Various pain sensations in a person can occur quite often and for various reasons. To get rid of them, the most common and cheapest means do not always help, and you have to look for more radical measures. One of these drugs is the analgesic Sedal-M. The instructions for use of the drug present it as a combined medicine for fever, inflammation, pain, cold symptoms and migraine.
General Features
The drug is indeed a complex remedy with sedative, antipyretic and analgesic properties. The medication belongs to the group of non-narcotic painkillers and antipyretic nonsteroidal anti-inflammatory drugs.
At the same time, you can buy Sedal-M tablets in a pharmacy only by prescription. This is due to the composition of the drug, possible side effects and other features.
Form and composition
The medicine is produced exclusively in the form of tablets for oral administration. They representa round flat and smooth pills with a risk and a chamfer. Color - white or almost white. Tablets are packed in cardboard packs with annotation and one or two blisters with the drug. Each plate contains 10 pills.
The composition of "Sedal-M" is represented by several active components at once, the combined action of which provides a therapeutic effect. So, each dose of the drug contains 0.3 g of paracetamol, 0.15 g of metamizole sodium, 0.05 g of caffeine, 15 mg of phenobarbital and 10 mg of codeine phosphate.
To give the tablets the desired shape and color, auxiliary components have been added to the composition of Sedal-M:
- cornstarch;
- povidone;
- magnesium stearate;
- glycerol;
- lictose;
- sodium carboxymethyl starch.
Pharmacodynamics
This section of the pharmacology of the drug is represented by the interaction of all the main components of the composition, which provide the medicinal effect. Paracetamol and metamizole have a sedative, antipyretic, analgesic and anti-inflammatory effect. These components are classified as non-narcotic analgesics, and they work by destroying the synthesis of prostaglandins by inhibiting cyclooxygenase in the nervous system. Metamizole in the preparation can also relieve spasms of smooth muscles of the biliary and urinary tract. Additionally, phenobarbital in the composition of Sedal-M also has a sedative effect. Also, this substance is able to potentiate the effect of other analgesic components of the drug.
Codeine should be classified as an opioid analgesic. In the medicinehelps relieve pain and reduce coughing.
Caffeine increases vascular tone, improves blood circulation, enhances concentration and performance, stimulating the nervous system. Headaches are reduced just due to the expansion of cerebral vessels. Additionally, caffeine enhances the effect of non-steroidal anti-inflammatory drugs.
Pharmacokinetics
The medication in question is quickly distributed throughout the body, providing the desired therapeutic effect. Some of the constituent components of the drug enter the blood immediately from the stomach, others need a little more time, but the removal of disturbing symptoms occurs almost instantly, alleviating the patient's condition. The half-life of the composition "Sedal-M" depends on its specific components. All of them leave the body with urine, but at different times. Paracetamol is the fastest excreted. The time of his stay in the body does not exceed three hours. Metamizole can stay in the blood for 1-4 hours, codeine for 3-4 hours, and caffeine for 3-6 hours.
Recommendations for admission
The drug is prescribed for patients with the need to relieve moderate or mild pain syndromes of various origins. According to the instructions, Sedal-M tablets do an excellent job with headaches, including migraines. In addition, the drug copes with toothache, alleviates the condition of a woman during painful critical days, is prescribed for radiculitis, neuritis, neuralgia and muscle pain of various etiologies.
The drug is also able to stop the symptoms of algomenorrhea provoked by surgeries, injuries, burns and so on. It also helps with joint pain.
In addition to all of the above, the drug is used as an antipyretic for fever that accompanies influenza, SARS and various other infectious and inflammatory pathologies.
Prohibited use
Instruction "Sedal-M" has a list of absolute and relative contraindications. Indisputable prohibitions include:
- bronchospasms;
- Children under 12;
- liver or kidney failure;
- acute myocardial infarction;
- traumatic brain injury;
- acute stages of peptic ulcers of the digestive system;
- high blood pressure;
- arrhythmia;
- oppressed breathing;
- drunk;
- any blood disease;
- hemorrhagic diathesis;
- deficiency of glucose-6-phosphate dehydrogenase.
In addition, taking the drug is strictly prohibited in case of individual sensitivity to any of the components of the composition, pregnancy and lactation. A doctor can prescribe a drug during gestation or breastfeeding only if the benefit to the mother outweighs the possible risks to the baby, but most often specialists simply replace the medication with the approved one.
Indications "Sedal-M" have a separate section "With caution". It indicates the diagnoses for which the drug can be used in treatment, but only under supervisionspecialists. Such a need arises in old age, even in the absence of he alth complications, in the presence of peptic ulcers of the digestive tract in remission, and in mild disorders of the kidneys and liver.
