Nootropic drugs are drugs that stimulate metabolism in nerve cells and improve the thought process. These drugs include Neipilept. The drug is produced in the form of a solution for intravenous or intramuscular use. You will learn about the features of treatment with this drug later in the article.
Composition of "Neipilept"
The composition of the preparation for parenteral administration includes the following substances:
- citicoline sodium;
- caustic soda;
- water for injection;
- hydrochloric acid solution.
Composition of 1 ml oral solution:
- citicoline sodium;
- methyl ester of para-hydroxybenzoic acid;
- sodium citric acid;
- potassium s alt of sorbic acid;
- p-hydroxybenzoic acid propyl ester;
- citric acid;
- glycine;
- glucite;
- sodium s alt of saccharin;
- water;
- flavourstrawberry.
According to the instructions and reviews for Neipilept, there are no pills. The drug is produced only in the form of a solution.
Pharmacological actions
The drug has a wide range of effects. By influencing the mechanisms of apoptosis, the drug prevents cell death, and by preventing the increased formation of free radicals, it helps to regenerate broken cell membranes.
In case of traumatic brain injury, "Neipilept" helps to reduce the duration of the recovery period, reducing the severity of neurological signs and the duration of post-traumatic coma. In acute stroke, the drug reduces the amount of damage to brain tissue.
The drug reduces the manifestation of memory loss. "Neipilept" improves attention and consciousness. The drug has increased effectiveness in sensory and motor neurological lesions of vascular and degenerative etiology.
Prescription conditions
"Neipilept" is recommended for admission in the following cases:
- Memory loss.
- Deterioration of mental performance.
- Decrease in cognitive functions (mental processes, thanks to which a person gets the opportunity to perceive, transmit, analyze and remember various information).
- Violation of the bones of the skull or soft tissues.
- Acute and recovery period.
- Spicyperiod of ischemic stroke (failure of brain microcirculation with damage to brain tissue, violation of its functions due to difficulty or cessation of blood flow to a particular department).
- Hemorrhagic stroke (acute cerebrovascular accident with cerebral hemorrhage).
Contraindications
The drug is prohibited for use under the following conditions:
- Severe vagotonia (a form of vegetovascular dystonia, in which the parasympathetic division of the autonomic nervous system becomes more active and suppresses the functions of the sympathetic division).
- Under the age of eighteen.
- Breastfeeding.
- Increased sensitivity.
Annotation to the medicine
Neipilept injection solution is used intramuscularly, as well as intravenously. Jet (within five minutes) or drip (at a rate of forty to sixty drops per minute).
From the reviews and instructions for "Neipilept" it is known that intravenous administration is most preferable. It is necessary to alternate the sites of parenteral administration. Neipilept should be used immediately after opening the package. The drug is compatible with all solutions.
Oral solution is taken orally with meals, dissolved in a small amount of water. Specific dosages and duration of therapy in each situation are determined individually, depending on the disease and the severity of the symptoms of the disease.
General recommendations:
- In an acute period of cranio-brain injury and ischemic stroke, 1,000 milligrams every twelve hours for at least 6 weeks.
- For behavioral and cognitive impairment in vascular and degenerative lesions of the brain, the recovery period after hemorrhagic and ischemic strokes, it is advised to use from 500-2000 mg per day.
Negative reactions
In most situations, the drug is well tolerated by patients. According to reviews and instructions for use for Neipilept, in rare cases, the following side effects may occur:
- Loss of appetite.
- Diarrhea (a pathology in which a person has frequent bowel movements, while the stool becomes watery).
- Nausea.
- Gagging.
- Feeling hot.
- Insomnia (sleep disorder, expressed by superficial, interrupted sleep, delayed onset or early awakening).
- Migraine (a neurological disease characterized by periodic or regular attacks of headache on one side).
- Hallucinations (an image that appears in the mind without an external stimulus).
- Dizziness.
- Excitement.
- Tremor -something averagevalue).
- Shortness of breath (impaired breathing, which is accompanied by a change in its frequency and depth).
- Edema.
- Rashes.
- Itchy skin.
- Anaphylactic shock (an acute and extremely severe allergic reaction that develops as a result of repeated exposure to the allergen).
- Orthostatic hypotension (a syndrome that is characterized by a violation of the body's ability to maintain a normal level of blood pressure in an upright position).
- Increased blood pressure.
- Tachycardia (a sharp increase in heart rate, a sign of serious disorders).
- Thrombocytopenia (a pathological condition characterized by a decrease in the number of platelets circulating in the peripheral blood).
