"Neo-Penotran" is a drug with a pronounced antiparasitic, antibacterial and antifungal effect. The drug is intended for local use, used in gynecological practice.
Medication description
"Neo-Penotran" refers to combined preparations, which include two active substances at once:
1. Miconazole, has an antifungal effect.
2. Metronidazole, which has a detrimental effect on harmful bacteria.
Together, these substances in the composition of "Neo-Penotran" eliminate pathogenic microorganisms that provoke the appearance of candidiasis, violation of the vaginal microflora and inflammation of the mucous membrane.
Having an antiprotozoal, antibacterial and antifungal effect, the drug actively and purposefully fights the problems of the female body of a gynecological nature.
Issue Forms
There are several variants of Neo-Penotran. All of them are available in the form of vaginal suppositories of seven pieces in one package. Types differ by name and number of active ingredients:
1. "Neo-Penotran". It contains 0.5 g of metronidazole and 0.1 g of miconazole. It also includes additional components.
2. "Neo-Penotran Forte". 0.75 g metronidazole and 0.2 g miconazole. The enhanced composition produces a much more active action aimed at the destruction of parasitic organisms.
3. "Neo-Penotran Forte L". It contains 0.75 g of metronidazole and 0.2 g of miconazole. The composition of this form of the drug is also supplemented with lidocaine.
Drug properties and indications for use
The effectiveness of the drug is due to the action of its main components - metronidazole and miconazole. They actively fight bacteria and fungi, and also have an anti-inflammatory effect.
Due to its composition, "Neo-Penotran" is able to withstand the following types of pathogenic pathogens:
1. Gardnerella.
2. Trichomonas.
3. Anaerobic bacteria, including anaerobic streptococcus.
4. Pathogenic fungi such as Candida.
Also, the drug is active against gram-positive bacteria.
"Neo-Penotran" is prescribed to women for the treatment of various gynecological diseases. The drug is prescribed for the following diagnoses:
1. Vaginal candidiasis.
2. Trichomonas vaginitis.
3. Mixed form of vaginitis.
4. Bacterial vaginitis.
5. Vulvovaginitis caused by fungal pathogens.
Another area of use of the drug is the prevention of fungal and bacterial infection before and after surgery. Clinical studies have shown that the drug significantly reduces the likelihood of complications in the postoperative period.
Let's figure out how to take "Neo-Penotran" during pregnancy.
Contraindications
Vaginal suppositories cannot be used in certain physiological and pathological conditions of the female body, namely:
1. First trimester of pregnancy.
2. Virginity.
3. Children under 18 years of age.
4. Severe liver dysfunction.
5. Epileptic seizures.
6. Porfiria.
7. Individual reaction to the components of suppositories, including local allergic reaction.
The above states that this medicine should not be used at the beginning of pregnancy. In the future, starting from the second trimester, Neo-Penotran suppositories can be used during pregnancy, but only if absolutely necessary. The doctor must adequately assess the potential risk to the fetus and woman when using suppositories.
Breastfeeding for the period of treatment with Neo-Penotran vaginal suppositories should be cancelled. It will be possible to return to lactation a few days after the completion of therapy.
How to use
Vaginal suppositories should be inserted deep into the vagina. At the same time, it is possibleuse special fingertips that are sold complete with suppositories. There are standard treatment regimens:
1. Intravaginal administration of one suppository at bedtime for a week.
2. If the patient is given a recurrent form of vaginitis, and also in the case when treatment with other drugs does not work, the use of Neo-Penotran can be extended up to two weeks.
Advanced age is not a contraindication for treatment with the drug and does not require adjustment of standard dosages.
Adverse reactions and overdose
Consider the side effects of Neo-Penotran. Like any other drug, this medication can have a negative effect on a woman's body and provoke the development of a number of unwanted reactions, including:
1. Changes in clinical blood parameters, including a decrease in the level of leukocytes.
2. An allergic reaction accompanied by hives, itching, swelling, rash, redness of the face, and anaphylactic shock.
3. Nausea and vomiting, diarrhea and constipation, decreased appetite, dry mouth and metallic taste, stomatitis, tenderness in the abdomen, impaired taste buds.
4. Discomfort in the vagina, manifested by burning and itching, redness and irritation. If the severity of irritation increases, stop using the suppositories and consult a doctor.
