What do you know about a drug like Komfoderm? Instructions for use, price, reviews, analogues and general characteristics of this medicine are known to few. Therefore, in this article, we decided to present all the information about this medication.
Form, composition and description
Comfoderm, the instructions for use of which are described below, is produced in the form of a white cream with a specific odor (may be without it, and also have a creamy tint).
The active ingredients in this topical formulation are methylprednisolone aceponate and urea. Also, the composition of the medicinal ointment includes auxiliary ingredients, which are presented in the form of liquid paraffin, propylene glycol, polysorbate-80, carbomer interpolymer (type A), trometamol, metipparahydroxybenzoate and purified water.
Healing properties
What is Comfoderm Topical (Cream)? Instructions for use informs that it is a glucocorticosteroid and a keratolytic agent at the same time. Its action is due to the characteristics of the components included in itscompound. Consider their properties in more detail.
Methylprednisolone aceponate is a synthetic, non-halogenated steroid. When used externally, it is able to suppress allergic and inflammatory skin reactions, as well as reactions that are associated with increased proliferation. Such exposure leads to a significant decrease in the objective signs of the inflammatory process (erythema, swelling, weeping) and subjective sensations (itching, irritation, pain, etc.).
It should also be said that when using this substance at the recommended dose, its systemic effect on the human body is minimal.
After prolonged and repeated use of methylprednisolone aceponate on large surfaces of the skin (40-60%), as well as when it is applied under an occlusive dressing, patients do not experience disorders in the adrenal glands, including the level of cortisol does not change.
The substance in question is capable of binding to intracellular glucocorticoid receptors, causing a range of biological effects. In particular, this chemical process leads to the induction of macrocortin synthesis. At the same time, the latter inhibits the release of arachidonic acid and the formation of inflammatory mediators such as leukotrienes and prostaglandins.
What role does urea play in Komfoderm? Instructions for use states that this component has moisturizing and keratolytic effects. It binds water, as a result of which it helps to soften the stratum corneum of the skin.covers.
In addition to keratolytic action, urea also exhibits proteolytic activity.
Kinetics
Is Komfoderm cream absorbed? Instructions for use states that after applying this agent, methylprednisolone aceponate is almost immediately hydrolyzed in the dermis and epidermis.
The most active and main metabolite of this substance is 6alpha-methyl-prednisolone-17-propionate.
The degree of skin absorption of the drug in question depends on the condition of the person's integument and the method of its application (without or with an occlusive dressing).
Percutaneous absorption of the drug in people with psoriasis and atopic dermatitis is about 2.5%, which is slightly higher than in he althy volunteers (about 0.6-1.5%).
When 6alpha-methylprednisolone-17-propionate enters the systemic bloodstream, it quickly conjugates with glucuronic acid, after which it is inactivated.
Metabolites of the drug in question are eliminated mainly through the kidneys, after 16 hours. The active components of this drug do not accumulate in the body. Due to the low absorption of urea when applied topically, the cream is unlikely to have systemic effects.
Indications
From what is Komfoderm (ointment) prescribed? Instructions for use contains the following list of indications:
- microbial eczema;
- allergic dermatitis(pin);
- neurodermatitis, atopic dermatitis;
- true eczema;
- simple contact dermatitis;
- dyshidrotic eczema.
In other words, the drug in question is prescribed for inflammatory skin diseases accompanied by a violation of keratinization, and also showing high sensitivity to treatment with topical glucocorticosteroids.
Contraindications
Comfoderm, the instructions for use of which are required reading for all patients, must not be used when:
- hypersensitivity to the elements of the cream;
- tuberculous or syphilitic processes in the area of drug application;
- viral diseases (including chickenpox, shingles);
- rosacea, perioral dermatitis in the area of application of the ointment;
- any manifestations for vaccination;
- underage.
Medication "Komfoderm" (ointment): instructions for use
The price of the funds in question is about 480-530 rubles. The drug is applied to the affected skin areas in a small layer, once a day.
Duration of continuous and daily treatment with this cream should not exceed 12 weeks. It should be noted that the therapy of facial skin lesions must be carried out for 5 days.
Side effects
What side effects can cause the drug "Comfoderm M2"? Instructions for usereports that such effects occur very rarely. As a rule, they manifest themselves in the form of the following local reactions: itching, erythema, burning, formation of a vesicular rash.
In the event that the drug was used for more than four weeks or on large areas of the skin, the patient may develop skin atrophy or telangiectasia, as well as acneiform changes, striae and systemic effects that are caused by absorption of the corticosteroid.
Also sometimes the drug in question causes hypertrichosis, folliculitis, skin depigmentation, perioral dermatitis and allergic reactions.
Consumer reviews and analogues of Komfoderma
The analogues of this drug include only Advantan cream.
What do patients say about Komfoderm ointment? According to their reviews, the medication in question is a very effective local remedy. Its use allows you to get rid of various skin diseases, including eczema, neurodermatitis and dermatitis. In some cases, this drug is used even for psoriasis.
The disadvantages of the Komfoderm ointment include its high cost, as well as the impossibility of using it in childhood.
