An agent called "Tranexamic acid" is an antifibrinolytic drug that has anti-inflammatory and anti-allergic effects, as well as a pronounced hemostatic effect on bleeding, which is associated with an increase in fibrinolysis. The basis of this drug is the inhibition of plasminogen activator and plasmin, the suppression of the formation of active peptides and kinins, which are directly involved in inflammatory and allergic reactions. In addition, a remedy such as "Tranexamic acid" significantly lengthens the thrombin time. As for the features of the pharmacokinetics of this antifibrinolytic drug, after oral administration, about 30-50% of its initial dosage is absorbed, with the highest plasma concentrationsare noted one hundred to one hundred and eighty minutes after use. The antifibrinolytic effect in tissues persists for fifteen to seventeen hours, and in plasma for seven to eight hours after the use of the drug "Tranexamic acid". The price of this product is about 1,300 rubles, and you can buy it in almost every pharmacy.
An antifibrinolytic drug is available in the form of tablets of two hundred and fifty or five hundred milligrams, in the form of a solution for injection, and also in the form of a solution intended for oral administration. All of these dosage forms are excellent for the treatment and prevention of bleeding, provoked by an increase in total fibrinolysis. For example, a remedy referred to as "Tranexamic acid" is often prescribed for malignant neoplasms of the prostate or pancreas, leukemia, surgical interventions on the chest organs, and liver diseases. Manual separation of the placenta and postpartum hemorrhage are also included in the list of indications for the appointment. In addition, the drug "Tranexamic acid" should be used for hematuria, angioedema, allergic dermatitis, eczema, toxic and drug rash, urticaria. In addition, this drug is actively prescribed for pharyngitis, laryngitis, tonsillitis, stomatitis, nasal, uterine and gastric bleeding, tooth extraction in patients diagnosed with hemorrhagic diathesis. It also helps a lot, like"Tranexamic acid", with menstruation, characterized by abundant discharge.
As for the features of the use and dosage of the drug, in each case they are set individually, based on a particular clinical situation. However, as a rule, no more than 1-1.5 grams is allowed to be taken orally at a time. In this case, the frequency of use is from two to four times a day, and the duration of treatment is from three to fifteen days. A single intravenous dose is 10–15 mg/kg.
The main contraindications to the use of this remedy are conditions such as subarachnoid hemorrhage, thromboembolic syndrome, renal failure, impaired color perception and deep vein thrombosis. In addition, you should not use this drug in case of increased individual sensitivity or pregnancy. Side effects associated with taking this antifibrinolytic agent include dizziness, drowsiness, hypotension, tachycardia, weakness, and chest pain.
