Human skin protects the body and is a kind of barrier between the external environment and the body. Such a cover has a complex structure, and also performs many functions. The skin has its own blood supply and innervation, and therefore it is more susceptible to various diseases than other organs.
"Timogen" - a cream intended for external use, which has immunostimulating properties and improves tissue regeneration. This drug is often used for skin diseases. Customer reviews about the cream "Timogen" are mostly positive. Its therapeutic properties and principle of action are described below.
Composition, description, packaging of the external agent
"Timogen" - a cream of white or almost white color (sometimes with a yellowish tint). Designed for outdoor use only.
The active component of the agent in question is alpha-glutamyl sodium tryptophan. Also, the composition of the drug includes excipients in the form of sorbitan monostearate, vaseline oil, vaseline,stearyl alcohol, polysorbate 60, xanthan gum, glycerol, cetyl alcohol, methyl parahydroxybenzoate, diethylene glycol monoethyl ether, propyl parahydroxybenzoate and purified water.
Instructions for use, including a description of the Thymogen cream, is contained in a cardboard box where the drug itself is placed (in 20 or 30 g aluminum tubes or in glass jars).
The principle of action of an external preparation
According to the instructions for use, the cream "Timogen" is an immunostimulating drug. This is a dipeptide that has a direct effect on the reactions of humoral and cellular immunity, as well as on the non-specific defense of the human body. By stimulating regeneration processes in their depressed state, this medication helps to improve the course of the cell metabolism process.
The active substance of the drug induces Thy-1 expression on thymocytes and activates 5'-ectonucleotidase. This effect of sodium alpha-glutamyl-tryptophan indicates its direct effect on the differentiation of lymphocytes in the thymus.
Thus, by inducing the expression of differentiated receptors on lymphocytes, Thymogen cream is able to normalize not only the number, but also the ratio of the subpopulation structure of lymphocytes in people with various types of immunodeficiency conditions.
It should also be noted that the drug in question, when applied externally, restores the ratio and expression of anti-inflammatory cytokines (in the presence of variousdiseases and pathological conditions that are accompanied by impaired immunoreactivity).
Pharmacokinetic properties
What is the probability of systemic absorption of the Timogen cream? According to the attached instructions, there are currently no data on the pharmacokinetics of this drug.
When applied?
In what cases can a patient be prescribed such an external drug as "Timogen" (cream)? Reviews of experts report that this drug is used only as part of complex treatment, namely when:
- chronic eczema (including true and microbial);
- atopic dermatitis (including complicated secondary bacterial infection);
- chronic pyoderma (including chronic diffuse streptoderma);
The instructions also say that the mentioned medicine for external use can be prescribed in the presence of mechanical, thermal and chemical injuries of the skin.
Contraindications
Cream "Timogen" is not recommended for use during pregnancy and lactation. Also, a contraindication to the use of this drug is the patient's hypersensitivity to the components of the drug (active or auxiliary).
Dose and duration of treatment
According to the instructions for use and reviews, the Timogen cream should be applied to the affected area of the skin with a thin layer 1-2 times a day (for example,in the morning and in the evening). The recommended daily dosage of the drug in question is 2 g or 1000 mcg of thymogen. It should be noted that one strip of cream from a tube with a diameter of 5 mm and a length of 4 cm is 1 g.
After applying the drug to the skin, it is forbidden to use any dressings.
The duration of treatment with an immunostimulating drug may depend on various circumstances (more often it is used until the local manifestations of skin diseases are completely eliminated). It must be remembered that the maximum duration of cream therapy is 20 days.
Actions of secondary character
Experts say that adverse reactions after using the Timogen cream are extremely rare. Sometimes, against the background of the use of the drug (for example, on large areas of the body), the patient may experience allergic responses to active and auxiliary components.
Overdose cases
About cases of overdose of the drug "Timogen" in the attached instructions, nothing is said. At the same time, experts report that it has been experimentally proven that such a drug is non-toxic in doses that exceed therapeutic doses by thousands of times.
Interaction with other drugs
Is it permissible to use Timogen cream simultaneously with other medicines? The instructions for the interaction of this drug with other drugs do not say anything. At the same time, doctors do not recommend using "Timogen" with other means of a similaractions intended for external application.
Information about other forms of issue
In addition to the cream, the drug "Timogen" can be purchased in the form of a spray and solution.
Intramuscular injection solution is practically colorless. It goes on sale in 1 ml ampoules, which are placed in cardboard packs of 5 pieces.
Spray "Timogen" is intended for nasal use, and therefore the dosed vial has a specific shape. The contents of the container may have a characteristic odor.
For prophylactic purposes, these forms of the drug can be used for:
- chemotherapy;
- chlamydial, viral and bacterial infections;
- treatment with high doses of antibiotics;
- oppression of one's own hematopoiesis;
- diseases of the respiratory system;
- slow down regenerative processes.
The choice of the dosage form of the drug in question in the treatment of a particular disease depends on many factors and is made only by the attending doctor.
Unlike Timogen cream, other forms of this drug may cause various reactions in case of overdose. For example, a tenfold excess of the therapeutic dose of a nasal spray contributes to the development of hay fever, as well as the appearance of mucous discharge from the nose and the onset of a flu-like syndrome.
As for the intramuscular injection of high doses of the drug, in this case, the severity of side effects increases.
Important to know
Before using the Timogen cream for the treatment of skin diseases, you should definitely study the attached instructions. It should also be noted that numerous clinical studies of this remedy confirm that it meets absolutely all the requirements for medicines for external application, which are actively used in the treatment of dermatosis (including the treatment of atopic dermatitis, strophulus, pyoderma, eczema of microbial origin) in pediatric practice.
It should be remembered that the drug in question has an immunocorrective effect. Its use improves the barrier function of the skin, which is achieved by quickly eliminating dryness and restoring the integrity of the epidermis.
Similar medicines
What can replace the solution, spray or cream "Timogen"? This drug has no analogues for the active substance. Therefore, when choosing a similar medication, you should pay attention to drugs that have the same immunomodulatory effect. For example, in certain cases (after consulting a doctor), the remedy in question can be replaced by means: Immunoglobulin, Tonsilgon N, Cycloferon, Broncho-munal, etc.
In the event that a patient needs an immunomodulator in the form of a cream, experts recommend using the following drugs: Losterin, Viferon, Panavir, etc.
Timogen cost
Cream price"Timogen" in Russian pharmacies varies between 200-250 rubles. As for the spray with the same name, that its cost is approximately 185 rubles. The solution for injection is the most expensive form of this drug. Ampoules can be purchased for 270 Russian rubles.
It should be recalled that the price of Timogen may differ from the above depending on the pharmacy chain and the region of sale.
Medication reviews
According to thematic reports that can be found on medical forums, the drug in question has established itself as an effective and reliable drug used to correct the activity of the human immune system.
Patients using "Timogen" talk about good tolerance of nasal and injectable forms of the drug. As for the spray, it is quite often and effectively used in pediatric practice. In children, this drug is used in the treatment of immunodeficiencies (in various age groups). Many parents claim that the spray is a very convenient dosage form, as the bottle is equipped with a dispenser.
Cream "Timogen" is also considered an effective remedy. When used externally (in the treatment of skin diseases), it never causes negative reactions. Patients are also pleased with the affordable price of this medicine in pharmacy chains.
