Skin problems are a concern for many people. They not only spoil the appearance of a person, but can also lead to more serious diseases and complications. To effectively combat them, you need to choose the right medicine. Remedies for acne on the face are not equally effective for everyone. Only an examination by a dermatologist will help you choose the right treatment.
"Tretinoin" from acne has already helped many. This tool has the necessary properties that allow you to cope with skin lesions. Before you start using the drug, you should consult with a specialist about possible negative consequences and consider in detail the action of Tretinoin, release forms and analogues.
Tretinoin release forms
There are several types of remedies for acne on the face. Many of them are produced under the same name, which helps to choose the most convenient tool to use. Tretinoin is no exception. The price of the drug may also depend on its form.
"Tretinoin" is available in the form of cream, lotion, gel, solution and capsules."Tretinoin"-lotion is designed to cleanse the skin of impurities, relieve inflammation and get rid of acne and other types of acne. This form is ideal for caring for young skin, normalizes the sebaceous glands, which helps to get rid of oily sheen.
"Tretinoin" cream is more suitable for older people with signs of skin aging. The cream has a fatty base, thanks to which it helps to smooth out age-related wrinkles. This cream is an anti-inflammatory agent that effectively fights most skin and subcutaneous tissue problems.
Gel has a lighter texture than cream and is suitable for oily and combination skin types. Like the cream, it has an anti-seborrheic effect. Tretinoin capsules are used to induce remission in acute promyelocytic leukemia and should be prescribed only after an accurate diagnosis has been established. Treatment with Tretinoin capsules should be supervised by an oncologist and hematologist.
Solution has the same pharmacological action as cream and lotion. It is used not only to solve visible skin problems, but can also draw out hidden blackheads. It is used as part of the complex treatment of various types of acne.
Composition of the drug
"Tretinoin"-cream contains an active substance - transretinoic acid (tretinoin) in an amount of 0.05% or 0.1%. The higher the mass fraction of the active substance, the more effective the effect of the drug. Tretinoin is a powderthe substance is yellow or light orange, so the cream contains auxiliary products that create a water-oil and oil-water base.
Gel "Tretinoin" has in its composition the active substance in the amount of 0.1%, 0.025% or 0.05% of the total mass. In addition to tretinoin, the gel also contains propylene glycol, carbomer, isopropyl alcohol, triethanolamine, butylated hydroxytoluene and some other substances in small quantities.
"Tretinoin"-lotion with zinc is available with an active substance concentration of 0.05%, and a solution with 0.1%. The lotion also contains propylene glycol and ethyl alcohol, which have a bactericidal effect.
Each capsule of "Tretinoin" contains 10 mg of the active substance and excipients such as beeswax, soybean oil. The gelatin shell of the capsule contains glycerol, carion-83, titanium dioxide and dyes.
Indications for use
The drug belongs to the group of retinoids, structurally similar to vitamin A. Obtained as a result of retinol metabolization. Tretinoin has antiseborrheic, antitumor, keratolytic and comedolytic effects. In addition, it stimulates tissue regeneration, strengthens the immune system, and also has a local anti-inflammatory effect. It is used to treat confluent and vulgar acne. In the form of capsules, the drug is effectively used for the processes of remission of myeloid leukemia.
"Tretinoin"-cream is used to suppress skininflammatory processes and has a general beneficial effect on the upper layer of the epidermis. May be used to treat certain types of dermatitis and other skin conditions.
Action taken
"Tretinoin"-cream (for acne) allows you to remove inflammation in different layers of the epidermis, is applied externally, but has a deeper effect. The active substance affects the formation of elastin by skin cells, which increases skin elasticity and helps reduce the appearance of wrinkles and other age-related changes.
Tretinoin affects the production of melanin, inhibiting the process of its formation in large quantities, which leads to a decrease in the risk of malignant tumors. It also stimulates the growth of epithelial cells and activates the processes of their division, which contributes to the restoration of the skin.
