In the article, instructions for use are considered for the preparation "MIG 400".
These tablets are representative of the clinical pharmacological group of medicines related to non-steroidal anti-inflammatory drugs. They are used for symptomatic and pathogenetic therapy of various inflammatory processes in the human body, which are accompanied by the appearance of pain syndrome.
Composition and formulation of the drug
According to the instructions, "MIG 400" is produced in the dosage form of tablets, which are coated with an enteric coating. They have an oval oblong shape with a biconvex surface. These pills are white. The main active ingredient of the drug is ibuprofen, which is contained in one tablet in the amount of 400 milligrams.
Excipients
Also, in addition, the drug contains auxiliary components in the form of silicon dioxide, corn starch, magnesium stearate,sodium carboxymethyl starch, titanium dioxide, macrogol, hypromellose and povidone. Tablets "MIG 400" are packaged in blisters of ten pieces. The cardboard pack contains one or two blisters along with instructions for using the drug.
Pharmacological effects
As the instructions for MIG 400 indicate, the active ingredient in the tablets is ibuprofen, which inhibits the enzyme cyclooxygenase. Such suppression leads to a decrease in prostaglandins in the tissues of the area of the inflammatory process and contributes to the following therapeutic effects:
- Decreased pain intensity.
- Decrease in hyperemia.
- Reducing the severity of edema.
Instructions for use for "MIG 400 mg" is very detailed.
Like other non-steroidal anti-inflammatory drugs, this drug reduces platelet aggregation along with the formation of blood clots, and also reduces the activity of the protective factor of the gastric mucosa, increasing the risk of ulcers in it.
After taking these tablets orally, ibuprofen is rapidly absorbed from the intestinal lumen, evenly distributed in body tissues. The presented drug is metabolized in the liver to inactive decay products, excreted mainly in the urine. The plasma half-life of the active ingredient is about four hours.
Indications for the use of tablets
What else does the user manual for MIG 400 tell us?
The intake of these tablets is indicated for symptomatic andpathogenetic therapy of inflammatory processes accompanied by pain syndrome:
- For headaches, including migraine.
- Against the background of painful omissions in the joints and muscles, regardless of their origin.
- For painful menstruation in women.
- Against the background of neuralgia, when pain appears due to aseptic inflammation of the peripheral nerves.
- When you have a toothache.
In addition, tablets are used to lower the temperature in the presence of a feverish condition, in particular, provoked by infectious processes in the body.
Instructions for "MIG 400" must be followed.
Contraindications for use
These pills are strictly contraindicated in a number of the following pathological and physiological conditions:
- The patient's hypersensitivity to ibuprofen, and, in addition, to its auxiliary components, as well as the presence of individual intolerance to acetylsalicylic acid or other representatives of the pharmacological category of non-steroidal anti-inflammatory drugs.
- The presence of erosive and ulcerative diseases of the digestive system. For example, this drug is not suitable for use in gastric ulcer disease in the acute stage.
- In the presence of hemophilia, hemorrhagic diathesis and other pathological disorders of blood coagulation.
- Against the background of the aspirin triad, when a person suffers from acetylsalicylic intoleranceacids, nasal polyposis and bronchial asthma.
- The presence of bleeding in the body of varying intensity and localization.
- Deficiency in the enzyme glucose phosphate dehydrogenase, which is required for the normal functioning of red blood cells.
- Presence of various pathologies of the optic nerve.
- Pregnancy period at any time.
This confirms the instructions for "MIG 400 mg".
When should a drug be taken with caution?
Use this drug with great care in the following cases:
- If you have hypertension or heart failure.
- Against the background of a decrease in functional liver activity.
- In the presence of a chronic course of peptic ulcer during remission.
- Against the background of inflammation of the stomach, that is, in the presence of gastritis.
- For enteritis and intestinal colitis.
- Against the background of hyperbilirubinemia, when the concentration of bilirubin in the blood rises.
- Against the background of blood pathologies of unknown origin.
Thus, before you start taking MIG 400, you need to make sure that there are no contraindications.
Method of application and dosage
According to the instructions, "MIG 400" is taken orally after meals. It is extremely important to take the drug after meals, as this reduces the negative effect of the active ingredient on the stomach and intestines. Tablets should not be chewed, washed down with plenty of water.
Initial TherapeuticThe dosage for adults and children who are over twelve years of age is 200 milligrams three times. If necessary, the dose is increased to 400 milligrams three times a day, and after achieving a therapeutic effect, the amount of the drug is reduced. Do not take these tablets for more than seven days. If pain persists, you should contact your doctor. For patients who have concomitant pathologies of the heart, kidneys or liver, the dosage is reduced.
So it says in the instructions for use for the drug "MIG 400".
