Candles "Flexen" belong to the pharmaceutical group of NSAIDs (non-steroidal anti-inflammatory drugs). They have anti-inflammatory, antipyretic, analgesic and antiaggregatory effects. The presented drug blocks the activity of enzymes (cyclooxygenases 1 and 2) and the synthesis of prostaglandins. This process prevents the formation of inflammatory mediators and inhibits the production of leukotrienes.
Suppositories "Flexen" exhibit anti-bradykinin activity, stabilize lysosomal biomembranes, cause inhibition of neutrophil activity in patients diagnosed with rheumatoid arthritis. Suppress platelet aggregation. The analgesic effect is due to both central and peripheral mechanisms. Many doctors prescribe Flexen (candles) to relieve pain and treat arthritis. The price of the drug allows it to be purchased by different categories of patients. Reviews of the drug indicate its high efficiency andhe alth safety when following the appropriate recommendations.
The instructions for using the medicine are quite simple, and the reviews confirm the visible therapeutic effect. What is included in the medication? What properties does it have? Are there any dangerous side effects? Many patients are looking for answers to these questions.
Chemical composition of the drug
The composition of the drug includes a complex of bioactive and excipients:
- ketoprofen (the main bioactive compound);
- beeswax;
- hydrogenated vegetable oil;
- colloidal silicon dioxide;
- sodium ethyl parahydroxybenzoate;
- sorbitol;
- gelatin;
- vegetable oil;
- glycerol;
- soy lecithin;
- titanium dioxide;
- sodium propyl parahydroxybenzoate.
Flexen, candles: analogues
In therapeutic practice, doctors quite actively use analogues of the above drug:
- Artrosilene.
- Ketonal Duo.
- Artrum.
- Quick Gel.
- Valusal.
- Quickcaps.
- Ketonal.
- Oruvel.
- Febrofit.
- Flamax.
- Profenid.
- Ketonal uno.
Drug Benefits
The main advantages of the drug include the following indicators:
- maximum therapeutic effect;
- high bioavailabilitymedicines compared to its peers.
Flaws of medicine
The main disadvantages of Flexsen include the following criteria:
- high price of the drug compared to analogues;
- out of daily (prolonged) release form.
Pharmacokinetics
The binding of the bioactive substances of the drug to plasma proteins is 99 percent. Candles "Flexen" are characterized by high bioavailability (more than 90%). Therapeutic concentration of "Flexen" in the blood is maintained for 6 hours. The main metabolic breakdown of the drug occurs in hepatocytes by glucorination. The half-life is about two hours. The drug does not accumulate, it is excreted mainly by the kidneys and through the intestines.
"Flexen" (candles): instructions for use, price
The above drug exhibits a wide therapeutic spectrum of action. In clinical practice, in the treatment of pain and inflammatory reactions of various origins, suppositories "Flexen" are often prescribed. The use of the drug is recommended for the following pathologies:
- migraine;
- psoriatic arthritis;
- tenosynovitis;
- renal colic;
- gouty arthritis;
- bursitis;
- dorsalgia;
- myalgia;
- rheumatoid arthritis;
- otitis media;
- osteoarthritis of various localization;
- polymyalgia rheumatica;
- bone pain;
- sciatica;
- phlebitis;
- ankylosing spondylitis;
- neuralgia;
- thrombophlebitis;
- sciatica;
- adnexitis;
- pathology in the lumbosacral plexus;
- sciatica;
- algodysmenoria;
- postoperative and post-traumatic syndrome;
- lymphangitis;
- pain syndrome in oncological pathologies.
You can buy the drug "Flexen", the price of which varies in the range of 200-300 rubles, if you have a prescription, you can at any pharmacy. It is also worth noting that Flexen suppositories are quite often used in gynecology, they are prescribed for ovarian cysts. According to the testimonies of many patients, the medicine works quite effectively. Many doctors claim that after treatment with Flexen for 10 days and the subsequent intake of additional medications, the cyst disappears.
Contraindications
If you decide to use "Flexen" (candles), the instructions for use indicate that this medication should not be used in the following cases:
- bleeding in the gastrointestinal tract;
- pronounced dysfunction of the liver and kidneys;
- lactation period and pregnancy;
- hypersensitivity to non-steroidal anti-inflammatory drugs;
- hemorrhoids;
- "aspirin" asthma;
- blood clotting disorders;
- proctitis;
- under 15;
- dysfunction of the hematopoietic system (leukopenia, hemocoagulation disorders, thrombocytopenia, hemophilia);
- diseases of the digestivetract in the acute phase.
