The drug "Sydnopharm" is an active peripheral agent that can expand the lumen of blood vessels and reduce pressure in them. Also, the drug helps to prevent and relieve angina attacks, is used to treat other symptoms of coronary insufficiency.
How the drug works
Means "Sydnopharm" is a donator of nitric oxide, released with the help of the drug in the process of metabolic reactions. This binary compound stimulates production
soluble guanylate cyclase, an increased concentration of which leads to relaxation of smooth muscle tissue in the vessels. As a result, the load on their walls is reduced, and as a result, the balance between the need for oxygen and its entry into the blood is restored. Narrowed vessels, which are capable of stretching, expand under the influence of the drug "Sydnopharm".
Also, the drug slows down the release and synthesis of thromboxane and serotonin, whichleads to the suppression of the early phase of aggregation of these enzymes and the prevention of blood clotting.
Pharmacological action
How does the drug "Sydnopharm" biologically act on the human body? Instructions for use states that as a result of the use of this agent in the lateral (bypass) pathways of blood flow, blood circulation improves. Also, the drug increases exercise tolerance and reduces the frequency of angina attacks that occur with physical efforts.
Among other things, the drug "Sydnopharm" narrows the chambers of the heart in case of chronic heart failure, lowers pressure in the arteries of the lungs. As a result of this effect, the left ventricle of the main human organ is less filled with blood, and myocardial muscle tension decreases.
Duration of drug action
How quickly does the patient's condition improve when he takes Sydnopharm? Reviews of numerous patients and instructions for use indicate that it is well and quickly absorbed by the digestive system. The effect of the drug "Sydnopharm" can be seen 20 minutes after its ingestion or after 5-10 minutes if you put the pill under the tongue. The peak reaction of the body to the drug is observed between 30 and 60 minutes after taking it. Effective for 6 hours.
Medication "Sydnopharm" practically does not bind to plasma proteins. The process of drug metabolism occurs in the liver, and it is excretedmostly through the kidneys. In the case of long-term therapy with this drug, resistance does not occur.
Sydnopharm tablets: indications for use
The drug is used in medicine in the following cases:
1. For relief and prevention of angina attacks.
2. With myocardial infarction at the stage of stabilization of hemodynamic parameters.
3. In acute left ventricular failure.
4. With increased pressure in the pulmonary circle of blood flow.
5. With chronic heart failure.
In the latter case, there is one feature of the use of the drug "Sydnopharm". Indications for its use in such a situation are diseases in which it is necessary to take more glycosides and diuretics in combination with the presented medicine.
How to use
In order to avoid complications and overdose, only a doctor should prescribe Sydnopharm. Indications for the use of this drug determine its use inside during or after a meal. It is necessary to take the tablets with water in sufficient quantity.
In order to prevent angina attacks, the drug "Sydnopharm" is prescribed 1-2 mg to be taken 4 to 6 times during the first and second days of treatment, 2-4 mg to be taken 2-3 times during each subsequent days. Sometimes the dose is increased to 6-8 mg or more, but the maximum is 12 mg.
The drug is dosed individually in each case. Histhe required amount for therapy depends on the stage and type of the disease, as well as on the symptoms. Depending on the course of the disease, the duration of the course of treatment is also prescribed.
Side effects
Does the use of Sydnopharm tablets have negative consequences? Instructions for use of the drug informs that the remedy can provoke the onset of a headache at the initial stage of its administration. After a short period of time, the feeling disappears.
Also, when using the drug "Sydnopharm", a decrease in blood pressure is possible, sometimes to the point of collapse. Occasionally, there is a slowdown in motor and mental reactions. This feature of the drug when using it must be taken into account by drivers of vehicles and people of other professions that require concentration and quick decisions in the workplace.
Among other things, due to the use of Sydnopharm tablets (patient reviews confirm the data), side effects such as nausea, itching, dizziness, skin rashes and other allergic reactions can be observed.
