All people know what pain is and how much it affects the quality of life. Modern pharmacology offers a large number of medicines that will help to cope with this problem.
One of the most effective drugs in this area is the powder "Nisulid". What does the drug help? The answer will be given in this article.
But it is not recommended to forget that it is impossible to use a medicine without a prescription from a medical specialist.
What is in the medicine
According to the instructions, the composition of the powder "Nisulid" includes one active ingredient - nimesulide. Additional components are:
- xanthan;
- silica;
- lemon oil;
- calcium s alt and stearic acid;
- citric acid;
- food additive E951;
- granulated sugar.
According to the instructions for use of the powder"Naisulid", Belarus is the country of origin.
Characteristic
The powder has a white or yellowish tint with a specific aroma. Naisulid is a non-steroidal anti-inflammatory drug that has analgesic as well as antipyretic properties.
After oral administration, nimesulide is well absorbed from the stomach and intestines. The maximum content in the blood is reached two to three hours after application.
Indications for "Nisulid" powder
According to the instructions, it is known that the medication is prescribed in the presence of the following diseases and conditions:
- Pain syndrome in gynecological diseases.
- Injuries.
- Osteoarthritis (a disease of the musculoskeletal system that affects the large and small joints of the hands and feet).
- Rheumatoid arthritis (a systemic connective tissue disease with a primary lesion of small joints, like erosive-destructive polyarthritis of unclear etiology with complex autoimmune pathogenesis).
- Bursitis (inflammation of mucous bags mainly in the joints).
- Tendinitis (inflammation and degeneration of tendon tissue, similar in symptoms to tendinosis).
- Dysmenorrhea (a pathology in which severe pain occurs in the lower abdomen during menstruation).
Restrictions
According to the instructions for the "Nisulid" powder,contraindications for use are:
- Hypersensitivity.
- Bronchoconstriction.
- Rhinitis (syndrome of inflammation of the nasal mucosa).
- Alcoholism.
- Nettle rash.
- Severe liver dysfunction.
- Kidney failure.
- Severe kidney disease.
- Ulcerative lesions.
- Phenylketonuria (a hereditary disease of a group of fermentopathies associated with impaired metabolism of amino acids, mainly phenylalanine).
- Pregnancy.
- Breastfeeding.
- Under the age of twelve.
- Increased body temperature.
How to take Nisulide powder during pregnancy?
Is the medication prescribed for "interesting position"
Like other non-steroidal anti-inflammatory drugs, Naisulid should not be used by women who are planning a pregnancy.
According to the instructions for the "Nisulid" powder, the active substance can provoke premature closure of the botallian duct, as well as a number of other problems:
- Pulmonary hypertension (a group of disorders characterized by a progressive increase in pulmonary vascular resistance leading to right ventricular failure and premature death).
- Increased chance of bleeding and peripheral edema.
In addition, there are reports of the birth of children with kidney disease in women who took "Nisulid" inlast trimester of "interesting position".
Powder "Nisulid": method of application
Before taking, you need to prepare a solution. To do this, the contents of the sachet must be diluted in 100 milliliters of water and mixed well. After that, the finished mixture is immediately consumed. Suspension must be taken after meals.
For adult patients, the drug is prescribed in a single concentration of 100 milligrams. Adolescents aged twelve to eighteen years and elderly patients do not require dose adjustment. The drug should not be given to children under 12.
Dosage adjustment is not required in renal insufficiency. In severe renal failure, the drug should not be used.
How to use: Naisulid powder is used for a short period to minimize the likelihood of side effects. The maximum duration of therapy should not exceed fifteen days.
Adverse reactions
Like any other medicine, "Nisulid" provokes the appearance of undesirable effects:
- Hypertension (a pathological process that consists in a significant increase in blood pressure, which requires systematic therapy).
- Tachycardia (increased heart rate).
- Change in blood pressure.
- Hyperkalemia (a disease characterized by an increase in the concentration of potassium in the bloodstream).
- Anemia (a disease thatcharacterized by a decrease in hemoglobin in the blood).
- Eosinophilia (a condition in which there is an absolute or relative increase in the number of eosinophils).
