Iron is one of the constituent elements of human blood. It contributes to the production of hemoglobin in the blood, which, in turn, saturates the tissues with oxygen. Also, this element is necessary for metabolic processes in the body, to maintain the immune system. Pregnant women especially need it. Iron is essential for the normal development of the fetus. You can fill its deficiency with the help of products, but this is not always possible, therefore, medications are prescribed. One of these is Sorbifer. Side effects, indications, features of the reception will be considered further.
Operation principle
Combined drug "Sorbifer" contains ferrous sulfate and ascorbic acid.
Iron plays a key role in the binding and transport of oxygen and carbon dioxide. Absorbed in the duodenum and proximal jejunum.
Vitamin C increases the absorption of iron in the stomach and intestines, and also participates in redoxprocesses.
Hydrochloric acid in the stomach and vitamin C promote iron absorption.
The manufacturing technology of the drug ensures the continuous release of iron ions. Over the course of 6 hours, the slow release of the active substance prevents dangerously high concentrations of iron. This avoids irritation of the intestines and stomach.
Once in the intestines, iron binds to apopheritin. One part enters the bloodstream, while the other remains in the intestine in the form of feritin, which is excreted in the feces or enters the bloodstream after 1-2 days. In the blood, iron binds to apotransferin or is converted to transferrin. In this form, it enters the organs and by endocytosis into the plasma.
What's in the product
"Sorbifer" is available in the form of round biconvex tablets. Covered with a shell, have a light yellow color. Z engraved on one side. They have a peculiar smell. Inside grey.
One tablet contains:
- ferrous sulfate - 320mg equivalent to 100mg Fe;
- ascorbic acid - 60 mg.
Auxiliary components of the drug:
- magnesium stearate;
- Povidone K-25;
- polyethylene powder;
- carbomer 934Р.
Included in shell:
- hypromellose;
- titanium dioxide;
- macrogol 6000;
- iron oxide yellow;
- solid paraffin.
Pills are packed in dark glass bottles of 30 or 50 pieces.
Next, we will get acquainted not only with the indications and contraindications when taking the drug "Sorbifer", we will also pay attention to side effects.
Assigned to
For taking a drug such as Sorbifer, there are the following indications:
- iron deficiency;
- iron deficiency anemia.
Prescribed as a prophylactic:
- during pregnancy;
- during lactation;
- blood donors.
Pregnant women, if Sorbifer is indicated, the side effects of the drug should not be ignored. If you experience any unusual symptoms while taking it, you should consult a doctor.
Contraindications
The instructions for the drug contain a list of diseases for which it should not be prescribed. Pregnant women and all who are prescribed this remedy should pay special attention to it in order to exclude these conditions from themselves. The list of contraindications includes:
- diabetes mellitus;
- diseases of the gastrointestinal tract;
- intestinal obstruction;
- anemia that is not associated with iron deficiency in the body;
- thrombosis;
- prone to thrombosis;
- kidney disease;
- high iron content in the body;
- use of drugs containing iron;
- urolithiasis;
- impaired iron excretion fromorganism;
- fructose intolerance;
- hypersensitivity to the constituent components of the drug.
It is important to follow the instructions for the Sorbifer preparation, in this case there may be a minimum of side effects.
How to take the drug
For preventive purposes, Sorbifer is prescribed:
- Children over 12 years old, 1 tablet daily.
- Adults - 1 tablet daily.
In the case of iron deficiency anemia, the drug is taken:
- Children over 12 years old and adults 1 tablet 2 times a day.
Pregnant women should use Sorbifer as follows:
- First 6 months 1 tablet daily.
- In the last trimester of pregnancy, 1 tablet 2 times a day.
During lactation appoint:
1 tablet 2 times a day
During the treatment period, the iron content in the blood plasma is monitored. The duration of therapy depends on this.
After the level of hemoglobin in the blood is restored, it is recommended to take the drug for another 2 months.
In the treatment of iron deficiency anemia, it is necessary to take the drug for 3 to 6 months.
Before taking Sorbifer, contraindications and side effects of the drug should be discussed with your doctor.
Application features
While carrying a child, a woman should be especially careful when taking any drugs. Therefore, it is necessary to familiarize yourself with the features of the reception"Sorbifer".
- Before treatment, it is necessary to establish the level of iron in the blood serum and the ability of iron to combine in the blood serum by laboratory method.
- Not effective for other types of anemia.
- Feces turn dark during treatment with the drug.
- Gastrointestinal disorders may worsen when taken orally.
- When taking a course, it is necessary to control the levels of hemoglobin and serum iron in the blood.
- In case of urolithiasis, the intake of ascorbic acid per day should not exceed 1 g.
- In case of increased blood clotting, do not use high doses of the drug.
- Long-term course treatment requires monitoring of such indicators: blood pressure, kidney function, pancreas function.
- With a deficiency of glucose-6-phosphate dehydrogenase, the drug should be used with caution.
- Do not take tablets with alkaline mineral water. This reduces the absorption of the drug.
- Ascorbic acid, which is part of the drug, can affect the following blood parameters: glucose levels, bilirubin, lactate dehydrogenase, transaminase activity.
