If you need a drug from nitrofurans, then "Furamag" is an excellent representative of this group. The drug has an antifungal effect. Excellent for fighting urogenital and gynecological infections, and is also effective for skin infections and severe burns.
Release form. Capsule composition
"Furamag" is available in capsule form of 50 and 25 mg (usually prescribed for children). There are 3 blisters in a carton box, each containing 10 tablets. Manual included.
One capsule accounts for 43.70 mg of furazadine - the active substance corresponding to furazidin potassium 50 mg.
Excipients include: 50mg magnesium hydroxycarbonate, 3mg talc, 2.5mg cornstarch, and 0.5mg stearyl fumarate.
All ingredients contained in No. 3 hard gelatin capsule: Titanium Dioxide 1.32%, Pigment Yellow (Quinoline) 1.2%, Gelatin 97.48%.
The instructions for use of "Furamag" describe the capsules and their contents. Externally, the capsules are dark yellow in color, there is no smell, soas well as taste. Inside the capsules is a bright orange powder (let's say brown-orange and red-brown shades). Powder content allows particles of different shades: white, orange, brown.
Pharmacodynamics
The agent is antimicrobial and has a wide spectrum of action. Resistance to the drug develops slowly and does not reach a high accumulation. Many antimicrobial agents during therapy can negatively affect the human immune system, inhibiting it. "Furamag" acts in the opposite direction and, conversely, stimulates the immune system.
When the influence of the group occurs, the process of suppression of the respiratory chain and the tricarboxylic acid cycle occurs within microbes and bacteria. In addition, other biochemical inflammatory processes are blocked. As a result, the microbial membranes (cell membranes) are destroyed. Microbes from exposure to nitrofurans begin to release significantly less toxic substances. Due to this effect of the fight, an improvement in the patient's condition to a pronounced suppression of the growth of microflora is observed.
"Furamag" is productive in the fight against gram-positive cocci, gram-negative rods. The reaction mechanism is associated with a slowdown in the synthesis of nucleic acids. Depending on the concentration, it has the ability to kill bacteria and suppress their reproduction in the human body. Instructions for use "Furamaga" indicates that the drug is the most active among all nitrofurans.
Pharmacokinetics
Instructions for the use of Furamag tablets indicate that absorption begins in the small intestine, by inactive ingestion. Absorption of nitrofurans from the nearest part of the small intestine exceeds absorption from the central segment by 3 times. Nitrofurans are difficult to penetrate into the large intestine, and this should be taken into account when taking other drugs in parallel in the treatment of urogenital infections and diseases of the gastrointestinal tract.
Higher bioavailability of the drug is achieved when taken orally as a mixture of potassium furazidin and magnesium hydroxycarbonate in a 1:1 ratio. Based on the instructions for use of the Furamaga tablets, in the acidic environment of the stomach, the conversion of potassium furazidin does not occur.
The drug is evenly distributed throughout the body. A large accumulation of the active substance in the lymph is very important, as it can block the spread of infections through the lymphatic tract. Saliva is able to accumulate about 29% of the component from its accumulation in the blood. The lowest concentration is observed in the cerebrospinal fluid. But bile accumulates a much larger number than in the blood and tissues.
A small concentration in the blood contributes to the rapid leaching of the substance. The maximum saturation in the blood is maintained, reaching 8 hours. In the urine, the component is detected after 4 hours from taking the capsule in higher concentrations than in blood and tissues.
Instructions for the use of "Furamag", as well as patient reviews, confirms that the pH of the urine does not change after takingtablets. Excretion occurs through the kidneys by glomerular filtration and tubular secretion, selectively observed reverse absorption in the tubules.
Furazidin in oxidized urine is not separated, as it refers to a weak acid. With alkalization of urine, the withdrawal of furazidin is enhanced. The substance is slightly biotransformed, with a decrease in the excretory function of the kidneys, the metabolic rate increases.
Indications for use
Urogenital infections, namely: urethritis (acute course), cystitis, pyelonephritis. Infectious diseases that are caused by the sensitivity of microorganisms to furazidin. Also skin infections, infected burns (severe) and gynecological diseases.
In the instructions for the use of Furamag tablets, it is noted that a course of therapy is allowed for urological surgical interventions, cystoscopy, catheterization, etc.
Contraindications
The drug should not be taken when:
- hypersensitivity to drugs of the nitrofuran group;
- pregnancy and lactation;
- renal failure (chronic);
- children's age - up to 3 years.
Instructions for use "Furamag" warns of careful therapy for deficiency of glucose-6-phosphate dehydrogenase.
