Many infectious and inflammatory processes in the body can not do without the use of antibiotics. A group of these drugs kills harmful microorganisms and pathogens. One of the well-known antibacterial drugs is "Gentamycin sulfate". It is considered an antibiotic with a wide range of uses and is used to treat humans and animals.
Form and composition of the drug
Produced in the form of a 4% solution for injection and eye drops. The main substance in the composition of the drug is gentamicin sulfate at a dose of 4 mg per milliliter. It belongs to the group of aminoglycosides and is considered a broad-spectrum antibiotic.
The drug has an anti-inflammatory and bactericidal effect. It has high activity against anaerobic gram-negative bacteria and gram-positive cocci. After intramuscular injection, the drug is rapidly absorbed. The maximum effect is achieved within an hour after the injection. Almost does not bind to blood proteins at all. The antibiotic is distributed in the extracellular fluid throughout all organs and systems. The drug is not metabolized and predominantlyexcreted by the kidneys, slightly - with bile. The drug "Gentamicin sulfate" has the property of passing through the placental barrier. Application, side effects - all this should be studied before planning therapy.
Indications
The drug is prescribed for infectious and inflammatory processes in the body, which are caused by antibiotic-sensitive microorganisms. For parenteral administration:
- cystitis;
- acute cholecystitis;
- purulent lesions of the skin;
- burns of varying degrees;
- pyelonephritis;
- cystitis;
- diseases of the joints and bones of an infectious nature;
- sepsis;
- peritonitis;
- pneumonia.
For external use:
- furunculosis;
- folliculitis;
- seborrheic dermatitis;
- infected burns;
- wound surfaces of various etiologies;
- sycosis.
To apply topically:
- blepharitis;
- blepharoconjunctivitis;
- dacryocystitis;
- conjuntivit;
- keratitis.
With such pathologies, "Gentamicin sulfate" is used. Instructions for use are in the middle of the pharmacy package with the medicine.
Contraindications:
- hypersensitivity to antibiotics;
- severe pathology of the kidneys and liver;
- disturbance in the functioning of the auditory nerve;
- bearing;
- breastfeeding.
Also no antibiotic prescribed"Gentamicin sulfate" in ampoules for uremia.
Dosage
The drug is prescribed individually for each patient. The dosage depends on the severity of the process and hypersensitivity to the agent. At one time, from 1 to 1.7 mg per kg of weight is administered. The drug is injected into a vein or intramuscularly. The medicine is used two to four times a day. The maximum dosage per day cannot be more than 5 mg. The course of therapy is 1.5 weeks.
Children after two years of age are given the drug several times a day in an amount of 1 mg per kilogram of body weight. For babies under the age of one month, the daily dosage cannot be more than 2-5 mg per kilogram of body weight. The antibiotic is administered several times a day.
For topical use, eye drops are instilled 1 drop every two hours. For external use, the substance is prescribed up to three times a day. For people with impaired renal function, depending on the clinical picture, the drug "Gentamicin sulfate" is corrected. Eye drops are instilled directly into the sac of the conjunctiva of the diseased eye.
Interaction with other tools
It is not recommended to take the following medicines together:
- Vancomycin;
- Cephalosporin;
- "Ethacrynic acid";
- "Indomethacin";
- anesthesia;
- analgesics;
- loop diuretics.
Before planning therapy, it is necessary to carefully study the interaction of other drugs and the antibiotic "Gentamycin sulfate".
Neglecting the recommendations may lead to the development of the following side effects:
- nausea;
- vomit;
- increase in blood bilirubin;
- anemia;
- thrombocytopenia;
- leukemia;
- migraine;
- dizziness;
- proteinuria;
- disorders of the vestibular apparatus.
Also can cause allergic reactions "Gentamycin sulfate". Drops and solution in rare cases can lead to Quincke's edema or anaphylactic shock, which is fraught with serious complications. When using an antibiotic, it is necessary to monitor the functions of the kidneys, hearing and vestibular apparatus.
