The drug "Mexidol" (reviews note that the drug helps relieve nervous tension, remove headaches and lower cholesterol) is a modern antioxidant. It is used to stimulate cerebral circulation, has a positive effect on memory. The body after treatment with "Mexidol" becomes more resistant to lack of oxygen. Used to treat adults, the elderly and children. It was created in 1996 by scientists from Russia. Widely used in medical practice for the treatment of vascular diseases.
Composition of the drug
In reviews of Mexidol, patients note that the drug improves the blood supply to the cerebral cortex. Acts quickly and effectively.
Mexidol injection solution is produced in the form of a colorless liquid with a yellowish tint. The active ingredient of this medication is ethylmethylhydroxypyridine succinate. Excipients are sodium metabisulphite and purified water.
Pharmacology
Reviews about "Mexidol" are positive, people call him "a real savior". They say that it alleviates the condition with vegetovascular dystonia, relieves vasospasm. Improvements come after the first injection.
The drug is characterized by nootropic, antihypoxic and anxiolytic properties. It has a membrane-protective and anticonvulsant effect. Makes the body more resistant to stressful situations and the influence of negative factors. Helps to endure the lack of oxygen that occurs in conditions such as:
- hypoxia;
- intoxication of the body;
- shock;
- ischemic heart disease;
- cerebrovascular accident.
"Mexidol" has a beneficial effect on brain metabolism. Improves blood supply to the brain, stimulates microcirculation, reduces platelet aggregation, has a positive effect on blood properties, normalizes the structure of plasma during hemolysis, stabilizes the content of platelets and erythrocytes.
Drug reduces cholesterol levels, as well as low-density lipoproteins. Possesses hypolipidemic quality. Reduces the degree of intoxication that occurs with pancreatitis in the acute stage of development.
"Mexidol" increases the amount of dopamine in the brain. It enhances the activity of glycolysis and reduces the inhibition of oxidative reactions that occur during hypoxia in the Krebs cycle. At the same time, the degree of content of creatine phosphate and ATP increases. going onstimulation of mitochondrial functions and normalization of cell membranes, metabolic processes in the myocardium are stabilized, the necrosis zone is reduced. Electrical activity is restored, myocardial contractility improves, coronary blood flow enters the ischemic zone in a larger volume. The consequences that appear in the reperfusion syndrome, coronary insufficiency, become less pronounced. The antianginal activity of nitropreparations increases.
The drug protects against damage to the optic nerve fiber, as well as retinal ganglion cells in neuropathy, improves visual acuity.
Indications for use
In reviews of the use of Mexidol, it is noted that the drug is often prescribed by neurologists to children with speech delay. It is said that the drug works effectively, and the child after therapy becomes calmer, begins to speak and learns new information better.
"Mexidol" is prescribed for problems of cerebral circulation. The drug is used for craniocerebral injuries and to eliminate the consequences after them. The indication is vegetovascular dystonia and dyscirculatory encephalopathy. An injection solution is prescribed for atherosclerotic cognitive disorders occurring in a mild stage of development. Use it for anxiety. Involved in the complex therapy of myocardial infarction, open-angle glaucoma and in inflammatory, purulent processes in the abdominal cavity (peritonitis, pancreatitis).
The drug is indicated for alcoholism, whenvegetovascular and neurotic disorders are observed. The drug relieves withdrawal symptoms in alcohol dependence. Intoxication of the body with various antipsychotic drugs is the reason for the appointment of this remedy.
The price of "Mexidol" in the reviews (analogues, if necessary, can replace this medicine, but they should be selected by a doctor) is indicated as overpriced, because the drug is Russian and could cost several times cheaper.
Contraindications
More than once confirmed the good preventive effect of thrombosis patients in the reviews of "Mexidol". Analogues, despite the content of succinic acid and lower cost, are inferior to this agent in terms of their effectiveness. Therefore, doctors use Mexidol in their practice and do not recommend replacing it with other medicines.
The drug has contraindications. It is not used in violation of the renal and hepatic organs. It is not used in case of hypersensitivity to the active ingredient and excipients of Mexidol.
