"Longidase" is an enzyme preparation. The drug is produced in the form of a lyophilizate for the manufacture of a solution for intramuscular and subcutaneous injections. In addition, the drug is available in the form of rectal and vaginal suppositories. What is in Longidaza?
Suppositories for rectal or vaginal use contain a hyaluronidase conjugate with polyoxidonium. The auxiliary component is cocoa butter.
One vial of powder contains hyaluronidase conjugate. An additional substance in Longidase is mannitol.
Healing properties
According to the instructions for use, it is known that the drug has a prolonged effect, and also has an antioxidant, immunostimulating and anti-inflammatory effect.
"Longidase" has an antifibrotic effect, facilitates the course of an inflammatory disease that is in the acute phase.
When used subcutaneously or intramuscularly in conjunction with other injectable drugs "Longidaza"enhances their absorption, and with the introduction of local analgesics, the drug accelerates pain relief. Why is Longidase prescribed?
According to the instructions for use, it is known that the use of pharmacological dosages of the drug during surgery does not adversely affect recovery in the postoperative period. In addition, after surgery, it does not provoke the progression of the infectious process.
Indications for the use of "Longidase"
According to the instructions for use, it is known that the lyophilizate for the manufacture of a solution for injection is recommended for adults with diseases that are accompanied by an increase in connective tissue:
- Adhesions in the pelvis.
- Chronic endometritis (inflammatory damage to the inner layer of the uterus, which can be triggered by various pathogens).
- Intrauterine synechia (fusions inside the uterus, which are complete or partial infection of the uterine cavity).
- In chronic prostatitis (inflammation of the prostate gland, which leads to a violation of the morphology and function of the prostate).
- Interstitial cystitis (a clinical syndrome in which an inflammatory process of a non-infectious nature develops, affecting not the mucous membrane of the bladder, but the tissue located between it and the muscle).
- When adhesive processes after surgical procedures on the abdominal organs.
- In the presence of hypertrophic scars (a typescar tissue, characterized by an excess of fibrous fibers).
- Pyoderma (pustular skin diseases caused by pyogenic bacteria, the main of which are staphylococci and streptococci).
- Long non-healing wounds.
- Limited scleroderma (a chronic disease that leads to the replacement of connective tissue with non-functional scar tissue).
- When forming scars after injuries, operations.
- Pneumosclerosis (pathological replacement of lung tissue with connective tissue, as a result of inflammatory or degenerative processes in the lungs).
- Fibrosing alveolitis (a disease that is caused by diffuse damage to the pulmonary interstitium with the development of respiratory failure).
- Tuberculosis (an infectious disease caused by Mycobacterium tuberculosis and accompanied by the formation of granulomas in various organs).
- With tuberculoma (a form of pulmonary tuberculosis that looks like a tumor).
- Contracture of the joints (sustained restriction of movement in the joint).
- Arthrosis (a chronic joint disease with slow destruction of cartilage, as well as an increase in pathological changes in the synovial membrane).
- In ankylosing spondylitis (chronic systemic inflammation of the joints that affects the spine and limits its mobility).
- Hematoma (a type of bruising, limited accumulation of blood in closed and open injuries of organs and tissues with rupture (injury) of blood vessels; this forms a cavity containing liquid or clotted blood).
Any form of release of "Longidaza" is also used in conjunction with antibiotics in gynecology, urology, dermatovenereology, pulmonology, as well as with local anesthetics.
Suppositories for rectal or vaginal administration are prescribed to adult patients and adolescents from 12 years of age for complex therapy or monotherapy of diseases.
Indications for the use of "Longidase":
- Chronic endomyometritis (an inflammatory lesion that affects the mucous and muscular membranes of the uterus).
- Tubal-peritoneal infertility (the impossibility of conception as a result of impaired patency of the fallopian tubes, when the egg formed in the ovary cannot penetrate into the uterine cavity, where it should meet the spermatozoon).
- Prevention and treatment of adhesions in the pelvis in chronic inflammatory pathologies of the internal genital organs.
- Strictures of the ureters and urethra (abnormal narrowing of the ureteral canal, completely or partially obstructing its patency).
- Peyronie's disease (deformation of the penis during erection).
- The initial stage of benign prostate enlargement (a benign growth that develops from the glandular epithelium or stromal component of the prostate).
- After surgery on the urethra, ureters.
- Limited scleroderma (a chronic disease that leads to the replacement of connective tissue with non-functional scar tissue).
- Interstitial pneumonia (chronic lesions of the lung tissue, which are manifested by an inflammatory lesion and a violation of the structure of the alveolar walls, as well as the endothelium of the pulmonary capillaries, perivasal and perilymphatic tissues).
- Pneumofibrosis (the process of growth of the connective tissue of the lungs, which occurs under the influence of dystrophic or inflammatory processes).