- Bleeding.
- Thrombocytopenia (a pathological condition characterized by a decrease in the number of platelets circulating in the peripheral blood).
- Pancytopenia (a hematological concept that refers to a decrease in the level of all types of peripheral blood cells).
- Purpura (a disease characterized by small-spotted capillary hemorrhages under the skin, in the epidermis or mucous membranes).
- Diarrhea (a pathological condition in which the patient has frequent bowel movements, while the stool becomes watery).
- Nausea.
- Gagging.
- Constipation.
- Bloating.
- Gastritis (inflammatory or inflammatory-dystrophic changes in the gastric mucosa; a long-term disease, characterized by dystrophic-inflammatory changes, occurs with impaired regeneration, as well as with atrophy of epithelial cells and replacement of normal glands by fibrous tissue).
- Abdominal pain (pain discomfort in the abdominal cavity, characterized by localization, nature of occurrence, indicating violations of the functions of the internal systems of the body).
- Dyspepsia (disturbance of the normal activity of the stomach, difficult and painful digestion).
- Stomatitis (lesion of the mucous membrane in the oral cavity, which has an inflammatory nature).
- Gastrointestinal bleeding(outflow of blood from eroded or pathologically damaged blood vessels into the lumen of the digestive organs).
- Ulcer of the stomach and duodenum (a chronic polyetiological pathology that occurs with the formation of ulcerative lesions in the stomach, a tendency to progression and the formation of complications).
- Hepatitis (diffuse inflammation of the liver tissue due to a toxic, infectious or autoimmune process).
- Jaundice (icteric coloration of the skin and visible mucous membranes, which is due to a high concentration of bilirubin in the blood and tissues).
- Cholestasis (a disease that manifests itself in the form of stagnation in the liver tissue of bile components with a concomitant decrease in its flow into the duodenum).
- Itching.
- Rashes.
- Hyperhidrosis (problems with sweating, which are characterized by increased sweat production, as a result of dysfunction of the autonomic nervous system).
- Increased sensitivity.
- Exanthema (dermatological rashes in the form of papules, vesicles, spots of various sizes).
What other adverse reactions does the drug provoke? According to the instructions, the powder "Nisulid" causes the following side effects:
- Erythema (limited intense reddening of the skin due to vasodilation of the dermis).
- Anaphylactic shock (immediate type allergic reaction, a state of sharply increased sensitivity of the body).
- Urticaria (disease of allergic or toxiccharacter, appearing as dotted red spots).
- Quincke's edema (a reaction to various biological and chemical factors, often of an allergic nature).
- Steven-Jones Syndrome (acute toxic-allergic disease, the main characteristic of which are rashes on the skin and mucous membranes).
- Epidermal necrolysis (a serious disease, accompanied by rejection of the surface layer of the skin and disruption of the internal organs).
- Dizziness.
- Worry.
- Irritable.
- Loss of sleep.
- Migraine (a primary form of headache characterized by intermittent attacks of moderate to severe headache).
- Encephalopathy
- Reye's Syndrome (a dangerous disease that is usually characterized by damage to the brain and accumulation of fat in the liver).
- Drowsy.
- Dysuria
- Hematuria (blood in the urine).
- Urine retention.
- Kidney failure.
- Oliguria (significant decrease in daily urine output).
- Interstitial nephritis (a pathological process characterized by an acute or chronic inflammatory process in the interstitial tissue and tubules of the kidneys).
- Difficulty breathing.
- Asthma (a chronic disease characterized by short-term attacks of breathlessness caused by spasms in the bronchi and swelling of the mucous membrane).
- Bronchospasm (a pathological condition that occurs when the smooth muscles of the bronchi contract and reduce their lumen).
- Edema.
- Impaired vision.
- Vertigo (a symptom known as dizziness, it is characteristic of an ear or brain disorder).
- Diseases.
- Asthenia (impotence, illness or chronic fatigue, manifested in the exhaustion of the body with increased fatigue and extreme mood instability, impatience, sleep disturbance, restlessness).