When taking Sorbifer, side effects in women are more likely to occur if there are the following diseases:
- chronic liver and kidney disease;
- leukemia;
- intestinal diseases;
- inflammatory pathologies of the gastrointestinal tract;
- ulcerstomach and duodenum.
Interaction with other drugs
Sorbifer drug often shows side effects during pregnancy if the doctor prescribes several drugs.
Sorbifer should not be used in conjunction with the following medicines:
- "Moxifloxacin";
- "Ciprofloxacin";
- "Levofloxacin";
- "Norfloxacin";
- "Ofloxacin".
The absorption of these medicines is significantly reduced.
It is necessary to observe an interval of at least 2 hours between taking "Sorbifer" and such drugs:
- "Captopril";
- drugs containing zinc, calcium, magnesium;
- "Clodronate";
- "Methyldopa";
- "Penicillinamine";
- "Risedronate";
- "Tocopherol";
- thyroid hormones;
- "Pancreatin";
- "Tetracycline";
- glucocorticosteroids;
- "Cimetidine".
Simultaneous administration with Sorbifer reduces the effect of ascorbic acid:
- oral contraceptives;
- fruit and vegetable juices;
- alkaline mineral water.
The drug "Deferoxamine" together with ascorbic acid increases the toxicity of iron, especially in the heart muscle.
Side effects
You should consider what side effects are possible when taking Sorbifer.
- Cardiovascular system: myocardial dystrophy, increased blood pressure.
- Gastrointestinal tract: constipation, diarrhea, nausea, stomach pain. Long-term use may cause heartburn, irritation of the gastric mucosa.
- Allergic reactions: itching, angioedema. Redness of the skin.
- Endocrine system: impaired glycogen synthesis, hyperglycemia, glucosuria.
- Blood system: thrombocytosis, neutrophilic leukocytosis, erythrocytopenia, hyperprothrombinemia.
- Nervous system: headaches, insomnia, irritability.
Also possible violation of the exchange of zinc and copper in the body.
Often "Sorbifer Durules" is prescribed during pregnancy. The doctor should warn the patient about the side effects of the drug.
Overdose
Need to know the symptoms of drug overdose:
- nausea;
- vomit;
- abdominal pain;
- diarrhea;
- drowsy;
- stools with blood;
- tachycardia;
- lower blood pressure;
- dehydration;
- hyperglycemia.
There is a risk of gastrointestinal perforation.
In severe cases, he alth may improve for a period of time, but after 6-24 hours the situation worsens again. Possible convulsions, liver and kidney failure, heart failure, coma.
Also possible laterseveral weeks or months the development of cirrhosis of the liver and persistent narrowing of the pylorus.
Vitamin C overdose can lead to hemolytic anemia and severe acidosis.
It is very important to know the symptoms of an overdose when taking Sorbifer Durules tablets. Side effects of the drug have similar symptoms, it is important to correctly assess the situation at an early stage. Timely assistance is very important.
Overdose care
In case of overdose, do the following:
- Drink enough liquid to induce vomiting. Milk can be used.
- Rinse the stomach with a solution of "Desferoxamine" 2 g/l.
- "Desferoxamine" 5 g + 50-100 ml of water enter into the stomach and leave.
- An adult can drink Sorbitol.
- An x-ray of the stomach should be taken after gastric lavage to check for remaining tablets.
- In severe cases, supportive therapy and intravenous Desferoxamine are prescribed.
- For less severe intoxication, "Desferoxamine" is administered intramuscularly.
The patient must be under constant supervision. It is necessary to monitor the level of iron in the blood serum.
Side effects of pregnancy
It is worth paying attention to the fact that most often the drug is prescribed for pregnant women. Therefore, let's pay attention to the side effects that are recorded in pregnant women:
- rash;
- itch;
- constipation;
- diarrhea;
- nausea;
- heartburn;
- headache;
- sleep disorder.
If women took Sorbifer, they wrote about side effects during pregnancy in the reviews, such as nausea, constipation.
As a rule, such deviations are very rarely noted. After consulting a doctor and adjusting the dose, the symptoms go away.
It is worth noting that many women have appreciated the increase in hemoglobin in the blood in a short period of time when taking Sorbifer. Side effects, in the reviews noticed, while not manifested. The effectiveness of the drug is confirmed not only during pregnancy, but also during lactation.
Reviews about the drug
"Sorbifer" is prescribed not only for pregnant women and during lactation, but also for people with iron deficiency anemia, both men and women.
A minor side effect of Sorbifer was noted in the reviews by patients. This is a metallic taste when taken for a long time. After stopping or adjusting the dose, everything is restored.
Reviews are mostly positive. They note the effectiveness of the drug, some noted a rapid decrease in blood counts after discontinuation of the drug. But it should be borne in mind that the drug is recommended to be taken in maintenance doses after reaching normal levels for at least another 2 months. Failure to comply with this condition leads to the following consequences.
Many have noticed that with the course of taking the drug "Sorbifer" a side effect manifests itself in the form of heartburn. There are cases of nausea, constipation, disturbances in the work of the digestive organs.
Adjusting the dose and following the instructions can reducemanifestation of side effects.
Some thought the high price was a disadvantage of the drug.
In general, Sorbifer is safe for both the elderly and children over 12 years of age. Before taking it is necessary to consult a doctor. Do not self-prescribe medication.