- Amenorrhoea (absence of menstruation for 6 months in a woman who previously had a normal menstrual cycle; absence of menstruation in girls under 16).
- Dysmenorrhea (a cyclic pathological process in which severe pains in the lower abdomen appear during menstruation. These pains may be accompanied by other symptoms: general weakness, nausea, vomiting, headache).
- Decreased libido (a disorder of sexual function characterized by lack of sexual desire).
- Hypervolemia (violation of the circulating blood volume through the blood vessels in the direction of increase).
- Hyperglycemia (a clinical symptom indicating an increase in serum glucose compared to normal).
What other negative manifestations can causedrug
According to reviews and instructions for use for Neipilept injections, as well as oral solution, the medication can cause certain side effects:
- Priapism
- Polyuria (increased amount of urine excreted per day).
- Urinary incontinence.
- Anorgasmia (lack of orgasm with sufficient sexual stimulation).
- Rhinitis (inflammation of the mucous membrane of the nasal cavity, which is characterized by swelling, congestion, secretion of mucous or serous secretion, deterioration of well-being and impaired sense of smell).
- Galactorrhea (a pathological process in which a milky liquid is secreted from the chest).
- Gynecomastia (breast enlargement with hypertrophy of glands and adipose tissue).
- Thrombopenia (reduction of platelets in the circulating blood).
- Thrombocytopenic purpura (a disease characterized by low levels of platelets in the blood).
- Rigidity (inability to easily change one's positions, opinions, actions in accordance with the situation).
- Hypokinesia (a state of insufficient motor activity of the body with limited pace and range of motion).
- Hypersalivation (increased secretion of saliva as a result of increased activity of the salivary glands).
- Akathisia (a syndrome characterized by an unpleasant feeling of internal motor restlessness, as well as an internal need to move orchange position, and manifests itself in the inability of the patient to sit quietly in one position for a long time or to remain motionless for a long time).
In rare situations, during treatment with Neipilept, activation of the parasympathetic system is noted, as well as a short-term change in blood pressure.
Features
When treating human patients with persistent intracranial hemorrhage, dosages of 1000 mg per day should not be exceeded. The drug is recommended to be administered drip, intravenously, at a rate of 30 drops per minute.
Crystals may form in the oral solution when cold, due to temporary partial crystallization of the preservative. In the future, with proper storage, they dissolve after a few months. These phenomena do not affect the effectiveness of the drug.
From the instructions and reviews for Neipilept, it is known that during treatment, patients should be especially careful while driving, as well as performing work that requires increased attention.
Use during pregnancy and lactation
There is no information on the safety of using the drug during the "interesting situation", so "Neipilept" can only be prescribed in situations where the probable benefit of therapy is higher than the risks.
Women during lactation, if treatment is necessary, should decide with the doctor on the termination of breastfeeding, sincethere is no information on the excretion of the active ingredient of the drug with breast milk.
Use in childhood and old age
There is no clinical information on the effectiveness and safety of using the drug in pediatrics, so Neipilept is not recommended for the treatment of children and adolescents under eighteen years of age. Patients of retirement age do not require dosage adjustments.
Does Neipilept interact with other drugs
According to the instructions, the drug can not be used in conjunction with drugs that include meclofenoxate in their structure. "Neipilept" when used simultaneously with levodopa enhances the effect of the latter.
Generics
According to reviews, analogues of "Neipilept" (injections and solution) are:
- "Quinel".
- "Neuroxon".
- "Neurocholine".
- "Recognan".
- "Proneiro".
- "Citimax".
- "Piracetam".
- "Bifren".
- "Phenibut".
- "Ceraxon".
- "Axobrex".
- "Aminalon".
- "Vasavital".
- "Ceresil Canon".
Neipilept's shelf life is twenty-four months. Keep the drug should be at a temperature of up to twenty-five degrees Celsius in a placeinaccessible to children. The medication is dispensed with a prescription from a specialist. The cost of the medicine varies from 350 to 1000 rubles.
Solution for oral administration and injections of "Neipilept": reviews of doctors and patients
Reactions about the drug are usually positive. The drug is well tolerated, almost has no restrictions. In addition, Neipilept improves the condition, including after a stroke or traumatic brain injury.
According to the responses, the drug is successfully used to provide a direct stimulating effect on learning, mental activity.
Patients in the reviews of "Neypilept" talk about the increased effectiveness of the drug in memory deterioration, as well as mental performance. The drug is recommended for use by most doctors, it is excellent for cerebrovascular accidents.
The opinions of medical specialists about the drug, as well as the responses that people leave on the forums, confirm that Neipilept is effective both in the acute period and during recovery after a stroke.
