High blood pressure is a consequence of arterial sclerosis and a cause of serious heart damage. Persons who have elevated these indicators are diagnosed with "Hypertension". Due to stenosis of some capillaries that have lost their elasticity, there is an increase in pressure in others. This slows down microcirculation and increases the load on the heart.
"Lortenza" is a complex antihypertensive medication. The drug is produced in tablet form, which combines two active ingredients: amlodipine and losartan. What is the price of "Lortenza"? More on that later.
Composition
The structure of the drug includes the following active ingredients:
- amlodipine besilate;
- losartan A substance granules.
According to the instructions for use of Lortenza, it is known that additional substances are:
- cellactose 80;
- cellulose;
- starch;
- sodium carboxymethyl starch;
- silicon dioxide;
- iron oxide yellow;
- magnesiumstearate.
Lortenza tablets: indications and contraindications
According to the annotation, the drug is recommended for use in the treatment of patients with arterial hypertension.
Prohibitions for use are:
- Reduce blood pressure.
- Severe liver failure.
- A heart defect in which narrowing of the aortic orifice occurs, which creates an obstacle to the expulsion of blood into the aorta when the left ventricle contracts.
- Pregnancy.
- Impaired kidney function.
- cardiogenic shock (left ventricular failure, which is characterized by a rapid decrease in the contractility of the heart muscles).
- Glucose-galactose malabsorption syndrome, provoked by inadequate absorption of monosaccharides in the gastrointestinal tract.
- Lactase deficiency (hereditary or acquired pathology, which is characterized by the absence or low content of the enzyme lactase).
- Under the age of eighteen.
- Breastfeeding.
- Individual intolerance.
- Low blood volume.
- Severe heart disease.
- Cerebrovascular disease (brain damage caused by gradual progressive damage to brain tissue against the background of chronic cerebrovascular accident).
- Angioneurotic edema (acute condition, which is characterized by the rapid development of local edema of the mucous membrane, subcutaneousfiber and the skin itself).
- Primary hyperaldosteronism (an endocrine pathology characterized by increased secretion of aldosterone).
- Stenosis of the artery of a single kidney (narrowing of the lumen of the vessel caused by congenital causes, atherosclerosis, inflammatory changes).
- Unstable angina
- Ischemia of the heart (damage to the muscles of the heart, which is provoked by a deficiency or cessation of the microcirculation of the heart muscle).
- Acute myocardial infarction (ischemic heart disease, which occurs with the death of the muscles of the heart, due to the absolute or relative deficiency of its microcirculation).
- Hyperkalemia (a disease that causes abnormally high levels of potassium in the blood).
- Hypotension (a common pathological condition that manifests itself as a regular, persistent blood pressure reading below normal).
- Liver failure.
- Tachycardia (a sharp increase in heart rate, a sign of serious disorders).
- Severe bradycardia (a type of sinus rhythm disorder that is controlled by the sinus node).
- Autosomal and dominant lesion characterized by enlargement of the wall of the left and occasionally right ventricle.
- Old age.
How to use
According to the annotation, the drug is taken orally, regardless of food intake, with water. Dosage is 1 tablet per day. "Lortenza" (5 + 50 milligrams) is used when monotherapy with "Amlodipine" and "Losartan" does not lead to stable control of blood pressure.
Dosing is determined by titrating the dosages of the active substance of the drug. If necessary, adjust the concentration of one of the active components in the composition of the fixed combination medication.
Adverse reactions
According to the instructions for use and reviews of Lortenze, it is known that the active substance (amlodipine) provokes certain negative effects:
- Thrombocytopenia (a disease characterized by a decrease in the number of platelets circulating in the peripheral blood).
- Leukopenia (decrease in white blood cells in plasma).
- Hypersensitivity reactions.
- Hyperglycemia (excessive serum sugar).
- Change of mood.
- Anxiety.
- Insomnia.
- Depressive disorders.
- Dysgeusia (a type of pathology of the taste sensory system, characterized by a violation of the activity of the bulbous nerve endings located in the oral cavity).
- Tremor.
- Hypesthesia (a pathological process in which there is a violation of sensitivity in the lower and upper limbs, certain parts of the body).
- Paresthesia (a type of sensory disorder characterized by spontaneous sensations of burning, tingling, crawling).
- Peripheralneuropathy (a disease in which damage to the peripheral nerves occurs).
- Muscular hypertonicity (disturbance of the normal state, threatening many adverse consequences).
- Impaired vision.
- Tinnitus.
- Feeling a heartbeat.
- Atrial fibrillation (impaired functioning of the heart, which is accompanied by regular, fibrillation of individual groups of atrial muscle fibers).
- Ventricular tachycardia (a sharp increase in heart rate over 180 beats per minute).
- Arrhythmia (a pathological condition leading to a violation of the frequency, rhythm and sequence of excitation and contraction of the heart).
- Feeling of a rush of blood to the skin of the face.
- Significant reduction in blood pressure.
- Rhinitis (syndrome of inflammation of the nasal mucosa).
- Shortness of breath.
- Cough.
- Nausea.
- Pain in the abdomen.
Other side effects from Lortenza 5+50
The drug provokes the following negative reactions:
- Diarrhea.
- Intestinal obstruction.
- Dyspepsia (disturbance of the normal functioning of the gastrointestinal tract, as well as difficult and painful digestion).
- Gagging.
- Pancreatitis (inflammatory disease of the pancreas).
