Does Retasol help with acne? Feedback from those who have ever used this tool will be presented in this article. Also in it you will find information about the composition of the mentioned medication, its features and contraindications.
Form and composition of the medicinal product
In what form is Retasol sold? Reviews report that this remedy can be purchased in the form of a 0.025% solution intended for external use. It is produced in 50 ml glass bottles made of dark glass, which are placed in cardboard packaging.
The active ingredient in this drug is isotretinoin. It also contains butyl hydroxyanisole, ethyl alcohol and butylhydroxytoluene.
Pharmacological features of the medical product
What is the purpose of using the Retasol solution? The reviews claim that the remedy in question is intended for the treatment of acne. It normalizes the terminal differentiation of cells, slows down the hyperproliferation of the epithelium of the sebaceous glands, or rather their excretory ducts, and promotes the formation of detritus, greatly facilitating its evacuation.
Due to this effect of the drug, the patient noticeablythe production of sebum is reduced, its composition is normalized and excretion is facilitated. Also, the use of this remedy reduces inflammation around the sebaceous glands.
With systemic and external use, the solution in question has anti-inflammatory, sebostatic, anti-seborrheic, immuno- and keratomodulatory effects. In addition, it enhances the regeneration of the skin.
Kinetic properties of the drug
When taken orally, isotretinoin is well absorbed from the gastrointestinal tract. At the same time, absorption may increase if the drug was taken with food.
Peak plasma concentration of the active substance of this drug is reached after 4 hours.
The bioavailability of isotretinoin is low. This is due to its parietal metabolism in the intestinal walls, as well as the “first pass” through the liver.
The active substance of the agent in question is highly bound to plasma proteins. It is metabolized in the liver with the formation of the main derivative - 4-oxo-isotretinoin. In the process, isotretinoin is partially isomerized to tretinoin.
The terminal half-life of tretinoin is 12-20 hours. The equivalent amount of this substance is determined unchanged in the feces, as well as in the form of metabolites in the urine.
As for the local use of isotretinoin, in this case its systemic absorption is low.
Indications for use
Fromwhat is the drug "Retasol" used for? Customer reviews report that this topical solution works well for papulo-pustular acne, seborrhea, acne rosacea and perioral dermatitis.
Prohibitions on the appointment of an external solution
In what cases can not use the drug "Retasol" for acne? Reviews say that when applied topically, the agent in question is not absorbed into the systemic bloodstream. But, despite this, it is not recommended to use it during pregnancy, with increased sensitivity to the main substance, lactation and the simultaneous use of antibiotics belonging to the tetracycline group.
It should also be said that oral medications containing isotretinoin are contraindicated for use in severe disorders of the liver and kidneys, elevated blood lipids, hypervitaminosis A and various neoplasms.
With caution, the medication in question is prescribed for chronic pancreatitis, cardiac decompensation, liver and kidney diseases, as well as chronic alcohol intoxication.
How should Retasol be used?
Reviews (a photo of this tool is presented in this article) experts report that this medication should be used only according to indications.
The solution for external use is applied to the skin with a cotton swab. In this case, the affected area is pre-cleaned with any cosmetic product without alcohol content.
How longshould the drug "Retasol" (solution) be used? Reviews say that the duration of treatment with this remedy is 4-12 weeks. If required, after consultation with a dermatologist, a second therapy can be carried out.
In case of exacerbation of the disease and the development of adverse reactions at 1 or 2 weeks of treatment (for example, when itching, redness, new rashes, swelling of the skin appear), the use of the medication should be stopped until all negative symptoms subside. After some time, treatment can be resumed.
According to the attached instructions, this drug should not be applied to mucous membranes, as well as areas of the skin located near the visual organs.
Side effects
What negative effects can cause the drug "Retasol"? Reviews say that against the background of the use of this remedy, patients often develop local allergic reactions in the form of swelling and itching of the skin, hyperemia, papular rash, headache, photosensitivity and excessive fatigue.
Interaction and overdose
What symptoms of an overdose does the Retasol solution cause? Feedback from experts report that at the moment they do not have such information.
Concomitant use of isotretinoin with other retinoids (eg, Adapalene, Tretinoin, Acitretin, Retinol) significantly increases the risk of hypervitaminosis A.
This drug should not be used with tetracyclines as it causes a significant increase in intracranial pressure.
The drug in question weakens the action of progesterone. In this regard, during its use, contraceptives containing this hormone should not be used.
Retasol together with drugs that increase photosensitivity (tetracyclines, thiazide diuretics or sulfamides) significantly increases the risk of sunburn.
Special Information
UV treatment should not be given to patients during treatment with this agent. Moreover, patients are advised to avoid direct exposure to sunlight.
When treated with Retasol, the patient may experience intolerance to contact lenses.
The safety of using the solution in question in children and prepubescents has not been established.
Analogues, cost
Does Retasol help with wrinkles? Reviews claim that this medication has no effect on age-related skin changes. It is intended only for the treatment of skin diseases, including acne.
If necessary, the drug in question can be replaced by means such as Retinoic ointment, Dermoretin, Roaccutane or Isotrexin.
The price of the Retasol solution in the pharmacy chain varies between 410-470 rubles per bottle.
Medication "Retasol": reviews
Narrows pores and eliminates acne rashes - almost all reviews that Retasol consumers leave behind contain such information.
Medication in question fromacne is a very popular remedy. Patients claim that he is able to remove acne on the face in just two weeks. However, some reports say that the effect of this drug is very slow. In addition, it strongly bakes and dries the skin.
As for doctors, they claim that "Retasol" has a high therapeutic efficacy. Especially quickly it affects oily skin.
For severe acne, experts recommend using the Retasol solution in conjunction with other antibacterial agents or anti-acne drugs.
