Cream "Advantan" refers to glucocorticoids of local effects, it is intended for external use. The drug itself is produced in several medicinal versions, for example, in the form of an ointment, cream and emulsion. We will consider the cream, analyze the instructions for use in detail, get acquainted with its analogues and find out what people write in reviews about this product.
Cream ingredients
The active ingredient in the composition of the cream "Advantan" is methylprednisolone aceponate. It is a non-halogenated synthetic steroid. Auxiliary substances are decyloleate along with glycerin, cetylsteryl alcohol, hard fat, softizan, polyoxyl, disodium, benzyl alcohol and purified water. The cream is white in color and almost opaque. As for the pharmacotherapeutic group, this drug is classified as a topical glucocorticosteroid.
What are the release forms? Cream "Advantan" is produced in aluminum tubes,closed with a plastic cap. One tube contains 15 grams of the drug. Instructions for use are placed in a cardboard box with a tube of cream.
Pharmacodynamics
According to the instructions for the Advantan cream, when used externally, the product can reduce inflammatory and allergic skin reactions. It also inhibits reactions that are associated with increased proliferation. Thus, the use of the cream leads to a decrease in objective symptoms in the form of erythema, edema and lichenification. In addition, this cream also eliminates subjective sensations in the form of itching, irritation and pain. Is Advantan cream suitable for children? The manual contains information about this.
With topical use of methylprednisolone aceponate at effective dosages, systemic exposure is usually minimal. After repeated application of the agent to large areas (from forty to sixty percent of the skin surface), as well as when it is used under an occlusive dressing, as a rule, no violations of the adrenal glands are noted. Thus, the volume of cortisol in the blood plasma, along with its circadian rhythm, remain within the normal range. In addition, there is no decrease in the level of cortisol in the urine. In the course of clinical studies against the background of the use of "Advantan" up to twelve weeks in adult patients, skin atrophy was not detected. No acne-like rashes were noted either.
Methylprednisolone aceponate, in particular its major metabolite, binds to intracellular glucocorticoid receptors. On the other hand, the steroid receptor complexbinds to certain regions of DNA, thereby causing a series of biological effects. Binding of the receptor complex to DNA leads to the process of induction of macrocortin synthesis. The latter, in turn, can inhibit the release of arachidonic acids. Inhibition of prostaglandin synthesis leads to a vasoconstrictor effect.
Pharmacokinetics
As the instructions for the Advantan cream indicate, methylprednisolone aceponate (the main component of the cream) is able to hydrolyze in the epidermis and dermis. The main and most active metabolite is methylprednisolone, which has a high affinity for corticoid skin receptors, which indicates its biological activation.
The intensity of absorption directly depends on the condition of the skin. Absorption in adolescents and adults who suffer from neurodermatitis or psoriasis is less than 2.5%. This differs slightly from absorption through intact skin.
After entering the systemic circulation, methylprednisolone is quickly conjugated with glucuronic acids and then inactivated. Metabolites of the active ingredient of the cream are eliminated mainly by the kidneys for about sixteen hours. Next, we will find out in which cases the Advantan cream is prescribed to patients.
Indications for use
This remedy is used against the background of inflammatory skin diseases. Indications for the use of Advantan cream are given below:
- Development of atopic dermatitis, neurodermatitis or childhoodeczema.
- The occurrence of true eczema.
- Development of microbial eczema.
- Having occupational eczema.
- Presence of dyshidrotic eczema.
- Appearance of simple contact dermatitis.
- Development of an allergic form of contact dermatitis.
- Occurrence of seborrheic dermatitis or eczema.
- Presence of photodermatitis or sunburn.
What else does the instruction manual for Advantan cream tell us?
Contraindications
The presented cream is not suitable for use in a number of the following cases:
- Presence of tuberculous or syphilitic processes in the area of application.
- Presence of viral diseases in the area of application of the drug. For example, this cream should not be used for chicken pox, as well as for shingles.
- Presence of rosacea or perioral dermatitis in the area of application.
- Do not apply this cream to areas of skin that show reactions to vaccinations.
- Advantan cream is not suitable for children under four months of age.
- Presence of hypersensitivity to the components of the cream.
Method of application and dosage
In accordance with the instructions for use, Advantan cream is used once a day. The product is applied in a thin layer on the affected foci of the skin. As a rule, the duration of continuous daily therapy with Advantan should not exceed twelve weeks for adults. For children, the duration of continuous treatment should not exceed fourweeks. According to reviews, Advantan cream is good for children.
Because it is a low-fat therapeutic formulation, it is useful in the treatment of virtually any acute inflammatory condition. The drug is especially good for the treatment of the weeping stage of eczema on the background of oily skin. In addition, it is suitable for use in the localization of pathological processes, not only on smooth skin, but also on hairy areas. Cream "Advantan" from allergies also quickly relieves.