5. From the side of the nervous system, increased fatigue, weakness anddizziness, seizures, mood swings, short temper, headache, false sensations, etc.
Not stated in the instructions, but (judging by the numerous reviews) uncharacteristic blood or pink discharge often appears after Neo-Penotran.
There can be many reasons, so if you experience such a symptom, you should immediately consult your doctor. The examination will show what caused such a reaction of the body.
Once the treatment is completed, the symptoms listed above will go away on their own, so they do not require specific treatment. In the case of using Neo-Penotran Forte L, adverse reactions may occur as a result of low absorption of lidocaine.
To date, there are no data on cases of overdose. If the candle was accidentally taken orally, you should immediately carry out the procedure for washing the stomach and intestines, and also take sorbents. If a significant amount of metronidazole is absorbed, symptomatic treatment is necessary, since there is no specific antidote for it.
Can I use "Neo-Penotran" during menstruation?
It is advisable to start the course of treatment one and a half to two weeks before menstruation. Candles during menstruation may not have the desired therapeutic effect. If necessary, you can lay the medicine on the days of minor discharge. As a rule, complex therapy is prescribed for sexually transmitted infections. At the time of critical days, it is necessary to stop treatment, and then use the missedcandles according to the scheme.
Special Recommendations
Before using suppositories, you should read some recommendations:
1. If we are talking about the treatment of trichomonas type vaginitis, then therapy must be carried out together with a sexual partner.
2. The specialist should inform the patient about the method of using the drug in order to avoid accidental ingestion.
3. Suppositories should be used with caution at the same time as barrier contraceptives, as they can be damaged when suppositories are inserted.
4. Alcoholic beverages should be avoided during treatment. After completion of the course of therapy, at least a day must pass before drinking alcohol. This is due to the fact that the combination of metronidazole and ethanol can lead to the development of disulfiram-like reactions.
5. When using suppositories, the levels of liver enzymes, theophylline, glucose and procainamide, as well as other clinical results of a blood test, may change.
Research results have shown that when using suppositories there is no risk of developing specific complications. The drug is practically safe, non-toxic. In addition, the active ingredients do not affect the reproductive functions of women.
Interaction with other drugs
Before the first use of Neo-Penotran vaginal suppositories, it is necessary to study their interaction with other drugs:
1. Simultaneous use withlithium leads to an increase in the toxicity of the latter.
2. In combination with phenobarbital, the concentration of metronidazole decreases.
3. The anticoagulant effect of various drugs is enhanced under the influence of Neo-Penotran.
4. Simultaneous use of suppositories with disulfiram may provoke unwanted reactions from the nervous system.
5. In combination with cimetidine, an increase in the concentration of metronidazole may occur, and the likelihood of adverse reactions from the nervous system also increases.
6. "Phenytoin" lowers the concentration of metronidazole, while the level of the substance itself rises.
7. Simultaneous reception with Astemizol and Terfenadine leads to an increase in their concentration in blood plasma while suppressing their metabolism.
Analogues of "Neo-Penotran"
If intolerance to the components of the drug has been identified, you can choose a similar drug from the following list:
1. Ketonazole.
2. Clomezol.
3. "Trichopol".
4. Klevazol.
5. Gravagin.
6. Livarol.
7. Mikogal.
8. "Ginalgin".
9. Pulsitex.
10. Metromicon-Neo.
All of the listed analogues of "Neo-Penotran" have similar actions, but their compositions differ significantly. Therefore, before using them, you should consult a specialist.
Price
The cost of the drug is 600-700 rubles perpackaging. The price depends on the region and the pharmacy chain.
Opinions of patients and specialists
Reviews of vaginal suppositories are rather contradictory and ambiguous. Many of them note the high effectiveness of the drug in the fight against thrush and various types of vaginitis. The advantages of this drug for women include ease of use of suppositories and their rapid action. The course of treatment is only a week, while the result occurs a few days after the start of therapy.
One of the drawbacks of the drug is the high price, which often exceeds 500 rubles per pack. Another significant disadvantage of the drug is discomfort in the vagina during the treatment period, accompanied by itching and burning. No less complaints are caused by the fact that the melted candle flows out. It is rather difficult to judge the effectiveness of the drug based on such reviews.
About the price of "Neo-Penotran" in the reviews, doctors also write that it is too high. At the same time, the chemical composition of the drug is quite simple
