The article will provide instructions for use for Ambroxol tablets.
They is a mucolytic drug with an expectorant effect. Thanks to him, the transport of sputum is enhanced. Slightly suppresses cough. Produced in the form of tablets, in one blister contour pack of ten tablets, in a cardboard bundle - two packs.
Pharmacological influence
Ambroxol is an expectorant and mucolytic agent, which is an active N-demethylated bromhexine metabolism. It has not only expectorant, but also secretolytic and secretomotor effects. It stimulates the serous cells of the glands of the bronchial mucosa, increasing the amount of mucous secretion and thus changing the disturbed proportion of the mucous andserous components of sputum. At the same time, there is an activation of hydrolyzing enzymes, as well as an increase in the release of lysosomes from Clara cells, and this leads to a decrease in sputum viscosity. The drug "Ambroxol" contributes to an increase in the content of endogenous surfactant in the lungs, associated with an increase in secretion and synthesis in alveolar pneumocytes and defects in its decay. Surfactant is a surface-active component that provides sliding of bronchial secretions in the lumen of the respiratory system.
Thanks to "Ambroxol" the content of the serous component in the bronchial secretion increases, its structure improves and the viscosity of sputum decreases, it liquefies; as a result, mucociliary transport is improved, sputum is more easily removed from the bronchial tree. After using Ambroxol, the effect on average occurs in half an hour and lasts from six to twelve hours, which is determined by a single dosage.
Pharmacokinetics
In accordance with the instructions for use for tablets, "Ambroxol", getting inside, is absorbed quickly and almost completely. The maximum time is from one to three hours. It binds to plasma proteins by about 85%. Passes through the placental barrier and is excreted along with breast milk. Metabolization of the drug is carried out in the liver, metabolites are formed (glucuronic conjugates, dibromanthranilic acid), excreted mainly by the kidneys (90% in the form of metabolites), unchanged - less than ten percent.
From-due to the high protein binding, as well as the large value of Vdand reverse slow penetration into the blood from the tissues, during forced diuresis or dialysis, there is no significant excretion of ambroxol. The clearance of the latter in patients with severe liver failure is reduced by 20-40%. Metabolite time is increased in severe kidney failure.
In what cases should adults use Ambroxol tablets according to the instructions for use?
When applicable
Ambroxol tablets are used for respiratory diseases, when viscous sputum is released:
- chronic and acute form of bronchitis;
- chronic obstructive pulmonary disease;
- bronchiectasis;
- bronchial asthma, which makes it difficult to expectorate.
Contraindications
According to the instructions for use, Ambroxol tablets are contraindicated in:
- excessive sensitivity of the patient to any of the substances of the drug;
- first trimester of pregnancy;
- liver and/or kidney failure;
- rare genetic diseases caused by intolerance to any of the auxiliary components that make up the drug.
With caution can be used by patients during pregnancy (second and third trimester) and breastfeeding, as well as those people who suffer from peptic ulcerduodenum and stomach. This is confirmed by the instructions for use for Ambroxol 30 mg tablets.
Pregnancy and lactation
Seriously controlled and adequate studies regarding the safety of the use of the drug during pregnancy and breastfeeding have not been conducted. The drug crosses the placental barrier. When animal studies were conducted, direct or indirect negative effects on pregnancy, embryonic or postnatal development of the fetus were not established. Extensive clinical experience has confirmed the absence of any symptoms of negative effects after the 28th week of gestation. However, there are some simple precautions that apply to any drug during pregnancy.
Ambroxol is undesirable to take in the first trimester of bearing a child. It also passes into mother's milk, and although the adverse effect of the drug on the baby is not expected, it is not recommended for women while breastfeeding.
Instructions for use for Ambroxol tablets allow children to give them.
Use of the drug and dosage features
"Ambroxol" is taken after meals and washed down with liquid. Children from twelve years of age and adults: one tablet three times a day (30 mg). This dosage may be reduced after 8-10 days - twice a day, one tablet of Ambroxol.
