"Ciprofloxacin" is a universal antibacterial drug, which compares favorably with a wide spectrum of action. The drug belongs to a large fluoroquinolone group of first-generation antibiotics. The universal composition of the drug is able to suppress the growth and reproduction of pathogenic microorganisms. Analogues of "Ciprofloxacin" in tablets are of interest to patients only in cases where they have contraindications to the use of this drug.
Pharmacological principle of action
Tablets "Ciprofloxacin" 500 mg in their antibacterial spectrum of influence on the human body are similar to other fluoroquinolones. The drug is highly active. Manufacturers produce the drug in the form of injections and tablets for oral use. It is better to take pills on an empty stomach so that the active substance is absorbed into the blood faster. The maximum plasma concentration of the drug is observed 2 hours after taking the tablets. The injections begin to work 30 minutes after the injection.
The drug is excreted after 24 hours with urine. The components practically do not bind to plasma proteins. The substance perfectly penetrates into tissues and organs, passes through the blood-brain barrier.
Composition and release form
What are the analogues of "Ciprofloxacin" in tablets, indications and contraindications? The drug has a wide range of applications, which is due to the universal composition of the drug. One tablet contains 250 or 500 mg of ciproflox tin.
Auxiliary components of the drug:
- Corn starch.
- Microcrystalline cellulose.
- Talc.
- Sodium glycol starch.
- Macrogoal 400.
- Magnesium stearate.
- Silicon dioxide.
The drug is also available in the form of a 0.2% solution for infusions of 50 or 100 ml. There are also ampoules of 1% of the substance, 10 ml each (this concentrate must be diluted with special preparations before use).
Indications for use
Before considering analogues of "Ciprofloxacin" in tablets, you need to familiarize yourself with the cases in which this medicine is used. The drug is prescribed for effective treatment and prevention of infectious and inflammatory pathologies.
The drug is used to combat such diseases:
- Sinusitis, frontal sinusitis, otitis media, sinusitis, pharyngitis, mastoiditis.
- Chronic or acute bronchitis, cystic fibrosis, bronchiectasis, pneumonia, respiratory infections.
- Gonorrhea, adnexitis, chlamydia, prostatitis.
- Cystitis, pyelonephritis.
- Burns, ulcerative infections, abscesses, phlegmon.
- Bacterial lesion of the gastrointestinal tract, bile ducts, intraperitoneal abscess.
- Prevention of infection after surgery.
- Pulmonary anthrax.
- Osteomyelitis, septic arthritis.
- Complex immunocompromised infections that result from the treatment of neutropenia with specific medications.
Analogues of "Ciprofloxacin" in tablets are prescribed to patients only if the therapy has not given the desired result. For children from 5 to 18 years old, this medication is prescribed to combat cystic fibrosis of the lungs. Solution for infusion is indicated for eye infections and blood poisoning. To understand what the tablets "Ciprofloxacin" 500 mg are from, you need to study the instructions for the drug. Experts note that the pills are effective for routine selective intestinal decontamination.
Contraindications
Before use, you should study the instructions for use of "Ciprofloxacin" in tablets. And analogues should be selected by a doctor. But first you need to consider that this medication should not be taken by those who are hypersensitive to quinolones. The drug is not prescribed to pregnant and lactating women, as well as children and adolescents. In case of impaired renal function, at the first stage givestandard dose, and only then gradually reduce taking into account creatinine clearance. The drug is also not recommended for use in combination with medicines, the action of which is aimed at reducing acidity in the stomach.
Instructions for the use of tablets "Ciprofloxacin"
Analogues of this drug are of interest to patients quite rarely, since in most cases it is well tolerated. The study drug can be taken with or without food. But taking the drug on an empty stomach significantly accelerates the process of absorption of the active substance by the mucous membrane of the gastrointestinal tract. Pills must be washed down with a small amount of non-carbonated water. In each case, the dosage and duration of the therapeutic course are selected individually, as everything depends on the patient's condition.
Standard single dosage of the drug is 500-750 mg, which must be divided into two doses. A maximum of 1500 milligrams of the drug can be consumed per day. Classical therapy is designed for 14 days. But in some cases, the patient needs to take "Ciprofloxacin" for two months.
200 to 400 mg given intravenously. Injections must be done in the morning and evening. The duration of treatment is selected in accordance with the pathology. For more effective therapy, "Ciprofloxacin" must be administered through a dropper. The ophthalmic form of the drug is instilled under the lower eyelid every 3 hours. Gradually increase the interval between procedures. The duration of treatment depends on the disease. The dosage of the drug is significantly adjusted ifThe patient was diagnosed with abnormal liver function.
Adverse reactions
Incorrect use of Ciprofloxacin 500mg tablets can adversely affect the functioning of the whole organism. In such a situation, the following adverse reactions may occur:
- Digestive system: diarrhea, flatulence, nausea, characteristic abdominal pain, cholesterol jaundice, vomiting, hepatitis, anorexia, hepatonecrosis.