In the treatment of open acne, the product evens out the top layer of the epidermis, leaving no scars or other signs of tissue damage. On closed acne, the drug has a pulling effect, which leads to their opening and further removal, while reducing inflammation and preventing tissue scarring. Also prevents new acne breakouts.
The anti-seborrheic effect of the drug "Tretinoin"-cream is to prevent the growth of epithelial cells, normalize the functioning of the sebaceous glands, and reduce inflammation at the locations of the sebaceous ducts.
The effect of using the drug appears after one and a half to two months. After one to two weeksuse, an increase in the number of acne may be observed. This happens in the process of bringing out and opening hidden blackheads.
Capsules "Tretinoin" are intended for oral administration. They are prescribed only to those patients who have an abnormal level of production and accumulation of promyelocytes, which leads to myeloid leukemia. Tretinoin inhibits the accumulation of myeloid cells, which leads to remission, which can last from two to four months.
Contraindications
Sensitivity to the active substance of the drug is a sufficient reason for the impossibility of its use. It is also impossible to use "Tretinoin" during pregnancy, as this can lead to impaired development of the embryo. During breastfeeding, you can also not use the drug orally.
The remedy is not prescribed for patients with acute inflammatory processes on the skin, the presence of skin lesions in the form of wounds or burns. It is also unacceptable to prescribe the drug to patients with skin epithelioma or who have a family predisposition to it. You can not use the drug for various types of eczema, pancreatitis, diabetes and increased intracranial pressure.
The drug has age restrictions. It is not given orally to children under one year of age, topically up to twelve years of age, and in any form to patients over fifty.
Side effects
When taking the drug orally, "retienic acid syndrome" can develop, which can lead to serious consequences.
When the first symptoms appear, appropriate treatment should be prescribed immediately. Symptoms of the syndrome are the appearance of shortness of breath, hyperleukocytosis, hypotension, fever, renal and hepatic multiple organ failure.
When using the forms of "Tretinoin" for external use, various skin reactions (peeling and dryness), rashes, itching, subcutaneous hemorrhages can be observed. Reactions such as dry mouth, increased sweating, sensitivity to ultraviolet rays, alopecia, hyper- and hypopigmentation may also occur.
In some cases, there are disorders in the digestive tract (nausea, vomiting, diarrhea), the central nervous system (depression, dizziness, hearing and vision disorders, increased intracranial pressure).
Disturbances in metabolic processes due to taking the drug are expressed in a change in body weight and the appearance of cellulite, as evidenced by the reviews. "Tretinoin" can also lead to respiratory tract infections, accompanied by coughing, shortness of breath, swelling of the mucous membranes and larynx, wheezing in the lungs.
Arrhythmia, pain in the muscles, chest and back, general weakness of the body and drowsiness were observed in some patients after taking the drug. With the development of several side effects at once or the threat of complications from taking the drug, the patient may be assigned a complete refusal of treatment or a decrease in the initially recommended dosages. There is a possibility of replacing Tretinoin with analogues.
Instructions for use
"Tretinoin" (cream or gel) should be applied in a thin layer with rubbing movements only on the affected areas of the skin once a day and left for six hours. After this time, it is recommended to wash off the drug with water. It should be remembered that overdose will not lead to faster results.
For those with fair skin or dry skin type, it is recommended to leave the preparation only for half an hour to begin with. With a normal skin reaction, the time can be gradually increased. It is allowed to remove matured pustules and comedones during the treatment. The course of treatment varies from two weeks to three months and depends on the degree of skin damage and the body's susceptibility to treatment.
The daily dose of the drug "Tretinoin" in capsules should not exceed 45 mg per square meter of skin. The course of treatment is three months. The dosage is the same for all ages not listed in the contraindications. If a patient is diagnosed with renal or hepatic insufficiency, the dose should be reduced to 25 mg.
The maximum allowable daily dose for an adult is 195 mg of the drug per square meter of skin and 60 mg for a child. With extensive tumors, the daily dose can be increased to a third of the maximum allowable.
