The drug "Prosulpin" is positioned by the instructions for use as a powerful antipsychotic agent that is used in the treatment of various disorders of the nervous system and other diseases. Read more about the above preparation.
Drug summary
This medicine belongs to the group of substituted benzamines. In another way, we can say that the drug "Prosulpin" is a typical antipsychotic. Reviews of experts indicate that its action is aimed at blocking dopamine receptors (D2 and D3). Due to this, the above drug produces an antipsychotic therapeutic effect.
50 or 200 mg of the substance sulpiride contains one tablet of the drug "Prosulpin".
Side effects when taking this medicine, of course, in some cases appear. Therefore, the patient during the course of therapy with the above antipsychotic agent should be under the strict supervision of a physician.
This medicine comes in several forms. It is available in tablet form, as well as in the form of capsules, solution for intramuscular injection and liquid for taking.inside.
The drug should be stored at normal room temperature, but not higher than 25 degrees Celsius. The place should be well protected from light and moisture. About two years is the shelf life of the drug "Prosulpin". Its analogues are easy to find. The drug market offers a wide range of substitutes for the above medicine.
Pharmacological action of the above remedy
The drug "Prosulpin", the photo of which is provided below, is an antipsychotic, that is, an antipsychotic. The substance sulpiride, due to the blocking of dopamine receptors in the tuberoinfudibular region, contributes to a significant increase in the level of prolactin. It should be noted that the degree of blocking of dopamine receptors fluctuates in the range of 60-80%.
The latter are distinguished by a rather high similarity with benzamides, which are characterized by such a feature as a biphasic effect on the neurotransmitter dopamine system. In addition, they block the increase in dopamine synthesis in the synaptic region, that is, they are antagonists of presynaptic D2 D3 auto-receptors.
It should be noted that the above drug has a moderate antipsychotic activity. The latter is combined with the thymoanaleptic and stimulating effects of this remedy.
The above medicine has the following pharmacological action:
- antiemetic (dopamine receptors block the trigger zone of the center of vomiting);
- antidepressive;
- antipsychotic.
Sulpiride has an antidepressant effect in doses up to 600 mg. Above this norm, the antipsychotic effect of this drug on the body is already observed.
In addition, the drug "Prosulpin", the instruction indicates this, produces a selective effect on the hypothalamus with symptoms of gastric ulcer and gastroduodenitis. At the same time, the high excitation of the centers of the sympathetic nervous system is suppressed, the gastric blood supply improves, the proliferation of granulation tissue and the processes of mucus secretion in the stomach are accelerated, a regenerated epithelium is formed, and the proliferation of capillaries in tissues improves.
Who is recommended to take this remedy?
What are the indications for the use of the drug "Prosulpin"? For medicinal purposes, the above medicine is used for such diseases:
- psychosomatic illness;
- stress ulcers of the digestive tract;
- symptomatic ulcers;
- gastroduodenitis;
- gastric ulcer;
- irritable bowel syndrome (colon);
- drug ulcers;
- ulcerative colitis;
- depressions of various etymologies;
- neuroses;
- reactive depressions;
- dysphoric disorders;
- schizophrenia;
- chronic mental disorders;
- migraine;
- acute mental disorders;
- dizziness of various etymologies (vestibular neuritis,vertebrobasilar insufficiency, Meniere's disease, otitis media).
The drug "Prosulpin" instructions for use suggest using for the treatment of behavioral disorders and psychosis in young patients, that is, in children. These are diseases such as self-mutilation, agitation, stereotypy. Also, the drug "Prosulpin" instructions for use strongly advises using it as part of a course of therapy for childhood autism. This tool is used to treat small patients aged 6 years.
Contraindications for the use of the above medication
The drug "Prosulpin" instructions for use do not recommend using if the patient has signs of the following diseases:
- hypersensitivity to drug components;
- hyperprolactinemia;
- prolactin-dependent tumors (breast cancer, pituitary prolactinomas);
- affective disorders;
- acute poisoning from drinks containing alcohol;
- aggressive behavior;
- pheochromocytoma;
- acute poisoning by drugs or sleeping pills;
- manic psychosis.
