Currently, the pharmaceutical market presents a huge variety of drugs that are used to treat diseases of the gastrointestinal tract. So, one of the most modern drugs is the Nolpaza remedy, which can eliminate the increased acidity of the stomach. The pharmaceutical company KRKA (Slovenia) is engaged in the production of this medicine.
Composition
Instructions for the use of "Nolpaza" contains information that one tablet may contain 20 or 40 mg of pantoprazole (in the form of sodium s alt) - the main component due to which the drug has a therapeutic effect.
The rest of the components are excipients. These include sorbitol, mannitol and s alts (calcium stearate, sodium carbonate).
Mechanism of action
The active substance of the drug is pantoprazole. This is the latest generation of proton pump inhibitors.
The mechanism of action of the drug is that it prevents the production of an enzyme responsible for transporthydrogen ions into the lumen of the stomach. If there are few of them, then hydrochloric acid is simply not produced. As a result, the environment of the stomach does not become very acidic. This is the therapeutic effect of Nolpaza.
It is worth noting that the medicine does not completely eliminate the acid, the stomach environment will still remain below 7, but within acceptable limits.
Issue form
The drug is available in the form of enteric-coated tablets.
Forms differ in dosage and number of tablets in one package. Nolpaza comes in 20mg and 40mg pantoprazole in each pill.
Pills, in turn, are packed in blisters and cartons of 14, 28 or 56 pieces.
There is another form of release of the drug - lyophilisate for the preparation of an injection solution. Its use is relevant in severe clinical cases, as well as in chronic pathological processes in the digestive system.
Pharmacodynamics
"Nolpaza" is taken orally, then pantoprazole is released from the tablet and absorbed into the systemic circulation.
The bioavailability of the drug is quite high and is approximately 75-80%. At the same time, it does not depend on food intake.
The maximum concentration of the drug component is found in the body after 2 hours.
Pantoprazole is almost completely dissolved in the liver, after which it is excreted in the urine and partially in the feces (about 5%).
Indications forapplication
Due to its effective mechanism of action, the drug is used for:
- Ulcer of the stomach and intestines, in the area of the duodenum.
- Zollinger-Ellison Syndrome - a disease in which there are benign tumors in certain cells of the pancreas.
- In addition, "Nolpaza" can be used in combination with antibacterial agents to destroy the bacterium Helicobacter pylori.
- Indications include reflux esophagitis - an inflammatory process on the esophageal mucosa.
Contraindications for use
"Nolpaza" is prohibited for use by patients suffering from indigestion due to any neurotic problems. When using the drug in this case, the situation can only get worse.
In addition, before you start taking the drug, you should exclude such a diagnosis as malignant neoplasms of the gastrointestinal tract, otherwise Nolpaza will eliminate the symptoms of oncology, thereby delaying its detection. Therefore, in case of cancer of the digestive system, this medicine is prohibited.
Another contraindication is hypersensitivity to any component of the medication. Otherwise, lightning-fast development of a powerful allergic reaction is possible.
Use during pregnancy and lactation
As a rule, doctors prescribe this drug to pregnant women, but only in case of urgent need, given the possible risks to the unborn child.
According to the information from the full instructions of Nolpaza, it is forbidden to take the drug while breastfeeding. The fact is that pantoprazole penetrates into mother's milk and can have a negative effect on the baby's body.
Negative reactions
And what can be said about the side effects of "Nolpaza"? Like any other drug, the drug is able to varying degrees to have a negative effect on various organs and systems. As a result, a certain number of side effects may develop. "Nolpaza" can cause violations:
- Digestive organs: nausea, bloating, diarrhea, epigastric pain.
- Side effects of "Nolpaza" can also cause from the nervous system. This usually manifests as headache and dizziness.
- Skin covers also suffer. Since a rash, itching is possible.
- Extremely rare, but depression, edema and fever to subfebrile values may occur.
When are the side effects of "Nolpaza" revealed? This usually happens within the first week of treatment. Patients begin to complain of rashes, headaches, and so on.
As a rule, all side effects of "Nolpaza" quickly disappear after adjusting the dose or discontinuing the drug.
Doses and method of administration
If "Nolpaza" is taken orally, a pill, regardless of the chosendosage, should be swallowed whole, and then washed down with a sufficient amount of clean drinking water. Usually half a glass of liquid is enough.
You don't need to chew, dissolve the pill. This will interfere with the drug release process. After all, it is extremely important that the drug is released from the lumen of the stomach, and not in the oral cavity.
Although there is no particular relationship between food intake and drug use, it is better to take the pill just before meals.
If the treatment regimen prescribed by the doctor suggests that you need to drink one tablet per day, it is better to do this in the morning, just before breakfast.
For patients suffering from reflux esophagitis, the doctor usually prescribes 20 mg of pantoprazole per day at one time. The duration of the course is set individually for each patient, but usually does not exceed one month. Although in some cases a person is forced to take the medicine for two months.
If there is a high likelihood of relapse, then the dose is temporarily increased to 40 mg for 1-2 weeks, after which the dosage is again reduced to 20 mg per day.
There is a category of people who are forced to use non-steroidal anti-inflammatory drugs (ibuprofen, dexalgin and others) for a long time, which have a negative effect on the walls of the gastrointestinal tract. In order to protect the digestive organs, such people are prescribed 20 mg of pantoprazole per day.