Caution should be exercised when treating pregnant and lactating women and children with this medication due to the lack of clinical trials.
"Mexidol": instructions for use
In the reviews (the price of an injection solution is 500 rubles for 10 ampoules of 2 ml), patients say that they were satisfied with Mexidol, which was used to treat cardiovascular diseases.
Mexidol solution is administered intramuscularly and intravenously. IntroductionThe drug is produced both by jet and drip. If the drug is administered by infusion, then the drug is diluted with sodium chloride.
Jet administration of the drug should be slow, for 5-7 minutes. The drip rate is 40-60 drops per minute. The daily maximum value is 1200 mg.
In case of circulatory disorders in the brain, Mexidol treatment is carried out for 10-14 days, drip. At a dosage of 200-500 ml two to four times a day. In the future, the drug is administered to the patient for another two weeks, but already intramuscularly. 200-500 ml two to three times a day.
Treatment of traumatic brain injury lasts 10-15 days. The drug is used drip, up to four times a day, at a dose of 200-500 mg.
When diagnosing dyscirculatory encephalopathy (therapy is carried out at the stage of decompensation), Mexidol is prescribed intravenously, 1-2 times a day. A single dosage is 200-500 mg. Thus, the treatment is carried out for two weeks. In the next fourteen days, the drug is administered intramuscularly once or twice a day. For course prevention of the occurrence of dyscirculatory encephalopathy, the drug is used for two weeks, twice a day, 200-250 mg. The drug is administered intramuscularly.
Cognitive impairment in the mild stage in aged persons, as well as anxiety conditions, are treated with intramuscular administration of "Mexidol", in an amount of 100 to 300 mg / day. Therapeutic course 2 - 4 weeks.
In case of myocardial infarction, Mexidol is used in complex therapy. Appointboth intramuscularly and intravenously. The course of treatment is two weeks. Doctors recommend five days to put the medicine intravenously, the remaining nine days to inject intramuscularly.
Intravenous administration is done only through drip infusion. Slowly. The drug is diluted with sodium chloride 0.9%. Dilution of the drug with glucose is allowed. "Mexidol" is administered to patients at a dosage of 100-150 ml for about 0.5-1.5 hours. Jet administration is allowed, lasting at least five minutes.
In a heart attack, the drug is administered three times a day, every eight hours. The daily dosage is 6-9 mg. This amount is calculated per kilogram of the patient's weight. A single dose of 2-3 mg per kilogram of body weight. The daily dose is 800 mg, it is recommended to administer no more than 250 mg at a time.
"Mexidol" with open-angle glaucoma is used only in complex therapy. It is administered intramuscularly, up to three times a day. The daily dosage is 100-300 mg. The duration of therapy is two weeks.
In the treatment of withdrawal syndrome that occurs with alcoholism, the drug is used intravenously and intramuscularly. The daily dose is 200-500 mg. The course of treatment is seven days.
In case of drug intoxication, Mexidol is used intravenously. The daily norm is 200-500 mg. Duration of therapy 1-2 weeks.
In purulent-inflammatory processes in the abdominal cavity, the drug is prescribed on the first day before surgery. In the future, it is administered to the patient throughout the postoperative period. The dosage depends on the severity and form of the disease. Cancel "Mexidol"gradually.
About strict observance of the rules for taking the medicine warns instructions for the use of "Mexidol". The price (in the reviews, some people claim that the drug helps well with stress and depression, positively affects the quality of sleep) of the drug is fully justified by its effectiveness.
Special Instructions
The reviews on the use of "Mexidol" indicate the good tolerability of this remedy. Accepters claim that it has practically no contraindications. It is noted that the medicine completely relieves headaches with vegetovascular dystonia.
The drug increases the effect of benzodiazepine anxiolytics on the body. Enhances the effect of anticonvulsant drugs, especially carbamazepine. Similarly, "Mexidol" affects antiparkinsonian drugs. It also reduces the toxicity of ethyl alcohol.
Warns about side effects in the treatment of "Mexidol" instructions for use. In the reviews, some people claim that they did not see any effect from the use of this remedy and say that the drug did not improve their condition in cardiovascular diseases.
