What can replace such a remedy as "Artra MSM Forte"? Analogues of this drug will be listed at the end of the article. You will also learn about the form in which this medication is produced, what users say about it, and how to use it correctly when there are indications for use.
Medication form, composition, description and packaging
"Artra MSM Forte" - tablets biconvex, oval, film-coated. They may have a light yellow-orange or dark orange color, as well as a specific smell.
The main ingredients of this medicine are sodium chondroitin sulfate, methylsulfonylmethane, glucosamine hydrochloride and sodium hyaluronate in the form of hyaluronic acid.
As for additional ingredients, they include microcrystalline cellulose, croscarmellose sodium, calcium hydrogen phosphate dihydrate, stearic acid, colloidal silicon dioxide and magnesium stearate.
The composition of the film shell of the drug in question includes: orange opadry II, talc, triglycerides,m altodextrin, dye sunset yellow.
Artra MSM Forte tablets are on sale in white bottles with a screw cap made of dense polyethylene.
Pharmacodynamic characteristics
What is Artra MSM Forte? Reviews of experts say that this medication is a stimulator of regenerative processes in cartilage tissues. The active ingredients of this drug are involved in the synthesis of connective tissues, and also prevent the destruction of cartilage and stimulate the regeneration of its tissues.
The use of exogenous glucosamine significantly enhances the production of cartilage matrix and protects (non-specifically) cartilage from possible chemical damage.
Product features
What are the remarkable tablets "Artra MSM Forte"? The instruction reports that the glucosamine contained in this drug in the form of a sulfate s alt is a kind of precursor of hexosamine. As for the sulfate anion, this substance is necessary for the production of connective tissue mucopolysaccharides.
Not to mention that glucosamine has another supposed function. This is the protection of already damaged cartilage tissues from their further destruction, which was caused by the use of GCS or NSAIDs.
What role does chondroitin play in Artra MSM Forte? According to the instructions, this component performs the work of an additional substrate that promotes the formation of a he althy cartilage matrix.
It should also be noted that chondroitin:
- stimulates the mechanisms of cartilage tissue repair;
- stimulates the synthesis of type II collagen, hyaluronan and proteoglycans;
- suppresses the action of enzymes that break down cartilage (elastase and hyaluronidase);
- suppresses free radical activity and also protects hyaluronan from degradation caused by enzymes and the aggressive action of free radicals;
- maintains proper synovial viscosity.
In addition, in people suffering from osteoarthritis, this substance eliminates the signs of the disease and reduces the need to take NSAIDs.
Kinetic ability
How are the active substances of Artra MSM Forte 60 absorbed? The bioavailability of glucosamine when taken orally is 25%. In the human body, this substance is found in the highest concentration in the kidneys, cartilage of the joints and liver.
About 1/3 of the dose taken remains in the bone tissue and muscles for a very long time. At the same time, most of the substance of this element is excreted by the kidneys unchanged, and the remainder - along with feces. The half-life of glucosamine is 68 hours.
After oral administration of 800 mg of chondroitin sulfate, its plasma concentration increases dramatically throughout the day. At the same time, the indicator of absolute bioavailability is 12%.
About 1/10 of the dose taken is absorbed as high molecular weight derivatives, and approximately 20% as low molecular weight metabolites.
This component is metabolized bydesulfurization. It is excreted from the patient's body by the kidneys. Its half-life is approximately 5 hours.
Indications for prescribing pills
In what diseases is the drug "Artra MSM Forte" most effective? Reviews of sick people report that this drug helps well with:
- osteochondrosis of the spine;
- osteoarthrosis of peripheral joints.
Prohibitions on prescribing medication
What are the contraindications to the use of tablets "Artra MSM Forte"? Experts say that this medication is not recommended for:
- carrying a fetus, that is, during pregnancy;
- during breastfeeding;
- in children under 15;
- high sensitivity to drug substances.
Also, this remedy is used with caution in violation of blood clotting, diabetes, bronchial asthma and intolerance to various seafood (including shrimp, shellfish).
The drug "Artra MSM Forte": instructions for use
What dosage should I take the medication in question? The attached instructions say that in the first three weeks of therapy, the tablets should be taken twice a day (one at a time). In subsequent weeks and months, the frequency of applications is reduced to once a day.
The drug in question is intended for the treatment of peopleover 15 years of age. It should be noted that the therapeutic effect and absorption of the active substance of this drug does not depend on the time of day, as well as food intake.
To achieve a stable therapeutic result, at least six months of therapy is required.
As an addition to the main treatment in order to improve the functional state of the musculoskeletal system, patients can be recommended capsules "Artro-Active". The daily dosage of such a dietary supplement is 4-6 capsules.
Treatment with the agent in question is carried out in courses lasting from two weeks to a month. The optimal time interval between courses is 14 days.
Negative actions
What are the side effects after taking Artra MSM Forte tablets? According to experts, against the background of the use of glucosamine, such digestive disorders as bloating or flatulence, constipation, pain in the epigastric region and diarrhea are very often recorded. It is also possible to develop the following negative reactions:
- headaches;
- dizziness;
- peripheral edema;
- drowsiness or, conversely, insomnia;
- allergy skin manifestations;
- pain in the legs;
- tachycardia.
It is impossible not to say that taking chondroitin often provokes the development of hypersensitivity reactions.
Overdose cases and interactions with other medicines
About cases of overdose with Artra MSM tabletsForte nothing is known today. However, experts say that when taking a large number of tablets (more than 10 pieces), the patient may experience nausea, diarrhea, hemorrhagic rashes and vomiting. Treatment of this condition is symptomatic (i.e. gastric lavage is required).
How does Artra MSM Forte interact with other drugs? The agent in question increases the absorption of tetracyclines, and also reduces the effect of semi-synthetic penicillins. It cannot be said that this medication is compatible with NSAIDs and GCS. At the same time, against the background of its use, it is possible to enhance the action of antiplatelet agents, indirect anticoagulants and fibrinolytics.
Special Information
With the development of adverse reactions from the digestive tract, it is recommended to reduce the dosage prescribed by the doctor to a minimum. If after this improvement does not occur, then you need to stop taking the medication.
It is highly undesirable to give Artra MSM Forte tablets to children under 15 years of age due to the lack of any scientific data for this category of people.
The drug in question does not have any effect on the process of driving a car, as well as the management of other dangerous mechanisms.
Similar drugs and drug costs
How much does the drug we are considering cost? Its price in the Russian Federation is approximately 750 rubles for 30 tablets.
If the effectiveness of this drug does not suit you, then it can be replaced with one ofthe following analogues: "KONDRONOVA", "Teraflex", "Tazan", "Chondroflex", "Adgelon", "Chondrogluxide", "Alflutop", "Gamma Plant", "Biaartrin", "Diskus Compositum", "Traumeel S", Synovial, Rumalaya, SINOART, Target T, Chondrotek Forte.
Reviews
Patient reviews about the drug in question are controversial. Some patients claim that within three months after starting to take this medication they felt a significant improvement, while other people say that already in the first days of treatment they experienced the development of unpleasant side effects and did not see the results of therapy at all.
According to experts, the peculiarity of this medication is that it contains active substances that are natural structural components of cartilage tissue and intra-articular fluid. Thus, the effect of the use of this drug is directly related to the replenishment of the deficiency of the mentioned compounds in the human body. It should be noted that most doctors are not very satisfied with the results of using the remedy in question. They argue that this medication cannot be used as the main drug. It is permissible to use it only for adjuvant therapy, in conjunction with other more effective means.