According to the instructions for use for children 3 years old, the drug is given in the form of a syrup of 7.5 mg of the active substance. This corresponds to 1 mlsolution for oral administration, half a measuring spoon of syrup containing Ambroxol 15 mg / 5 ml or 1/4 measuring spoon of syrup with a higher concentration (30 mg / 5 ml).
Children 6 to 12: Half tablet 2-3 times daily (15mg). The duration of treatment is individually determined by the doctor, it depends on the severity of the disease. If one or two doses of the drug are missed, then it is not allowed to take a larger dose next time. The missed dose should be taken the next day. If the dosing regimen is not followed, then there may be a decrease in the effectiveness of therapy.
Side effects
As confirmed by the instructions for use and reviews of Ambroxol tablets, side effects can be observed from the gastrointestinal tract: in rare cases - dry mouth, diarrhea, constipation; if the drug is used for a long time and in large doses, then vomiting, nausea, gastralgia and heartburn occur.
Allergic reactions: skin rash, angioedema, urticaria, itching; individual cases - allergic contact dermatitis, single manifestations of anaphylactic reactions of the patient.
Other side effects: rarely - headache and weakness. If the listed negative reactions appear, as well as side symptoms that are not described in the instructions, you should contact your doctor.
Overdose
According to the instructions for use for Ambroxol tablets, withOverdose symptoms are as follows: dyspepsia, vomiting, nausea and diarrhea. Therapy is carried out with the help of gastric lavage within one to two hours after taking the drug, inducing vomiting artificially, the use of products containing fat, as well as symptomatic treatment.
Features of interaction with other drugs
Simultaneous use with antitussive drugs causes difficulty in sputum discharge with a decrease in cough manifestations. Helps to increase the penetration of doxycycline, erythromycin, cefuroxime and amoxicillin into the secretion of the bronchi.
What else does the instructions for use for Ambroxol cough tablets tell us?
Precautions
It is not recommended to use it simultaneously with antitussive drugs that make it difficult to expectorate. Several cases of serious skin damage have been reported, including Stevens-Johnson syndrome and epidermal toxic necrolysis associated with the use of the expectorant Ambroxol. These cases can most often be explained by the severity of comorbidities or the simultaneous use of other drugs.
In addition, in the early stages of toxic epidermal necrolysis and Stevens-Johnson syndrome, people may develop symptoms of a non-specific flu-like illness: body aches, fever, cough, rhinitis, and sore throat. If athese signs appear, this may cause unnecessary treatment with anti-cold drugs. That is why, if various lesions of the mucous membrane or skin occur, you should consult a specialist, and therapy should be discontinued as a precaution. This is confirmed by the instructions for use for Ambroxol Hydrochloride tablets.
If the functioning of the kidneys is impaired, then the medication should be taken only after talking with the doctor.
This medicinal product contains lactose and should therefore not be used in patients with rare birth galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption.
"Ambroxol": analogues
The Ambroxol drug has the following analogues for the main active ingredient: AmbroGEXAL, Halixol, Ambrobene, Flavamed, Ambroxol Vramed, Fervex, Ambroxol retard, Suprima- kof", "Ambroxol-Verte", "Remebrox", "Ambroxol-Vial", "Neo-Bronchol", "Ambroxol-Richter", "Mukobron", "Ambroxol-Teva", "Medox", "Bronchorus", " Ambroxol-Hemofarm", "Lazolvan", "Ambrolan", "Lazolangin", "Bronhoksol", "Ambrosan", "Bronhovern" (drops), "Ambrosol", "Deflegmin".
Reviews about the drug
Feedback on the use of "Ambroxol" is predominantly positive. Among its advantages are affordability, excellent sputum removal, good quality, efficiency. He isanalogue of expensive imported medicines. Many patients consider Ambroxol to be the best drug to prevent expectorant cough. Tablets do not cause allergic reactions, are not harmful, there are no significant contraindications. It removes phlegm well and quickly, helps to alleviate cough, both wet and dry. The effect is observed after 3-4 days.
Among the shortcomings is the frequent absence of the drug in a conspicuous place in pharmacies. In some cases, it still turns out to be ineffective, but there are much fewer negative reviews than positive ones.
We reviewed the instructions for use for Ambroxol 30 mg tablets.
