The drug "Sanpraz" is a drug used in the treatment of stomach ulcers and is an inhibitor.
According to the instructions for use for "Sanpraz", the main substances of this medication are able to block the final stage of the production of hydrochloric (hydrochloric) acid, reduce the level of stimulated (regardless of the type of stimulus) and basal secretion of the substance in the stomach cavity.
How does the drug work?
In case of duodenal ulcer, which is provoked by such an infectious agent as Helicobacter pylori, a decrease in the level of gastric secretion increases the threshold of sensitivity of the pathological microorganism to antibacterial drugs.
Means affects the motility of the digestive tract. Secretory activity stabilizes approximately three to four days after discontinuation of its use. The instructions for "Sanpraz" are very detailed, considerthe main points that will help you use the drug correctly.
Forms of release and constituent substances
The drug is available in two main dosage forms:
- As a lyophilisate for the preparation of solutions for intravenous use: almost or completely white powder. The solvent is a clear, colorless solution. The drug is available in glass bottles of 10 ml of 40 mg. The instructions for Sanpraz indicate that the carton packs contain one such bottle in a set with an ampoule of solvent.
- Pills, coated with a special enteric coating, have a round biconvex shape and yellow color (packed in 10 pieces in aluminum strips, and in carton packs in one or three strips).
Instructions for use for "Sanpraz" informs that the composition of the lyophilizate includes the main active element pantoprazole (in the form of pantoprazole sodium sesquihydrate) and an additional component (solvent): isotonic sodium chloride solution. One tablet contains the main active ingredient and auxiliary elements: calcium stearate, magnesium oxide, colloidal silicon dioxide, sodium lauryl sulfate, calcium carbonate, crospovidone. The enteric coating contains methacrylic acid ethyl acrylate copolymer and copovidone, macrogol 6000, titanium dioxide, triethyl citrate, yellow iron oxide, talc.
Indications for prescribing the drug
According to the instructions forapplication to "Sanpraz", the main pathological conditions in which this drug is prescribed are:
- gastrinoma (Ellison-Zollinger syndrome);
- eliminate Helicobacter pylori bacteria (as part of a combined antibiotic treatment);
- gastric and duodenal ulcer in the period of exacerbation;
- hemorrhagic (erosive) gastritis caused by the bacterium Helicobacter pylori;
- ulcerative-erosive lesions of the above organs caused by the use of anti-inflammatory nonsteroidal drugs;
- treatment for reflux gastroesophageal disease;
- treatment and prevention of ulcers caused by nerves due to stress, as well as their consequences (bleeding, penetration of ulcers, perforation).
Contraindications
According to the instructions for use, "Sanpraz" is contraindicated for use in the following cases:
- dyspeptic disorder of neurotic origin;
- malignant neoplasm in the area of the digestive organs;
- children and adolescents under 18 years of age (because there is no data on the use of the drug in pediatric clinical practice);
- lactation;
- hypersensitivity or individual intolerance to any of the medicinal elements of the medication.
The medicine "Sanpraz" is prescribed with some caution in pregnancy and liver failure.
Doses and method of administration
Tablets of the drug "Sanpraz" are intended for oral use. The drug is taken, as a rule, in the morning, one hour before meals. When prescribing a dosage twice a day, the second dose is taken before the evening meal (also, one hour before). The tablet is recommended to be swallowed whole and washed down with the required amount of liquid. Adult patients "Sanpraz" is prescribed in the following dosages: destruction of Helicobacter pylori bacteria - one tablet twice a day. The therapeutic course in this case is 7-14 days. Treatment may be combined with certain antimicrobial medications. With hemorrhagic gastritis, ulcerative lesions of the stomach and duodenum, patients are prescribed 1-2 tablets per day. The course of therapy is selected, as a rule, on an individual basis, taking into account the stage of the disease and the progression of ulcers.
With prolonged use of anti-inflammatory non-steroidal drugs, "Sanpraz" is used for preventive purposes, half a tablet a day.
Adjustment of the dosing regimen is required for severe hepatic impairment. The drug is taken 1 piece every other day. At the same time, monitoring of biochemical parameters of blood is regularly carried out. With an increase in the functionality of liver enzymes, the drug "Sanpraz" must be canceled. If oral use of the drug is not possible, patients are prescribed intravenous administration of medicinal solutions. As soon as the opportunity arisesfunds inside, then the patient is immediately transferred to the tablet form of the drug. This is confirmed by the instructions for the use of "Sanpraz". Analogues will be considered below.
Preparation of solutions
To prepare solutions, you need to restore the bottle with the lyophilizate contained in it using the solvent that is included in the kit. The finished medicine is administered intravenously by stream or in the form of infusions, lasting from 3 to 15 minutes.
To prepare a solution for infusion, the reconstituted lyophilisate should be mixed with 100 ml of physiological or glucose solution, while it should have a pH of 9-10. The shelf life of the finished product is three hours from the date of manufacture. With the intravenous form of drug administration, the recommended dosage per day is 40 mg.