Side effects
Taking the remedy can lead to the development of many unwanted reactions, for example:
- The digestive system may react to this drug with nausea, heartburn, vomiting, decreased appetite, stomach pain, flatulence, constipation or diarrhea, dry or painful mouth. Inflammatory reactions of the oral mucosa are also possible, followed by the formation of various defects in it in the form, for example, aphthous stomatitis. Liver inflammation, pancreatitis and gingivitis are not ruled out.
- The nervous system may respond to these pills with headache, insomnia or drowsiness, dizziness, anxiety, irritability, nervousness, depression, psychomotor agitation and confusion, followed by the development of hallucinations. Rarely enough, aseptic meningitis occurs, which is an inflammation of the meninges of the brain.
- Possible increase in pressure along with developmentheart failure and tachycardia.
- There may be a decrease in the number of leukocytes, erythrocytes, granulocytes and platelets in the blood.
- The development of bronchial spasms and shortness of breath is quite likely.
- Hearing impairment is also possible, along with a decrease in its severity, the appearance of tinnitus, toxic damage to the optic nerve and visual impairment. In this case, blurred vision is quite likely, and, in addition, double vision. The appearance of scotoma is also possible.
- In laboratory values, there may be an increase in the duration of capillary bleeding along with a decrease in hematocrit and hemoglobin. An increase in the concentration of creatinine in the blood and the activity of liver enzymes is not excluded.
- As an allergic reaction, a rash may appear along with itching of the skin, urticaria, severe necrotic lesions of the tissue integument. Quincke's edema, allergic inflammation of the nasal mucosa and anaphylactic shock are not excluded.
The likelihood of side effects tends to increase with prolonged use of the drug. If adverse reactions occur, use should be discontinued immediately.
This information is contained in the instructions for the drug "MIG 400".
Special Instructions
Immediately before you start taking the drug, you should definitely carefully study the instructions and make sure that there are no contraindications. It is extremely important to pay attention to the list of special instructions regarding hisapplications:
- Signs of internal bleeding require immediate discontinuation of medication.
- Taking medication can mask the symptoms of pathological processes, which should be taken into account during diagnostic measures.
- The development of pain in the abdomen against the background of the use of these tablets requires a thorough examination in relation to the likely occurrence of peptic ulcer.
- The intake of alcohol during the period of drug treatment is completely excluded.
- The presented tablets can interact with the means of various pharmacological groups.
- During long-term treatment with this drug, it is necessary to monitor laboratory parameters of functional liver activity, and it is also necessary to monitor the state of the blood.
- If it is necessary to perform a laboratory determination of the amount of ketosteroids, the medication should be stopped two days before the test.
- During the use of the drug, it is recommended to abandon activities that require increased attention and speed of psychomotor reaction.
In pharmacies, "MIG 400" is released without a prescription. If you have any questions or doubts about the use, you should consult your doctor.
Overdose
Instructions for the drug "MIG 400" indicates that if the recommended therapeutic dosage is exceeded, overdose symptoms develop, which include abdominal pain along with nausea, vomiting, mental retardation up tooccurrence of coma. Depression, drowsiness, headaches, tinnitus, acute kidney failure, and, in addition, a critical decrease in blood pressure are also likely. A violation of the rhythm of the heart contraction is not excluded.
Overdose therapy consists primarily of gastric lavage, taking sorbents, and symptomatic treatment is also necessary.
So says the instructions for use.
"MIG 400" and analogues
Similar medications of this drug, which are the same as MIG 400 tablets in terms of therapeutic effect and composition, are Nurofen and Ibuprofen. It should be noted that the presented analogues are most often prescribed to patients to replace the drug "MIG 400".
Storage conditions and price
In accordance with the instructions for use for tablets "MIG 400", the shelf life of the described drug is exactly three years from the date of its manufacture. These tablets should be stored in a dry place, which should be dark and out of the reach of children. The temperature of the medicine content should not exceed thirty degrees.
The average price for ten tablets in Russian pharmacies varies from sixty to eighty rubles.
Reviews about the drug
It should be said right away that the reviews on the Internet about this drug are positive, and the rating of its assessment is almost ninety percent. It is noted that this drug very well helps to cope with anykind of pain.
Consumers write about this drug that its effect occurs twenty to twenty-five minutes after taking the pills. People like that such an effective medication is very inexpensive and available to absolutely every customer.
The negative point is various contraindications, and, in addition, side effects. For example, people say that while using this medicine, their blood pressure increased, dizziness was observed, and nervousness arose. Patients are also afraid that with the help of this medicine it is possible to harm various organs, since the drug is very strong and not entirely safe.
In addition to the negative comments, it is reported that MIG 400 is not effective enough for very severe pain, besides, it costs buyers a little more than its Ibuprofen counterpart.
So most people find this medicine to be very effective and efficient. But it should be borne in mind that in the presence of very strong pain, a suitable substitute should be selected.
We reviewed the instructions for the MIG 400 tablets.
