Fungal diseases are a common problem that can be solved with the use of effective drugs, which are Fluconazole or Nystatin. Doctors have been prescribing them for many years, that is, they are considered time-tested remedies. But sometimes it is not easy to decide which is better: Nystatin or Fluconazole? Let's look into this issue in more detail.
Antifungal properties of drugs
Medicines that belong to several groups are used to get rid of a fungal infection. They suppress vital activity and slow down the growth of fungi.
So, drugs are divided into two groups according to the method of exposure. They can be:
- Local.
- System.
Medications in the form of ointments forexternal use, vaginal and rectal suppositories. Systemic drugs include tablets or capsules. Against the background of taking these drugs, a therapeutic effect is produced on the body.
When using drugs, it is important to strictly follow the instructions for use. To determine which is better - "Nystatin" or "Fluconazole", we give a description of each medication.
Drug "Fluconazole"
Doctors often prescribe Fluconazole, which belongs to the azole group, to patients. It shows its effectiveness against many fungi, prevents the development of spores and their spread. However, it is worth noting that the tissues and cells of the human body itself do not suffer from Fluconazole in any way.
This drug has many analogues, which include a similar active ingredient. In this case, we are talking about Diflucan; "Flukostat" and others.
Any of these medicines can replace Fluconazole in antifungal treatment.
On sale you can find capsules for oral administration and injection solution. Depending on what specific disease a person has, doctors select the appropriate treatment regimen. The dosage of capsules is 50 and 150 mg of fluconazole. In some cases, it is enough to take 150 mg once for recovery to occur. If the case is severe and neglected, simultaneous administration with Nystatin is prescribed.
Drug "Nystatin"
What is better against thrush -"Nystatin" or "Fluconazole", the doctor will tell you. In "Nystatin" the active substance is different, it is a polyene antibiotic. In especially difficult situations, its effectiveness is significantly inferior to azoles. "Nystatin" affects the cell walls of fungi, as a result, their internal environment cannot be maintained. The focus of this drug is narrower when compared with Fluconazole, since its activity is limited mainly by fungi belonging to the genus Candida.
Fungistatic drug is produced in convenient forms. It's about:
- ointments for external use;
- oral tablets;
- candlelight.
The course of therapy with "Nystatin" includes, as a rule, the simultaneous use of several forms of release, this ensures a complex effect and achieves the best result.
Combining the use of "Nystatin" and "Fluconazole" is not prohibited, but usually such therapy is not prescribed, since there is an overlap of the action of these two medicines in relation to Candida.
We continue to find out what is better for candidiasis - Fluconazole or Nystatin. To conduct a full comparison of drugs, it is necessary to evaluate not only the effectiveness of the impact, but also the list of indications and contraindications.
Indications and contraindications of "Nystatin"
This drug is available in several formulations, making it suitable for therapy:
- skin candidiasis;
- vaginal;
- fungal lesions of internal organs;
- mucosal candidiasis.
Nystatin medication is contraindicated in:
- individual intolerance to active or auxiliary components;
- pancreatitis;
- ulcerative lesions of the stomach and intestines;
- pregnancy;
- breastfeeding.
Is there a difference between Nystatin and Fluconazole in indications and contraindications, it is important to find out in advance.
Indications and contraindications of "Fluconazole"
This drug has a wide range of indications. It is assigned at:
- mycosis;
- candidiasis of the skin and mucous membranes;
- cryptococcosis;
- thrush;
- generalized disease.
Drug banned:
- in children under 3;
- with individual intolerance to the drug;
- taking certain heart medications;
- pregnancy and breastfeeding;
- serious kidney and liver pathologies;
- exacerbation of diseases of the gastrointestinal tract.
Before using any of these drugs, you should consult a specialist. The doctor will definitely take into account the general condition, the presence of other ailments and the severity of the lesion.
Side effects
What is better for thrush - "Nystatin" or "Fluconazole" in terms of side effects?The negative reactions of the body to taking these drugs are similar. The drugs have a negative effect on the gastrointestinal tract, leading to nausea, abdominal pain, etc. The development of allergies, headaches, and hair loss is also possible.
It is possible to replace Fluconazole with Nystatin if necessary. It happens that during the treatment of candidiasis, intolerance to the latter is detected.
How thrush is treated with Nystatin and Fluconazole
A common type of fungal infection is thrush, it occurs in most women, and men rarely suffer from it. Both partners should be treated at the same time, sexual intercourse should not be carried out until full recovery occurs.
Vaginal candidiasis has one peculiarity. The body of even a he althy woman contains fungi in small quantities. This is considered the norm. But if some external or internal factors begin to influence, the fungi become active, which is fraught with pathological processes.
Due to the occurrence of curdled discharge from the vagina during this disease, candidiasis was called "thrush". Women suffer from itching and an unpleasant burning sensation that causes severe discomfort.
As a means of therapy, drugs such as Fluconazole and Nystatin are prescribed. Therapy can be oral, in which Fluconazole acts as an analogue of Nystatin, or complex, combining systemic and local effects.
Many patients wonder which is better -"Nystatin" or "Fluconazole". Consider below the role in Nystatin therapy.
What is the role of Nystatin?
When using it, there is a different effect on microorganisms, which depends on the concentration of the active ingredient:
- if there is a high concentration - the death of fungi occurs:
- if the concentration is low, their development slows down.
Nystatin vaginal suppositories have a rather high efficiency. But they do not affect the entire body. Their use can be supplemented with an ointment that should be applied to the external genitalia, which is very convenient for the treatment of a woman's sexual partner. Tablets can be used for prevention, as well as a comprehensive measure to combat vaginal or intestinal candidiasis.
The drug "Nystatin" can be replaced by "Fluconazole". This is a good alternative. It is often combined with topical preparations, such as suppositories. If thrush occurs for the first time, only 150 mg is prescribed once.
Which is more effective - Fluconazole or Nystatin?
If we consider the antifungal intensity of action, then Fluconazole is definitely more effective. Many clinical studies and analyzes confirm this.
For example, in the presence of oral candidiasis (in the mouth), both drugs were used. In adults, after a week of therapy, improvement occurred in 82% of cases from Nystatin and in 91% of cases from Fluconazole. In children, the difference is stunning: 32% and 100%. This can be explained by the factthat the action of the suspension "Nystatin" was carried out only at the site of entry into the mouth (in small patients it is difficult to control), and "Fluconazole" worked everywhere. Only a doctor can prescribe drugs for candidiasis to a child. In this case, the correct calculation of the dosage by body weight is important.
We found out which is better - "Nystatin" or "Fluconazole" in the development of thrush.