Instructions for use for "Sanpraz" reports that the duration of the therapeutic course is approximately seven to ten days, and if necessary, it can be extended for a few more days.
In Ellison-Zollinger syndrome, this drug is used for a very long period of time, while the initial daily dosage can be up to 80 mg, subsequently reduced.
You must strictly follow the instructions for use for the tablets "Sanpraz". Exceeding the recommended dosages can adversely affect the body.
When prescribing a drug in a dose of more than 80 mg, it is divided into two stages of administration. In certain cases, a temporary increase in doses up to 160 mg is required. To eradicate bacteriaHelicobacter medicine is used in a daily dosage of 80 mg in two applications. This requires systematic monitoring of the biochemical properties of blood.
In elderly patients and people with impaired renal function, the drug is prescribed in the doses recommended by the instructions for use, and correction of this regimen is usually not required.
Adverse reactions
According to the instructions for use and reviews, "Sanpraz" can cause a number of negative side reactions, the list of which includes:
- Digestion system: dry mouth, pain in the upper abdomen, dyspepsia, stool disorders, functional deficiency of liver cells, accompanied by jaundice, increased production of liver enzymes flatulence.
- Nervous system: headaches, blurred vision and disorientation, dizziness, confusion, depression, hallucinations, weakness.
- Hematopoietic system: decrease in the number of platelets and leukocytes.
- Musculoskeletal system: arthralgia, myalgia.
- Allergic and dermatological reactions: itching and rash on the skin, anaphylactic shock, urticaria, sensitivity to light, Lyell's syndrome, angioedema, erythema multiforme, Johnson-Stevens syndrome.
- Local reactions at injection sites: phlebitis and thrombophlebitis.
- Other reactions: peripheral edema, breast tenderness and tenderness, hyperthermia, interstitial nephritis, increased triglycerides.
When using this medication for the indications and in the recommended dosages, adverse reactions are extremely rare. This is confirmed by the instructions and reviews for "Sanpraz".
Special Recommendations
Therapy with the drug "Sanpraz" can mask the symptoms of malignant neoplasms in the stomach or esophagus, so patients are advised to undergo an endoscopy before using the substance pantoprazole and after the end of therapeutic procedures.
When dyspeptic disorders of neurogenic etiology occur, the drug is ineffective.
In addition, this medicine does not affect the ability to drive a car and engage in other potentially hazardous activities that are associated with a high risk of harm to he alth.
Instructions for use of the drug "Sanpraz" does not end there.
Drug Interactions
With the parallel use of the drug with ketoconazole, ritonavir and iron s alts, the rate of their absorption is significantly reduced; with warfarin - the prothrombin time is lengthened and there is a risk of bleeding, sometimes with a fatal outcome; with atazanavir - its effectiveness decreases.
No clinically significant therapeutic interaction has been found with the following drugs: ethinylestradiol, nifedipine, amoxicillin, ethanol, caffeine, digoxin, diclofenac, metronidazole, cisapride, glibenclamide, naproxen, cyclosporine,levothyroxine sodium, diazepam, phenytoin, tacrolimus, carbamazepine, piroxicamphenazone, midazolam, theophylline, metoprolol, clarithromycin.
In the instructions analogues of "Sanpraz" are not indicated. We will look at them below.
Analogues
Medications similar in effect or composition in this case are:
- "De-nol";
- "Drotaverine";
- Gaviscon;
- Kvamatel;
- Ectis;
- "Abisib";
- Metrogil;
- Beta-Clatinol;
- Famotidine;
- Vis-nol;
- "Talcid";
- "Pantasan";
- Proxium;
- Limzer;
- "Gastrofitol";
- Vikair;
- Alumag;
- "Almagel";
- "Renorm";
- "Diaprazole";
- Yazbin;
- "Pariet".
Reviews about the drug
The drug "Sanpraz" is currently widely used and prescribed by specialists in the treatment of certain gastric pathologies. Patient reviews are mixed. One category of patients is of the opinion that the drug is very effective and helps to cope with gastritis and ulcers in the stomach, without causing significant inconvenience associated with the development of negative side reactions.
Other patients prefer other drugs to Sanpraz, because they did not notice any particular clinical effect from taking it, and in some of themsevere side effects were observed, for example, severe dry mouth, dyspepsia, pain syndrome, for the elimination of which analgesics had to be used. It is also not uncommon to experience dizziness, sleep disorders and psychological disorders.
What do the experts say?
Experts do not recommend using this medication alone, as it can cause a number of complications. It is prescribed only upon detection of conditions included in the list of indications for use and in strictly controlled dosages. Otherwise, doctors warn that with the development of acute negative symptoms, it is urgent to stop taking this remedy.
We reviewed the instructions for use for "Sanpraz" and reviews, this information will be useful to those who suffer from gastrointestinal diseases.
