The drug with the trade name "De-Nol" is recognized as an effective gastroprotector. Doctors also prescribe this remedy for various pathologies of the stomach. De-Nol tablets have antiseptic, astringent, antiulcer and anti-inflammatory effects.
Indications
Painful sensations in the epigastric zone, indigestion, belching, heartburn - this is just a short list of alarming signs with which a person turns to a gastroenterologist or therapist. After carrying out all the necessary diagnostic measures, the doctor draws up the most effective treatment regimen, which often includes the use of De-Nol tablets.
The drug is not an antibiotic. Nevertheless, based on the information specified in the instructions for use, "De-Nol" helps to rid the body of pyloric Helicobacter pylori - the causative agent of functional dyspepsia and gastritis. The active substance of the drug penetrates directly to the site of pathogenicmicroorganisms, and then destroys them in a short time. The drug also improves the course of many ailments that affect the gastrointestinal tract.
Indications for "De-Nol":
- Gastritis, gastroduodenitis (both acute and chronic).
- Loss of the duodenum, perforation of the walls of the stomach of any severity, including the peptic form.
- IBS.
- Functional dyspepsia.
- Destruction of the mucous membrane of the digestive organ, which is a consequence of taking hormonal and non-steroidal anti-inflammatory drugs.
- GERD is a pathology of a chronic nature, the course of which is accompanied by the penetration of the contents of the stomach back into the esophagus.
- Iron deficiency anemia that persists for a long time. However, the reason for its appearance has not been established.
Also an indication for "De-Nol" is the prevention of relapses after surgery in the stomach, performed to treat an ulcer or remove a malignant neoplasm. In addition, the drug is recommended for people whose next of kin suffered from cancer of the digestive organ.
Release form, composition
Medication "De-Nol" is sold in cardboard boxes. Each of them contains 7 or 14 blisters of 8 tablets. The manufacturer specifies that a slight ammonia smell may be present in the package.
Pills are round and biconvex. Each one is sheathed. Tablet color -light cream. The manufacturer has thought out a system of protection against counterfeiting. On each tablet, you can see the graphic embossing of gbr 152 on both sides. They also feature a square pattern with broken side lines and slightly rounded corners.
The instructions for use of "De-Nol" indicate that the active ingredient of the drug is tripotassium bismuth decitrate. One tablet contains 304 mg. In addition, the composition is represented by the following auxiliary components: corn starch, magnesium stearate, hypromellose, potassium polyacrylate, povidone K30.
The active substance, when interacting with water, forms a colloid, which, in turn, is able to penetrate into the mucous layer that envelops the walls of the stomach. There it breaks down into compounds, forming a protective film.
Bismuth tripotassium decitrate has the following positive effects:
- Increases the degree of resistance of the digestive mucosa to adverse factors.
- Destroys pathogens. The active substance destroys their shell, prevents the vital activity and fixation of bacteria to the wall of the organ.
- Promotes the speedy recovery of the mucosa.
- Reduces the degree of activity of gastric juice.
The advantages of the drug include the fact that its action does not violate the process of digestion. Even with long-term treatment, pathogens do not develop resistance to the agent.
Instructions for use
"De-Nol" is prescribed only by the attending physician, who takes into account the results of the diagnosis. At the same time, there should be no drugs containing bismuth in the therapy regimen.
The important thing is how to take "De-Nol" - before meals or after a meal. In order for the active substance to be beneficial, it must penetrate the walls of the stomach. If there is even a small amount of food in the organ at this time, tripotassium bismuth decitrate will mix with it and leave the body naturally. As a result, even a minimal positive impact will not be exerted on the body. That is why the drug must be taken strictly on an empty stomach. For the next 30 minutes, it is forbidden to drink and eat any food.
Based on the instructions for use, "De-Nol" is recommended to be taken according to the following scheme:
- Children under 12 and adults. The daily dose of the active substance is 480 mg. During the day, you need to drink 4 tablets. They can be divided into 2 or 4 doses.
- Persons 8-12 years old. Daily dosage - 240 mg. You need to take 1 tablet twice a day.
- Children 4-8 years old. The pediatrician calculates the daily dosage individually. For 1 kg of body weight of a child, there should be 8 mg of the active substance.
Pills must be swallowed whole. It is unacceptable to chew them, break them, or grind them in any other way. While taking the drug, it is necessary to ensure that a sufficient amount of liquid enters the stomach. It is recommended to take the tablets with clean non-carbonated water. It is forbidden to drink milk, nectars, vegetable and fruit juices simultaneously with the medicine.
Duration of De-Nol treatment is from 3 weeks to 2 months. This period is explained by the fact that even after getting rid of pathogenic microorganisms, a high activity of inflammatory processes remains in the stomach. The exact duration of treatment is indicated by the doctor when prescribing De-Nol. The course at the same time depends on the existing disease, its severity. The individual characteristics of the patient's he alth are also taken into account.
Contraindications
"De-Nol" is not recommended for people suffering from the following ailments:
- kidney disorders;
- Severe allergic adverse reaction;
- individual intolerance to the components of the drug.
The drug is forbidden to be taken by women during pregnancy and lactation. This is due to the likely negative effect on the fetus and the penetration of the active substance into breast milk. Bismuth is a heavy metal, therefore, if there is a vital need for taking it, it is necessary to stop breastfeeding the baby during treatment.
In addition, a contraindication to "De-Nol" is the age of children under 4 years of age. It is also not prescribed if the patient has recently taken drugs containing bismuth for the treatment of other pathologies.