Contraindications
Pathologies in which the use of the drug "Sydnopharm" is contraindicated:
- acute stage of myocardial infarction;
- glaucoma (especially angle-closure);
- craniocerebral, arterial hypertension;
- vascular collapse;
- circulatory disorders of the brain;
- pregnancy (first trimester) and lactation;
- old age;
- individual intolerance to the drug.
Interaction with other drugs
Is it permissible to use tablets with other medicines during therapy
Sydnopharm? Instructions for use of the drug states that the drug can be used simultaneously with calcium antagonists and beta-adrenergic blockers.
When using the drug "Sydnopharm" for medicinal purposes, it is necessary to completely exclude the ingress of alcohol into the body.
Features of the use of the drug
When should you use Sydnopharm with extreme caution? The instruction for its use explains that one should be wary of unforeseen reactions of the body to the drug in case of impaired blood circulation of the brain, with increased intracranial pressure, with arterial hypotension, glaucoma, and also in the period after a hemorrhagic stroke or after myocardial infarction.
Elderly patients with kidney or liver failure should consume the minimum amount of Sydnopharm tablets. Instructions for use of the drug also warns that the dye E110, which is contained in this drug, can cause allergic reactions.
During pregnancy, it is necessary to carefully analyze the ratio of risk to the fetus and benefit to the expectant mother before starting treatment with Sydnopharm. The use of the drug during lactation is strictly contraindicated. If applicationmedication is vital at this time, then breastfeeding must be stopped. Children and adolescents under 18 years of age are also prohibited from using this medicine.
Overdose
What are the consequences when Sydnopharm tablets are taken in excess? First of all, this is fraught with a sharp decrease in blood pressure. This causes dizziness, nausea, vomiting.
Treatment for overdose depends on symptoms. A prerequisite is measures aimed at the speedy cleansing of the body from the drug "Sydnopharm" - forced diuresis or gastric lavage.
Issue form
Sydnopharm is produced in the form of tablets of 4 mg or 2 mg, as well as in the form of prolonged-release pills of 8 mg. The drug is packaged in contour cellular plates. Each of them contains 10 tablets. The records are packed in cardboard boxes of 3 pieces (one box contains 30 pills).
Storage conditions
Sydnopharm tablets are potent medicines. They must be stored for no more than three years in a cool, dry place out of the reach of children, at a temperature of 15 to 25ºС.
Composition
The main active ingredient in Sydnopharm is molsidomine. The auxiliary components of the drug include Avicel PH 101, mint oil, starch, hydroxypropyl methylcellulose, lactose, magnesium stearate, aerosil 200,mannitol.
Analogues
Can I replace Sydnopharm tablets with other drugs? Analogues of this drug exist. These include medicines "Dilasid", "Corvamin" and "Corvaton". The characteristics of each are listed below.
Drug "Dilasidom" ("Dilasidom"). Produced in Poland. Its active substance is, as in Sidnopharm, molsidomine (molsidomine). According to the anatomical-therapeutic-chemical (ATC) classification, the drug "Dilasid" refers to peripheral vasodilators used to treat heart diseases and antianginal drugs.
Means "Corvamin" ("Corvamin"). Produced in the Netherlands. The active substance of the drug is also molsidomine. According to the ATC classification, the drug "Corvamin" refers to antianginal drugs and peripheral vasodilators, which are used in the treatment of heart diseases.
The medicine "Corvaton". Produced in Germany. The active, main substance of this remedy is, like other analogues of Sidnopharm tablets, molsidomine. According to the ATC classification, the drug "Corvaton" is included in the group of antianginal drugs and peripheral vasodilators, which are used to treat heart ailments.
Under no circumstances is it recommended to use Sydnopharm tablets or their analogues without a doctor's prescription. Self-medication can lead toirreversible negative consequences. It is also strictly forbidden to change the dosage and duration of the course of therapy, according to your own feelings, without consulting a doctor.
