Ciprofloxacin is the main active element of the medical drug "Ciprobai", which is characterized by a high degree of antibacterial activity.
The considered pharmacological agent is active against a variety of gram-negative and gram-positive pathogens. The bactericidal property of the active substance is due to the process of suppression of bacterial topoisomerases of the II type (topoisomerase IV and topoisomerase II), without which the process of replication, transcription, repair and recombination of bacterial DNA is impossible.
Indications for use
According to the instructions for use for Ciprobay and other ciprofloxacin-based drugs, they are prescribed for the treatment of uncomplicated and complicated infections that are provoked by microorganisms that are sensitive to the effects of ciprofloxacin and affect the urinary tract, eyes, kidneys, joints, genitals organs, bones, abdominal cavity (inincluding peritonitis, bacterial diseases of the biliary tract or digestive tract), soft tissues, skin. Also, drugs are used in the treatment of respiratory tract infections - they are recommended for pneumonia caused by Haemophilus spp., Enterobacter spp., Staphylococcus spp., Legionella spp., Branhamella spp., Klebsiella spp., Escherichia coli, Proteus spp., Pseudomonas spp. Sinusitis, otitis media, gonorrhea, sepsis, infections in people with weak immunity, selective decontamination of the intestine, anthrax in the pulmonary forms are treated with Tsiprobay and its analogues.
Contraindications for prescribing
As indicated by the instructions for use for "Tsiprobay", absolute contraindications are:
- combined use simultaneously with tizanidine (associated with an increase in the plasma concentration of the latter in the blood and the occurrence of clinically significant adverse reactions, for example, drowsiness, hypotension);
- under 18 years of age, except for treatment of certain complications of CF in the lung and prevention of anthrax;
- pregnancy, lactation process;
- individual intolerance;
- Hypersensitivity to fluoroquinolones.
Relative contraindications can be considered:
- pathologies of the central nervous system (epileptic seizures, reduced level of convulsive readiness or severe anamnesis);
- limitation of blood flow in the cerebral vessels, stroke or organic brain damage;
- hepatic and renalfailure;
- mental disorders: psychosis, depression;
- old age.
Regulations for taking and dosing instructions
Tsiprobay and analogues of the drug based on ciprofloxacin are taken orally, on an empty stomach, with water, regardless of food. It is undesirable to drink tablets with milk or liquids enriched with calcium. If it is impossible to take this medication inside, it is prescribed in the form of infusion solutions. After normalization of the patient's condition, they are transferred to taking the drug orally.
The infusion solution is administered intravenously into a large vein, the duration of the infusion is at least 1 hour. The drug can be administered in combination with other compatible solutions. The following dosing regimen is recommended for adults:
- infections of the respiratory organs - 500 mg of Ciprobay 2 times a day;
- complicated urinary tract diseases - 250 or 500 mg 2 times;
- inflammation of the bladder - once 250 mg;
- extragenital gonorrhea - 130 mg 2 times;
- uncomplicated gonorrhea - single dose 250mg;
- diarrhea -2 times a day, 500 mg;
- other infectious diseases - 500 mg 2 times;
- anthrax - 2 times a day, 500 mg;
- infectious pathologies that threaten life (septicemia, peritonitis, streptococcal pneumonia, diseases of the joints and bones) - 2 times a day, 750 mg.
Drug cost
Price of Ciprobay may vary depending onthe pharmacy chain selling it and the dosage of the drug and ranges from 240 to 420 rubles per package. Cost varies by region.
Tsiprobay analogues
The structural analogues of the drug are:
- "Aphenoxin";
- Betaciprol;
- "Basijen";
- "Vero-Ciprofloxacin";
- "Ificipro";
- "Zindolin";
- Quintor;
- Liprokhin;
- Quipro;
- Microflox;
- Oftocypro;
- "Nirtsip";
- Cyflox;
- Cyloxane;
- "Tseprova";
- Ciprinol;
- Cyprobid;
- Ciprodox;
- Ciprobrin;
- Ciprolaker;
- Ciproxil;
- "Tsiprolet";
- Ciprolon.
Let's look at some drugs in more detail.
Zindolin
A broad-spectrum antimicrobial drug, a fluoroquinolone derivative. The drug is able to suppress bacterial DNA gyrase (topoisomerases II and IV, which are responsible for the supercoiling of chromosome DNA around the RNA nucleus, which is necessary for reading information), disrupts DNA production, division and growth of bacteria. In addition, the drug causes significant morphological transformations (including membranes and cell walls) and rapid death of the pathological cell.
It has a bactericidal effect on gram-negative organisms at rest and division (because it has a pronounced effect not only on DNA gyrase, but also promotes wall lysiscells), into gram-positive microbes - only during division.
Low toxicity is due to the absence of DNA gyrase in the cells of the body. During treatment with ciprofloxacin, there is no concomitant resistance to other antibiotics that do not belong to the category of gyrase inhibitors, which makes it most effective against microbes that are resistant to aminoglycosides, cephalosporins, penicillins, tetracyclines and other drugs.
What other Tsiprobay analogues are known?
Ificipro
This drug is an absolute structural analogue of the drug, and is based on the same active element - it is ciprofloxacin.
This drug is highly effective against almost all types of aerobic bacteria, indole-negative and indole-positive microorganisms: Proteus spp., Enterobacter spp., Morganella morganii, Hafnia spp., Providencia stuartii, Salmonella spp., Citrobacter spp., Vibrio cholerae, Yersinia enterocolitica, Vibrio parahaemolyticus, Moraxella catarrhalis, Neisseria meningitidis, Neisseria gonorrhoeae, Providencia spp., Haemophilus influenzae, Pseudomonas aeruginosa, Acinetobacter anitratus, Pasteurella multocida, Shigella spp., Campylobacter spp. etc.
Medication is prescribed for almost any infectious pathology, including severe forms. Their list includes diseases of the respiratory organs, gynecological problems, diseases of the urinary system, musculoskeletal and joint apparatus, purulent lesions, peritonitis,sepsis.
Analogues of "Tsiprobaya" should be selected by a doctor.
Lyproquin
The pharmacological action of this drug is antibacterial, the main element is ciprofloxacin. Suppresses DNA gyrase, disrupts the biological synthesis of DNA, the division and growth of bacteria. Acts on microbes during dormancy and growth. Rapidly absorbed from the gastrointestinal tract in the small intestine and duodenum. Penetrates into tissues, cells and fluids, creating a high concentration in the kidneys, liver structures, gallbladder ducts, lungs, sinus and bronchial mucosa, genital organs, urine, phagocytic cells, bile, sputum, found in the prostate, cerebrospinal saliva, fluid, fatty tissue, skin, bones, muscle fibers, passes through the placenta. Broken down in the liver, excreted by the kidneys with urine.
Reviews
There are many positive reviews about the drug "Ciprobai" and its analogues based on the substance ciprofloxacin, due to its high efficiency during the treatment of infectious diseases and complications.
Patients report that they have used this drug for severe inflammation of the respiratory organs, urinary system, digestive organs, reproductive system, joints.
The drug, according to patients, is tolerated normally, does not cause severe disorders of the general condition, as well as symptoms of dyspepsia. The condition of patients does not normalize immediately, approximately on the fifth or seventh day of therapy for serious diseases, and on the third or fourth - for conditions of moderatedifficulty.
Children are not prescribed this medication, however, there is information in the reviews that the medicine was used for life-threatening diseases in children after 10 years. In this case, the dosages were calculated by specialists in accordance with the body weight of the child and the characteristics of the disease.
Experts do not recommend using the medication in question on your own, it is best to get a doctor's recommendation.