Side effect on the background of using the product
Usually, as practice shows, this drug is well tolerated by patients. In isolated cases, local reactions are sometimes observed in the form of itching, burning, erythema and blistering. Like the external use of other glucocorticosteroids, against the background of the use of this agent, phenomena such as folliculitis along with hypertrichosis, perioral dermatitis and allergic reactions to one of the components of the drug can be observed in rare cases. This is confirmed by the instructions and reviews for the Advantan cream.
Overdose
As part of the study of acute toxicity of the main component of the cream (methylprednisolone aceponate), no risks of acute intoxication were identified against the background of excessive single skin application (when applied to a large area under favorable conditions for absorption). As a result of unintentional ingestion, no risks should also be detected.
On the backgroundexcessively long and intensive topical application of glucocorticosteroids may develop skin atrophy, resulting in some thinning of the skin. In the event of skin atrophy against the background of this kind of overdose, the remedy must be canceled.
What is better - cream or ointment "Advantan"? More on that later.
Precautions
In the presence of bacterial dermatosis or dermatomycosis, it is desirable to carry out specific antibacterial therapy as an addition to the treatment with Advantan. In the event that the skin is too dry against the background of prolonged use of the Advantan cream, then it is necessary to switch to a medicinal variant with a higher content of fat in the product. For example, Advantan ointment is perfect for these purposes.
It is very important to avoid getting this drug in the eyes. Similar to systemic corticosteroids, glaucoma may occur after using large doses of this medication. Against the background of too long use, as well as when applying the cream to the skin around the eyes, there are also risks of unwanted reactions.
Indications of the cream "Advantan" must be strictly observed.
Use during pregnancy
If you need to use Advantan cream during pregnancy or lactation, you must carefully weigh the potential risks with the expected benefits of treatment. At this time, women are not recommended to use this drug for a long time on extensive skin surfaces. For breastfeeding women, doctors do not recommend applying the cream to the mammary glands.
Many people wonderhormone cream "Advantan" or not?
Storage conditions
The presented cream is stored at a temperature that should not exceed twenty-five degrees for three years. The medicine is stored in places inaccessible to children. This product should not be used after the expiration date stated on the package.
This cream can be purchased at any pharmacy without a prescription.
Cream or ointment "Advantan" - which is better?
For dry skin, it is better to choose an ointment, it is oil-based. In chronic ailments, this form will be more effective. A cream is applied to weeping areas. It does not retain liquid and does not provoke a thermal effect.
Structural analogues
Analogues that have the same active ingredient as the main drug are called structural. One of the structural analogues of the Advantan cream is Metizolone. Indications for its use are the presence of atopic dermatitis, as well as any eczema in patients, regardless of their age. Contraindications to the use of this drug are in many ways similar to those described in the instructions for Advantan. Among them, individual intolerance is indicated along with skin diseases of viral etiology, tuberculosis, syphilis and allergic reactions to drug components.
At the beginning of pregnancy, this analog should not be used categorically. During the feeding period, it can be used only after agreement with the attending physician. The cream is usually applied toaffected areas once a day with a thin layer. Adult patients should not use Metizolone for more than two weeks.
Another structural analogue of "Advantan" is a cream for external use called "Sterocort". This composition is allowed for children from six months of age, and it is often prescribed for the treatment of diaper dermatitis. In addition, among the indications for the use of this drug is neurodermatitis, along with contact and atopic dermatitis.
Both presented structural analogues of "Advantan" are able to completely replace it. Directly at a cost, they are even somewhat cheaper. For example, Metizolone can be bought at a pharmacy for more than two hundred rubles. For comparison, it is worth noting that Advantan will cost the buyer six hundred rubles per tube.
Among the creams "Advantan" has no analogues. The remaining funds, similar to it in indications for use, differ in another active substance in their composition. In this regard, their appointment must be agreed with a dermatologist.
Non-structural analogues
Among the non-structural analogues of this cream, the following medications are as close as possible to it in terms of their effect, as well as according to their indications:
- Means "Beloderm". This cream is made on the basis of betamethasone. It is used to combat dermatitis, eczema, psoriasis, lichen, lupus erythematosus and erythema. "Beloderm" can not be used for pathologies such as tuberculosis, syphilis, viral diseases, fungallesions, wounds and ulcers, as well as tumors on the skin. This remedy is allowed for children from six months of age, but it is forbidden to apply it to the skin under bandages or diapers. Thus, "Beloderm" is a drug with a wider spectrum of effects compared to "Advantan", but it is quite capable of replacing it. In the role of structural analogues of Beloderm, Betamethasone is usually used along with Betazone, Betlibene and Mesoderm.
- Cream "Elozon". This drug is made on the basis of mometasone. It is used to eliminate itching and skin redness, it is also suitable for the treatment of dermatitis, eczema and psoriasis. You can not use "Elozon" in relation to babies under two years old, and in addition, to persons suffering from an allergic reaction to the main components of the cream. This remedy is applied to the skin once a day. Therapy lasts no more than twenty days. During the period of bearing a child, this drug can be used only in cases of emergency. Elozon's analogues are drugs such as Moleskin, along with Momezon and Elocom.