All these conditions are strict contraindications. Also, the drug "Prosulpin" instructions for use prohibits women who are breastfeeding their baby, children under 18 years old (for 200 mg pills), small patients under 6 years old (for 50 mg pills).
In addition, it should be remembered that with congenital lactose deficiency,malabsorption of glucose-galactose, lactose intolerance is also undesirable to use the drug "Prosulpin". Contraindications to the use of the above remedy also apply to pregnant women. It should only be used in such patients if the expected benefit of the drug is much greater than the potential risk to the fetus.
Side effects
When taking the drug "Prosulpin" (the instruction indicates this), some side effects may occur:
- from the endocrine system - galactorrhea, dysmenorrhea, amenorrhea, frigidity, impotence;
- from the side of the nerves - sedation, tremor, dizziness, early dyskinesia, extrapyramidal syndrome, drowsiness, akinesia with muscle hypertonicity, akathisia, motor agitation;
- increased enzyme activity (from the side of digestion);
- hemolytic anemia, leukocytosis, aplastic anemia, granulocytosis, thrombocytopenic purpura occur with increasing doses of Prosulpin (action from the lymph and blood system);
- tachycardia, orthostatic hypotension, decrease or increase in blood pressure, prolongation of the QT interval, in some cases, the development of such a dangerous disease as torsade des pointes syndrome (from the heart and its system).
Also, other side effects are caused by taking this medicine. The drug "Prosulpin" (instruction, doctors' reviews and patient responses indicate this) canprovoke such unpleasant phenomena as tardive dyskinesia, which is characterized by involuntary rhythmic movements of the face or tongue (with a long therapeutic course of neuroleptics of all groups), hyperthermia. Experts warn that in the latter case, it is especially important to cancel the above remedy in time, since an increase in temperature can be a sign of the development of such a dangerous disease as neuroleptic malignant syndrome.
Weight gain, excessive sweating, skin rash and itching - all these side effects can also cause the drug "Prosulpin". Instructions, expert reviews recommend in such cases to stop taking the above medication and immediately consult a doctor for medical help and advice.
Using the above remedy during pregnancy
The teratogenic effect of the drug was not found as a result of experiments on animals. Some women who have taken this medicine during their pregnancy have also not seen the above effect. But these patients took strictly low doses of Prosulpin. Instructions for use, expert reviews do not have specific information regarding the use of a higher amount of a substance such as sulpiride. There is also no data on the effect of the above drug on fetal brain development.
As a precautionary measure, experts do not recommend using this medicine for pregnant women. Although in some cases it is still possible to treat the abovea drug for patients who are expecting a baby, but strictly in minimal doses.
Experts note that if a mother received antipsychotic therapy for a long period, then newborn babies had problems with the functioning of the digestive tract (for example, bloating).
If a woman takes medicine in the period before childbirth, then control over her body and the development of the fetus by the doctor is mandatory.
It should also be remembered that the drug "Prosulpin" penetrates into breast milk. Instructions for use, reviews of experts do not recommend taking it during lactation.
How to take Prosulpin?
Instruction suggests that patients take the above antipsychotic drug every 8 hours, one pill. It is not recommended to take the medicine after 16.00 hours, since its activity is very increasing at this time. It should be noted that the drug "Prosulpin" is used regardless of the meal and is washed down with a sufficient amount of liquid.
Tablets that contain 200 mg of sulpiride are taken for symptoms of acute schizophrenia, delirious psychosis and depression. The drug can be taken in several doses. Its maximum daily dose is 100 mg, that is, about 5 pills.
Tablets, which include 50 mg of sulpiride, the instruction suggests taking if the patient has signs of neurosis, anxiety. Within 4 weeks, such patients should consume at least one and a maximum of 3tablets a day.
Also, these pills can be taken by children with severe behavioral disorders. The age of such patients must necessarily be above 6 years. The maximum daily dose for patients in this category is from 5 to 10 mg per 10 kg of body weight of the child.