"Gentamicin sulfate" - an antibiotic for animals
Pets can also be susceptible to bacterial infection. To treat a sick animal, special groups of antibiotics are used. These drugs include "Gentamycin sulfate". It belongs to the group of aminoglycosides and is a mixture of C1, C2 and C1a gentamicins. The composition of the drug includes gentamicin at a dose of 40 and 50 mg in one milliliter of solution. The product is stored at a temperature not exceeding 25 degrees, in a dry and inaccessible place for children. Two years - the shelf life of the drug "Gentamycin sulfate". Instructions for use for animals will tell in detail about the indications and dosage of the drug.
Action
The drug has a wide spectrum of effects and is active against gram-positive and gram-negative microorganisms. After the introduction of the drug, it in a short timepenetrates into all organs and systems. After one hour, its maximum activity is observed and continues for 8 hours. It is excreted mainly in the urine and in small concentrations in the feces of the animal.
The medicine is prescribed for the treatment of pathologies of the stomach, intestines, peritonitis, meningitis, pyelonephritis and other diseases in pets. The drug is administered twice a day with an interval of 10 hours. An oral remedy "Gentamicin sulfate" for animals is also prescribed.
Dosage
For the treatment of horses, the antibiotic is administered intramuscularly at a dose of 2.5 mg per kilogram of body weight. The duration of therapy is from 3 to 5 days. In cattle, the dose is administered at the rate of 3 mg per kilogram of body weight for 5 days. Also, the drug can be taken orally at a dosage of 8 mg per kilogram of body weight.
Pigs solution is injected intramuscularly at the rate of 4 mg per 1 kilogram of weight. The duration of therapy should not exceed three days. Orally, the drug is used at a dose of 4 mg per kilogram of body weight for 5 days. Dogs and cats are injected intramuscularly with 2.5 mg of solution per kilogram of body weight. Treatment takes up to seven days.
When administered orally, the drug is not absorbed in the stomach, but only after 12 hours in the intestines. Only a veterinarian can administer the antibiotic "Gentamycin sulfate" intramuscularly. The instructions for animals describe how to administer the drug.
Special Instructions
It is forbidden to use an antibiotic with other groupsnephrotic agents, especially with kidney pathology and hearing impairment. Animal slaughter is allowed only three weeks after the last dose of the drug. The tool does not affect the simplest fungi, viruses and anaerobic bacteria. Only a professional veterinarian will be able to correctly calculate the dose of the drug "Gentamycin sulfate 4%" and cure the pet.
Drug "Gentamicin"
The drug belongs to the group of aminoglycoside antibiotics, which are widely used to treat many diseases. The tool has the following effects on the body:
- bactericidal;
- anti-inflammatory;
- has high activity against gram-positive and gram-negative bacteria.
The drug is available in the form of a solution. After intramuscular injection, the drug is rapidly absorbed into the tissues of the whole body. The greatest bioavailability is observed after half an hour. Half of the funds are excreted in the urine after 3 hours. Penetrates through the placenta, so it is not recommended to prescribe the drug "Gentamicin" and its analogue "Gentamicin sulfate" during pregnancy. Instructions for use of these products contain useful information and a description of antibiotics.
Indications and contraindications
Therapy of infectious and inflammatory diseases, which are caused by microorganisms sensitive to the active ingredient, can be carried out using "Gentamicin". The drug is used for parenteral, external and local use.
Contraindications:
- hypersensitivity to the aminoglycoside group;
- bearing;
- lactation;
- severe renal failure;
Before starting the treatment process, you should carefully study all contraindications to the use of antibiotics "Gentamicin" and "Gentamicin sulfate".
