Consider reviews of Diprospan for psoriasis. Usually, in such a serious skin disease, not only external agents are used to eliminate symptoms and reduce the number of plaques, but also systemic drugs for internal use or injection. In severe stages, inflammatory processes develop, exudate is formed, which is accompanied by severe itching and other unpleasant symptoms. It is better to read reviews about injections from Diprospan psoriasis in advance.
Description of pathology
Psoriasis is a common chronic skin disease characterized by the appearance of a monomorphic rash of flat papules that tend to merge into large plaques that are covered with silvery-white loose scales. The disease is characterized by an undulating course.
The etiology of psoriasis is not fully understood, but scientists believe that infectious,hereditary and neurogenic nature of the origin of this disease. The risk group includes people with frequent skin trauma, with disorders of the central nervous system, with the presence of streptococcal skin infections, endocrine pathologies.
The initial element of psoriasis is a single papule, pinkish in color, covered with white scales. At the stage of development of the disease, there are few rashes, but their number gradually increases. The next stage is characterized by the appearance of new elements at the sites of injuries, scratches and abrasions on the skin. The newly emerged elements begin to merge with the existing ones, and form symmetrical plaques. At the third stage, the intensity of plaque growth decreases, they become clearer from the border, the skin becomes cyanotic. There is pronounced peeling. Exudative psoriasis differs from ordinary psoriasis by the presence of crusts on plaques, which are formed as a result of impregnation with exudate. Psoriasis of the soles and palms may also occur.
In severe forms of the disease, small intraepidermal pustules appear on the infiltrated skin, which merge and form purulent areas. According to reviews, Diprospan is very effective for psoriasis. This is also noted by doctors.
What is Diprospan medicine?
To similar symptoms of psoriasis, it is not enough only local medical. This requires the use of hormonal drugs, such as Diprospan. This is a glucocorticosteroid medication that is intended for the treatment of inflammatory diseases. It is oftenis prescribed for complex forms for the treatment of psoriasis. Reviews of "Diprospan" will be presented at the end of the article.
Composition, release form
This medicine is produced in the form of an injection suspension: colorless or slightly yellowish, transparent, slightly viscous, containing white suspended particles, free from impurities. Dissolving produces a white or yellowish suspension.
The preparation contains the following active elements: betamethasone sodium phosphate and betamethasone dipropionate. The excipients are: sodium hydrogen phosphate dihydrate, disodium edetate, sodium chloride, polyoxyethylene sorbitan monooleate, methyl parahydroxybenzoate, benzyl alcohol, propyl parahydroxybenzoate, macrogol, sodium carmellose, hydrochloric acid.
The suspension is packaged in glass ampoules and plastic blister strip packs of 1 or 5 ampoules.
Pharmacological properties
Reviews of Diprospan injections for psoriasis are mostly positive. The drug has immunosuppressive (immune suppression), anti-inflammatory, anti-shock, anti-allergic and desensitizing (reducing the sensitivity of the body) effects. The active ingredient - betamethasone - in the drug is presented in 2 forms: betamethasone disodium phosphate, which ensures the rapid onset of the desired effect, as well as betamethasone dipropionate, which serves to prolong the action of this drug.
The widespread use of the drug in psoriasis and other diseases is due to itsthe ability to suppress the production of substances that cause inflammatory reactions, block the inflammatory process at the cellular level. In addition, the drug has a slight ability to retain sodium in the body and increase the level of excretion of potassium, hydrogen and ammonium ions, but when used in recommended doses, these properties have no clinical significance. This is confirmed by the instructions and reviews of Diprospan injections for psoriasis.
Indications
The drug is recommended for use in psoriasis, as well as some complications caused by this pathology:
- psoriatic arthritis;
- erythroderma;
- generalized psoriasis.