In people with asthma who are particularly sensitive to sulfites, the drug may cause negative symptoms of hypersensitivity.
Among the adverse reactions of the use of "Mexidol" was noted:
- nausea;
- allergic reactions;
- dry mouth;
- appearancesleepiness.
If negative symptoms appear, you should consult a doctor and stop the drug.
Mexidol: analogues
Reviews (the instruction describes in detail the features of the use of the drug and must be studied before using the medication) contain information that the drug is not suitable for everyone, and therefore it is important that a doctor prescribe it. Self-medication should be completely excluded.
If "Mexidol" is not suitable for treatment, then it can always be replaced by analogues, these are:
- Neurox;
- Mexicor;
- Cerecard;
- "Astroks";
- Mexiprim;
- Mexifin;
- Mexidol Pharmasoft.
When choosing analogues, do not forget to consult a doctor to avoid side effects.
Based on the feedback on the use of "Mexidol", consumers consider the price of analogues of the drug more affordable.
Form of issue, cost
"Mexidol" for injection is produced in the form of a solution intended for intravenous and intramuscular administration. The drug is enclosed in glass ampoules with a break point. There are three marking rings on the ampoules. The top ring is colored yellow, the middle ring is white, and the bottom ring is red.
Ampoules are produced in volumes of 2 and 5 ml. Five pieces are enclosed in cell blisters. A cardboard box may contain one or two blisters with Mexidol ampoules and instructions for use.
Price (in reviews, analogues are considered not the bestan option for the treatment of vegetovascular dystonia and those who have undergone a course of treatment are advised not to replace Mexidol with them), the medication fluctuates around 500 rubles for 5 5 ml ampoules. 10 ampoules of 2 ml cost the same.
Patient testimonials
Mexidol has found its application in neuropsychiatric, cardiological and ophthalmological practice. In the reviews, the price of the drug is indicated as overpriced. It is said that the treatment is expensive, especially if the medicine needs to be used for a long period.
People note that the medicine in ampoules is more effective than in tablets. In addition, patients say that the drug is often prescribed to them for vegetovascular dystonia. In this case, it lowers cholesterol well. Removes headaches, chills, limb tremors and dizziness.
The drug has shown itself well in stress and depression. Removes panic attacks. Clears the head and improves memory. Against this background, people's perception of the world is changing. They become calmer and more confident in themselves. Stop being afraid of others.
According to patients, the drug is often prescribed in the treatment of cardiovascular diseases, in combination with other drugs. The medicine strengthens blood vessels and improves blood circulation. Relieves cramps, numbness of the limbs. Stabilizes sleep.
The remedy is prescribed for diseases of the visual apparatus, to activate blood circulation in the eyeball. According to patients, it increases visual acuity, gives clarity to the eyes. To avoid side effects, specialistsit is advised to read the instructions before treatment.
There are also negative reviews about Mexidol. They compare the drug with a dummy and say that it does not help with vascular dystonia and cardiovascular diseases. For some, the drug worsened the symptoms of the disease. Panic attacks became more pronounced, anxiety, absent-mindedness and headache appeared.
Some believe that "Mexidol" gives only a temporary effect, and negative symptoms, after its cancellation, return.
There are much fewer negative opinions about the drug than positive ones. Most of the people were satisfied with the treatment.
Reviews of doctors
Injection solution "Mexidol" ("Pharmasoft") is widely used by doctors in their practice. They consider the drug effective. It is said that he successfully treats cardiovascular pathologies. It gives a good and stable result in the treatment of traumatic brain injuries. He showed himself worthy in the treatment of anxiety, emotional lability, encephalopathy and asthenia. Very often it is used in acute cerebrovascular accident.
The positive aspects of the doctor's medication include the fact that patients of various age categories can use it. Doctors also note a wide range of uses for the drug. Some doctors combine the injectable form of the drug with the tablet form. Injections are used at the very beginning of therapy, and the result obtained is fixed with tablets.
Specialists noted the side effects that occur during treatment with Mexidol. This is heaviness in the head, dry mouth, nausea, increasedand jumps in blood pressure, weakness.
Some doctors consider the drug ineffective. They say it is short term and little studied.
