How does Nandrolone Decanoate work? You can find reviews about this tool at the very end of the article. You will also learn about the form in which this medication is produced, how it should be used, whether it has contraindications, analogues and side reactions.
Composition, description, packaging and form
"Nandrolone Decanoate" is sold as an oily solution for injection. A transparent white preparation is available in ampoules of 10 pieces in a carton. Its active substance is nandrolone. As auxiliary components, isopropyl and benzyl alcohols, as well as sunflower oil are used.
Pharmacodynamics
What is Nandrolone Decanoate? The instruction says that this is a drug related to anabolic steroids of prolonged action. After the drug enters the systemic circulation, it interacts with receptor proteins that are located on the surface of target organs. As a result, a complex compound is formed.
The drug in question is able to stimulate the synthesis of ribonucleic and deoxyribonucleic acids, enhance tissue respiration and phosphorylation reactions in muscles. As a result of such an impact, the muscle mass of a person increases, and his fat deposits are actively burned.
The drug promotes the accumulation of ATP and creatine phosphate, which accelerates the growth of male genital organs and stimulates the formation of secondary sexual characteristics.
Drug properties
What properties does Nandrolone Decanoate have? The description attached to the drug indicates that it is able to stimulate spermatogenesis, sex and sebaceous male glands.
Within a week after the start of injections, the anabolic effect is actively manifested. In the integumentary and glandular epithelium, as well as in muscles and bones, reparative processes are activated. In addition, the fullness increases and the rate of absorption of amino acids from the small intestine increases. This effect is especially noticeable when eating protein foods.
Pharmacokinetics
As a result of treatment with this drug, the synthesis of K-dependent coagulation factors in the liver tissues is disrupted. Blood lipids also change. Due to the reabsorption of sodium and fluid in the kidneys, this drug often causes swelling.
After intramuscular injection of 100 mg of an oily solution, its highest concentration in the blood is noted after 7-12 days. The bioavailability of the drug is 100%.
In the bodythe drug is metabolized in the liver to form 17-ketosteroids. The drug is excreted along with urine and feces. Its half-life is 7 days.
Indications for use
Why is Nandrolone Decanoate prescribed? This remedy is effective for:
- anemia that occurs against the background of kidney disease, myelosclerosis, myelofibrosis and myeloid aplasia of the bone marrow;
- diabetic retinopathy;
- Werdnig-Hoffmann syndrome;
- inoperable breast carcinoma (in women), after ovariectomy and in the postmenopausal period.
It should also be noted that this medication is used for:
- eliminate anemia caused by metastases from malignant neoplasms, various drugs and s alts of heavy metals;
- increased catabolism and generation rate in chronic infectious diseases, as well as after severe injuries, operations and steroid myopathy;
- elimination of hypocalcemia in postmenopausal and senile osteoporosis, as well as after treatment with corticosteroids;
- stimulate the growth of children with growth hormone deficiency.
Among other things, the drug in question is often prescribed to people with progressive muscular dystrophy.
Contraindications for use
Nandrolone Decanoate is contraindicated in the following conditions:
- for ischemia;
- if allergic to activesubstance;
- while breastfeeding;
- people with prostatic hypertrophy or carcinoma;
- during pregnancy;
- for malignant tumors of the mammary glands in men;
- people with severe atherosclerosis;
- women with breast carcinoma, including those with hypercalcemia;
- with a tendency to form edema due to heart failure, as well as due to acute or chronic diseases of the kidneys and liver (with nephritis);
- people suffering from alcoholism, as well as patients with alcoholic damage to the kidneys, liver or heart.
How to take Nandrolone Decanoate?
The course of treatment with this remedy should be prescribed only by a doctor. According to the attached instructions, the oily solution must be administered deep, intramuscularly.
The dosage of the drug, as well as the duration of therapy depends on the indications:
For anemia
In the treatment of anemia, this medicine should be combined with iron supplements. The dosage for men should be 100-200 mg once a week. As for women, they are recommended to use 50-100 mg of the drug with the same multiplicity.
The duration of therapy is determined by the attending physician.
As an anabolic
Most often, the drug "Nandrolone Decanoate" is used as an anabolic agent. For men, it must be administered in an amount of no more than 200 mg once every 7-28 days. For women, this dose should be reduced to 100 mg.
If the drug is used in relation to children 2-14 years old, then dosages of 25-50 mg should be used. In this case, the frequency of administration is the same as in adults.
The course of therapy is 12 weeks. After 2 months, injections can be resumed.
To build muscle mass, Nandrolone treatment should be combined with a protein diet.
Side effects
Does Nandrolone Decanoate cause side effects? Athletes' reviews say that if the recommended dosages are observed, no undesirable effects are observed.
Most often, adverse reactions develop when taking large doses of medication. In this case, the drug may cause:
- vomiting, abdominal pain, liver problems (eg jaundice), nausea;
- progression of atherosclerosis, iron deficiency anemia, swelling around the periphery;
- leukemic syndrome;
- bleeding, clotting disorders;
- hepatic purpura;
- breathing disorders, headaches, bloody vomiting, dark stools and other signs of hepatonecrosis;
- impaired spermatogenesis, hepatocellular carcinoma;
- Dark-colored urine, pain in the right side, yellowing of the skin, discoloration of the stool and other signs of cholestatic hepatitis.
Women with an overdose may experience:
- hypercalcemia;
- dysmenorrhea or amenorrhea;
- clitoris growth,increased hair growth, voice changes.
The nature of side effects in men depends on age:
- In the prepubertal period, there are such phenomena as penis growth, skin rashes, accelerated formation of secondary sexual characteristics, cessation or acceleration of growth, acne, skin hyperpigmentation.
- In the post-pubertal period, gynecomastia, an increase in the frequency of the urge to urinate, as well as an increase in the density of the mammary glands and their sensitivity are noted.
- In older men, this drug may cause carcinoma or enlargement of the prostate.
Drug Interactions
Before taking the drug in question, you should always consult with your doctor. You should also read the included instructions. It says that this medication may have a trade name such as Retabolil.
Nandrolone Decanoate enhances the effects of insulin, indirect anticoagulants, antiplatelet agents, and oral diabetes medications.
Products containing sodium, corticotropin, mineralcorticoids, corticosteroids increase water retention in the body, thereby increasing the likelihood of acne and edema.
Medication "Nandrolone Decanoate" noticeably weakens the action of somatotropic hormone, as well as its derivatives. When combined with hepatotoxic drugs, it protects the liver.
Specialrecommendations
Despite the fact that this drug does not have androgenic properties, it should be recommended to women with extreme caution.
Treatment with this drug can be combined with radiation therapy, as well as with cytostatics and glucocorticosteroids.
Special care must be taken with glaucoma, epilepsy and migraine. During therapy, periodic monitoring of the condition of the prostate gland, intraocular pressure and liver function tests is required.
In the presence of a progressive malignant tumor, the duration of treatment is determined by the doctor and depends on the condition of the patient.
Analogues of the drug and its price
What drugs based on nandrolone do you know? You can replace the medication in question with the following means: Nandrolone D, Phenobolin, Retabolil, Deca-Durabolin.
"Nandrolone Decanoate" in the form of an oily solution in ampoules can be purchased for 2000 rubles.
Medication opinions
Reviews about this product are mainly from people involved in sports who want to improve their physical data, accelerate the growth of muscle tissue and reduce fat.
As athletes note, "Nandrolone Decanoate" is well tolerated. However, in some cases, it can cause headaches, allergic reactions, and back pain.
Women rarely use this drug. At the same time, they note that in small dosages the androgenic effect does not appear.