In addition, injections can be prescribed for extensive severe skin lesions with plaques, when they are formed in large quantities, bleed heavily, exudate. It is impossible to use Diprospan injections for psoriasis on your own. The decision on the need to administer the medication can only be taken by the attending physician.
According to the instructions, Diprospan is also prescribed for the following pathologies:
- diseases of the musculoskeletal system, including osteoarthritis, rheumatoid arthritis, bursitis, epicondylitis, ankylosing spondylitis, sciatica and more;
- allergic diseases, including hay fever, asthma, rhinitis and more;
- dermatological diseases, including nummular eczema, atopic dermatitis, neurodermatitis, contact dermatitis, photodermatitis;
- systemic connective tissue diseases;
- hemoblastosis;
- adrenal cortex insufficiency.
This list includes many other diseases that require the use of glucocorticosteroids.
Instructions for the use of "Diprospan" from psoriasis
This drug is used in the form of intramuscular injections, as well as for peri- and intra-articular, intradermal, intralesional, intrabursal and interstitial administration. The small size of betamethasone dipropionate crystals allows the use of small diameter needles for direct injection into the lesion. Injections should be carried out with strict observance of asepsis, according to the instructions. "Diprospan" for psoriasis is administered and dosed on an individual basis, which depends on the indications, the clinical picture, the severity of the pathological process and the patient's response.
With systemic use, the initial dosage of the drug in most cases is 1-2 ml. The course of treatment "Diprospan" for psoriasis should be repeated as necessary, taking into account the patient's condition.
How exactly do you inject?
The most common way to introduce a drug into the body is intramuscular. How to inject "Diprospan" with psoriasis, it is better to find out in advance. The drug is injected deep into a large muscle, avoiding penetration into other tissues (to prevent the development of tissue atrophy).
In the presence of severe conditions that require emergency treatment, the initial volume of the suspension is 2 ml. For moderate diseaseand other dermatological diseases, in most cases, the introduction of 1 ml of the drug is sufficient. What else does the instruction for use for Diprospan injections from psoriasis tell us?
In addition, local administration of the drug is used in the treatment. In this case, the simultaneous use of a local anesthetic is necessary only in rare cases. If necessary, in such a situation, use 1% or 2% solutions of lidocaine or procaine hydrochloride, or other similar substances that do not contain propylparaben, methylparaben and phenol. Liquids are mixed in a syringe - first of all, the required dosage of Diprospan is drawn into it, after that the required volume of local anesthetic is drawn with the same syringe.
In psoriasis, it is also very effective to inject a medication into the lesion, which is evenly cut with a tuberculin syringe and a needle with a diameter of no more than 0.9 mm.
After the desired therapeutic effect is achieved, the maintenance dosage is selected by lowering the dose of betamethasone, which is carried out at intervals until the minimum dose is reached.
If there is a threat of occurrence or in the event of a direct occurrence of stressful situations (a risk factor for the development of exacerbation of psoriasis), an increase in the dosage of the Diprospan suspension may be required. Cancellation of the drug after long-term treatment is carried out by gradually reducing the dosage.
The patient should be monitored for at leastthroughout the year after the end of therapy or the use of the drug in high dosages.
With caution, injections of "Diprospan" should be taken to such groups of patients:
- People suffering from hypertension (high blood pressure).
- Those who suffer from serious disorders of the nervous system experience strong psycho-emotional experiences.
- "Diprospan" and psoriasis are incompatible in the presence of purulent-infectious processes on the skin.
- Do not inject the drug to those whose skin is affected by viral and fungal infections.
- The drug is contraindicated in patients with type I and type II diabetes.
- People with osteoporosis.
- You can not give Diprospan injections for glaucoma, tuberculosis, thromboembolism, stomach ulcers.
Medication to combat the symptoms of psoriasis is prescribed for short courses. This is a powerful drug, an overdose of which is fraught with a number of serious side effects. Reviews of the treatment of psoriasis "Diprospan" confirm this.