- Tuberculosis.
- Fibrosing alveolitis (a pathological process based on extensive damage to the interstitial tissue of the lungs, leading to the development of fibrotic changes and respiratory failure).
- Siderosis (a type of pneumoconiosis that develops when working in dusty conditions with small metal shavings).
- Pleuritis (inflammation of the pleural sheets, with fibrin deposition on their surface).
- Non-healing wounds.
Restrictions
According to the instructions for use, it is known that contraindications to "Longidase":
- Hemoptysis (sputum coughing up blood from the larynx, bronchi or lungs).
- Pulmonary bleeding (a complication of various respiratory diseases, which is accompanied by the outflow of blood from bronchial or pulmonary vessels).
- Malignant tumors.
- Acute kidney disease.
- Pregnancy period.
- For solution - up to 18 years, for candles - up to 12 years.
- Fresh hemophthalmus (hemorrhage into the vitreous body of the eyeball and its surrounding structures, caused by damage to the vessels of the retina and subretinalspace).
- Breastfeeding.
- Acute infectious diseases.
- Increased individual sensitivity to drugs based on hyaluronidase.
With extreme caution recommend "Longidase" in chronic kidney disease.
How to use mortar
Before injection, add 1.5-2 milliliters of 0.5% procaine solution or water for injection to the contents of the ampoule or vial of powder. Ready solution cannot be stored.
The doctor sets the required dosage based on the patient's individual indicators, as well as the severity of the disease and age. Subcutaneous injections are used under scar tissue or near the affected area.
According to the instructions for use, it is known that the standard dosage of the drug for prostatitis "Longidase": 3000 IU once a day every 3-10 days. Given the severity of the disease, five to fifteen injections are prescribed.
If necessary, re-treatment should be carried out after two to three months. After passing the prescribed treatment, which is complicated by a severe chronic form in the connective tissue, the patient is prescribed a maintenance concentration of 3000 IU per day with an interval between injections of two weeks.
Use of injections "Longidase":
- Respiratory system: intramuscularly - 3000 microunits every five days, the course will require 10 injections. Further therapy is possible, which varies from 3 to 12 months in the sameconcentration with a time interval between treatments of two weeks.
- For lesions of the pelvic organs, intramuscular injections of 3000 IU are also prescribed once every 5 days, the duration of therapy is 5-15 injections.
- With limited scleroderma, 3000-4500 IU is prescribed intramuscularly per day every three days, the course of therapy is from 5 to 15 injections, the duration of treatment and dosage is selected by the doctor depending on the characteristics of the patient.
- In case of hypertrophic scars after burns, as well as pyoderma and surgical interventions, 3000 IU per day are used intramuscularly with a time interval between injections of three to five days, the duration of therapy is no more than 10 injections subcutaneously or intramuscularly - from 1 to 2 once a week.
When else is the drug prescribed? If the wounds do not heal for a long time, then 1500-3000 IU per day is administered intramuscularly every 5 days, the course of therapy is 5-7 injections.
According to the instructions for use, it is known that for arthritis, hematomas, intramuscular injections of 3000 IU per day every 7 days are prescribed, the total duration of therapy is from 7 to 15 injections.
In case of adhesive disease, 3000 IU is administered intramuscularly per day after 3-5 days, the course of treatment with Longidaza varies from 7 to 15 injections.
To increase the bioavailability of antibiotics, anesthetics are prescribed 1500 IU every 3 three days, the duration of therapy is no more than 10 injections.
Using candles
According to the instructions, suppositories are administered rectally or vaginally once a day before going to bed. According to the instructions for use for "Longidase" in gynecology, suppositories are inserted into the vagina in a supine position.
For rectal use, suppositories must be used after a bowel movement. The general course of therapy varies from 10 to 20 suppositories. The frequency of use of the drug depends on the severity and duration of the disease.
In urology "Longidase" is used 1 suppository every two days, the duration of therapy is 10 procedures. Further, with a time interval of three days - 10 suppositories, the duration of treatment - 20 suppositories.
In dermatovenereology, it is recommended to use 1 suppository every one or two days, the duration varies from 10 to 15 injections.
In surgery, 1 suppository is used every three days, the duration of treatment is 10 procedures.
According to the instructions for use for Longidase, candles in gynecology are used both rectally and vaginally: 1 suppository once every two days, the duration of therapy is 10 injections.
In pneumology, 1 suppository is prescribed once every two days, the duration of treatment varies from 10 to 20 applications.
As a maintenance treatment, it is recommended to use 1 suppository once every five to seven days, the duration is from three to four months.
Retreatment is possible after three months. In patients with kidney disease, the frequency of application of the solution or suppositories should not exceed once a week.