Side effects
Most often, while taking the remedy, patients experience the following conditions:
- nausea;
- flatulence;
- increased urge to defecate or, conversely, constipation;
- appetite disorder;
- metal taste in the mouth;
- feces change color (from dark brown to black).
The presence of the above side effects of De-Nol is not a reason to see a doctor. Their occurrence is due to the adaptation period. These conditions disappear without any intervention, their presence does not mean that the course of treatment must be interrupted.
Rarely, patients experience allergic reactions. As a rule, they manifest themselves in the form of itching and rashes on the skin. The decision as to whether it is advisable to continue treatment should be made by the doctor. Isolated cases of anaphylactic shock as a side effect of De-Nol have been recorded.
Duration of treatment with the drug should be no more than 2 months. This period can be increased by a doctor, but only if there is a vital need. This is due to the fact that long-term treatment significantly increases the risk of developing the following diseases:
- nephropathy;
- arthralgia;
- gingivitis;
- pseudomembranous colitis;
- encephalopathy.
The triggering factor for the occurrence of these pathologies is the accumulation of bismuth in the central nervous system.
With strict adherence to the prescribed treatment regimen, the risk of complications is minimal. They disappear on their own after the end of the medication. As a rule, serious complications are extremely rare. In most cases they area consequence of an unjustified increase in dosage or duration of treatment. When they appear, you need to see a doctor.
Overdose
Judging by the reviews, "De-Nol" is well tolerated by patients. The threat to he alth is taking the drug at a dosage 10 times higher than the standard. In such cases, kidney failure develops.
Deterioration of well-being can occur against the background of long-term treatment, in which a large amount of bismuth has accumulated in the tissues of the central nervous system. In this situation, symptomatic therapy is indicated. At the same time, the course of treatment with De-Nol is completed.
In case of acute poisoning, you need to call an ambulance. Before the arrival of doctors, it is recommended to wash the affected stomach, give him sorbents and saline laxatives. In severe cases, the patient is hospitalized. In the hospital, the patient is prescribed hemodialysis and taking medications that restore the normal functioning of the kidneys.
Compatibility with other drugs and alcohol
It happens that the patient simultaneously with "De-Nol" takes other drugs designed to get rid of gastrointestinal pathologies.
In this case, their compatibility must be taken into account:
- Proton pump inhibitors. These include: Omez, Omeprazole, Nolpaza, Pantan, Ulsepan, Pariet, Rabiet, Ontime, Epicurus, Lancid, Helicol, etc. At least half an hour must pass between taking any of these funds and using De-Nol.
- Antacids. The most common drugs:Gastracid, Phosphalugel, Maalox, Rennie, Vikalin. Means containing bismuth and antacids are incompatible. There should be at least half an hour between their doses.
In addition, De-Nol and alcohol are incompatible. With any type of treatment, it is not recommended to drink alcohol-containing drinks, especially for people with certain stomach diseases. Alcohol irritates the walls of the organ, preventing the penetration of the active substance into them. Also, the drug is often prescribed simultaneously with antibiotics. If you take both alcohol and De-Nol at the same time, the toxic effect on the liver will increase significantly.
Analogues
Currently, there are several products on the pharmaceutical market, the active ingredient of which is bismuth tripotassium dicitrate.
The most famous analogues of "De-Nol" are the following drugs:
- Ulkavis. Contains 303 mg of active substance. It is an anti-ulcer and anti-inflammatory agent that inhibits the vital activity of the Helicobacter pylori bacteria. The drug must be taken 4 times a day for half an hour before a meal. Dosage for children - 1 tablet twice a day. While taking the drug, the following side effects may occur: nausea, vomiting, frequent urge to defecate, allergic reactions. Ulcavis is most often recommended by doctors as an analogue of De-Nol.
- Novobismol. An antiseptic and antiulcer agent, the regimen of which is also identical to the dosing regimen of De-Nol. Manufacturernotes that during the treatment of Novobismol, not only feces, but also the tongue may darken. The duration of treatment should also not exceed 8 weeks.
- "Escape". Antiulcer and gastroprotective agent with bactericidal activity against Helicobacter pylori. It has the same indications and limitations as De-Nol. The reception scheme is also identical to the last one.
The drug "Venter" has a similar effect. Its active ingredient is sucraf alt. Unlike products containing bismuth, this drug has the ability to bind fatty acids much better. However, the active substance has no effect on the bacterium Helicobacter pylori.
Reviews
Most patients feel better within a few days of starting the drug. Judging by the reviews, "De-Nol" in a short time eliminates the unpleasant symptoms associated with the development of gastritis, peptic ulcer and other pathologies of the gastrointestinal tract.
Doctors prescribe this drug to their patients most often. This is due to its high degree of efficiency. In most cases, when re-examination, specialists reveal significant improvements in patients.
In conclusion
Currently, diseases of the digestive system are diagnosed very often. To combat them, doctors in most cases prescribe "De-Nol". This is a modern drug, the active substance of which penetrates the walls of the stomach and forms a protective layer that preventsimpact on the body of negative factors. In addition, it contributes to the speedy recovery of its mucous membrane.
According to the instructions for use, "De-Nol" must be taken 4 times a day (or twice a day, but 2 tablets at once). The main contraindications are: pregnancy, lactation and children under 4 years of age. Based on the information in the instructions for use, the drug has a number of side effects, the risk of which is minimal if the dosage regimen and dosage regimen are strictly followed.
