in very rare cases - defects in taste and visual sensations, depression.
Respiratory:
- rhinitis, cough, pharyngitis may appear;
- in more rare cases, bronchitis, sinusitis are possible.
Allergic reactions:
- very rare skin rashes may occur;
- In isolated cases, itching may occur.
Other side effectssigns:
- pain in the back, flu-like syndrome;
- very rare - chest pain, muscle cramps, chills, myalgia;
- in isolated cases, increased sweating or the occurrence of leukocytosis, weight gain.
Nature of interaction with other drugs
If you take Beretta tablets simultaneously with ketoconazole, then its bioavailability characteristics will decrease. If taken together with digoxin, it is possible to increase the concentration of this drug in plasma.
Influence on plasma gastrin levels
During clinical studies, patients were taking ten or twenty milligrams of rabeprazole sodium every day. The duration of therapy is up to forty-three months. At the same time, an increase in plasma gastrin levels was noted during the first two to eight weeks, which is an indicator of an inhibitory effect on acid secretion. The concentration of gastrin returned to the initial state mainly one to two weeks after the completion of therapy. This is important in the treatment of gastroesophageal reflux in children.
Effect on enterochromaffin-like cells
During the analysis of biopsy samples of the human stomach from the antrum and gastric fundus in five hundred patients who received rabeprazole sodium or a comparator drug for eight weeks, no stable changes were found in the morphological structure of the severity of gastritis, metaplasiaintestines, the frequency of atrophic gastritis or the prevalence of the bacterium Helicobacter pylori.
In a study of more than four hundred people who took rabeprazole sodium at ten or twenty milligrams a day for one year, there was a low incidence of hyperplasia, equal to that of omeprazole (twenty milligrams per kilogram). There were no cases of adenomatous transformations or carcinoid tumors that were observed in rats.
Some recommendations
Before starting therapy, it is necessary to eliminate the presence of malignant gastric neoplasms, since the use of rabeprazole can mask the characteristic symptoms and delay the correct diagnosis for some time. If the patient has defects in the functioning of the kidneys or liver, there is no need to adjust the dose, with severe liver dysfunction, rabeprazole should be used with caution.
If digoxin and ketoconazole are taken concomitantly with rabeprazole, doses need to be adjusted.
Carcinogenic effects of rabeprazole under experimental conditions have not been established, but during the study of mutagenicity, results of an ambiguous nature were noted. In mice, tests on lymphoma cells were positive, while in vitro and in vivo DNA repair and in vivo micronucleus tests were negative. This confirms the instructions for use for Beretta tablets.
Analogues of the drug
Pills have similardrugs that are similar in pharmacological effects, but their cost is much higher. These include the following medicines:
- Zulbeks.
- "Pariet".
- Noflux.
- Ontime.
All of these products also come in tablet form.
Producer of the drug "Bereta"
The manufacturer of this medicinal product is Veropharm OJSC (Russian Federation). This joint-stock company manages all stages, including the issuing quality control. The pharmaceutical substance, namely rabeprazole sodium, is produced by the Indian manufacturer Nosh Labs Private Limited. Let's consider what are the reviews about Beret tablets.
Reviews
It is worth noting that there are not too many reviews about the drug "Bereta", and therefore it is rather problematic to draw any definite conclusion about the effectiveness of the influence of this drug, as well as the safety of its use. However, reviews of rabeprazole, which is the active ingredient, suggest that this drug should act fairly quickly, even if small doses are used. The undoubted advantage of Beret tablets is the small number of side effects and the widely available cost in comparison with the price of analogues.
There is a positive effect of the drug on acidity and a decrease in reflux. Quite well, it helps to correct hemorrhagic gastritis. Some reviews note the temporary nature of the effect of the drug, in suchcases required a course of other pills.
Price
“Bereta” differs from similar expensive drugs in that it has a fairly reasonable cost, averaging no more than two hundred and fifty rubles.