Side effects
According to instructions for useit is known that the substances that make up Longidaza in rare situations can provoke the occurrence of allergic reactions. A negative effect of the injection may be pain at the injection site, and sometimes swelling, redness of the skin.
Such side effects are temporary and disappear after 2-3 days. The use of suppositories in rare situations can provoke increased sensitivity, which is characterized by hyperemia, swelling, itching.
Application features
When an allergy occurs, the use of "Longidaza" should be immediately canceled. It is forbidden to apply the solution to the tumor area, as well as acute inflammation or infection.
In case of exacerbation of the disease, the use of the drug must be prescribed in combination with antimicrobial agents. If it is necessary to stop treatment with Longidaza, the drug can be discontinued without a gradual decrease in the concentration of the drug. Having missed the next dosage, the next injection is carried out in the standard mode, which is indicated in the annotation or recommended by the doctor.
You can not use a double dosage to compensate for the previous one. Before starting treatment, the patient must inform the doctor about all medications that are currently being taken.
Women in position and during lactation are prohibited from using the drug. Patients with acute kidney disease are contraindicated to use any form of release of Longidaza.
Recommendations
No suppositories, no injections"Longidases" do not affect driving in any way, and also do not reduce attention and the speed of psychomotor reactions.
Before therapy, it is necessary to take into account the compatibility of "Longidase" with other drugs, as well as substances and its effect on humans.
Compatibility of alcohol and "Longidase"
The drug should not be taken with alcohol. The minimum time that must elapse before using the medication is 8 hours after drinking alcohol for men and 14 hours for women. You can take alcohol the day before the injections or the use of suppositories.
According to doctors, it is generally better to refrain from drinking "alcoholic beverages" during therapy. During illness, immunity is lowered in the body, resistance to the disease is reduced. Additional load on the liver and internal organs during the processing of ethanol is unacceptable.
It doesn't matter which dosage form of "Longidaza" is used in the treatment: injections or suppositories, the active substances affect the body in the same way.
In the liver, as well as in the bloodstream, when confronted with products of the processing of wine alcohol, the influence of "Longidaza" is reduced. Therefore, the drug is not recommended to be combined with alcoholic beverages.
The main rules for taking products that contain ethanol and drugs without harm to he alth:
- Take the medicine two days before drinking.
- Do not exceed the safe concentration of alcoholdrinks regardless of the type - wine, beer or something strong.
- Drink enough water during a hangover.
- Continue therapy with the drug after removing alcohol from the body (2 days).
The main mistake of people is the failure to comply with the last paragraph. On the day when it is necessary to continue the use of the medicine, it is required to completely abandon alcoholic beverages. To drink alcohol during the treatment with "Longidaza" or not, it is up to the person to decide.
Doctors during therapy require the exclusion of ethyl alcohol. After the end of therapy with Longidaza, the recovery course may last, so the deadlines for resolving libations are postponed.
But it is best to exclude alcohol from the diet for the entire duration of therapy. If this is not done, then the effectiveness of treatment will greatly slow down. Since Longidase contains substances that are designed to regulate the processes of creating tissue matters, in medicine it is used to stop the growth of tissue cells.
Interaction with drugs
You can use "Longidase" with antibacterial, antiviral, bronchodilator, antifungal agents, as well as glucocorticosteroids, cytostatics.
Adrenocorticotropic hormone, cortisone, high concentrations of estrogens can reduce the action of the hyaluronidase enzyme. The drug increases the effect of local anesthetic drugs. How can "Longidaza" be replaced?
Generics
Substitute drugs"Longidases" perform:
- "Lidaza".
- "Polyoxidonium"
- "Ronidase".
- "Biostrepta".
- "Distreptaza".
- "Liraza".
- "Laproth".
An analogue of "Longidaza" in tablets is "Polyoxidonium".
"Longidase" must be kept away from children. Keep the medicine should be at a temperature of 2 to 15 degrees away from light, in a dry place. Shelf life - 24 months.
Prescription powder for injections, over-the-counter suppositories. The cost of the drug varies from 1500 to 3000 rubles. The manufacturer of Longidaza is the Russian pharmaceutical company NPO Petrovax Pharm.
Reviews about "Longidase"
Patients leave only good feedback about the drug. Both the suppositories and the lyophilisate show increased effectiveness on fresh adhesions, and also help dissolve old scars and prevent the formation of new ones.
Women, as a rule, the medication helps with gynecological diseases. "Longidaza" helps to eliminate adhesions, helps with ovarian cysts, and the drug is also effective for endometriosis. There are responses that tell that after the treatment of gynecological ailments with Longidaza, pregnancy finally occurred. Men are also positivespeak of "Longidase" in the treatment of prostatitis. They especially note the absence of negative reactions and the convenience of its use.
As cons, some patients point to the unpleasant smell of candles, and when injecting, they talk about pain at the injection site.