- Central nervous system: nightmares, dizziness, sleep disturbance, depression, increased intracranial pressure, cerebral artery thrombosis, hallucinations, fatigue, peripheral paramnesia, nightmares.
- Urinary system: crystalluria, urinary retention, albuminuria, urethral bleeding, polyuria, urinary retention.
- Cardiovascular system: tachycardia, hypotension, facial flushing, bradycardia.
- Hematopoietic system: thrombocytopenia, hemolytic anemia, leukopenia, leukocytosis.
- Lab tests: hyperglycemia, elevated liver transaminases, hyperglycemia, hypoprothrombinemia.
- Arthritis, tendon rupture, arthralgia, myalgia, vasculitis, general weakness, candidiasis, pseudomembranous colitis.
- Local reactions: general soreness, phlebitis, hyperemia.
- Allergic manifestations: urticaria, swelling of the face, shortness of breath, drug fever, petechial hemorrhages, erythema nodosum, Quincke's edema.
Overdose
Negative consequences can be avoided only if you study the instructions for using Ciprofloxacin 500 tablets. Analogues of the drug are needed if the patient has an individual sensitivity to the components of the drug. Exceeding the permissible dosage is fraught with the development of nausea, headache, vomiting, dizziness, muscle cramps, impaired consciousness, hallucinations. In such a situation, doctors recommend washing the patient's stomach, taking an intestinal sorbent. There is no specific antidote.
Analogues of "Ciprofloxacin" in tablets
Without side effects, medicines are extremely rare. The patient can choose a drug with the same active substance or a drug with a similar principle of action, but a completely different composition.
Substitutes for "Ciprofloxacin" in tablets:
- Ciprobai.
- "Tsiprolet".
- "Ekotsifol".
- "Tseprova".
- Procipro.
- Quintor.
- "Tsiprolet".
The patient must first study the instructions for use. Analogues of tablets "Ciprofloxacin" 500 mg are sold in every pharmacy. Drops can be replaced with Rocip, Betaciprol, Ciprolon. The selection of analogues of "Ciprofloxacin" in tablets of 500 mg is best entrusted to the doctor. Only after a full examination and diagnosis of the disease, you can choose the right medicine that will affect the patient's body exclusively from the positive side.
Special Instructions
The drug "Ciprofloxacin" is prescribed with caution in violation of cerebral circulation, which is accompanied by pronounced atherosclerosis of cerebral vessels, epilepsy, mental pathologies, convulsive syndrome, and renal failure. During treatment, the patient must drink plenty of fluids. In order not to provoke the development of adverse reactions, contact with direct sunlight should be avoided.
In patients with alkaline urine, cases of crystalluria have been repeatedly recorded. Experts do not recommend exceeding the allowable therapeutic dose, so as not to aggravate the situation. Pain in the tendons and the manifestation of signs of tendovaginitis are the main signal to stop therapy. The components of "Ciprofloxacin" can suspend the speed of the psychomotor reaction, which must be remembered by patients who work with potentially dangerous mechanisms.
Use of medication during pregnancy and lactation
The safety of using the drug for pregnant women has not been established. The use of "Ciprofloxacin" during pregnancy is possible only if indicated. Physicians must be sure that the benefits to the mother's body will outweigh the risks to the fetus. The active components of the drug are excreted along with breast milk, which is why lactating women need to decide whether to stop breastfeeding or refuse treatment. Drops in periodlactation is used as carefully as possible to minimize the likelihood of negative effects on the fetus.
Interaction with other medicines
Combining "Ciprofloxacin" with multifunctional barbiturates should be accompanied by increased control of the ECG, heart rate and blood pressure. In combination with Didanosine, the absorption of Ciprofloxacin by the mucous membrane of the stomach and intestines is significantly reduced. If the patient combines the medication with Warfarin, this will significantly increase the risk of developing internal bleeding.
Due to the joint use with Theophylline, an increase in the content of the active substance in the blood plasma is possible. This situation is fraught with destructive toxic effects of the drug on the body. The combined use of universal antacids and drugs containing zinc, aluminum, magnesium or iron ions can significantly reduce the absorption of Ciprofloxacin. The minimum interval between taking these medications should be 5 hours.
Multifunctional infusion solution "Ciprofloxacin" is incompatible with all concentrated drugs and drugs that are physically and chemically unstable at acidic pH. It is strictly forbidden to mix the intravenous solution with substances having a pH greater than 7. Adverse reactions can be very unpredictable, which is why it is better not to experiment with your own he alth.
Recommendations from experts
Hemodialysis patients take pills"Ciprofloxacin" is needed only after the procedure. Patients in the elderly need to reduce the standard dosage by 35%. The drug is prescribed with the utmost care when lowering the threshold of convulsive readiness, severe cerebrosclerosis, brain damage. The drug should not be used for serious violations of kidney and liver function. During the treatment period, increased physical activity should be avoided. Be sure to control the level of acidity of urine and drinking regimen. Otherwise, it will be difficult to avoid the development of adverse reactions.