When using drugs containing tretinoin, you should avoid prolonged exposure to direct sunlight. In case of sunburn in a patient, it is worth postponing the treatment until the skin lightens naturally.
Drug interactions
Drugs that affect the activity of the production of liver enzymes, significantly reduce the effectiveness of the drug "Tretinoin Retin A". Liver enzyme activity stimulants include glucocorticosteroids, rifampicin, pentobarbetal, and phenobarbital. Suppress the activity of liver enzymes Verapamil", "Erythromycin", "Ketoconazole" and others. Experts say that "Tretinoin" does not affect the effectiveness of these drugs, as evidenced by studies and their reviews. "Tretinoin" reduces the effectiveness of contraceptives in tablets based on progesterone (mil-drank).
Caution should be exercised when using Tretinoin and antifibrinolytic agents at the same time, as some patients have experienced thrombotic complications with a fatal outcome.
A feature of the action of "Tretinoid" is a possible increase in intracranial pressure. The same effect is observed with tetracycline drugs, so you should not use these drugs at the same time.
"Tretinoin": analogues
To solve skin problems, there are several similar products that also do a good job. "Tretinoin", the price of which is quite high, for some reason may not be suitable (individual sensitivity and other contraindications) for a particular person.
"Retinoic ointment" is a cheaper analogue of "Tretinoin" and contains vitamin A and isotretinoin. If the ointment is used incorrectly and the instructions are not followed, you can get a skin burn. Initially, the product was intended to combat acne and other rashes, but during use it turned out that the ointment, with a short exposure, activates the production of collagen and thereby smoothes shallow wrinkles.
"Differin" in its composition has the active substance adapalene, which is a synthetically derived analogue of retinoic acid. It has a milder effect in comparison with "Tretinoin". Also available as a gel for oily skin and as a cream for dry skin types. The drug is not intended to get rid of neoplasms and seborrheic dermatitis. The presence of these diseases is a contraindication to the use of Differin, as it requires stronger means.
Drug price
"Tretinoin"-cream, the price of which depends on the form of release of the drug and its manufacturer, is quite popular for solving skin problems. Generic drugs are supplied to Russia. Numerous reviews testify to this. "Tretinoin" in the form of a cream or lotion with zinc of Italian production is called "Airol". It has a more affordable price compared to other manufacturers, an average of 2500 rubles for 50 ml of lotion or 30 mg of cream.
"Lokatsid" is a cream containing tretinoin, the price of which is only 1500rubles. Under this name, you can also find a solution for external use with tretinoin. But, according to patients, it has a less effective effect or requires more cream.
Under the name "Retin-A" you can find "Tretinoin" - an ointment and gel made in India. "Vesanoid" - Swiss-made tretinoin capsules. Their cost per pack of 100 pcs. is more than 10,000 rubles, but one package is enough for a course of therapy.
Application reviews
"Tretinoin" is considered one of the best solutions for getting rid of many skin problems. In the absence of contraindications, you can count on an excellent result and smooth skin after a few weeks of using the drug. The tool may not be recommended by experts due to a wide range of side effects and contraindications, as evidenced by numerous reviews. "Tretinoin" should be used only under medical supervision. Self-use may be fraught with consequences.
"Tretinoin" from wrinkles also has its contraindications for use, unlike cosmetics, it cannot be used without consulting a specialist who will select the optimal dosage and duration of the course of use.
Those patients who used the drug to get rid of acne and acne note its beneficial effect on the skin of the face and body. Patients report he althier looking skin in just a couple of weeksafter the start of using the product. A long-lasting effect was also noted, which allows infrequent use of the drug and minimizes the side effects of the drug. In comparison with other similar means, "Tretinoin" has a fairly quick effect and allows you to quickly get rid of the problem or make its manifestations less noticeable.
Many other products that can be purchased at the pharmacy are designed to get rid of acne, wrinkles and solve various skin problems. They are much easier to buy, as they are much cheaper, but they do not have the same effect as Tretinoin. This drug has proven to be one of the best in the fight against skin problems.