Possible negative reactions
The use of "Sedal-M" in rare cases may lead to secondary negative reactions from the body. Among them, the most common are drowsiness, dizziness, urticaria, rash, itching, the appearance of headaches or their intensification, impaired coordination in space and speed of psychomotor reactions.
Among the less common are tremor of the extremities, a feeling of one's own heartbeat, disturbed sleep and wakefulness, increased anxiety and excitability, abdominal pain, nausea, diarrhea, vomiting, low blood pressure, tachycardia and dryness of the oral mucosa.
Of the rarest side effects, possible kidney disorders and blood diseases stand out.
According to reviews, "Sedal-M" very rarely causes negative reactions in the body, but if you feel worse or at least one of the listed symptoms appears, you should immediately consult a doctor.
Admission rules
The drug is produced only in the form of tablets for oral administration, therefore, it can only be used for treatment. Drinking pills is recommended with water in sufficient quantities. For reception, it is better to choose a period either during or afterfood to minimize the risk of side effects.
Since the drug is a prescription drug, only a doctor can prescribe the dose based on the individual diagnosis and characteristics of the patient's body.
The minimum dosage for a therapeutic effect, according to the instructions "Sedal-M", is only 1 tablet per day. If there is no effect, the frequency of administration and a single dose may be increased. So, the maximum daily dosage is 6 tablets, and you can drink a maximum of 2 tablets per dose. The multiplicity of reception can be increased up to four times a day.
The course of therapy depends on the initial diagnosis. As an antipyretic, the drug should not be used for more than three days, and as an analgesic - for more than five days.
Overdose
Uncontrolled medication quickly leads to overdose symptoms. The first sign of exceeding the allowable amount of medication is drowsiness, dizziness and headaches. Nausea, dry mouth, asthenia, bradycardia, and respiratory depression follow. In rare cases, symptoms can lead to loss of consciousness.
The drug has no antidote, so treatment should be carried out symptomatically. The first step is to wash the stomach, causing vomiting, and then give the patient an enterosorbent.
Prolonged uncontrolled use causes an overdose, accompanied by other symptoms. In such cases, the drug is addictive and lacktherapeutic effect in further treatment. Drug dependence can also occur due to codeine in the composition. Long-term use of tablets can also cause liver and kidney damage.
Special Instructions
If you need a longer medication than recommended in the instructions, you must regularly monitor the functioning of the kidneys, liver and blood composition, since an overdose can adversely affect he alth.
In patients with a history of bronchial asthma and pollinosis, a high risk of side effects due to increased sensitivity to the components of the composition. With caution, you should prescribe a medication if you suspect abdominal pain, since taking pills makes it difficult to make an accurate diagnosis in the future.
In indications for the use of Sedal-M, it is recommended to take the drug with caution in the presence of hereditary diseases associated with intolerance to fructose, galactose and other compounds, since the drug contains lactose.
You should also not take pills if you need to drive complex mechanisms or vehicles, since Sedal-M can inhibit psychomotor reactions.
Professional athletes should also refrain from taking the drug, as its composition can change doping test scores.
Interaction with other drugs
The toxic effect of the medication in question and other non-opioid analgesics is observed when they are parallelreception. Also, the negative impact on the body of metamizole increases while taking contraceptive hormonal drugs, tricyclic antidepressants, phenylbutazone, barbiturate or allopurinol. Metamizole also reduces the concentration of cyclosporine in the blood.
Additional use of paracetamol enhances the effect of anticoagulants. The absorption of this substance is enhanced by the parallel administration of metoclopramide. Similarly, the absorption of caffeine is accelerated by ergotamine.
Enhance the sedative effect of the drug other sedatives and tranquilizers. Enterosorbents, adsorbents, astringents and enveloping preparations reduce it.
Storage and producer
This medication is produced by a Bulgarian pharmaceutical company. The shelf life of the tablets is 3 years from the date of issue, but only if all storage conditions are observed. The drug should be kept away from direct sunlight, high humidity and children. The temperature should not exceed 25 ˚С.
Reviews
Analogues of "Sedal-M" are more common and known to buyers. Among them, Pentalgin, Trialgin, Anlipal, Sedalgin, Quintalgin, Quatrox and other painkillers should be noted.
As for the opinion of the inhabitants, the medication perfectly helps to cope with pain syndromes that require only symptomatic therapy. These include toothache, headache, muscle spasms and everything that does not accompany serious illness. HonoredThe drug also receives positive reviews due to the minimal risk of side effects, which is confirmed by many patients. Of course, the abuse of pills negatively affects not only the result of treatment, but also he alth in general, so you should strictly follow all the doctor's recommendations.
Among the disadvantages of the drug, many note only the dysbacteriosis and gastrointestinal disorders that occur during treatment, as after taking antibiotics. At the same time, taking Linex and other probiotics helps to normalize the microflora, but only in compliance with the time interval with the main medicine.