In order to destroy Helicobacter pylori "Nolpaza" should be used in conjunction with antibiotic therapy, 40mg 2 times a day.
The highest dosages are indicated for patients suffering from Zollinger-Ellison syndrome and similar diseases in which there is a particularly strong secretion of hydrochloric acid. Treatment regimens for such conditions are 2x40 mg doses. If necessary, the patient may be prescribed 80 mg 2 times a day.
It should be taken into account that if the patient has any abnormalities in the liver, then he is shown no more than 20 mg of pantoprazole per day.
Before starting treatment, it is necessary to exclude the presence of malignant tumors in the patient's stomach and esophagus.
Instructions for the use of Nolpaza injections states that the drug should be prepared immediately before administration.
Pantoprazole powder should be dissolved in 10 ml of sodium chloride 0.9% (saline) and administered intravenously. In addition, the introduction of the drug drip is acceptable. To do this, the drug must be mixed with 100 ml of saline or 5% glucose solution.
It is very important to start the injection of the drug 2-15 minutes after the preparation of the solution. Also, this dosage form should be resorted to only when the effectiveness of oral forms is insufficient.
Terms of dispensing from pharmacies
"Nolpaza", containing 40 mg of pantoprazole, refers to drugs dispensed only on prescription. Therefore, the drug is not freely available to the buyerto find. Before selling a drug, a pharmacist or pharmacist will definitely ask the patient for a prescription form of a strictly defined form, check it for correctness and then release the drug.
Nolpaza 20mg can be sold without a prescription.
Terms and conditions of storage
"Nolpaza" should be stored in a dry place, away from direct sunlight. The air temperature should not be lower than 15 and not higher than 30 degrees.
It is extremely important to keep these tablets out of the reach of small children.
Under proper conditions, the product can be stored for two years from the date of manufacture.
Reviews
Why is Nolpaza prescribed most often? As a rule, for the treatment of peptic ulcer of the stomach and intestines.
If you study in detail the reviews of patients about this drug, we can conclude that about 70% of them are positive.
Most people who have been treated with this medicine claim that the drug really effectively eliminates unpleasant symptoms. Feeling better already after a day or two after starting the medication.
The main disadvantages that can be found in the reviews of "Nolpaz" are side effects, which sometimes appear quite pronouncedly. A small percentage of patients had to stop taking the drug or reduce its dosage.
The second drawback is the high cost of treatment. After all, there are cheaper drugs on the pharmaceutical market withsimilar but not the same action.
However, there is no doubt whether the drug will justify its cost. After all, pantoprazole is one of the most effective substances that reduce the acidity of the stomach. At the same time, this remedy causes not very pronounced side effects.
The therapeutic effect is especially noticeable when using the injectable form of the drug. According to reviews, the effect is noticeable after one or two injections. However, do not forget that this method of using "Nolpaza" is permissible only in extreme cases and only when prescribed by a doctor. In addition, the side effects of "Nolpaza" in the form of injections, as a rule, manifest themselves more pronounced.
Therapists and gastroenterologists speak positively about the drug, prescribing it to their patients for various diseases and syndromes. They choose the drug because:
- Confident in its quality.
- It suits most patients.
- Patients don't start complaining that the doctor prescribes the most expensive remedy. This favorably affects the reputation of the specialist.
- The drug rarely causes severe side effects.
The required dosage of "Nolpaza" and the correct mode of administration provide the most pronounced therapeutic effect with a minimum of negative consequences.
Drug cost
The price depends on the selected dosage and form of release. So, the more pantoprazole is contained in one tablet and the more of these tablets are in the package, the higher the cost.
"Nolpaza" 20mg:
- 14 tablets - 130-180 rubles.
- 28 pills - 240-290 rubles.
- 56 tablets - 350-400 rubles.
"Nolpaza" 40 mg:
- 14 tablets - 200-250 rubles.
- 28 pills - 380-430 rubles.
- 56 tablets - 580-630 rubles.
Analogues
"Nolpaza" refers to those drugs that have a rich selection of structural analogues.
Medications containing pantoprazole as the active ingredient include drugs such as:
- "Controllock" (Germany).
- "Sanpraz" (India).
- Ultera (Russia).
All these drugs have the same indications and contraindications, side effects and dosing regimens. Plus, they're all prescription drugs.
They differ from each other by the manufacturer and pricing policy. As a rule, Russian and Indian drugs are cheaper than their German counterparts.
So, for example, "Controllock" will cost the buyer 300-350 rubles for 14 tablets containing 20 mg of pantoprazole each. And at 590-640 rubles - for 28 tablets of 40 mg.
"Sanpraz" will cost approximately 470-520 rubles for 1 package containing 30 tablets of 40 mg.
Thus, we can conclude that "Nolpaza" is in the middle price category.
Conclusion
The drug to which this article is devoted is an effective means to reducestomach acidity. However, before starting the reception, you should get a doctor's prescription, familiarize yourself with the contraindications and side effects of Nolpaza.
The fact is that the drug has a systemic effect on the human body, so in rare cases it can cause certain complications. Another disadvantage of the product is its price.
Analogues of "Nolpaza" are quite widely represented on pharmacy shelves, which allows the patient to choose the best option among all representatives of pantoprazole. Nevertheless, based on the results of the study of analogues, it can be concluded that Nolpaza represents the optimal ratio of quality and price among drugs containing pantoprazole.
