If it is impossible to relieve pain by oral administration of the drug, then use the solution for injections "Caver". Instructions for use advises injections for pain syndrome of moderate and high severity. This may be a postoperative condition of the patient, renal colic or lumbar pain.
Composition and formulation of the drug
In 1 ml of solution for injection is 25 mg of the active substance - dexketoprofen. The auxiliary ingredients of the substance include 96% ethanol, sodium chloride, sodium hydroxide and water for injection.
The drug is a clear, colorless liquid. Packaged in glass ampoules, which are enclosed in a cardboard box of 5-10 pieces. Each ampoule contains 2 ml of Caver.
Instructions for the use of injections refers to non-steroidal anti-inflammatory and antirheumatic drugs that are derivatives of propionic acid.
Pharmacological properties
Dexketoprofen trometamol (the active ingredient in this drug) is a s alt of propionic acid. It is characterized by analgesic, antipyretic and anti-inflammatory properties. Belongs to the class of non-steroidal anti-inflammatory drugs, or NSAIDs.
The mechanism of work is aimed at reducing the synthesis of prostaglandins as a result of inhibition of cyclooxygenase. That is, the conversion of arachidonic acid into endoperoxides PGG2 and PGH2 of a cyclic nature is slowed down. Of these, in turn, prostaglandins PGEi, PGE2, PGF2a, PGD2 are formed, including such a substance as prostacyclin PGI2, as well as thromboxanes TxAg and TxBr. Suppression of prostaglandin synthesis affects the impulses of the inflammatory process, for example, kinins, which affect the main functions of the drug. The inhibitory effect of dexketoprofen on the activity of cyclooxygenase-1, cyclooxygenase-2 was revealed.
Conducted clinical trials have established the analgesic effect of the drug with varying degrees of pain. Found its analgesic properties by injecting the solution inside. An analysis of the intensive effect on pain during the postoperative period was carried out. These are orthopedic and gynecological surgical procedures, as well as operations on the abdominal cavity. Used for varying degrees of pain in the spine, the drug "Caver". Instructions for use recommends injections for renal colic.
Studies have shown that the medicinal product acts instantly, and its maximum effectivenessmanifests itself for forty-five minutes. The analgesic effect on the body lasts about eight hours, but only on condition that at least 50 mg of the Kaver agent (injections) has been administered. Description, indications for the drug - all this is very important to study before using it.
With intramuscular injection of dexketoprofen trometamol, the highest concentration is observed after twenty minutes. It has a high degree of connection of blood plasma proteins - 99%. The distribution of dexketoprofen fluctuates around 0.25 l/kg. The half-life is 0.35 hours. Displayed after 1-2.7 hours.
Indications for use of the drug
Should be administered intramuscularly or intravenously in acute pain syndrome of moderate and high intensity, the drug "Caver". Instructions for use advises injections only when oral therapy does not help. It is advisable to use them after surgery, in case of renal colic and severe pain in the lumbar region.
Contraindications for use
Has the drug "Caver" (injections) indications and contraindications. The second includes:
- hypersensitivity to the active substance dexketoprofen and to additional components of the solution;
- asthma attacks and bronchospasms;
- acute rhinitis, nasal polyps, urticaria, angioedema;
- ulcer and bleeding;
- gastrointestinalbleeding;
- Crohn's disease or ulcerative colitis;
- history of bronchial asthma;
- heart failure;
- moderate to severe kidney disease;
- blood clotting disorders;
- severe liver disease;
- use for neuraxial (intrathecal or epidural) administration;
- pregnancy, especially the third trimester;
- lactation period.
None of these factors should be discounted when prescribing Caver (injections). The instructions for use describe all the features of the correct use of this drug.
The drug is not prescribed to young patients due to the lack of knowledge of its effects on the children's body. Caution should also be taken by the elderly.
Kaver drug (injections): instructions for use
For adults, the recommended dose is 50 mg. The interval between injections should be at least 8-12 hours. If necessary, a second injection is carried out after six hours. The daily dose is 150 mg. The drug is used for a one-time relief of acute pain. It is not used for more than two days in a row. After the initial pain relief, if the situation allows, the patient is transferred to oral painkillers.
Side effects on the body are reduced by introducing the minimum allowable dose. After surgery, with pain sensations of severe and moderate severity, the drug is used strictly according totestimony. Possible drug compatibility with opioid analgesics.
Do not adjust the dose for the elderly. But since the metabolic processes in the kidneys slow down at an older age, it is still recommended to reduce the dosage. The maximum permitted dose for mild renal impairment is 50 mg.
Patients with liver ailments (5-9 points on the Child-Pugh scale) reduce the daily dose to 50 mg. After the introduction of the drug into the body, the work of this organ is carefully monitored. With a more severe stage of liver disease, the drug is not prescribed (10-15 points on the Child-Pugh scale).
With mild kidney disease (creatinine clearance - 50-80 ml / min.), The daily norm should not exceed 50 mg. With moderate or severe renal impairment, in which creatinine clearance is < 50 ml / min, the drug is strictly prohibited.
Injection solution is administered both intramuscularly and intravenously. For intramuscular manipulations, the “Kaver” (injections) are injected slowly and deep enough.
How to dilute the drug for intravenous infusion
The liquid in the 2 ml ampoule for injection into a vein should be diluted. To the contents of the ampoule, add 30-100 ml of 0.9% sodium chloride, glucose or Ringer's lactate solution. The liquid for intravenous injection is prepared under sterile conditions. The prepared substance must be absolutely transparent and free of any impurities. The infusion is carried out for ten to thirty minutes. Do not expose to daytime sunlightsolution both during its preparation and during the period of drug administration.