- Hyperplasia of the gums (a disease of the gum tissue that is mostly found in adults).
- Dryness of the oral mucosa.
- Gastritis (inflammatory or inflammatorydystrophic changes in the mucous membrane of the gastrointestinal tract).
- Jaundice (icteric coloration of the skin and visible mucous membranes due to increased levels of bilirubin in the blood and tissues).
- Hepatitis (inflammatory liver disease, usually of viral origin).
- Purpura (pathological changes in the body in the body, characterized by the appearance of small capillary hemorrhages on the skin).
- Alopecia (hair loss, which leads to their disappearance in certain areas of the head or trunk).
- Stevens-Johnson syndrome (acute toxic-allergic disease, the main characteristic of which are rashes on the skin and mucous membranes).
- Exfoliative dermatitis (a serious illness that can cause serious complications and even death).
- Erythema multiforme exudative (an acute inflammatory process affecting the skin and mucous membranes).
- Photosensitivity (skin reaction to sunlight involving the immune system).
- Painful urge to empty the bladder.
- Nettle rash.
- Nycturia (symptom of various diseases, in which nocturnal diuresis prevails over daytime).
- Swelling of the ankles.
- Arthralgia (pain in the joints, volatile in nature, in the absence of objective symptoms of joint damage).
- Myalgia (muscle pain).
- Muscle cramps.
- Increased urination.
- Gynecomastia (breast enlargement with hypertrophy of glands and fattyfabric).
- Impotence.
- Erectile dysfunction (a disease in which insufficient pressure appears in the cavernous or cavernous bodies of the penis).
- Peripheral edema (a condition of the extremities characterized by accumulation of fluid in the soft tissues).
- Fatigue.
- Pain.
- Unwell.
- Asthenia (nervous mental weakness, chronic fatigue syndrome).
Adverse reactions due to (active ingredient) losartan:
- Urinary tract infection.
- Anemia (a pathological condition characterized by a decrease in the concentration of hemoglobin and, in the vast majority of cases, the number of red blood cells per unit volume of blood).
- Dizziness.
- Sleep disorders.
- Drowsy.
- Migraine.
- Taste disorders.
- Vertigo (these are neurological symptoms such as dizziness, loss of balance, unsteady gait, blurred vision).
- Tinnitus.
- Hyperkalemia (a pathological condition that causes an abnormally high concentration of potassium in the blood).
- Hyponatremia (a condition in which the concentration of sodium ions in the blood plasma drops below normal).
What are the side effects of the heart
From the side of the cardiovascular system, the following negative reactions may occur when taking the drug "Lortenza":
- Angina (attacks of sudden onset chest pain that develop as a result of an acute deficiencymyocardial blood supply).
- Orthostatic hypotension (a clinical syndrome characterized by an inability of the body to maintain normal blood pressure in an upright position).
Recommendations
During treatment with the medicine, it is necessary to monitor weight and s alt intake, as well as adhere to an appropriate diet. In addition, it is recommended to visit the dentist from time to time and constantly maintain oral hygiene, as gum hyperplasia is likely to occur.
In people who received monotherapy with Losartan, there was an increase in the level of calcium in the blood. According to the annotation and reviews of Lortenz, it is known that discontinuation of therapy in none of these situations is required.
The simultaneous use of Losartan with s alt substitutes, as well as drugs with potassium, potassium-sparing diuretics, which can increase the concentration of potassium in the bloodstream, should be justified.
According to the instructions for "Lortenza", it is known that the use of the drug can cause transient arterial hypotension, which is accompanied by shortness of breath. It is important for people to take special care when performing potentially hazardous activities and driving a car while using the medicine, as dizziness may occur.
The drug is prohibited for use during pregnancy and during breastfeeding. Contraindication"Lortens", as mentioned above, is also under the age of eighteen.
Drug Interactions
According to the instructions for use, it is known that other antihypertensive drugs can enhance the antihypertensive effect of Lortenza, and therefore their use should be justified.
In the process of taking medication with lithium medications, there is an increase in neurotoxicity. Losartan, which is part of Lortenza, is able to reduce the excretion of lithium when used in combination with lithium-containing drugs, and therefore monitoring the concentration of this element in the blood is important.
When using the drug simultaneously with inhibitors of the CYP3A4 isoenzyme, regular monitoring of signs of arterial hypotension and peripheral edema is required.
When combined with beta-blockers, an exacerbation of the course of chronic heart disease is likely. According to the instructions and reviews of "Lortens", it is known that with the simultaneous use of the drug with "Dantrolene" for intravenous administration, hyperkalemia and arrhythmias appear.
In the complex therapy of drugs with inducers of the CYP3A4 isoenzyme, it is necessary to constantly monitor blood pressure.
Substitutes
Analogues of "Lortens" are:
- "Vamloset".
- "Aprovask".
- "Amzaar".
- "Exforge".
- "Combisart".
- "Amlosartan".
- "Lozap Plus".
- "Valsartan".
- "Walz N".
- "Casark N".
- "Atakand Plus".
- "Ko-Irbesan".
- "Diocor".
- "Phosicard N".
- "Combisartan".
The price of "Lortens" varies from 240 to 650 rubles.
Medication opinions
Reactions about the drug, as a rule, can be found on medical forums. As a rule, reviews about the drug "Lortenza" are positive, which confirms the beneficial effect of the use of antihypertensive drugs.
According to reviews, "Lortenza" is considered an effective drug that rarely causes negative reactions.