Dosage
The drug is prescribed on an individual basis, the dose depends on the severity of the disease. For intramuscular and intravenous administration, the drug is calculated at a dose of 1 to 1.7 mg per kilogram of body weight at a time. The drug is administered two or three times a day. The maximum daily allowance for an adult should not exceed 5 mg / kg, and for children - 3 mg per kilogram of weight. The medicine is administered for 7 days. Eye drops are used three times a day and one drop is instilled directly into the affected eye. The antibiotic is applied externally four times a day. In severe renal pathology, the drug is prescribed according to the clinical picture, and the dosage can be adjusted. For children, the daily allowance depends on the age and condition of the body.
Drug Interactions
Gentamicin is not recommended in combination with the following drugs:
- Vancomycin;
- Cephalosporin;
- "Ethacrynic acid";
- "Indomethacin";
- analgesics;
- drugs for anesthesia;
- diuretics.
The drug "Gentamicin" and the solution "Gentamicin sulfate 4%" have the same composition and indications for use. Bothproducts have an increased bacterial and anti-inflammatory property.
Drug "Gentamicin-Ferein"
The drug belongs to the group of aminoglycosides and is widely used to treat many organs and systems. It has increased activity against gram-positive and gram-negative anaerobic bacteria. It has a bactericidal effect. After intramuscular and intravenous administration, the antibiotic is absorbed into all organs and tissues of the body.
40 minutes after the injection, the drug reaches its maximum activity, which lasts for 12 hours. The drug is not metabolized and is excreted in the urine. Has the ability to cross the placental barrier.
Indications and contraindications
The medicine is used for parenteral, local and external use in the treatment of infectious and inflammatory diseases.
Contraindications:
- pregnancy;
- breastfeeding;
- pathology of the kidneys and liver;
- hypersensitivity;
- Acoustic neuritis.
Dose of the drug "Gentamicin-Ferein"
For adults, the drug is administered in an amount not exceeding 5 mg per kilogram of body weight per day. At one dose, the dose is from 1 to 1.7 mg per 1 kilogram of the patient's weight. The course of treatment depends on the severity of the process and ranges from 7 to 10 days. The drug is administered two or three times a day
For children, the dosage is 3 mg per kilogram of body weight forone introduction. The medicine is injected twice a day. In patients with renal insufficiency, the dosage of the antibiotic is constantly adjusted and depends on the clinical indications.
Eye drops are used every 4 hours and are instilled into the affected eye one drop at a time. Externally, the remedy is prescribed three or four times a day.
Possible side effects:
- nausea;
- vomit;
- increased bilirubin;
- anemia;
- leucopenia;
- drowsy;
- migraine;
- disorders of the vestibular apparatus;
- deafness;
- allergic reactions, up to angioedema.
Gentamicin sulfate 4% solution may have similar side effects during the treatment of infectious and inflammatory processes in the body.
Reviews on drugs based on gentamicin sulfate
Drugs do not belong to the new generation of antibiotics, but they are quite good and are currently used to treat microbial diseases. Therefore, there are many products on the pharmaceutical market that contain gentamicin. These are not only solutions for injections, but also creams, ointments, eye drops. The drug affects the genetic information that is embedded in the cells of the pathogen. The active ingredient is absorbed into the tissues of the body in a short time and begins its antibacterial effect.
In most cases, the drug is well tolerated, but may cause an allergic reaction. Also, the antibiotic can be taken from birth. There is a special calculation scheme for this.dosage. This antibiotic is widely used in veterinary medicine. It helps animals get rid of infection and normalize the functioning of the stomach and intestines.
Sometimes the drug "Gentamicin" can lead to hearing loss, and this is its main drawback. By studying all the reviews, especially doctors, you can understand what a powerful antibiotic this drug is. It has high activity against Gram-positive and Gram-negative anaerobic organisms. Also in the complex is prescribed for the treatment of pneumonia and meningitis. It is necessary to strictly observe the dosage of the drug in order to avoid side effects. According to many experts, the drug "Gentamycin sulfate" is toxic. Its constant use can affect the work of all body systems. Antibacterial agents should not be used without the advice of a specialist.
