If your doctor has diagnosed a "viral infection", then this means that it needs to be treated appropriately. A fairly large group of our fellow citizens believe that antibiotics are the best remedy for all diseases. Unfortunately, this erroneous opinion can cause much more harm than the malaise itself. Antibiotics are active only against a bacterial infection, and they are powerless against viruses.
How does the drug work?
There are a fairly large number of drugs with antiviral activity. One of the most common substances with this property is pentanedioic acid imidazolylethanamide.
It is active against influenza A and B pathogens, adenoviruses, helps with parainfluenza and respiratory syncytial infection.
This active substance has a unique mechanism of action. It suppresses the reproductive process in viruses at the nuclear phase stage, and also delays migration.newly synthesized infectious agent from the cytoplasmic medium to the cell nucleus.
Also, pentanedioic acid imidazolylethanamide is actively involved in the human immune system, exerting a modulating effect. The substance increases the content of interferon in the blood to the level of the physiological norm. It also has a stimulating effect on the process of α-, γ-interferon production by leukocytes, bringing these functions into the appropriate state.
Studies of this active substance have shown that pentanedioic acid imidazolylethanamide promotes the generation of cytotoxic lymphocytes. In addition, it increases the number of NK-T agents, which have an unsurpassed ability to destroy cells transformed by viruses, and also act directly on infectious agents.
The advantage of the medicinal substance is that it has anti-inflammatory properties. They are provided by suppressing the production of profile cytokines, as well as a decrease in the activity of the enzyme myeloperoxidase.
Therapeutic effect
Imidazolyl ethanamide pentanedioic acid, reviews of which are positive, exhibits the following therapeutic effect in the treatment of SARS and influenza:
- Reduces the duration of the hectic process.
- Reduces signs of body intoxication (dizziness, pain, general weakness).
- Reduces the number of catarrhal manifestations.
- Minimizes the complications of past illness.
- Shortensperiod of illness.
Pentanedioic acid imidazolylethanamide preparations
In the pharmacy you can find the following preparations containing imidazolylethanamide pentanedioic acid:
- "Vitaglutam" in the form of powders.
- "Ingavirin" in the form of capsules.
- Dicarbamine tablets.
Contraindications
Like all medicines, pentanedioic acid imidazolylethanamide is a medicine that must be prescribed by your doctor. This pharmaceutical product has contraindications, including:
- Pregnancy and lactation.
- Children under 18.
- Individual intolerance to the components of the drug.
Side effects from taking medicines containing the described active substance can be expressed as an allergic reaction.
This effect occurs under the condition that a person has an individual sensitivity to pentanedioic acid imidazolylethanamide or to excipients that are part of the drug.
Safety
Some people tend to avoid this drug, believing that pentanedioic acid imidazolylethanamide is an antibiotic. This opinion is erroneous, since this active substance exhibits only antiviral activity. The named quality deprives him of all those side effects that are inherent in antimicrobial drugs. This medicinal product has no immunotoxic, carcinogenic,mutagenic or allergenic, does not irritate the gastrointestinal tract, does not reduce reproductive function, does not have a teratogenic or embryotoxic effect.
A rather high activity of drugs containing imidazolylethanamide pentanedioic acid, analogues of which are taken orally, has been noted. They are rapidly absorbed in the gastrointestinal tract and evenly distributed in organs and tissues. Already half an hour after ingestion, this medicinal substance reaches its maximum concentration and is retained in the blood for 37 hours. The duration of treatment is 5 days. With each dose of the drug, there is a jump in its content in the blood, which slowly decreases during the day. The drug is not metabolized in the human body, it is excreted unchanged by the kidneys and intestines.
Reception Feature
It is very important to follow the dosage regimen for this drug. Imidazolylethanamide pentanedioic acid, its analogues are characterized by approximately the same recommendation for use, should be taken orally once a day in an amount of 90 mg for a period of 5-7 days, regardless of food intake.
The peculiarity of the treatment with this pharmaceutical agent is that the greatest efficiency is achieved when taken after the first signs of the disease are detected within the first two days.
Vitaglutam is the source of a group of antiviral drugs
The history of this drug dates back to the 70s of the last century. It was developedfamous Russian pulmonologist Alexander Chuchalin. This medicinal product contains pentanedioic acid imidazolylethanamide as the main active ingredient. "Vitaglutam" until 2008 was presented for sale under the trade name "Dicarbamine". Its purpose was to stimulate the process of hematopoiesis in patients who had undergone cancer treatment.
In 2009, humanity faced a terrible viral infection - swine flu, or A/H1N1. At this time, the development of Vitaglutam turned out to be very relevant. Alexander Chuchalin, who at that time was the chief therapist of the Russian Federation, decided to test his offspring against the swine flu virus and achieved successful results. He stated that the domestic drug, which is based on pentanedioic acid imidazolylethanamide, Vitaglutam, is much more effective against a formidable infection than the American pharmaceutical product Tamiflu. It actively integrates into the viral genome and destroys it.
New life of Vitaglutam: Ingavirin
Chuchalin made a proposal to Gennady Onishchenko, the chief sanitary doctor of the Russian Federation, to use his invention as an effective tool in the treatment of swine flu. As a result, clinical trials of the drug were carried out, during which it confirmed its effectiveness against various viral infections. The drug received a new name "Ingavirin" and was registered in the register of a group of antiviral and immunostimulating drugs.
After this product of the pharmaceutical company "Valenta" went on sale, it was officially recommended by the Ministry of He alth as a remedy for swine flu and began to break records of popularity among the population. Thus, we can say about the parallel "Dicarbamine" - imidazolylethanamide of pentanedioic acid - "Vitaglutam", that this is, in fact, the same medicine.
It is worth noting the fact that Ingavirin went on sale in 2008 without full-fledged clinical trials. With the assistance of Onishchenko in 2009, accelerated clinical trials on laboratory mice were organized. About 100 patients also took part in this event. Based on the results obtained during the study, a group of scientists led by Chuchalin concluded that Ingavirin showed high efficiency against pathogens during the first 48 hours from the onset of infection. Its action was expressed in the reduction of the febrile period, the reduction of intoxication of patients and laboratory animals and the reduction of catarrhal manifestations.
Therefore, there is no reason to think that pentanedioic acid imidazolylethanamide is a dummy - its effectiveness has been clinically proven.
Dicarbamine today
Currently, all three drugs based on imidazolylethanamide pentanedioic acid are commercially available and are positioned as analogues of each other.
Dicarbamine is recommended foruse by patients with malignant tumors. In addition to the main active ingredient, it contains milk sugar, talc, potato starch, magnesium stearate, colloidal silicon dioxide and stearic acid.
"Dicarbamine" has the following therapeutic effects:
- Acceleration of neutrophil differentiation and their functional maturity.
- Hematoprotection in myelosuppressive chemotherapy.
- Reduce the incidence and degree of toxic neutropenia, limiting leukopenia.
This drug is recommended for use between chemotherapy courses.
It's effective after 21-28 days of taking the pills daily.
A single dose of the drug - 100 mg (1 tablet) - is taken 5 days before the start of the course of chemotherapy and continues throughout the treatment. "Dicarbamine" has the ability to enhance and prolong the action of antitumor cytostatics, reduce the toxic effects of cyclophosphamide and platinum-based drugs, and also normalize hematopoiesis.
