The defeat of ulcers and erosions of the stomach and duodenum is becoming more common. Peptic ulcer significantly affects the quality of human life, causes discomfort and a lot of unpleasant sensations. In addition, if left untreated, an ulcer can lead to the formation of a malignant tumor, as well as cause damage to adjacent organs and systems. In the article, we will consider antiulcer drugs for the stomach.
How to treat the disease?
The pharmaceutical market is ready to offer a wide range of medicines that relieve symptoms and treat gastric and duodenal ulcers. However, you should not take any anti-ulcer medication without consulting a doctor.
Omeprazole in the treatment of peptic ulcer disease
A whole group of drugs will stand out, which include omeprazole as an active ingredient. Particularly effectivesubstance in combination with antibacterial therapy in case of damage to the body by the bacterium Helicobacter pylori, which provokes the appearance of ulcers. Such treatment in a short time allows you to normalize the patient's condition and eliminate the pathogen without damaging the sensitive mucous membranes of the stomach and intestines. Omeprazole-based drugs are often included in the therapeutic regimen with drugs that contain bismuth.
How to take?
Omeprazole anti-ulcer medications are taken at least 15 minutes before meals. These drugs are most effective on an empty stomach in the morning. The gastro-coated capsules are swallowed whole and washed down with water. It is advisable to take the drug at the same time.
Against the background of gastric ulcer, omeprazole is taken 20 mg in the morning and evening. If the ulcer is caused by the defeat of Helicobacter pylori, then the therapy is supplemented with antibiotics. An anti-ulcer drug is taken for two months until the ulcers are completely healed. Omeprazole creates a kind of film that reduces the aggressiveness of the stomach environment and accelerates the healing process of erosions and ulcers.
Antibiotics
Medicine highlights many causes of stomach and intestinal ulcers. If laboratory tests show the presence of pathogenic bacteria Helicobacter pylori in the body, the specialist prescribes broad-spectrum antibiotics as anti-ulcer drugs.
There are several groups of antibiotics that can be used in this pathology. Most often, gastroenterologists prefer the following groups of drugs:
- Macrolides - Erythromycin, Fromilid, Clarithromycin. These drugs interfere with the production of protein in the bacterial cell, which leads to its death.
- Penicillin series - "Amoxiclav", "Amoxicillin". They have a detrimental effect on the shell of a harmful microorganism.
- Tetracycline series - "Doxycycline", "Tetracycline". Prescribed for intolerance to penicillin.
The antiulcer drug for the stomach and duodenum "Clarithromycin" is recognized as the safest antibiotic, as it has a small list of possible adverse reactions. The drug is taken in the morning and evening at a dosage of 250 mg. It should not be used during pregnancy, breastfeeding, or under the age of 12.
What other anti-ulcer drugs are effective? Consider further.
Antacids
Any drugs of this group should be taken 30-40 minutes after eating, as they can disrupt the digestive process. Antacids coat the stomach and intestines, reducing acidity. The following drugs are considered the most effective:
- Maalox. Produced in the form of a suspension and chewable tablets. The active substances are magnesium and aluminum hydroxide. The drug is well tolerated by most patients. Maalox is taken one sachet or tablet after meals. The course is at least three months. Rare side effects may include constipation or diarrhea. Maalox is not recommended for severe renal impairment.
- "Alumag". Available in tablets of 20 or 30 pieces. For adult patients, the drug is prescribed two tablets three times a day. Adverse reactions to the reception of "Alumaga" are constipation, nausea and vomiting. The active ingredient of the drug is aluminum hydroxide. Like other antacids, this drug is not prescribed for pathological disorders of the kidneys.
- "Gastal". Produced in the form of chewable tablets. The active ingredients of the drug are magnesium carbonate and aluminum hydroxide. The drug is taken 1-2 tablets after meals. A maximum of eight tablets per day is allowed. Treatment is carried out for two weeks. Taking pills can lead to a change in taste perception, as well as constipation and nausea. Do not take the drug against the background of kidney disease and Alzheimer's disease.
Histamine receptor blockers
Antiulcer drugs for the stomach from this group affect the glands of the mucous membrane of the organ, preventing the production of histamine and digestive enzymes, as well as reducing the impact of an aggressive environment. Drugs for the treatment of stomach ulcers are divided into several generations:
- "Cimetidine" is a typical representative of the first generation of histamine blockersreceptors. Adverse reactions with this drug are quite serious, including decreased potency, diarrhea, headaches, disruption of the nervous system, etc. Cimetidine is considered an outdated drug and is practically not used in the treatment of peptic ulcer.
- The second generation of drugs that block histamine receptors is represented by Ranitidine. The drug is prescribed during the period of exacerbation to relieve symptoms. The drug is taken at 150 mg for one month. Ranitidine also causes a number of side effects, including kidney and liver damage.
- The third generation drug from this group is Famotidine. There are practically no contraindications for this drug. Taking the drug also rarely leads to the occurrence of adverse reactions. The most common adverse reactions are dry mouth, skin rash and dizziness.
- Nizatidine is a fourth generation drug. The action of its active components allows you to quickly reduce the acidity of the stomach without causing side effects and without contraindications for taking. With peptic ulcer, the drug is taken at 15 mg in the morning and evening. The duration of the course is determined by the doctor on an individual basis.