- Hypothermia (a condition in which body temperature drops below what is required to maintain normal metabolism and function).
Analogues
According to reviews, Naisulid powder has certain substitutes:
- "Nimesulide".
- "Novolid".
- "Mesulide".
- "Nimesil".
- "Nimulid".
- "Nimika".
- "Nemulex".
- "Nise".
- "Prolid".
- "Aponil".
- "Ameolin".
- "Actasulide".
Before replacing the original drug with a generic, you need to consultwith Dr.
Interaction
According to the instructions for use for the powder "Nisulid", its simultaneous use with "Warfarin" or other anticoagulants, as well as "Aspirin" causes the likelihood of bleeding. Therefore, this combination is not recommended and prohibited for patients with various blood clotting disorders.
The combination of taking "Nisulid" with diuretic drugs can adversely affect renal hemodynamics. With the simultaneous use of the drug and Furosemide, the excretion of sodium and potassium decreases for a short time, and as a result, the effect of diuretics worsens.
This combination requires increased attention in people with heart or kidney problems. Simultaneous use of Naisulid with diuretic drugs can adversely affect renal hemodynamics.
Intake of nimesulide less than one day before or after methotrexate therapy leads to an increase in the content of the latter in the blood, which increases its toxicity.
The effect of "Nisulid" on prostaglandin synthetase and on renal prostaglandins can lead to increased nephrotoxicity of "Cyclosporin".
With alcohol
During the treatment of various diseases with the use of "Nisulid" it is not recommended to take any strong drinks. This combination can lead to an increase in negative side effects and lead to severe deterioration in he alth.
Recommendations
The likelihood of adverse reactions can be reduced by using Naisulid powder for a short time. In the absence of a therapeutic effect, it is necessary to stop using the medicine.
Rarely, hepatotoxic effects may occur, which include fatal situations. If anorexia, nausea, vomiting, abdominal pain, fatigue and dark urine occur, treatment should be discontinued. Most cases of liver damage can be eliminated if Naisulid is used for a short time.
It is necessary to avoid the combination of nimesulide with other hepatotoxic drugs and alcoholic beverages due to an increased risk of hepatotoxic effects. "Nisulid" is used with extreme caution with other painkillers. Combining the drug with other non-steroidal anti-inflammatory drugs is not recommended.
Gastric and intestinal bleeding may occur throughout the entire period of therapy without symptoms or with severe signs, even in the absence of gastric and intestinal diseases. With the development of adverse reactions, treatment with Naisulid should be discontinued. The drug is used with extreme caution in the defeat of the gastrointestinal tract, including peptic ulcers, ulcerative colitis or Crohn's disease.
Patients of retirement age are especially sensitive to non-steroidal anti-inflammatory drugs. When using Naisulid, they may develop gastrointestinal hemorrhages and perforations, as well as diseases of the kidneys, heart andliver, so you need to be constantly under the supervision of a medical specialist.
Because the drug can suppress platelet activity, it should be used with caution in people with bleeding problems. But "Nisulid" is not considered a substitute for "Aspirin" for the prevention of cardiovascular disease.
Since the drug has an antipyretic effect, when it is used for infectious pathologies, the temperature does not rise, which can make it difficult to diagnose the disease.
There is no information on the effect of Naisulid on concentration. But patients with side effects from the central nervous system and the vestibular apparatus should refrain from driving a car and work that requires increased concentration. The structure of the drug includes sugar, which is important to consider when treating patients with diabetes.
How to properly store medication
Keep the medicine away from light and at a temperature of no more than twenty-five degrees Celsius. Keep "Nisulid" away from children.
Shelf life - 2 years. The cost of the medication varies from 180 to 200 rubles. Dispense medicine by doctor's prescription.
Opinions
A large number of reviews about "Naysulide" are positive. The drug quite effectively manifests itself in the elimination of pain syndromes, temperature, various kinds of inflammatory processes. "Nisulid" helps instantly and its effectlong.
It is rare to find negative feedback regarding the side effects of the drug. If the dosage is exceeded, a person may develop nausea, vomiting, heart palpitations, which disappear immediately after the drug is discontinued.