- Prednitop drug. This is an inexpensive analogue of Anvantan cream. Prednicarbate is used as the main component. This tool is used to treat skin inflammation, as well as eye pathologies. Against the background of the treatment of fungal and bacterial infections, Prednitop should be combined with antibacterial drugs. This cream should not be given to infants. The main contraindications include some bacterial and viral pathologies along with individual intolerance. Sometimes, against the background of using this cream, there areside effects in the form of skin redness, itching, poor wound healing, and so on. During pregnancy, it is better to refuse the use of this medicine. The therapeutic composition is applied to the skin only once a day. If necessary, the dosage can be increased to twice the application. The general course of treatment is usually two weeks.
- Means "Flucinar". The main active ingredient in this case is fluocinolone acetonide. This ointment is actively used to treat eczema, psoriasis, seborrheic dermatitis and lichen. Among the contraindications are diseases that are caused by fungi, and in addition, various bacteria and viruses. This analogue is not suitable for children under two years of age. Against the background of the use of this ointment, side effects may appear, mainly allergic symptoms that occur on the skin are noted. In the event that this drug gets into the eyes, a burning sensation with itching is possible. As a result of prolonged exposure, the development of glaucoma or cataracts is not excluded. This medicine is completely prohibited for pregnant women. Ointment "Flucinar" is applied to the skin once a day, and the total duration of therapy is usually no more than two weeks. The analogues of this drug are Sinaflan and Flutsar.
- Cream "Kutiwait". In the event that a person is looking for a cheap substitute for Advantan, then it is advisable to use the Kutiwait cream. The active ingredient is fluticasone propionate. The range of effects of this cream is very wide. For example, it can be used for ailments such as dermatitis along withwith eczema, psoriasis, lichen, lupus, erythroderma, and also this composition helps with insect bites. Cream "Cutiveit" is suitable for babies, but after a year. Contraindications to the use of this medication are individual sensitivity, the presence of acne, viral and fungal infections. Also, this cream is not suitable for use in perioral dermatitis. It should be applied to the affected area of the skin no more than twice a day. This drug should not be used for more than two weeks.
- Means "Halovat". The main active ingredient of this drug is halobetasol. This drug is used for dermatoses, in addition, it is effective against the background of dermatitis, eczema and psoriasis. For children under the age of twelve, this cream is strictly contraindicated. The presented preparation should be applied in a thin layer. You can use the cream no more than twice a day. Do not use this remedy for more than two weeks. It is also not recommended to use Halovat cream for acne, skin diseases caused by fungi, pathogenic bacteria or viruses. Against the background of its use, the occurrence of side effects in the form of itching and redness is not excluded.
Analogue reviews and pricing
All of the above analogues differ not only in the range of their impact, but also in price. So, for example, Beloderm differs little in its cost from Advantan. It, like "Advantan", can be purchased for six hundred rubles. Elozon sells for four hundred rubles a tube. A "Afloderm"will cost the buyer five hundred rubles.
All reviews about Advantan, as well as its analogues, are extremely contradictory, which proves that the drug should be replaced only with the permission of a doctor. After all, each organism reacts purely individually to the active substances of medicinal formulations, and once again it is not worth risking your he alth.
Reviews about "Advantan"
When reading reviews of "Advantane" we can say that the opinions of buyers about this cream are very different. In general, in the comments, the cream is characterized as a fairly effective remedy, but there are also dissatisfied reviews about it.
As for the positive aspects of this cream, people write the following about it:
- Effective and easy to use.
- Economy.
- Can even be used to treat small children.
- Good anti-inflammatory effect, thanks to which many skin diseases are successfully treated.
- Easy to apply and quickly absorbed.
Among the dissatisfaction there are complaints about the following drawbacks of the drug:
- Cost too high.
- Helps far from all dermatoses.
- Side effects are observed mainly in the form of allergic reactions.
- Pack too small.
- The hormonal basis of the drug.
Despite the fact that there are many comments regarding the medicinal composition, in general, judging by the reviews, it can be argued that buyers are satisfied with the use of the cream"Advantan". In particular, many note its speed. For example, it is said that the drug can help in just two days, and the effect is felt after the first application. People recommend using this remedy when there is unbearable itching and pain, which you want to get rid of as soon as possible. This remedy is also praised for helping with dermatitis and eczema.
The disadvantage of "Advantan", according to reviews, is that rashes can double on the skin after its cancellation. In this regard, it is desirable to cancel this remedy gradually. Also, some report that this cream dries out the skin, causing excessive dryness and flaking. It is extremely rare to read in reviews that this drug did not help at all.
Thus, Advantan cream acts as a good anti-inflammatory agent that helps to cope with various skin diseases. Its main disadvantage is the rather high cost, as well as some side effects, mainly associated with individual intolerance.