- The fifth, most modern and safest generation of antiulcer drugs is represented by Roxatidine. This drug is an improved version of Nizatidine. Contraindications and possible side effects for both drugs are identical. accepted"Roxatidin" one tablet in the morning and in the evening.
In general, new generation gastric antiulcers should be preferred.
Gastroprotectors
For the treatment of stomach ulcers, preparations based on bismuth and its derivatives are often prescribed. This substance has a pronounced anti-inflammatory, analgesic and regenerating effect. Thanks to bismuth, ulcers heal faster. Gastroprotectors are used to prevent diseases of the gastrointestinal tract, as well as during an exacerbation of the disease. The most common antiulcer drugs for the duodenum and stomach of this group are:
- Venter. Take two tablets three times a day for 4-6 weeks. The active ingredient is sucralfate, which increases the amount of mucus produced by the stomach and reduces the aggressive effect of acids and bile s alts on the stomach walls. It is not recommended to prescribe Venter during childbearing and breastfeeding. In some cases, the drug may cause dry mouth, nausea, and diarrhea.
- "De-Nol". This new generation antiulcer drug has a pronounced regenerating effect. The composition of the drug includes bismuth tripotassium dicitrate. For the treatment of ulcerative pathology, De-Nol is taken one tablet four times a day, half an hour before meals. Treatment should continue for up to two months. Contraindications for taking the drug are pregnancy, lactation, as well as pathological disorders of the kidneys. by-productsreactions to the reception may be nausea and vomiting, constipation and diarrhea. The latest anti-ulcer drugs can be purchased at any pharmacy chain.
- "Solcoseryl". It is a gastroprotector for emergency care to a patient during an exacerbation of peptic ulcer. The drug is produced in the form of a solution for intramuscular or intravenous administration. There are virtually no contraindications, however, during treatment, adverse reactions may occur in the form of allergies, accompanied by swelling, itching and urticaria.
- "Misoprostol". A drug with antisecretory activity that reduces the production of hydrochloric acid and digestive enzymes. The specialist prescribes the dosage and duration of administration, depending on the severity of the patient's condition. "Misoprostol" should not be taken with pathologies of the kidneys or liver, against the background of an inflammatory process in the intestines, etc. The drug is released only after a prescription from a doctor.
- "Methyluracil". Helps improve tissue trophism. For the treatment of ulcers, the drug is taken at 0.5 g four times a day. The course of treatment is 40 days. Methyluracil is a contraindication for malignant bone marrow diseases.
Anti-ulcer drugs for the stomach and duodenum don't stop there.
Proton pump inhibitors
In some cases, it may not be enough to take only histamine receptor blockers to reduce stomach acid. Proton pump inhibitors aremodern drugs for the treatment of long-acting ulcers. Medicines from this group inhibit the work of parietal gastric cells that produce hydrochloric acid. Blocking occurs due to a special protein that moves protons. All antiulcer drugs for the duodenum and stomach of this group are resistant to the effects of gastric juice.
The most common proton pump inhibitors include:
- "Lantsid" based on lansoprazole as an active ingredient. The course of admission is two weeks. One tablet is allowed per day. Treatment with Lancid can cause diarrhea, abdominal pain, and drowsiness. It is not allowed to take the drug for diseases of the kidneys and liver, as well as during the gestation period.
- "Pariet" which includes rabeprazole. The drug is prescribed to relieve symptoms during exacerbation of peptic ulcer. One tablet is taken daily. The drug is not prescribed for severe kidney pathologies. Adverse reactions during treatment are extremely rare and do not have a pronounced form, therefore, do not require discontinuation of the drug.
- "Omez" and "Esomeprazole". Preparations based on omeprazole, which was mentioned at the beginning of the article. If the first drug is dispensed without a prescription, then it will not be possible to purchase Esomeprazole without the recommendation of a specialist.
- "Pantoprazole". The active ingredient is pantoprazole sodium sesquihydrate. It is taken as a course for two months at 80 mg per day. Most oftenthere are such adverse reactions to taking the drug as pain in the head, dry mouth, rash on the body and nausea. The drug is also not dispensed without a prescription.
Reviews
The defeat of the stomach with ulcers and erosions is a serious violation in the work of the whole organism. The quality of human life with an exacerbation of the pathology deteriorates significantly. In the reviews, there is often a positive opinion about De-Nol. For many, the drug helped to cope with gastritis, as well as alleviate the condition during exacerbation of the ulcer. The same applies to preparations based on omeprazole as an active ingredient. Many, including doctors, are of the opinion that omeprazole helps to cope with an exacerbation, relieve symptoms, but cannot eliminate the very cause of the disease.
Negative comments
Some patients took antiulcer drugs and did not get the expected effect, since the disease was provoked by Helicobacter pylori, which can only be eliminated with antibiotics. After the appointment of antibacterial drugs and a course of treatment with gastroprotectors, the pathology is eliminated.
The disadvantages of drugs for the treatment of peptic ulcer are adverse reactions. Especially often patients complain of dyspeptic disorders, as well as nausea when taking antiulcer drugs. However, these disorders disappear after a course of treatment, while drug withdrawal is considered inappropriate. Often multiple treatments are required to achievestable remission pathology.