"Caver" (injections in ampoules) the instruction recommends diluting for combination with narcotic drugs. To do this, add 100 ml of 0.9% sodium chloride to a 2 ml ampoule. If necessary, the drug can be diluted with glucose in the same ratio.
It is forbidden to combine Promethazine and Pentazocine in injection solution with Caver medicine (injections).
How do I use a bolus medication? For this purpose, the 2 ml solution is not diluted for infusion. Pour in quickly, within fifteen seconds. This injection time should not be shortened. In small doses, the combination of "Kaver" with such injection liquids as "Heparin", "Lidocaine", "Morphine" and "Theophylline" is allowed.
Do not mix injection fluid with small doses of Dopamine, Promethazine, Pentazocine, Pethidine and Hydrocortisone. This is recommended due to the risk of a white precipitate, which is highly undesirable during the procedure.
The drug is not subject to even a second storage and must be administered immediately after sampling from a glass ampoule. The solution should also be applied immediately after mixing all the necessary medicines. The responsibility for the correctness of the procedure lies entirely with the he alth worker.
Injection solution after preparation retains all properties unchanged throughout the day. This condition is feasible if the prepared preparation is completely protected from daylight, and the temperature regime does not exceed 25 ° C.
Ampoule "Caver" is designed for a single injection. Residues of the solution are immediately disposed of. Immediately before infusion, make sure that the solution is clear and colorless. If any particulate matter is present, the medicine should not be used.
Side effects of the drug
There may be a number of side effects after the introduction of the drug "Caver" (injections). The instruction includes information that such phenomena as nausea and vomiting often occur. There is pain at the injection site, bleeding, inflammation and hematoma. Sometimes anemia and insomnia, dizziness, drowsiness and headache appear. Rarely, fever and fatigue, blurred vision, chills are recorded. Pain in the abdomen, dyspepsia were noted. After the injection, diarrhea or constipation, vomiting with an admixture of blood sometimes occur. Excessive dryness of the oral cavity was noticed. Some patients complained of dermatitis, itching, rashes and excessive sweating.
In rare cases, hyperglycemia, hypertriglyceridemia and anorexia have been reported. Paresthesia and unconsciousness appeared. The patients were disturbed by ringing in the ears, extrasystole and tachycardia. In rare cases, symptoms of arterial hypertension, thrombophlebitis, bradypnea were recorded. There were ulcers, jaundice, urticaria, acne, muscle rigidity, joint stiffness. The appearance of cramps in the muscles and pain in the back was noted. Partially observed increased urination, renal colic, acetonuria. Occurredfailures of the menstrual cycle and the functioning of the prostate gland. There was muscle tremor, peripheral edema.
In exceptional cases, neutropenia and thrombocytopenia were noted in patients. Single examples indicate anaphylactic reactions, for example, anaphylactic shock. Very rarely manifest bronchospasm, shortness of breath. Pancreatitis and Stevens-Johnson syndrome, epidermal necrolysis are sometimes disturbing. Patients suffer after injection from angioedema, swelling of the face, photosensitivity. One in ten thousand cases of nephritis and nephrotic syndrome have been recorded.
No officially established facts of overdose have been identified. If the recommended doses are exceeded, the drug negatively affects the digestive tract, causing vomiting, pain in the abdomen and anorexia. Drowsiness and disorientation in space, dizziness, headaches may appear. If an overdose is detected, certain measures should be taken immediately and the drug removed from the body using dialysis.
Medication analogues
The Kaver drug (injections) is distinguished by a high price. Analogues of this drug can be found in any pharmacy. The following medicines have the same ATC code and active ingredient:
- Alfort Dexa.
- Decafene.
- "Delsangin".
- "Delsangin Inekt"
- "Depiofen".
- "Rastel".
- Sertofen.
The indicated drugs can, if necessary, completelyreplace "Kaver" (injections). Analogues and substitutes for this drug act in a similar way and have exactly the same active ingredient, but they should not be selected independently. Before substituting one drug for another, you should consult your doctor who will help you choose the most appropriate option.
Medication cost
Produced in Ukraine, the drug "Caver" (injections). The instruction recommends using it not regularly, but only occasionally and no more than two days. In Russia, this medicine is not widely used and is not sold in pharmacies, so only an approximate price can be given. It was formed in translation from the hryvnia to the Russian ruble, taking into account the official exchange rate, at which 1 hryvnia is currently. equal to 3.21 rubles. In Ukraine, this drug can be bought for 200 hryvnia. In recalculation, the cost will be equal to 640 Russian rubles.
Storage method and expiry date
No need to store more than two years from the date of manufacture indicated on the package, the medical preparation "Caver" (injections). The description of the medicine notes that after the expiration date, the drug is unsuitable for use. It is necessary to store the product in the original box at a temperature not higher than + 25 ° C. The medication should be kept in a cool place out of the reach of children and protected from direct sunlight.
Available in pharmacies strictly by prescription. The manufacturer is the Ukrainian company PAO Farmak.
Kaver is a reliable and highly effective drug for the relief of acute pain. Designed forshort-term use. Appeared on the market relatively recently and has not yet managed to win the favor of consumers. It can be purchased both through online pharmacies and through large pharmacies in large cities of Ukraine.