Special Instructions
"Flexen" (candles) instruction shows to prescribe with extreme caution to patients with dysfunction of the kidneys, liver, digestive tract, bronchial asthma, alcoholism, rhinitis, with polyps on the nasal mucosa, dehydration, urticaria, smoking, liver cirrhosis, hyperbilirubinemia, blood diseases, sepsis, diabetes mellitus, cerebrospinal pathologies, the elderly. In the process of treatment with this medication, systematic monitoring of kidney and liver function is necessary. If suppositories "Flexen" are prescribed in conjunction with anticoagulants (heparin), the risk of bleeding increases. A long therapeutic course is possible only in a hospital setting. Avoid alcohol during treatment.
Side effect
Have you been assigned "Flexen" (candles)? Instructions for use does not exclude the development of side effects. This is:
- severe headaches;
- nausea;
- heartburn;
- dizziness;
- vomit;
- loss of appetite;
- insomnia;
- gastrointestinal hemorrhages;
- asthenia;
- drowsy;
- conjunctivitis;
- xerophthalmia;
- nervousness;
- constipation;
- tinnitus;
- forgetfulness;
- blurred vision;
- hepatitis;
- hearing loss;
- vertigo;
- peripheral neuropathy;
- gastralgia;
- tachycardia;
- transient dysuria;
- hyperemia;
- eczema;
- cystitis;
- nephrotic syndrome;
- urethritis;
- photodermatitis;
- laryngeal edema;
- hematuria;
- exudative erythema;
- kidney dysfunction;
- edematous syndrome;
- itchy skin;
- skin allergies;
- increased activity of aminotransferases (alanine- and aspartate aminotransferase) in blood serum;
- shortness of breath;
- rhinitis;
- nosebleed;
- bronchospasm;
- anaphylactic shock.
The use of suppositories can also cause diarrhea, burning sensation and tenesmus.
Symptoms of drug overdose
Candles "Flexen" are intended for rectal use - 1 suppository (100 mg) 1-2 times a day. The maximum allowable daily dose of ketoprofen is 300 mg. In case of an overdose of the drug, the following symptoms are observed:
- liver and kidney dysfunction;
- drowsy;
- nausea;
- bleeding;
- severe pain in the epigastric region;
- vomit.
If the above signs are detected, symptomatic therapy is prescribed. There are no specific antidotes. Activated carbon, Sorbex, Medetopek or Neointestopan are prescribed as adsorbents. Hemodialysis, forced diuresis are ineffective methods of treatment. Alkalizing drugs are prescribed to relieve symptoms from the alimentary canal. If necessary, glucocorticoids may be used. Atkidney failure, hemodialysis is performed. For convulsions, Diazepam or other benzodiazepan anticonvulsants are prescribed; in case of severe hypotension, plasma substitutes are administered ("Reopoliglyukin", "Polyglukin", "Enterodez", "Polidez", "Hemodez"). The patient requires constant observation for several days, as there is a risk of later manifestation of some gastrointestinal pathologies (bleeding, ulceration).
Interaction with other medicines
Enhances the effect of anticoagulants, fibrinolytics, ethanol, antiplatelet agents, reduces the effect of peripheral vasodilators, spironolactone, the effectiveness of uricosuric drugs, antihypertensive pharmaceuticals and diuretics. The above medicine is incompatible with Tramadol. The combined use of Flexen with other non-steroidal anti-inflammatory drugs, ethyl alcohol, glucocorticosteroids, corticotropin provokes the formation of ulcers and the development of gastrointestinal bleeding. Antacids reduce the absorption efficiency of the drug. Two days before the test for the content of 17-ketosteroids, the drug is canceled.
"Flexen" increases the hypoglycemic effect of insulin, as well as oral hypoglycemic drugs. Myelotoxic drugs increase the manifestations of hematotoxicity of the drug. Inducers of microsomal biooxidation in the liver (Phenylbutazone, ethanol, tricyclic antidepressants, Phenytoin, Rifampicin, barbiturates) activate the biosynthesis of hydroxylatedactive metabolites. The simultaneous use of "Flexen" with "Sodium Valproate" causes a violation of platelet aggregation.
Reviews about the drug
Many patients are interested in the question of what the Flexen candles really are. Instructions for use, the cost of the drug, indications and contraindications - these are, of course, the main points. Nevertheless, it is worth getting acquainted with the opinion of specialists and patients on this matter. Most doctors believe that the best analgesic and anti-inflammatory agent is Flexen (candles). Patient reviews in most cases (80 to 90%) are positive, due to the high efficacy of the drug, reliable relief of pain of various etiology and localization, long-term effect, and ease of use. A positive effect can be noted from the first days of admission. Negative reviews about the drug are mainly associated with the appearance of side effects and its cost, however, such disadvantages of the drug are not able to overshadow its high efficiency.
Terms of dispensing from pharmacies
The drug in the form of suppositories and capsules is released strictly on prescription. The gel medicine is available without a prescription.
Storage conditions
Keep out of the reach of children at a temperature not exceeding 25–30°C. The specified temperature regime applies to all forms of release. The expiration date is indicated on the packaging. The medicine should not be taken after the expiration date!