Overdose
The instruction indicates that information on sulpiride overdose is limited. The following symptoms may be observed in this condition in a patient:
- tongue protrusion;
- dyskinesia with spastic torticollis;
- fuzziness of visual perception;
- dry mouth;
- may develop NMS;
- extrapyramidal symptoms;
- excessive sweating;
- nausea;
- sedation;
- gynecomastia;
- parkinsonism;
- increased blood pressure.
The above condition of the patient is treated as follows:
- the patient's stomach is washed;
- assigned activated carbon;
- systematic therapy is applied.
If necessary, in especially severe cases, the doctor may prescribe additional manipulations, such as forced diuresis with infusion of alkaline solutions or monitoring of vital body functions.
It should be noted that this drug is partially excreted during hemodialysis.
Some categories of patients should take special precautions when using the drug "Prosulpin". This applies primarily to women withirregular periods, patients with severe hypotension and hypertensive patients.
It is also important to conduct a preliminary electrophysiological and clinical examination in patients with epilepsy. It should be remembered that the drug "Prosulpin" lowers the threshold for seizure activity.
In addition, when driving, special care should be taken during the period of treatment with the above medicine. It is also important to limit activities that require quick psychomotor reactions and increased concentration.
Interaction with other medicinal products
The instruction strictly does not recommend including the above drug in complex therapy with levodopa. The two active substances are antagonists. If a patient who suffers from Parkinson's disease is taking levodopa, then the doctor should choose one that has minimal extrapyramidal effects.
Arrhythmia like torsades de pointes can be caused by a combination of Prosulpin with:
- antiarrhythmic drugs that belong to class Ia (drugs "Disopyramide", "Quinidine");
- Pimozide, Haloperidol, Thioridazine, Cisapride, Pentamidine, imipramine antidepressants;
- antiarrhythmic drugs, which are included in the 3rd class (Sotalol, Kakamiodarone);
- drugs that cause symptoms of bradycardia (beta-calcium channel blockers);
- drugs that contribute tothe appearance of signs of hypokalemia (laxatives that are stimulant, hypokalemic diuretics, tetracosactides, glucocorticoids);
- dopamine antagonists (antiparkinsonian): Apomorphine, Amantadine, Lizuride, Ropinirole, Entacapone, Bromocriptine, Selegiline, Pramipexole, Piribedil);
- neuroleptics that have the ability to cause symptoms of torsades de pointes (Chlorpromazine, Amisulpride, Cyamemazine, Pimozide, Droperidol, Levomepromazine, Tiapride, Sertindol, Veraliprid), "Sulpiride");
- preparations that contain lithium (the latter significantly increases the risk of extrapyramidal disorders).
Also, in no case should Prosulpin be used with alcohol. The latter potentiates the sedative effect of neuroleptics.
In addition, if the above medicine is taken in combination with centrally stimulating substances (anti-asthma, anorectics), the patient may experience symptoms of intense agitation, nervousness, anxiety, restlessness.
Be aware that this antipsychotic drug reduces the effectiveness of ropinirole.
Substitutes for the therapeutic agent "Prosulpin"
Analogues of the above antipsychotic drug:
- "Betamak T100";
- "Vero-Sulpiride";
- "Betamax T50";
- "Depral";
- "Betamax";
- "Dogmatil";
- "Betamax T200";
- "Sulpiride";
- "Eglonil";
- "Sulpiril";
- "Eglek".
But replace without prior consultation with the doctor does not recommend "Prosulpin" instructions for use. Its analogues also have their own individual side effects. They can bring great harm to the he alth of the patient.
Reviews about the therapeutic agent "Prosulpin"
Reviews about the above medicine are mostly positive. A lot of patients take it for depression. They claim that this remedy helps to eliminate the symptoms of this disease by almost 100%.
In addition, there are a lot of responses from patients who, with diseases such as schizophrenia, enterocolitis, colitis, psychosis, enteritis, peptic ulcer, irritable bowel syndrome, took the drug "Prosulpin". Their reviews indicate that in all cases this remedy produces an incredible therapeutic effect. In addition, patients note that side effects are very rare.
The drug discussed above has serious side effects, so it is strictly forbidden to use it without first consulting a doctor.
