"Pregnil" is used in the treatment of anovulatory infertility in women, miscarriage, the threat of self-abortion, as well as for the purpose of controlled ovarian hyperstimulation, ovulation induction and increase in estrogen levels. Its use is effective in the regimen of endogenous luteal hormone replacement therapy to stimulate the maturation of follicles.
Indications for use in men are delayed sexual development associated with hypofunction of the gonads, cryptorchidism, impaired spermatogenesis. Consider the most famous analogue of "Pregnil" in this article.
Description of the drug "Pregnil"
"Pregnil" contains human chorionic gonadotropin (HCG). This hormone begins to be produced by chorionic tissues after the process of implantation of the embryo is completed. CG has follicle-stimulating and luteinizing activity, enhances estrogen secretion and initiates the process of ovulation. In the future, it maintains the functional activity of the corpus luteum until the onsetproduction of estrogen and progesterone by the placenta.
The use of exogenous human chorionic gonadotropin not only enhances the secretion of estrogen and progesterone by the ovaries, but also induces ovulation, promotes subsequent luteinization of the burst follicle.
The use of CG preparations is most effective in the scheme with the appointment of human menopausal and follicle-stimulating hormones.
Therapy regimens
"Pregnil" (an analogue of "Pregnil" is available in the same dosage) is available in dosages of 1500 and 5000 MO. Used for intramuscular injection.
In the treatment of anovulatory infertility in women, a single injection of 5,000-10,000 IU is recommended, after completing a course of therapy with FSH (follicle-stimulating hormone) or HMG (human menopausal gonadotropin).
Before puncture, for control stimulation of the ovaries, after the end of treatment, 5000 MO is administered.
Luteal phase support is carried out by cyclic injections at a dosage of 1000 to 3000 IU every three days - 3 times.
In men, it is used for hypofunction of the gonads and impaired spermatogenesis in dosages from 1000 to 2000 MO several times a week (an analogue of Pregnil can be taken according to the same scheme).
In the treatment of cryptorchidism in children, the drug is used 2 times a week, recommended dosages:
- up to 2 years - 250 MO;
- up to 6 years appoint from 500 to 1000 MO;
- after 6 years - 1500 MO.
We reviewed the regimen for the use of the drug. But it is best before starting therapyconsult a doctor and get a prescription from him.
Analogues of "Pregnil"
What are the analogues of the drug "Pregnil"? In fact, there are a lot of them, there are cheaper drugs, there are expensive ones.
Chorionic Gonadotropin
Chorionic Gonadotropin is an inexpensive analogue of Pregnil. Produced in a dosage of 500; 1000; 1500 units It is applied intramuscularly. It is prescribed at a dosage of 1500 IU every other day or 3000 IU 2-3 times a week in the treatment of infertility in women. In the treatment of sexual infantilism, 500 to 1000 IU are prescribed several times a week, for up to 2 months. Children are prescribed 500-1000 MO up to ten years, then - 1500 IU up to a month with repeated courses. That is, the drug "Pregnil" has cheap analogues.
Ovitrelle
"Ovitrelle" contains hCG alpha. Available in a dosage of 250 mcg (6500 IU). It is applied subcutaneously. Stimulates the formation of the corpus luteum, the maturation of follicles and ovulation. 250 mcg equates to 5000 units of human chorionic gonadotropin. When stimulating the ovaries and obtaining superovulation, 250 mcg is used, after a course of therapy with human menopausal or follicle-stimulating hormones. In the treatment of anovulation, 1 dose is prescribed the day before sexual intercourse.
Horagon
Another analogue of "Pregnil". Available in dosages of 1500 and 5000 MO. It is administered intramuscularly. It is used for dysmenorrhea, hypoplasia of the genital glands, sexual infantilism in order to accelerate sexual development, the threat of spontaneous abortion, forsuperovulation induction. For the induction of superovulation, it is prescribed in a dosage of 5,000 to 10,000 IU once. In the treatment of habitual abortions, it is recommended to use from the first day of pregnancy until 14 weeks, twice a week for 10,000 MO. Treatment of hypogonadism includes the appointment of 1500 to 6000 IU once a week. Androgen deficiency in men is treated with HCG once every two weeks for three months.
Horiomon
Produced in a dosage of 5000 IU / ml, for intramuscular injection. It is highly effective in the treatment of amenorrhea and anovulatory cycle. It is used in combination with human menopausal gonadotropin (75 MO) for up to 10 days subcutaneously or intramuscularly to increase estrogen secretion. When a mature follicle appears on ultrasound, 5,000 to 10,000 MOs of Choriomon are administered to induce ovulation. The drug is administered 1-2 days after the last injection of HMG or FSH. Intercourse is recommended daily before ovulation.
For infertility due to insufficiency of the luteal phase, Choriomon is used at 5000 MO on the 21st, 23rd and 25th days of the cycle.
Profazi
"Profazi" - an analogue of "Pregnil 5000". Available in dosages of 2000 and 5000 MO. It is applied intramuscularly. Therapy of anovulatory infertility is carried out by the introduction of 10,000 MO in the middle of the cycle, after treatment with HMG or FSH. To induce superovulation, 10,000 MO are prescribed the day before egg collection. In case of corpus luteum insufficiency, the introduction of 5000 MO is recommended, on the fifth and ninth days after ovulation."Profazi" is highly effective in the treatment of recurrent miscarriage. Applied at 10,000 MO first time, then 5,000 MO twice a week for up to 14 weeks.
Contraindications
Contraindications to the use of CG drugs:
- Postmenopause.
- Hormone-producing tumors of the gonads.
- Tumors of the hypothalamus and pituitary gland.
- Uterine tumors incompatible with pregnancy.
- Thrombophlebitis.
- Hypothyroidism.
- History of tubal pregnancy three months before therapy.
- Polycystic ovaries.
- Lactation period.
Side effects
Side effects of human chorionic gonadotropin:
- Increased irritability, emotional lability, headaches, anxiety.
- Dyspeptic disorders (nausea, vomiting).
- Increased nipple sensitivity.
- Gynecomastia in men.
- Rash, hives.
- Ovarian hyperstimulation syndrome.
- Temporary penis enlargement, abnormal erection.
- Reduced pituitary function.
- Reduced blood volume (hypovolemia).
- Accumulation of blood in the abdomen.
- Thromboembolism.
- Multiple pregnancy.
- Fluid retention, pronounced, widespread edema.
Analogue "Pregnil 1500" is ineffective in congenital defects in the development of the uterus,adnexa and vagina, adhesions in the fallopian tubes, primary ovarian failure, large fibrous tumors in the uterus.
All therapy takes place strictly under the supervision of a specialist and control of changes in analyzes, the use of these drugs at home is unacceptable and can lead to irreparable he alth consequences.
Treatment of anovulatory infertility should be carried out under ultrasound control of follicle growth and constant assessment of the cervical index.
It is important to monitor the level of estradiol concentration daily. With a symptom of unwanted ovarian hyperstimulation, chorionic gonadotropin therapy is stopped immediately.
We have reviewed analogues for the Pregnil preparation, instructions for use for them are also described.