Adverse reactions
The severity and frequency of adverse reactions when using a medical product depend on the dose used and the duration of the therapeutic course. These phenomena are usually reversible and can be stopped or reduced by lowering dosages. According to reviews of "Diprospan" from psoriasis, the following are considered the most common adverse reactions.
- Metabolism: increased excretion of potassium and calcium, hypokalemic alkalosis, hypernatremia, negative nitrogen balance (as a result of protein catabolism), fluid retention in the body, lipomatosis (epidural and mediastinal, which can provoke neurological complications), weight gain.
- Heart and blood vessels: chronic heart failure (in patients with a predisposition), increased blood pressure.
- Musculoskeletal system: weakness in the muscles, decreased muscle mass, steroid myopathy, increased intensity of myasthenic symptoms in severe forms of pseudoparalytic myasthenia gravis, compression fractures of the spine, osteoporosis, aseptic necrosis of the head of the humerus or femur, tendon ruptures, tubular fracture bones, articular instability.
- Digestion system: erosive and ulcerative lesions of the mucous membranes of the digestive organs with possible further perforation and bleeding, flatulence, pancreatitis, hiccups.
- CNS: increase in intracranial pressure with swelling of the optic nerve head (in most cases at the end of therapy), convulsions, dizziness, cephalgia, euphoria, depression (with intense psychotic reactions), mood swings, personality disorders, excessive irritability, sleep disturbances.
- Dermatological reactions: thinning and atrophy of the skin, impaired healing of wound surfaces, petechiae, excessive sweating, ecchymosis, dermatitis, striae, steroid acne, a tendency to develop candidiasis andpyoderma, decreased skin test reactions.
- Endocrine system: menstrual disorders, secondary adrenal insufficiency (especially during periods of stress due to injury, illness, surgery), decreased carbohydrate tolerance, Itsenko-Cushing's syndrome, steroid diabetes mellitus or manifestation of latent diabetes mellitus, increased need for insulin or hypoglycemic medications, intrauterine developmental disorders, delayed puberty and growth in childhood.
- Organs of vision: increased intraocular pressure, glaucoma, posterior subcapsular cataract, exophthalmos; in some cases, blindness.
- Local reactions: hyper- or hypopigmentation, skin and subcutaneous atrophy, aseptic abscess.
- Allergic manifestations: shock, anaphylactic reactions, arterial hypotension.
- Other: flushing of the face after administration of the suspension, as well as neurogenic arthropathy.
Contraindications for use
"Diprospan" for the treatment of psoriasis is contraindicated in the following cases:
- systemic mycoses;
- introduction to infected skin surfaces and intervertebral space;
- s/c or i/v introduction;
- high sensitivity to betamethasone.
This must be considered before appointment. With caution, "Diprospan" from psoriasis can be injected with cirrhosis of the liver, hypothyroidism, eye diseases of herpes etiology, withulcerative colitis, abscess or other purulent infections, in the presence of intestinal anastomoses, diverticulitis, peptic ulcer, osteoporosis, arterial hypertension, thrombocytopenic purpura and myasthenia gravis.
Special Recommendations
In clinical medical practice, cases of severe complications from the central nervous system (up to death) are known to develop against the background of the use of Diprospan for psoriasis. Among these complications are: spinal cord infarction, quadriplegia, paraplegia, stroke and cortical blindness. Since nothing is known about the efficacy and safety of corticosteroids when the drug is administered epidurally, this route of administration is not used. It is also necessary to avoid getting the drug into the vascular bed.
The method of application and dosing regimen for psoriasis are set individually, depending on the severity of this pathology and the patient's response. The drug should be used at the lowest effective dosage. The application period should also be as short as possible.
The initial dose is adjusted until the desired therapeutic effect is obtained. After that, the dose of the drug "Diprospan" is gradually reduced to maintenance. In the absence of a positive result from the ongoing treatment or with its duration, the drug is canceled, also slowly reducing the dose. According to doctors about "Diprospan" from psoriasis, this happens extremely rarely.