Side effects
The drug has low toxicity. When therapy with drugs from the nitrofuran group is rare, but still there are such side effects as:
- dizziness and headache;
- loss of appetite, nausea and vomiting;
- polyneuritis;
- liver dysfunction;
- skin reactions (allergy in the form of a rash, rash or itching).
If side effects were noticed during the course of therapy with Furamag, then you should consult your doctor.
No influence on the functions of driving a vehicle and other electrical mechanisms was noted.
Method of administration and dosage
The package contains full instructions "Furamaga", which describes in detail its use, so if the doctor's prescription is lost or incomprehensible, do not worry.
The medicine is taken strictly after eating, drinking a sufficiently large amount of liquid.
Adults are prescribed 50-100 mg three times a day (i.e. 1-2 capsules). The course of treatment is about 10 days. If necessary, the course is repeated after a 15-day (maximum) break.
If the drug is prescribed as a prophylaxis before surgery, then 50 mg will be enough. Take once and half an hour before the procedure.
If you forget to take a pill, then you should refrain from taking a double dose to replace the missed dose. Next appointment at regular course time.
When taking medicine, follow strictly the instructions for use of "Furamag", the price and properties do not allow uncontrolled and free therapy.
Overdose
Intoxication of the body is possible. Symptoms are observedneurotoxic nature, ataxia and tremor.
In case of an overdose, the patient should drink the maximum amount of water, be sure to take antihistamines, stopping acute symptoms.
Special instructions and interactions
To eliminate the occurrence of side effects, "Furamag" is washed down with plenty of water. Symptoms are inherent in patients who have reduced renal excretory function. If these occur, then the drug should be discontinued.
It is forbidden to drink alcohol during the entire course of therapy, as it is possible to provoke the occurrence of side effects.
To reduce the risk of hematopoiesis suppression, it is forbidden to use Furamag in parallel with ristomycin, chloramphenicol and sulfonamides. It is also worth excluding the use of drugs that can "acidify" urine (including ascorbic acid and calcium chloride).
The drug is allowed to be sold from pharmacies by prescription.
Storage conditions and expiration dates are indicated in the instructions for use of Furamag tablets. The price of the drug for 30 capsules of 50 mg is 860 rubles.
Medicine analogues
Due to the cost of the drug, many patients are interested in analogues. These include "Furagin". Both medicines contain furazidin. The difference lies in the mechanism of action, since the auxiliary components of the composition are not the same. The instructions for use of "Furamag" and its analogue are different,plan based on body weight. The price for it is from 190 to 300 rubles.
"Furadonin" also belongs to the group of nitrofurans. It is used in the treatment of the bladder. The drug is able to quickly relieve pain syndromes. Instructions for the use of Furamag tablets are a little simpler than the budget analogue, since the second one is taken taking into account the patient's weight 3 times a day. But the price of tablets is 89 rubles for 20 pieces of 50 mg. Usually prescribed for women with chronic cystitis.
Excellent antibacterial drug for diseases of the genitourinary system - "5-NOC". It is convenient to use, based on the instructions for use of the Furamagu analogue. The price is 188 rubles for 50 tablets of 50 mg. The downside of the drug is the duration of therapy from 15 to 30 days.
"Urofuragin" is an antimicrobial agent with a wide range of effects. The principle is based on a slow exchange of nucleic acid. A package with 30 tablets of 50 mg costs 265 rubles. It’s just that it’s almost impossible to meet this analogue on the medicinal windows of pharmacies.
Reviews about "Furamag"
Instructions for use, containing a detailed description of the drug, in practice coincides with the main purpose. Many patients who have experienced urological infections note an improvement in their general condition after an 8-day course of therapy. They also emphasize the effectiveness of the drug, which actively manifests itself in reducing the urge to urinate (after a few hoursafter taking the dose) and the removal of pain syndromes on the 2nd day of admission.
Very few cases confirming the occurrence of side effects that are described in the instructions for use. The price of Furamag tablets is expensive, but 1 package is usually enough for treatment, since the course of therapy is prescribed for no more than 10 days.
Some patients claim that after taking the drug for cystitis, burning and unbearable pain go away in just 10-15 minutes. And after completing the course, they forgot about the disease for several years. The main thing is to strictly follow the instructions for use. The price of "Furamag" (reviews confirm) is justified by its effectiveness.
Also, patients claim that when taking the drug, urine turns into a bright acid color, which immediately normalizes after the end of therapy. And someone even notes relief in the inflammatory process of the upper respiratory tract (prevents the spread of infection through the lymph).
But whatever symptoms appear, it is worth discussing it with your doctor to make sure that everything is within the normal range. Each patient's body is individual and can give an unpredictable reaction to any drug. And Furamag is still a remedy that belongs to antibiotics, which means that therapy should be carried out under the strict supervision of a specialist.