The introduction of a drug into the lesion or into soft tissue structures with a pronounced local effect can simultaneouslylead to systemic action.
Because of the potential for anaphylactoid reactions, it is recommended to take precautions before using the drug, especially if you have a history of allergic reactions to medications.
Diprospan contains two active ingredients, both of which are betamethasone compounds. One of these - betamethasone sodium phosphate - is a rapidly soluble fraction, due to which it is able to quickly penetrate into the systemic circulation. Therefore, consider the possible systemic effect of this drug.
"Diprospan" helps with psoriasis quite effectively. But against the background of the use of the drug, various mental disorders are possible, especially in patients with emotional instability or a predisposition to psychosis. When it is administered to people with diabetes, correction of hypoglycemic treatment is required.
Patients receiving this medicine should not be vaccinated against smallpox. Other immunizations should also not be carried out, due to the possibility of neurological complications and a decrease in the immune response. Implementation of immunization is possible during substitution treatment. Patients receiving the drug "Diprospan" in dosages that depress the immune defense should be warned about the need to avoid contact with patients with measles and chickenpox.
Drug Interactions
During the combined use of the drug "Diprospan" with phenobarbital,phenytoin, rifampin or ephedrine may increase the metabolism of betamethasone while reducing its therapeutic efficacy.
When used together with indirect anticoagulants, blood clotting disorders are possible, which requires dosage adjustments.
When used simultaneously with potassium excreting diuretics, the risk of hypokalemia increases.
The drug can activate the processes of potassium excretion, which is due to amphotericin B.
When used together with estrogens, dosage adjustment of drugs may be required (due to the risk of overdose).
Concomitant use of this medicine with cardiac glycosides increases the risk of digitalis intoxication and arrhythmias.
When combined with NSAIDs and ethanol-containing drugs, an increase in the incidence of ulcerative lesions of the digestive system is possible.
Simultaneous administration of a drug and somatotropin can lead to inhibition of the absorption of the latter. Below will be reviews of "Diprospan" from psoriasis by doctors and patients.
Doctors' opinion
Medical specialists in the field of dermatology characterize the drug as a highly effective hormonal drug used to eliminate severe symptoms of inflammatory processes. According to doctors, "Diprospan" from psoriasis helps to quickly eliminate the manifestations of the disease, significantly reduce the likelihood of developing numerous complications, improve the appearance of the skin and psychological statepatient.
Nevertheless, doctors point out the numerous side effects of the drug, among which there can be very life-threatening conditions. With this in mind, they warn patients that they should not use it on their own - before starting treatment, it is necessary to consult a doctor who will study the clinical picture of the disease, conduct all the necessary diagnostic studies, select the most appropriate treatment tactics and dosage of the drug.
Patient testimonials
Regarding the pharmacological agent, in addition to doctors, leave comments and numerous patients suffering from such an unpleasant ailment and who have undergone therapy with this medication. Positive feedback from patients about "Diprospan" from psoriasis reflects the information that the drug is excellent at helping to stop the symptoms of the disease. Patients note that inflamed psoriatic plaques heal quickly, signs of inflammation disappear, the skin acquires a natural color and he althy appearance. Since the drug has a hormonal origin, the improvement in the condition of patients was observed quite quickly.
Negative feedback from patients about "Diprospan" from psoriasis in most cases describe a variety of side symptoms against the background of the use of the suspension. Patients indicate the occurrence of dyspeptic phenomena that occur with the development of nausea attacks, digestive disorders. These are the most common side effects from the use of the drug. less oftenthere were various disorders in the functioning of the nervous system. At the same time, patients experienced depression, mood changes, increased anxiety, headaches, and panic attacks.
We reviewed the instructions and reviews of Diprospan injections for psoriasis. We hope that now the features of the medication have become clearer to you.
